fluorouracil and Drug-Induced Stevens Johnson Syndrome studies

fluorouracil and Drug-Induced Stevens Johnson Syndrome

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

Excerpt	Relevance	Reference
"Capecitabine can cause severe hypersensitivity reactions which can be dangerous and life-threatening."	1.72	Capecitabine induced Steven-Johnson syndrome: A rare case report. ( Karthikeyan, K; Madhu, CS; Sameera, KV; Shaji, S; Swetha, MAC, 2022)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (25.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	1 (25.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

1 (25.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (25.00)

29.6817

2010's

1 (25.00)

24.3611

2020's

1 (25.00)

2.80

Authors

Authors	Studies
Karthikeyan, K	1
Sameera, KV	1
Shaji, S	1
Swetha, MAC	1
Madhu, CS	1
Sendur, MA	1
Kilickap, S	1
Yaffee, HS	1
Grots, I	1

Studies

Karthikeyan, K

Sameera, KV

Shaji, S

Swetha, MAC

Madhu, CS

Sendur, MA

Kilickap, S

Yaffee, HS

Grots, I

Other Studies

4 other studies available for fluorouracil and Drug-Induced Stevens Johnson Syndrome

Article	Year
Capecitabine induced Steven-Johnson syndrome: A rare case report. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:1 Topics: Aged; Antineoplastic Agents; Capecitabine; Fluorouracil; Humans; Male; Neoplasms; Stevens-Johnson Sy	2022
Capecitabine: toxic epidermal necrolysis and Stevens-Johnson syndrome. Prescrire international, 2014, Volume: 23, Issue:150 Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Hu	2014
Stevens-Johnson syndrome after treatment with capecitabine. Clinical oncology (Royal College of Radiologists (Great Britain)), 2008, Volume: 20, Issue:2 Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Middle A	2008
"Ecdysis" secondary to 5-fluorouracil. Cutis, 1980, Volume: 25, Issue:6 Topics: Aged; Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Middle Aged; Skin; Skin Neoplasms; Steven	1980

Article

Year

Capecitabine induced Steven-Johnson syndrome: A rare case report.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:1

Topics: Aged; Antineoplastic Agents; Capecitabine; Fluorouracil; Humans; Male; Neoplasms; Stevens-Johnson Sy

2022

Capecitabine: toxic epidermal necrolysis and Stevens-Johnson syndrome.

Prescrire international, 2014, Volume: 23, Issue:150

Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Hu

2014

Stevens-Johnson syndrome after treatment with capecitabine.

Clinical oncology (Royal College of Radiologists (Great Britain)), 2008, Volume: 20, Issue:2

Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Middle A

2008

"Ecdysis" secondary to 5-fluorouracil.

Cutis, 1980, Volume: 25, Issue:6

Topics: Aged; Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Middle Aged; Skin; Skin Neoplasms; Steven

1980