fluorouracil has been researched along with Disease Models, Animal in 493 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits in a prospective, randomized, double-masked and placebo-controlled fashion." | 9.06 | The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery. ( Eng, CT; Glasgow, BJ; Lee, DA; Leong, KW; Panek, WC, 1988) |
| "5-Fluorouracil (5-Fu) is a first-line drug for colorectal cancer (CRC) therapy." | 8.31 | Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells. ( Chen, A; Chen, W; Chen, Z; Dai, W; Jiang, R; Li, X; Ling, Y; Ma, Y; Ni, M; Wu, J; Yao, Q; Zhou, Y, 2023) |
| "Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have not yielded success." | 8.12 | ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer. ( Cheng, Z; Dong, S; Hu, S; Li, L; Li, S; Liang, S; Luo, L; Xu, Q; Zhang, G; Zhang, W; Zhang, X; Zhong, M; Zhu, J, 2022) |
| " Reactive oxygen species (ROS) have been reported to be involved in the induction of intestinal mucositis and diarrhea, which are common side effects of treatment with fluoropyrimidine 5-fluorouracil (5-FU)." | 8.02 | Oral administration of cystine and theanine attenuates 5-fluorouracil-induced intestinal mucositis and diarrhea by suppressing both glutathione level decrease and ROS production in the small intestine of mucositis mouse model. ( Kurihara, S; Nishikawa, S; Yoneda, J, 2021) |
| "Intestinal mucositis is a commonly encountered toxic side effect in patients undergoing 5-fluorouracil (5-FU)-based chemotherapy." | 8.02 | Amelioration of 5-fluorouracil-induced intestinal mucositis by Streptococcus thermophilus ST4 in a mouse model. ( Chen, WJ; Chu, HF; Shen, SR; Shen, TL; Wang, YR; Wu, SH, 2021) |
| "FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer." | 7.96 | Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer. ( Chang, CW; Chen, MJ; Chen, YJ; Chiang Chiau, JS; Chuang, WH; Lee, HC; Li, LH; Liu, CY; Shih, SC; Tsai, TH; Wang, HY; Wang, TE, 2020) |
| "Intestinal mucositis is the most common side effect of 5-fluorouracil (5-Fu) treatment in cancer patients." | 7.96 | Protective effect of Andrographolide on 5-Fu induced intestinal mucositis by regulating p38 MAPK signaling pathway. ( Li, M; Liu, D; Xiang, DC; Xu, YJ; Yang, JY; Zhang, CL; Zhang, S; Zhu, C, 2020) |
| "We used 90 mice of the CF-1 strain in which oral mucositis was induced using a protocol with 5-fluorouracil (5-FU) chemotherapy." | 7.96 | Cannabidiol on 5-FU-induced oral mucositis in mice. ( Borghetti, RL; Cherubini, K; Cuba, LF; de Figueiredo, MAZ; Guimarães, FS; Salum, FG, 2020) |
| "5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment." | 7.91 | Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer. ( Kim, CW; Kim, HG; Lee, DH; Lee, JS; Oh, ET; Park, HJ, 2019) |
| "5-Fluorouracil (5-FU)-induced intestinal mucositis (IM) is one of the most common oncological problem." | 7.91 | Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model. ( Ali, H; Ali, J; Islam, SU; Khan, AU; Khan, S; Kim, YS; Shah, FA, 2019) |
| "In the present study, we aimed to determine the efficacy of trabectedin (TRAB) combined with oxaliplatinum (OXA)+5-fluorouracil (5-FU) on a colorectal cancer (CRC) patient-derived orthotopic xenograft (PDOX) mouse model." | 7.91 | Combination of Trabectedin With Oxaliplatinum and 5-Fluorouracil Arrests a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. ( Bouvet, M; Han, Q; Hoffman, RM; Singh, SR; Sun, YU; Tan, Y; Ye, J; Zhao, M; Zhu, G, 2019) |
| " We sought to characterize the effects of 5 fluorouracil (5FU) chemotherapy on colon inflammation and functional measures in colorectal cancer (CRC) and to further determine whether gut microbiota can influence this response." | 7.91 | Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota. ( Bader, JE; Carson, JA; Carson, M; Chatzistamou, I; Enos, RT; Kubinak, JL; Murphy, EA; Nagarkatti, M; Pena, MM; Sougiannis, AT; VanderVeen, BN; Velazquez, KT; Walla, M, 2019) |
| "5-Fluorouracil (5-FU) remains the gold standard of first-line treatment for colorectal cancer (CRC)." | 7.91 | Establishment and Characterization of 5-Fluorouracil-Resistant Human Colorectal Cancer Stem-Like Cells: Tumor Dynamics under Selection Pressure. ( Bulanin, D; Francipane, MG; Lagasse, E, 2019) |
| "Mice body weight, food consumption, faeces consistency and the presence of blood in faeces were assessed daily during experimental mucositis induced by 5-fluorouracil (5FU)." | 7.91 | Treatment with selenium-enriched Saccharomyces cerevisiae UFMG A-905 partially ameliorates mucositis induced by 5-fluorouracil in mice. ( Almeida-Leite, CM; Alvarez-Leite, JI; Cardoso, VN; Generoso, SV; Leocádio, PCL; Martins, FS; Monteiro, CF; Nicoli, JR; Pessione, E; Porto, BAA; Santos, DA; Santos, JRA; Souza, ÉLS, 2019) |
| "Although DNA-mismatch-repair-deficient (dMMR) status and aberrant expression of miRNAs are both critically implicated in the pathogenesis of resistance to 5-fluorouracil (5-FU) in colorectal cancer (CRC), whether these two factors regulate tumor response to 5-FU in a coordinated manner remains unknown." | 7.91 | MicroRNA-552 deficiency mediates 5-fluorouracil resistance by targeting SMAD2 signaling in DNA-mismatch-repair-deficient colorectal cancer. ( Dai, ZJ; Guan, HT; Liu, D; Ma, YG; Yan, CY; Zhao, P; Zhao, Y, 2019) |
| "We investigated the role of vitamin D (Vit D) alone and in combination with 5-fluorouracil (5-FU) in thioacetamide (TAA)-induced hepatocellular carcinoma (HCC) in rats." | 7.88 | Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-β1 expression in hepatocellular carcinoma-induced in rats. ( Eissa, LA; El-Karef, A; El-Mesery, M; R Ebrahim, A, 2018) |
| "simvastatin has pleiotropic anti-inflammatory and immunomodulatory effects potentially usefull to prevent chemotherapy-induced gastrointestinal mucositis." | 7.88 | Effects of simvastatin on 5-fluorouracil-induced gastrointestinal mucositis in rats. ( Araújo Filho, I; Azevedo, ÍM; Lima, ML; Medeiros, ADC; Moreira, MD, 2018) |
| "The objective of the present study was to evaluate the effect of mulberry leaf extract (ME) fermented with Lactobacillus acidophilus A4 (A4) on intestinal mucositis induced by 5-fluorouracil (5-FU) in a rat model." | 7.85 | Mulberry leaf extract fermented with Lactobacillus acidophilus A4 ameliorates 5-fluorouracil-induced intestinal mucositis in rats. ( Kim, Y; Lee, JM; Lee, JY; Lee, KW; Oh, NS, 2017) |
