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fluorouracil and Dyskeratosis Congenita, X-Linked

fluorouracil has been researched along with Dyskeratosis Congenita, X-Linked in 1 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
" To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres."1.33Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. ( Armanios, M; Feldser, DM; Greider, CW; Hao, LY; Huso, D; Karim, B; Strong, MA, 2005)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hao, LY1
Armanios, M1
Strong, MA1
Karim, B1
Feldser, DM1
Huso, D1
Greider, CW1

Other Studies

1 other study available for fluorouracil and Dyskeratosis Congenita, X-Linked

ArticleYear
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
    Cell, 2005, Dec-16, Volume: 123, Issue:6

    Topics: Animals; Anticipation, Genetic; Blood Cell Count; Bone Marrow Transplantation; Crosses, Genetic; Dys

2005