fluorouracil has been researched along with Drug Overdose in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors of this study reported a case of hepatotoxicity in a patient treated with capecitabine for breast cancer." | 7.80 | [Hepatotoxicity of acetaminophen in a patient treated with capecitabine due to breast cancer]. ( Drzymała, M; Golon, K; Karczmarek-Borowska, B, 2014) |
| "Uridine triacetate has been shown to be an effective antidote against mortality and toxicity caused by either overdoses or exaggerated susceptibility to the widely used anticancer agents 5-fluorouracil (5-FU) and capecitabine." | 5.48 | Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency. ( Bamat, MK; Garcia, RAG; Saydoff, JA; von Borstel, RW, 2018) |
| " The authors of this study reported a case of hepatotoxicity in a patient treated with capecitabine for breast cancer." | 3.80 | [Hepatotoxicity of acetaminophen in a patient treated with capecitabine due to breast cancer]. ( Drzymała, M; Golon, K; Karczmarek-Borowska, B, 2014) |
| "Uridine triacetate has been shown to be an effective antidote against mortality and toxicity caused by either overdoses or exaggerated susceptibility to the widely used anticancer agents 5-fluorouracil (5-FU) and capecitabine." | 1.48 | Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency. ( Bamat, MK; Garcia, RAG; Saydoff, JA; von Borstel, RW, 2018) |
| " Uridine triacetate delivers high concentrations of uridine, which competes with toxic 5-FU metabolites." | 1.46 | Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. ( Bamat, MK; Cartwright, TH; El-Rayes, BF; Fakih, MG; King, TR; Ma, WW; Posey, JA; Saif, MW; von Borstel, RW, 2017) |
| "Treatment with uridine triacetate was arranged in the emergency department." | 1.46 | The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV/AIDS with uridine triacetate. ( Geller, RJ; Morgan, BW; Santos, C, 2017) |
| "A patient with colon cancer who had received an overdose of fluorouracil was successfully treated with a five-day course of oral uridine triacetate." | 1.37 | Use of uridine triacetate for the management of fluorouracil overdose. ( McEvilly, M; Popelas, C; Tremmel, B, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (92.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shastay, A | 1 |
| Garcia, RAG | 1 |
| Saydoff, JA | 1 |
| Bamat, MK | 2 |
| von Borstel, RW | 2 |
| Karczmarek-Borowska, B | 1 |
| Drzymała, M | 1 |
| Golon, K | 1 |
| Traynor, K | 1 |
| Gilbert, RE | 1 |
| Ma, WW | 1 |
| Saif, MW | 1 |
| El-Rayes, BF | 1 |
| Fakih, MG | 1 |
| Cartwright, TH | 1 |
| Posey, JA | 1 |
| King, TR | 1 |
| Wilkinson, E | 1 |
| Santos, C | 1 |
| Morgan, BW | 1 |
| Geller, RJ | 1 |
| Green, E | 1 |
| White, R | 1 |
| Janes, K | 1 |
| Fields, A | 1 |
| Easty, A | 1 |
| McEvilly, M | 1 |
| Popelas, C | 1 |
| Tremmel, B | 1 |
| Steger, GG | 1 |
| Mader, RM | 1 |
| Gnant, MF | 1 |
| Marosi, C | 1 |
| Lenz, K | 1 |
| Jakesz, R | 1 |
13 other studies available for fluorouracil and Drug Overdose
| Article | Year |
|---|---|
Accidental Overdoses Involving Fluorouracil Infusions.
Topics: Antimetabolites, Antineoplastic; Drug Overdose; Fluorouracil; Humans; Infusions, Intravenous; Medica | 2017 |
Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency.
Topics: Acetates; Animals; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehyd | 2018 |
[Hepatotoxicity of acetaminophen in a patient treated with capecitabine due to breast cancer].
Topics: Acetaminophen; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug | 2014 |
Fluorouracil: dosing errors with infusion pumps.
Topics: Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Dosage Calculations; Drug Overdo | 2014 |
FDA approves therapy to treat overdose of fluorouracil, capecitabine.
Topics: Acetates; Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Chemistry, Pharmaceut | 2016 |
The Human Factor: Designing Safety Into Oncology Practice.
Topics: Adult; Antimetabolites, Antineoplastic; Drug Dosage Calculations; Drug Overdose; Ergonomics; Fatal O | 2016 |
In brief: uridine triacetate (Vistogard) for fluorouracil overdose.
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Drug Overdose; Fluorouracil; Humans; Treatment | 2016 |
Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity.
Topics: Acetates; Antimetabolites, Antineoplastic; Capecitabine; Drug Overdose; Female; Fluorouracil; Humans | 2017 |
An antidote to fluorouracil and capecitabine toxicity.
Topics: Acetates; Antidotes; Antineoplastic Agents; Capecitabine; Drug Costs; Drug Overdose; Fluorouracil; H | 2016 |
The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV/AIDS with uridine triacetate.
Topics: Acetates; Antimetabolites, Antineoplastic; Anus Neoplasms; Depression; Drug Overdose; Emergency Medi | 2017 |
Courage, collaboration, complexity and chemotherapy safety: the view from the sharp end.
Topics: Alberta; Antineoplastic Agents; Community Participation; Drug Overdose; Female; Fluorouracil; Humans | 2011 |
Use of uridine triacetate for the management of fluorouracil overdose.
Topics: Antiemetics; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Coloni | 2011 |
GM-CSF in the treatment of a patient with severe methotrexate intoxication.
Topics: Acute Disease; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combine | 1993 |