| "5-Fluorouracil (5-FU) is widely used as an anti cancer drug and is known to cause severe diarrhea." | 7.85 | Active Ingredients of Hange-shashin-to, Baicalelin and 6-Gingerol, Inhibit 5-Fluorouracil-Induced Upregulation of CXCL1 in the Colon to Attenuate Diarrhea Development. ( Isa, Y; Kai, Y; Kimura, M; Miyano, K; Narita, M; Sakai, H; Sato, F; Tabata, S; Uezono, Y; Yabe, S; Yumoto, T, 2017) |
| "Here we assessed the impact of L-citrulline (CIT) on a murine model of 5-fluorouracil (5FU)-induced mucositis." | 7.83 | Pretreatment With L-Citrulline Positively Affects the Mucosal Architecture and Permeability of the Small Intestine in a Murine Mucositis Model. ( Alvarez-Leite, JI; Antunes, MM; Cara, DC; Cardoso, VN; Correia, MI; Generoso, Sde V; Leocádio, PC; Leonel, AJ; Menezes, GB; Teixeira, LG, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 7.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "Wei-Chang-An pill (WCA pill), a traditional Chinese pharmaceutical preparation, possessed potential anti-inflammatory advantages and noteworthy gastrointestinal regulations in digestive diseases, which might represent a promising candidate for the treatment of intestinal mucositis (IM) induced by 5-fluorouracil (5-FU)." | 7.83 | Protective effect and potential mechanisms of Wei-Chang-An pill on high-dose 5-fluorouracil-induced intestinal mucositis in mice. ( Chen, Y; Gao, W; Jin, Z; Wang, L; Zhang, J; Zheng, H, 2016) |
| " Furthermore and interestingly, in contrast to the currently used antiangiogenic agents, DA also prevented 5-fluorouracil (5FU) induced neutropenia in HT29 colon cancer bearing mice." | 7.81 | Dopamine is a safe antiangiogenic drug which can also prevent 5-fluorouracil induced neutropenia. ( Basu, S; Chakroborty, D; Dasgupta, PS; Sarkar, C, 2015) |
| "After intraperitoneal administration of carboplatin, each measured characteristics of bone marrow function was more significantly suppressed and the induced neutropenia was more serious in db/db mice than in the controls." | 7.81 | Myelotoxicity of carboplatin is increased in vivo in db/db mice, the animal model of obesity-associated diabetes mellitus. ( Aradi, J; Benkő, I; Géresi, K; Megyeri, A; Németh, J; Szabó, B; Szabó, Z, 2015) |
| "The purpose of our article was to explore the effect of ethosomes containing 5-fluorouracil (5-FU) with different sizes on laryngotracheal stenosis treatment." | 7.81 | A Novel Therapy for Laryngotracheal Stenosis: Treatment With Ethosomes Containing 5-Fluorouracil. ( Ao, H; Gu, J; Li, C; Mao, X; Yang, X, 2015) |
| "5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines." | 7.81 | Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015) |
| "The aim of this study was to evaluate the effect of 5-fluorouracil mobilized bone marrow regenerative cells (BMRCs) transplantation on brain injury following focal cerebral ischemia and to explore the mechanisms." | 7.81 | Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats. ( Li, M; Liao, H; Liu, XL; Xiao, LH; Xu, FF; Xu, ZP; Yang, B, 2015) |
| "To assess whether multiple low doses of 5-fluorouracil could repress myeloid derived suppressor cells in low frequency and, in turn, could enhance anti-tumor responses and promote a more prolonged survival in a murine melanoma model." | 7.81 | Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model. ( Ajami, M; Ashourpour, M; Hadjati, J; Jadidi-Niaragh, F; Mirzaei, HR; Namdar, A; Rezaei, A, 2015) |
| " We used a mouse model to examine the benefits of quercetin on CIF as measured by voluntary wheel running activity and sought to determine whether quercetin may be associated with a decrease in inflammation and/or anemia." | 7.80 | Dietary quercetin reduces chemotherapy-induced fatigue in mice. ( Davis, JM; Mahoney, SE; McClellan, JL; Murphy, EA; Pena, MM, 2014) |
| " We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model." | 7.80 | Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model. ( Aihara, M; Asakura, M; Furukita, Y; Goto, M; Harada, N; Mawatari, K; Minato, T; Nakaya, Y; Nishino, T; Seike, J; Takechi, H; Takizawa, H; Tangoku, A; Yamai, H; Yamamoto, Y; Yoshida, T; Yuasa, Y, 2014) |
| "To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-fluorouracil (5-FU) for the treatment of colorectal cancer." | 7.79 | Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil. ( Allen, TM; Anantha, M; Bally, MB; Dos Santos, N; Harasym, N; Hare, JI; Neijzen, RW; Waterhouse, DN; Webb, MS, 2013) |
| "Although 5-fluorouracil (5-FU) is a widely used as chemotherapy agent, severe mucositis develops in approximately 80% of patients." | 7.79 | Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. ( Arakawa, K; Horie, S; Kato, S; Matsumoto, K; Nakajima, T; Narita, M; Sagara, A; Sakai, H; Tashima, K, 2013) |
| " Body weight loss results, diarrhea scores, and villi measurements showed that minocycline attenuated the severity of intestinal mucositis induced by 5-fluorouracil (5-FU)." | 7.75 | Minocycline attenuates 5-fluorouracil-induced small intestinal mucositis in mouse model. ( Chao, YC; Chu, HC; Ho, WH; Hou, HS; Huang, TY; Liao, CL; Lin, YL, 2009) |
| "To observe the effect of 5-fluorouracil (5-FU) on modulation of the disorders of proinflammatory and anti-inflammatory cytokines in the severe sepsis as a result of intra-abdominal infection in rat, and to investigate the mechanism of efficacy of 5-FU in the treatment of severe sepsis." | 7.74 | [Effect of 5-fluorouracil on modulation of immunity-associated cytokine during severe sepsis in rat]. ( Chen, XL; Lu, LJ; Xu, N, 2008) |
| "The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited high antitumor activity against human colorectal cancer xenografts." | 7.74 | Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil. ( Hamaguchi, T; Kano, Y; Kato, K; Koizumi, F; Matsumura, Y; Nakajima, TE; Shimada, Y; Shirao, K; Yamada, Y; Yasunaga, M, 2008) |
| "The aim of this study was to investigate the influence of low dosage (131)I-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody C50 ((131)I-C50) on tumor growth and the therapeutic efficacy of combination of low dosage (131)I-C50 with chemotherapy using 5-fluorouracil (5-FU) on human colorectal cancer xenografts in nude mice." | 7.72 | [Influence of combination of low dosage 131I-labeled anti-carcinoembryonic antigen antibody C50 and 5-fluorouracil on tumor growth of colorectal cancer xenografts in nude mice]. ( Cai, SR; He, YL; Lin, ZJ; Zhan, WH; Zheng, CX, 2003) |
| "Preclinical in vitro and in vivo studies have demonstrated synergistic interactions between 5-fluorouracil (5-FU) and type I and II IFNs against human colorectal cancer cells." | 7.72 | Combined 5-fluorouracil/systemic interferon-beta gene therapy results in long-term survival in mice with established colorectal liver metastases. ( Barsoum, J; Choi, EA; Fraker, DL; Lei, H; Maron, DJ; Mick, R; Spitz, FR; Wilson, JM; Yu, QC, 2004) |
