fluorouracil has been researched along with Dupuytren Contracture in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Dupuytren Contracture: A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil has been used to treat fibroproliferative disorders of the eye and skin and is thought to inhibit thymidylate synthetase blocking DNA replication." | 1.33 | 5-fluorouracil selectively inhibits collagen synthesis. ( Bulstrode, NW; Cambrey, AD; Grobbelaar, AO; McGrouther, DA; Mudera, V, 2005) |
| "Dupuytren's disease is a proliferative disease with contractile properties, prone to recur after surgery." | 1.31 | The effect of 5-fluorouracil on Dupuytren fibroblast proliferation and differentiation. ( Grobbelaar, AO; Jemec, B; Linge, C; McGrouther, DA; Sanders, R; Smith, PJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bulstrode, NW | 2 |
| Bisson, M | 1 |
| Jemec, B | 2 |
| Pratt, AL | 1 |
| McGrouther, DA | 3 |
| Grobbelaar, AO | 3 |
| Mudera, V | 1 |
| Cambrey, AD | 1 |
| Linge, C | 1 |
| Smith, PJ | 1 |
| Sanders, R | 1 |
1 trial available for fluorouracil and Dupuytren Contracture
| Article | Year |
|---|---|
A prospective randomised clinical trial of the intra-operative use of 5-fluorouracil on the outcome of dupuytren's disease.
Topics: Antimetabolites; Double-Blind Method; Dupuytren Contracture; Fluorouracil; Humans; Intraoperative Pe | 2004 |
2 other studies available for fluorouracil and Dupuytren Contracture
| Article | Year |
|---|---|
5-fluorouracil selectively inhibits collagen synthesis.
Topics: Antimetabolites; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Down-Regulation; Dupuy | 2005 |
The effect of 5-fluorouracil on Dupuytren fibroblast proliferation and differentiation.
Topics: Aged; Antimetabolites; Case-Control Studies; Cell Count; Cell Differentiation; Cell Division; Cells, | 2000 |