| "To determine the potential of an intravitreal sustained release naproxen and 5-fluorouracil (NA/5-FU) codrug for the treatment of experimental proliferative vitreoretinopathy (PVR) in a model for trauma associated tractional retinal detachment (TRD)." | 7.72 | An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy. ( Ashton, P; Cardillo, JA; Costa, RA; Farah, ME; Jorge, R; Kuppermann, B; Melo, LA; Mitre, J; Morales, PH, 2004) |
| "Docetaxel and capecitabine are being prescribed for the treatment of breast cancer." | 7.71 | Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models. ( Fujimoto-Ouchi, K; Tanaka, Y; Tominaga, T, 2001) |
| "To determine the efficacy and pharmacokinetics of an intravitreal sustained-release triamcinolone acetonide and 5-fluorouracil (TA/5-FU) codrug in the treatment of experimental proliferative vitreoretinopathy (PVR)." | 7.70 | An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. ( Ashton, P; Chen, SN; Guo, H; Hainsworth, DP; Jaffe, GJ; Khawly, JA; Yang, CS, 1998) |
| "Unfortunately, complexity in treating cachexia is amplified by both the underlying malignancy and the anti-cancer therapy which can independently promote cachexia." | 5.72 | Quercetin Improved Muscle Mass and Mitochondrial Content in a Murine Model of Cancer and Chemotherapy-Induced Cachexia. ( Bullard, BM; Cardaci, TD; Cunningham, P; Fan, D; McDonald, SJ; Murphy, EA; VanderVeen, BN; Velázquez, KT, 2022) |
| "Fatty liver is a side effect of chemotherapy that limits the ability to treat colorectal cancer (CRC) patients in the most effective way." | 5.62 | Alterations in hepatic fatty acids reveal depletion of total polyunsaturated fatty acids following irinotecan plus 5-fluorouracil treatment in an animal model of colorectal cancer. ( Bathe, O; Jacobs, R; Mazurak, VC; Monirujjaman, M; Nelson, R; Pant, A, 2021) |
| "Intestinal mucositis is a common side effect of chemotherapy and radiotherapy." | 5.62 | TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2. ( Deng, S; Li, J; Li, L; Wu, D; Xu, Y, 2021) |
| "5-Fluorouracil (5-FU) is a chemotherapeutic drug with a good anti-cancer effect on various types of cancers, such as colorectal cancer and breast cancer." | 5.62 | Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice. ( Abulizi, A; An, Y; Huang, Z; Li, M; Lin, D; Lin, S; Lin, Z; Ran, J; Wang, L; Yang, B; Ye, Y; Zhang, Y; Zhou, H, 2021) |
| "Mucositis was induced by intraperitoneal injection (300 mg/kg) of 5-fluorouracil (5-FU)." | 5.62 | Prophylactic and therapeutic supplementation using fructo-oligosaccharide improves the intestinal homeostasis after mucositis induced by 5- fluorouracil. ( Alvarez-Leite, JI; Andrade, MER; Cardoso, VN; Carvalho, PLA; Cassali, GD; Dos Reis, DC; Dos Santos Martins, F; Fernandes, SOA; Generoso, SV; Gouveia Peluzio, MDC; Leocádio, PCL; Souza E Melo, ÉLS; Trindade, LM, 2021) |
| "5-Fluorouracil (5-FU) is a chemotherapy agent that is widely used in clinical oncologic practice." | 5.62 | Anti-inflammatory effects of Radix Aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice. ( Chang, CW; Chen, YJ; Hsieh, CH; Liu, CY; Liu, JH; Tsai, TH, 2021) |
| "Glycine has been shown to protect livers from CTx-induced injury and oxidative stress, and it reduces platelet aggregation and improves microperfusion." | 5.56 | Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats. ( Bausys, A; Feldbacher, N; Hoefler, G; Kolb-Lenz, D; Leber, B; Maneikyte, J; Schemmer, P; Stiegler, P; Strupas, K, 2020) |
| "Zinc sulfate has a beneficial role, decreasing the severity of gut mucosal injuries induced by 5-FU in Wistar rats." | 5.56 | Beneficial effect of oral administration of zinc sulfate on 5-fluorouracil-induced gastrointestinal mucositis in rats. ( Berce, C; Ciobanu, L; Meșter, A; Onica, S; Tanțău, M; Taulescu, M; Tefas, C; Toma, C, 2020) |
| "Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU." | 5.48 | Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model. ( Alvarez Leite, JI; Antunes Fernandes, SO; Cardoso, VN; Cassali, GD; da Gama, MAS; de Barros, PAV; de Sales E Souza, ÉL; de Vasconcelos Generoso, S; Dos Reis, DC; Dos Santos Martins, F; Lacerda Leocádio, PC; Mendes Miranda, SE; Rabelo Andrade, ME, 2018) |
| "Mucositis was induced by daily injections of 5-fluororacil (5-FU) after which mice were either given L." | 5.48 | Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice. ( de Moreno de LeBlanc, A; LeBlanc, JG; Levit, R; Savoy de Giori, G, 2018) |
| "Crocin was able to ameliorate the severe inflammation with mucosal ulcers and high-grade dysplastic crypts as detected by inflammation score, crypt loss, pathological changes and histology scores." | 5.48 | Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer. ( Amerizadeh, F; Avan, A; Boroumand, N; Ferns, GA; Fiuji, H; Ghayour-Mobarhan, M; Hassanian, SM; Khazaei, M; Moradi-Marjaneh, R; Nosrati-Tirkani, A; Rahmani, F; Rezaei, N, 2018) |
| "Chemotherapy-associated steatohepatitis is attracting increasing attention because it heralds an increased risk of morbidity and mortality in patients undergoing surgery because of liver metastases." | 5.46 | Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice. ( Bosserhoff, AK; Freese, K; Hellerbrand, C; Kuecuekoktay, FS; Mahli, A; Müller, M; Schiergens, TS; Sommer, J; Teufel, A; Thasler, WE, 2017) |
| "Cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) possess tumor-initiating, metastatic, and drug resistance properties." | 5.43 | Comparative study of the effects of PEGylated interferon-α2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma. ( El-Boghdady, NA; El-Sayed, AM; Helmy, HS; Motawi, TK, 2016) |
| "Thus, magnetic 5-FU-IP is promising for breast cancer therapy with high efficacy." | 5.43 | Evaluation of magnetic nanoparticles coated by 5-fluorouracil imprinted polymer for controlled drug delivery in mouse breast cancer model. ( Hashemi-Moghaddam, H; Jamili, M; Kazemi-Bagsangani, S; Zavareh, S, 2016) |
| "Intestinal mucositis is one of the major troublesome side effects of anticancer chemotherapy leading to poor patient compliance." | 5.38 | Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. ( Araújo, CV; Azevedo, OG; Costa, TB; Guerrant, RL; Lima, AÂ; Lima, RC; Lucena, HB; Oliveira, BC; Oliveira, RA; Oriá, RB; Ribeiro, RA; Vitek, MP; Warren, CA; Wong, DV; Zaja-Milatovic, S, 2012) |
| " The paper aims to study whether mood disorder alters drug metabolism process through the pharmacokinetic research on some clinically important anticancer drugs in depression model rats." | 5.38 | Pharmacokinetics of 5-fluorouracil and cyclophosphamide in depression rats. ( Chen, X; Duan, JJ; Wang, Y; Wen, YG; Xu, F; Zhou, T, 2012) |
| " We also observed bioavailability of ursolic acid in the serum and tissue of animals." | 5.38 | Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. ( Aggarwal, BB; Baladandayuthapani, V; Deorukhkar, A; Diagaradjane, P; Guha, S; Kannappan, R; Krishnan, S; Prasad, S; Reuter, S; Sung, B; Wei, C; Yadav, VR, 2012) |
| "Intestinal mucositis is a common and debilitating side-effect of chemotherapy, associated with severe small intestinal inflammation." | 5.35 | Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis. ( Butler, RN; Geier, MS; Howarth, GS; Smith, CL; Tooley, KL; Torres, DM, 2008) |
| "Previously published work has demonstrated that combining gemcitabine with irreversible electroporation (IRE) results in increased drug delivery to pancreatic adenocarcinoma cells in vivo." | 5.34 | Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma. ( Bhutiani, N; Chen, Y; Li, Y; Martin, RCG; Pandit, H; Pulliam, ZR; Shi, X; Tan, M; Yu, Y; Zheng, Q, 2020) |
| "Microsatellite instability is a recognised pathway of colorectal carcinogenesis responsible for about 15% of all sporadic colorectal cancers." | 5.33 | 5-fluorouracil (5FU) treatment does not influence invasion and metastasis in microsatellite unstable (MSI-H) colorectal cancer. ( Kaufman, A; Ramanathan, P; Robinson, BG; Schnitzler, M; Warusavitarne, J, 2006) |
| "5-fluorouracil (5-FU) has been combined in the past with other drugs for the combination chemotherapy for cancers of the breast, ovary, and colon." | 5.32 | Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms. ( Akbulut, H; Deisseroth, A; Maynard, J; Pizzorno, G; Tang, Y; Zhang, L, 2004) |
| "A study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits in a prospective, randomized, double-masked and placebo-controlled fashion." | 5.06 | The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery. ( Eng, CT; Glasgow, BJ; Lee, DA; Leong, KW; Panek, WC, 1988) |
| " For those epothilones that have gone on to clinical development (epothilone B, ixabepilone, BMS-310705, ZK-EPO, KOS-862, and KOS-1584), preclinical investigations in breast cancer models are reviewed." | 4.84 | Preclinical investigations with epothilones in breast cancer models. ( Burris, HA, 2008) |
| "5-Fluorouracil (5-Fu) is a first-line drug for colorectal cancer (CRC) therapy." | 4.31 | Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells. ( Chen, A; Chen, W; Chen, Z; Dai, W; Jiang, R; Li, X; Ling, Y; Ma, Y; Ni, M; Wu, J; Yao, Q; Zhou, Y, 2023) |
| "Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have not yielded success." | 4.12 | ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer. ( Cheng, Z; Dong, S; Hu, S; Li, L; Li, S; Liang, S; Luo, L; Xu, Q; Zhang, G; Zhang, W; Zhang, X; Zhong, M; Zhu, J, 2022) |
| " Reactive oxygen species (ROS) have been reported to be involved in the induction of intestinal mucositis and diarrhea, which are common side effects of treatment with fluoropyrimidine 5-fluorouracil (5-FU)." | 4.02 | Oral administration of cystine and theanine attenuates 5-fluorouracil-induced intestinal mucositis and diarrhea by suppressing both glutathione level decrease and ROS production in the small intestine of mucositis mouse model. ( Kurihara, S; Nishikawa, S; Yoneda, J, 2021) |
| "To evaluate a mixture of selected lactic acid bacteria (LAB) (a riboflavin-producer, a folate-producer and an immunomodulatory strain) as co-adjuvant for 5-fluorouracil (5-FU) chemotherapy in cell culture and using a 4T1 cell animal model of breast cancer." | 4.02 | Evaluation of vitamin-producing and immunomodulatory lactic acid bacteria as a potential co-adjuvant for cancer therapy in a mouse model. ( de Moreno de LeBlanc, A; LeBlanc, JG; Levit, R; Savoy de Giori, G, 2021) |
| "FOLFOX is a combinational regimen of folinic acid (FnA, FOL), fluorouracil (5-Fu, F) and oxaliplatin (OxP, OX), and has been long considered as the standard treatment of colorectal cancer (CRC) and hepatocellular carcinoma (HCC)." | 4.02 | Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma. ( Guo, J; Huang, L; Liu, Y; Sun, D; Yu, Z; Zou, Y, 2021) |
| " Loading of oxaliplatin (Ox) and 5-Fluorouracil (5-FU) into the thermogel were able to significantly decreased peritoneal carcinomatosis index (PCI) (-58%) and ascites (-70%) in a murine model of peritoneal metastases." | 4.02 | Combination of tumor cell anti-adhesion and anti-tumor effect to prevent recurrence after cytoreductive surgery in a mice model. ( Al Sabbagh, C; Boudy, V; Mignet, N; Pimpie, C; Pocard, M; Roy, P; Seguin, J, 2021) |
| "Intestinal mucositis is a commonly encountered toxic side effect in patients undergoing 5-fluorouracil (5-FU)-based chemotherapy." | 4.02 | Amelioration of 5-fluorouracil-induced intestinal mucositis by Streptococcus thermophilus ST4 in a mouse model. ( Chen, WJ; Chu, HF; Shen, SR; Shen, TL; Wang, YR; Wu, SH, 2021) |
| "Although first-line chemotherapy drugs, including 5-fluorouracil (5-FU), remain one of the major choice for cancer treatment, the clinical use is also accompanied with dose-depending toxicities, such as intestinal mucositis (IM), in cancer patients undergoing treatment." | 4.02 | RNA-seq and ( Cai, BY; Lu, Y; Wang, XY; Wang, YJ; Xu, L; Yao, QH; Zhang, B, 2021) |
| "FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer." | 3.96 | Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer. ( Chang, CW; Chen, MJ; Chen, YJ; Chiang Chiau, JS; Chuang, WH; Lee, HC; Li, LH; Liu, CY; Shih, SC; Tsai, TH; Wang, HY; Wang, TE, 2020) |
| "Intestinal mucositis is the most common side effect of 5-fluorouracil (5-Fu) treatment in cancer patients." | 3.96 | Protective effect of Andrographolide on 5-Fu induced intestinal mucositis by regulating p38 MAPK signaling pathway. ( Li, M; Liu, D; Xiang, DC; Xu, YJ; Yang, JY; Zhang, CL; Zhang, S; Zhu, C, 2020) |
| "We used 90 mice of the CF-1 strain in which oral mucositis was induced using a protocol with 5-fluorouracil (5-FU) chemotherapy." | 3.96 | Cannabidiol on 5-FU-induced oral mucositis in mice. ( Borghetti, RL; Cherubini, K; Cuba, LF; de Figueiredo, MAZ; Guimarães, FS; Salum, FG, 2020) |
| "5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment." | 3.91 | Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer. ( Kim, CW; Kim, HG; Lee, DH; Lee, JS; Oh, ET; Park, HJ, 2019) |
| "These findings suggest that the combination of 5-FU and cefepime exacerbates early-onset convulsive seizures and elicits delayed-onset convulsive status epilepticus." | 3.91 | 5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice. ( Aso, H; Suemaru, K; Watanabe, M; Yoshikawa, M, 2019) |
| "5-Fluorouracil (5-FU)-induced intestinal mucositis (IM) is one of the most common oncological problem." | 3.91 | Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model. ( Ali, H; Ali, J; Islam, SU; Khan, AU; Khan, S; Kim, YS; Shah, FA, 2019) |
| "In the present study, we aimed to determine the efficacy of trabectedin (TRAB) combined with oxaliplatinum (OXA)+5-fluorouracil (5-FU) on a colorectal cancer (CRC) patient-derived orthotopic xenograft (PDOX) mouse model." | 3.91 | Combination of Trabectedin With Oxaliplatinum and 5-Fluorouracil Arrests a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model. ( Bouvet, M; Han, Q; Hoffman, RM; Singh, SR; Sun, YU; Tan, Y; Ye, J; Zhao, M; Zhu, G, 2019) |
| " We sought to characterize the effects of 5 fluorouracil (5FU) chemotherapy on colon inflammation and functional measures in colorectal cancer (CRC) and to further determine whether gut microbiota can influence this response." | 3.91 | Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota. ( Bader, JE; Carson, JA; Carson, M; Chatzistamou, I; Enos, RT; Kubinak, JL; Murphy, EA; Nagarkatti, M; Pena, MM; Sougiannis, AT; VanderVeen, BN; Velazquez, KT; Walla, M, 2019) |
| "5-Fluorouracil (5-FU) remains the gold standard of first-line treatment for colorectal cancer (CRC)." | 3.91 | Establishment and Characterization of 5-Fluorouracil-Resistant Human Colorectal Cancer Stem-Like Cells: Tumor Dynamics under Selection Pressure. ( Bulanin, D; Francipane, MG; Lagasse, E, 2019) |
| "Mice body weight, food consumption, faeces consistency and the presence of blood in faeces were assessed daily during experimental mucositis induced by 5-fluorouracil (5FU)." | 3.91 | Treatment with selenium-enriched Saccharomyces cerevisiae UFMG A-905 partially ameliorates mucositis induced by 5-fluorouracil in mice. ( Almeida-Leite, CM; Alvarez-Leite, JI; Cardoso, VN; Generoso, SV; Leocádio, PCL; Martins, FS; Monteiro, CF; Nicoli, JR; Pessione, E; Porto, BAA; Santos, DA; Santos, JRA; Souza, ÉLS, 2019) |
| "Although DNA-mismatch-repair-deficient (dMMR) status and aberrant expression of miRNAs are both critically implicated in the pathogenesis of resistance to 5-fluorouracil (5-FU) in colorectal cancer (CRC), whether these two factors regulate tumor response to 5-FU in a coordinated manner remains unknown." | 3.91 | MicroRNA-552 deficiency mediates 5-fluorouracil resistance by targeting SMAD2 signaling in DNA-mismatch-repair-deficient colorectal cancer. ( Dai, ZJ; Guan, HT; Liu, D; Ma, YG; Yan, CY; Zhao, P; Zhao, Y, 2019) |
| "We investigated the role of vitamin D (Vit D) alone and in combination with 5-fluorouracil (5-FU) in thioacetamide (TAA)-induced hepatocellular carcinoma (HCC) in rats." | 3.88 | Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-β1 expression in hepatocellular carcinoma-induced in rats. ( Eissa, LA; El-Karef, A; El-Mesery, M; R Ebrahim, A, 2018) |
| "simvastatin has pleiotropic anti-inflammatory and immunomodulatory effects potentially usefull to prevent chemotherapy-induced gastrointestinal mucositis." | 3.88 | Effects of simvastatin on 5-fluorouracil-induced gastrointestinal mucositis in rats. ( Araújo Filho, I; Azevedo, ÍM; Lima, ML; Medeiros, ADC; Moreira, MD, 2018) |
| "The objective of the present study was to evaluate the effect of mulberry leaf extract (ME) fermented with Lactobacillus acidophilus A4 (A4) on intestinal mucositis induced by 5-fluorouracil (5-FU) in a rat model." | 3.85 | Mulberry leaf extract fermented with Lactobacillus acidophilus A4 ameliorates 5-fluorouracil-induced intestinal mucositis in rats. ( Kim, Y; Lee, JM; Lee, JY; Lee, KW; Oh, NS, 2017) |
| "5-Fluorouracil (5-FU) is widely used as an anti cancer drug and is known to cause severe diarrhea." | 3.85 | Active Ingredients of Hange-shashin-to, Baicalelin and 6-Gingerol, Inhibit 5-Fluorouracil-Induced Upregulation of CXCL1 in the Colon to Attenuate Diarrhea Development. ( Isa, Y; Kai, Y; Kimura, M; Miyano, K; Narita, M; Sakai, H; Sato, F; Tabata, S; Uezono, Y; Yabe, S; Yumoto, T, 2017) |
| "Here we assessed the impact of L-citrulline (CIT) on a murine model of 5-fluorouracil (5FU)-induced mucositis." | 3.83 | Pretreatment With L-Citrulline Positively Affects the Mucosal Architecture and Permeability of the Small Intestine in a Murine Mucositis Model. ( Alvarez-Leite, JI; Antunes, MM; Cara, DC; Cardoso, VN; Correia, MI; Generoso, Sde V; Leocádio, PC; Leonel, AJ; Menezes, GB; Teixeira, LG, 2016) |
| " In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats." | 3.83 | Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016) |
| "Wei-Chang-An pill (WCA pill), a traditional Chinese pharmaceutical preparation, possessed potential anti-inflammatory advantages and noteworthy gastrointestinal regulations in digestive diseases, which might represent a promising candidate for the treatment of intestinal mucositis (IM) induced by 5-fluorouracil (5-FU)." | 3.83 | Protective effect and potential mechanisms of Wei-Chang-An pill on high-dose 5-fluorouracil-induced intestinal mucositis in mice. ( Chen, Y; Gao, W; Jin, Z; Wang, L; Zhang, J; Zheng, H, 2016) |
| " Chemotherapy-induced mouse model of intestinal mucositis was prepared by a single injection of the chemotherapeutic agent 5-fluorouracil (5-FU)." | 3.81 | The chemokine CXCL9 exacerbates chemotherapy-induced acute intestinal damage through inhibition of mucosal restitution. ( Han, L; Han, W; Liu, H; Lu, H; Moldenhauer, A; Qian, L; Shen, J; Sun, T; Wang, J; Weng, S; Wu, M; Yu, Y; Zhu, J; Zhu, S, 2015) |
| " Furthermore and interestingly, in contrast to the currently used antiangiogenic agents, DA also prevented 5-fluorouracil (5FU) induced neutropenia in HT29 colon cancer bearing mice." | 3.81 | Dopamine is a safe antiangiogenic drug which can also prevent 5-fluorouracil induced neutropenia. ( Basu, S; Chakroborty, D; Dasgupta, PS; Sarkar, C, 2015) |
| "After intraperitoneal administration of carboplatin, each measured characteristics of bone marrow function was more significantly suppressed and the induced neutropenia was more serious in db/db mice than in the controls." | 3.81 | Myelotoxicity of carboplatin is increased in vivo in db/db mice, the animal model of obesity-associated diabetes mellitus. ( Aradi, J; Benkő, I; Géresi, K; Megyeri, A; Németh, J; Szabó, B; Szabó, Z, 2015) |
| "The purpose of our article was to explore the effect of ethosomes containing 5-fluorouracil (5-FU) with different sizes on laryngotracheal stenosis treatment." | 3.81 | A Novel Therapy for Laryngotracheal Stenosis: Treatment With Ethosomes Containing 5-Fluorouracil. ( Ao, H; Gu, J; Li, C; Mao, X; Yang, X, 2015) |
| "5-Fluorouracil (5-FU)-induced intestinal mucositis is one of the most common morbidities in chemotherapy and involves the reactive oxygen species (ROS) system, apoptosis, and inflammatory cytokines." | 3.81 | Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model. ( Han, SH; Kim, HJ; Kim, JH; Lee, JH; Moon, W; Park, J; Park, SJ; Song, GA, 2015) |
| "The aim of this study was to evaluate the effect of 5-fluorouracil mobilized bone marrow regenerative cells (BMRCs) transplantation on brain injury following focal cerebral ischemia and to explore the mechanisms." | 3.81 | Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats. ( Li, M; Liao, H; Liu, XL; Xiao, LH; Xu, FF; Xu, ZP; Yang, B, 2015) |
| "To assess whether multiple low doses of 5-fluorouracil could repress myeloid derived suppressor cells in low frequency and, in turn, could enhance anti-tumor responses and promote a more prolonged survival in a murine melanoma model." | 3.81 | Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model. ( Ajami, M; Ashourpour, M; Hadjati, J; Jadidi-Niaragh, F; Mirzaei, HR; Namdar, A; Rezaei, A, 2015) |
| "The aim of the present study was to compare the effectiveness of four different laser wavelengths (660, 810, 980, and 1,064 nm) used for low-level laser therapy (LLLT) on the healing of mucositis in an animal model of wound healing by investigating the expression of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), and blood-derived fibroblast growth factor (bFGF)." | 3.80 | Effects of laser irradiation at different wavelengths (660, 810, 980, and 1,064 nm) on mucositis in an animal model of wound healing. ( Aras, MH; Cengiz, B; Demir, T; Gutknecht, N; Oztuzcu, S; Usumez, A, 2014) |
| " We tested whether SGLT-1 engagement might protect the intestinal mucosa from doxorubicin (DXR)- and 5-fluorouracil (5-FU)-induced injury in animal models mimicking acute or chronic mucositis." | 3.80 | Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis. ( Balsari, A; Cardani, D; D'Orazio, G; Koepsell, H; La Ferla, B; Marcucci, F; Nicotra, F; Olivero, D; Rumio, C; Sardi, C; Sommariva, M; Tagliabue, E, 2014) |
| " We used a mouse model to examine the benefits of quercetin on CIF as measured by voluntary wheel running activity and sought to determine whether quercetin may be associated with a decrease in inflammation and/or anemia." | 3.80 | Dietary quercetin reduces chemotherapy-induced fatigue in mice. ( Davis, JM; Mahoney, SE; McClellan, JL; Murphy, EA; Pena, MM, 2014) |
| " We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model." | 3.80 | Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model. ( Aihara, M; Asakura, M; Furukita, Y; Goto, M; Harada, N; Mawatari, K; Minato, T; Nakaya, Y; Nishino, T; Seike, J; Takechi, H; Takizawa, H; Tangoku, A; Yamai, H; Yamamoto, Y; Yoshida, T; Yuasa, Y, 2014) |
| "To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-fluorouracil (5-FU) for the treatment of colorectal cancer." | 3.79 | Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil. ( Allen, TM; Anantha, M; Bally, MB; Dos Santos, N; Harasym, N; Hare, JI; Neijzen, RW; Waterhouse, DN; Webb, MS, 2013) |
| "Although 5-fluorouracil (5-FU) is a widely used as chemotherapy agent, severe mucositis develops in approximately 80% of patients." | 3.79 | Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. ( Arakawa, K; Horie, S; Kato, S; Matsumoto, K; Nakajima, T; Narita, M; Sagara, A; Sakai, H; Tashima, K, 2013) |
| "We examined the efficacy of chemoendocrine therapy using capecitabine as a chemotherapeutic agent in premenopausal and postmenopausal models with estrogen receptor (ER)-positive human breast cancer xenografts." | 3.78 | Antitumor activity of chemoendocrine therapy in premenopausal and postmenopausal models with human breast cancer xenografts. ( Evans, DB; Hayashi, S; Kataoka, M; Kondoh, K; Mori, K; Moriya, Y; Sawada, N; Yamaguchi, Y; Yasuno, H, 2012) |
| " An in-vitro comparison of swelling, degradation and permeability of the free films was carried out in simulated colon fluids containing caecal contents from normal rats with colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) or oxazolone." | 3.75 | Pectin/Kollicoat SR30D isolated films for colonic delivery [I]: a comparison of normal and colitis-induced models to assess the efficiency of microbially triggered drug delivery. ( Bai, X; De-Ying, C; Feng, W; Li-Fang, F; Min, B; Min, Q; Qing, D; Wei, H; Yong-Zhen, C, 2009) |
| " Body weight loss results, diarrhea scores, and villi measurements showed that minocycline attenuated the severity of intestinal mucositis induced by 5-fluorouracil (5-FU)." | 3.75 | Minocycline attenuates 5-fluorouracil-induced small intestinal mucositis in mouse model. ( Chao, YC; Chu, HC; Ho, WH; Hou, HS; Huang, TY; Liao, CL; Lin, YL, 2009) |
| "To observe the effect of 5-fluorouracil (5-FU) on modulation of the disorders of proinflammatory and anti-inflammatory cytokines in the severe sepsis as a result of intra-abdominal infection in rat, and to investigate the mechanism of efficacy of 5-FU in the treatment of severe sepsis." | 3.74 | [Effect of 5-fluorouracil on modulation of immunity-associated cytokine during severe sepsis in rat]. ( Chen, XL; Lu, LJ; Xu, N, 2008) |
| "The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited high antitumor activity against human colorectal cancer xenografts." | 3.74 | Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil. ( Hamaguchi, T; Kano, Y; Kato, K; Koizumi, F; Matsumura, Y; Nakajima, TE; Shimada, Y; Shirao, K; Yamada, Y; Yasunaga, M, 2008) |
| "The mean patency of tympanic membrane perforations following incisional myringotomy was significantly longer in the 5-fluorouracil-treated group (11." | 3.73 | [The effect of topical application of 5-fluorouracil on patency times after incisional myringotomy of guinea pig tympanic membrane]. ( Ateş, G; Aydin, S; Bozkurt, Z; Eken, M; Evren, C; Sanli, A, 2006) |
| "The aim of this study was to investigate the influence of low dosage (131)I-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody C50 ((131)I-C50) on tumor growth and the therapeutic efficacy of combination of low dosage (131)I-C50 with chemotherapy using 5-fluorouracil (5-FU) on human colorectal cancer xenografts in nude mice." | 3.72 | [Influence of combination of low dosage 131I-labeled anti-carcinoembryonic antigen antibody C50 and 5-fluorouracil on tumor growth of colorectal cancer xenografts in nude mice]. ( Cai, SR; He, YL; Lin, ZJ; Zhan, WH; Zheng, CX, 2003) |
| "Hepatic intra-arterial infusion chemotherapy of 5-fluorouracil (5-FU) or fluorodeoxyuridine (FUDR) has been a treatment option for liver metastasis from colorectal cancer." | 3.72 | Pharmacokinetics of 5-fluorouracil following hepatic intra-arterial infusion in a VX2 hepatic metastasis model. ( Ishikawa, K; Makuuchi, H; Masuda, T; Murayama, C; Nakamura, T; Sadahiro, S; Suzuki, T; Tanaka, Y; Yasuda, S, 2003) |
| "The regional administration of 5-fluorouracil (5-FU) has been the fundamental therapy against liver metastases for the improvement of patient prognosis; however, there have been few reports about the immunological effects of this agent." | 3.72 | Antitumor effect of a splenic injection of 5-fluorouracil on metastatic liver cancer in mice. ( Asao, T; Kanoh, K; Kuwano, H; Nomoto, K; Shimura, T; Suzuki, H, 2004) |
| "Preclinical in vitro and in vivo studies have demonstrated synergistic interactions between 5-fluorouracil (5-FU) and type I and II IFNs against human colorectal cancer cells." | 3.72 | Combined 5-fluorouracil/systemic interferon-beta gene therapy results in long-term survival in mice with established colorectal liver metastases. ( Barsoum, J; Choi, EA; Fraker, DL; Lei, H; Maron, DJ; Mick, R; Spitz, FR; Wilson, JM; Yu, QC, 2004) |
| "To determine the potential of an intravitreal sustained release naproxen and 5-fluorouracil (NA/5-FU) codrug for the treatment of experimental proliferative vitreoretinopathy (PVR) in a model for trauma associated tractional retinal detachment (TRD)." | 3.72 | An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy. ( Ashton, P; Cardillo, JA; Costa, RA; Farah, ME; Jorge, R; Kuppermann, B; Melo, LA; Mitre, J; Morales, PH, 2004) |
| "Docetaxel and capecitabine are being prescribed for the treatment of breast cancer." | 3.71 | Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models. ( Fujimoto-Ouchi, K; Tanaka, Y; Tominaga, T, 2001) |
| "To determine the efficacy and pharmacokinetics of an intravitreal sustained-release triamcinolone acetonide and 5-fluorouracil (TA/5-FU) codrug in the treatment of experimental proliferative vitreoretinopathy (PVR)." | 3.70 | An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. ( Ashton, P; Chen, SN; Guo, H; Hainsworth, DP; Jaffe, GJ; Khawly, JA; Yang, CS, 1998) |
| "In an effort to improve the therapeutic selectivity of 5-fluorouracil (FUra) against colorectal cancer, S-1, a combination agent including a prodrug of FUra with two modulators, was recently developed by Taiho Pharmaceuticals Co." | 3.70 | Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model. ( Cao, S; Lu, K; Rustum, YM; Shirasaka, T; Slocum, HK; Tóth, K, 1999) |
| "To test the efficacy of a biodegradable device for the intravitreal sustained release of fluorouracil in the treatment of tractional retinal detachment due to proliferative vitreoretinopathy." | 3.69 | Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. ( Cousins, SW; Davis, PA; Hernandez, E; O'Grady, GE; Rubsamen, PE, 1994) |
| "Administration of subconjunctival 5-fluorouracil (5-FU) and topical mitomycin-C (MMC) has been shown to improve the success rate of glaucoma-filtering surgery." | 3.69 | A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies. ( Akata, RF; Gökçe, M; Kiremitçi-Gümüşderelioglu, M, 1996) |
| "Rabbits undergoing full-thickness glaucoma filtering surgery were exposed for 5 minutes to one of three intraoperative treatments: (1) distilled water; (2) fluorouracil, 50 mg/mL; or (3) mitomycin C, 0." | 3.68 | Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C. ( Doyle, JW; Grierson, I; Khaw, PT; McGorray, S; Schultz, G; Sherwood, MB, 1993) |
| "The rate of retinal detachment in fellow control eyes of rabbits following fibroblast administration is progressively lower with increased dose of 5-Fluorouracil in the test eyes." | 3.68 | Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil. ( Ophir, A, 1991) |
| "Fluorouracil effectively inhibits epiretinal membrane formation and traction retinal detachment after vitrectomy surgery." | 3.66 | Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy. ( Anderson, DH; Erickson, PA; Fisher, SK; Guerin, CJ; Lewis, GP; O'Donnell, JJ; Stern, WH, 1983) |
| " It has been found that maternal administration of hydroxyurea, mitomycin C, or 5-fluorouracil on day 9 of pregnancy, that is, when the fetal neural tube is in the final stages of closure, leads to a significant reduction in the proportion of NTD (to 15 to 20%) in the offspring, while total litter size is unaffected." | 3.66 | The cause of neural tube defects: some experiments and a hypothesis. ( Seller, MJ, 1983) |
| "Celecoxib was administered as 400 mg, twice daily starting on day 2 of cycle 1." | 2.73 | Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil. ( Cao, S; Creaven, PJ; Durrani, FA; Iyer, RV; Javle, MM; Lawrence, DD; Noel, DC; Pendyala, L; Rustum, YM; Smith, PF, 2007) |
| "5-Fluorouracil (5-FU) is an anticancer drug widely used to treat many cancers in the human body." | 2.61 | Dihydropyrimidine dehydrogenase in the metabolism of the anticancer drugs. ( Gupta, SK; Sharma, V; Verma, M, 2019) |
| "Chemotherapy-induced diarrhea (CID) is a common and often severe side effect experienced by colorectal cancer (CRC) patients during their treatment." | 2.50 | Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation. ( Doherty, GA; Lee, CS; Ryan, EJ, 2014) |
| " Pharmacogenomics is the study of inherited differences in interindividual drug disposition and effects, with the goal of selecting the optimal drug therapy and dosage for each patient." | 2.42 | Cancer pharmacogenomics: current and future applications. ( McLeod, HL; Watters, JW, 2003) |
| "Capecitabine has a favourable safety profile, the most frequent adverse events being hand-foot syndrome, stomatitis and diarrhoea." | 2.42 | Development of and clinical experience with capecitabine (Xeloda) in the treatment of solid tumours. ( Holland, M; Reichardt, P; Sternberg, CN, 2004) |
| "Gemcitabine has been well studied in the laboratory, with respect to mechanisms of radiosensitization and strategies that may increase the therapeutic index." | 2.41 | Recent advances in the use of radiosensitizing nucleosides. ( Lawrence, TS; McGinn, CJ, 2001) |
| "Capecitabine has additional characteristics not found with 5-FU, such as potent antimetastatic and anticachectic actions in mouse tumor models." | 2.40 | [Discovery and development of novel anticancer drug capecitabine]. ( Horii, I; Ishitsuka, H; Shimma, N, 1999) |
| "Oral and intestinal mucositis are debilitating inflammatory diseases observed in cancer patients undergoing chemo-radiotherapy." | 1.91 | Characterization of a novel dual murine model of chemotherapy-induced oral and intestinal mucositis. ( Celentano, A; Cirillo, N; Low, JT; McCullough, MJ; Mohammed, AI; O' Reilly, LA; Paolini, R, 2023) |
| "5-Fluorouracil (5-FU)-induced oral mucositis has a severe negative impact on the patient's quality of life." | 1.72 | Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis. ( Cao, YN; Chen, C; Hou, Y; Li, M; Shan, E; Shan, J; Wang, J; Wang, Y; Zhang, L; Zhou, Y, 2022) |
| "Pancreatic cancer is one of the most recalcitrant cancers, and more effective therapy is needed." | 1.72 | Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease. ( Aoki, Y; Han, Q; Hoffman, RM; Hozumi, C; Kubota, Y; Masaki, N; Tsunoda, T; Yamamoto, J, 2022) |
| "Colon cancer is a major malignant neoplasm with a low survival rate for late-stage patients." | 1.72 | Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo. ( Chang, CH; Cho, EC; Hsieh, YC; Lee, CH; Liu, HH; Liu, YR; Zheng, JH, 2022) |
| "Unfortunately, complexity in treating cachexia is amplified by both the underlying malignancy and the anti-cancer therapy which can independently promote cachexia." | 1.72 | Quercetin Improved Muscle Mass and Mitochondrial Content in a Murine Model of Cancer and Chemotherapy-Induced Cachexia. ( Bullard, BM; Cardaci, TD; Cunningham, P; Fan, D; McDonald, SJ; Murphy, EA; VanderVeen, BN; Velázquez, KT, 2022) |
| "Changes in body weight and white blood cell count were measured to determine the optimal dosing schedule." | 1.62 | Therapeutic Effects of GGsTop ( Makino, K; Takeuchi, I; Tanaka, K, 2021) |
| "Fatty liver is a side effect of chemotherapy that limits the ability to treat colorectal cancer (CRC) patients in the most effective way." | 1.62 | Alterations in hepatic fatty acids reveal depletion of total polyunsaturated fatty acids following irinotecan plus 5-fluorouracil treatment in an animal model of colorectal cancer. ( Bathe, O; Jacobs, R; Mazurak, VC; Monirujjaman, M; Nelson, R; Pant, A, 2021) |
| "Intestinal mucositis is a common side effect of chemotherapy and radiotherapy." | 1.62 | TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2. ( Deng, S; Li, J; Li, L; Wu, D; Xu, Y, 2021) |
| "5-Fluorouracil (5-FU) is a chemotherapeutic drug with a good anti-cancer effect on various types of cancers, such as colorectal cancer and breast cancer." | 1.62 | Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice. ( Abulizi, A; An, Y; Huang, Z; Li, M; Lin, D; Lin, S; Lin, Z; Ran, J; Wang, L; Yang, B; Ye, Y; Zhang, Y; Zhou, H, 2021) |
| "Mucositis was induced by intraperitoneal injection (300 mg/kg) of 5-fluorouracil (5-FU)." | 1.62 | Prophylactic and therapeutic supplementation using fructo-oligosaccharide improves the intestinal homeostasis after mucositis induced by 5- fluorouracil. ( Alvarez-Leite, JI; Andrade, MER; Cardoso, VN; Carvalho, PLA; Cassali, GD; Dos Reis, DC; Dos Santos Martins, F; Fernandes, SOA; Generoso, SV; Gouveia Peluzio, MDC; Leocádio, PCL; Souza E Melo, ÉLS; Trindade, LM, 2021) |
| "5-Fluorouracil (5-FU) is a chemotherapy agent that is widely used in clinical oncologic practice." | 1.62 | Anti-inflammatory effects of Radix Aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice. ( Chang, CW; Chen, YJ; Hsieh, CH; Liu, CY; Liu, JH; Tsai, TH, 2021) |
| "Lung cancer is the most common cause of cancer-related death in developed countries; therefore, the generation of effective targeted therapeutic regimens is essential." | 1.62 | Targeting stanniocalcin-1-expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer. ( Abe, K; Fujiwara, T; Harigae, H; Kanehira, M; Kumata, S; Miyauchi, E; Noda, M; Ohkouchi, S; Oishi, H; Okada, Y; Sakurada, A; Suzuki, Y, 2021) |
| " We investigated the pharmacokinetic and toxicodynamic evaluation of 5-fluorouracil (5-FU) during liver regeneration after major hepatectomy in a rat model." | 1.56 | Pharmacokinetic and toxicodynamic evaluation of 5-fluorouracil administration after major hepatectomy in a rat model. ( Endo, Y; Hirashita, T; Inomata, M; Itoh, H; Iwashita, Y; Masuda, T; Nakanuma, H; Ohta, M; Oshima, Y; Sato, Y; Shiraiwa, K; Tada, K; Takeuchi, Y; Uchida, H, 2020) |
| "EGFR contributed to 5-FU resistance in colon cancer cells through autophagy induction, and EGFR overexpression in 5-FU resistant colon cancer was regulated by RARA." | 1.56 | Over-expression of EGFR regulated by RARA contributes to 5-FU resistance in colon cancer. ( Cui, BB; Gu, XY; Han, P; Jiang, Y; Li, MQ; Liu, YL, 2020) |
| "Multiple myeloma is a plasma cell malignancy that thrives in the bone marrow (BM), with frequent progression to new local and distant bone sites." | 1.56 | Runx2 Deficiency in Osteoblasts Promotes Myeloma Progression by Altering the Bone Microenvironment at New Bone Sites. ( Gowda, PS; Javed, A; Li, J; Lu, Y; Ponnazhagan, S; Trotter, TN; Xu, X; Yang, Y; Zhang, C, 2020) |
| "Oral mucositis was induced in hamsters by administration of 5-fluorouracil (day 0, 2, 4) followed by mechanical trauma (day 1, 2, 4)." | 1.56 | Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model. ( Jung, H; Kim, HS; Lee, JH; Lee, JJ; Park, HS, 2020) |
| " Particularly, the expression of tumour-suppressing gene Ccdc80 was induced by vactosertib and further induced by vactosertib in combination with nal-IRI/5-FU/LV." | 1.56 | Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models. ( An, H; Heo, JS; Hong, CP; Hong, E; Kang, JM; Kim, SJ; Lee, S; Ooshima, A; Park, J; Park, JO; Park, S; Park, SH, 2020) |
| " Physiological information of treatment response derived via diffuse reflectance spectroscopy (DRS) from murine primary CRC tumors provide a better understanding for the development of new drugs and dosing strategies in CRC." | 1.56 | Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response. ( Bullard, EA; Fahr, MJ; Greening, GJ; Hale, LN; Muldoon, TJ; Mundo, AI; Rajaram, N, 2020) |
| "A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered." | 1.56 | A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments. ( Kawamata, R; Makino, K; Takeuchi, I, 2020) |
| "Dihydrotanshinone I (DHTS) is a liposoluble extract of Salvia miltiorrhiza Bunge with many bioactivities." | 1.56 | Dihydrotanshinone attenuates chemotherapy-induced intestinal mucositis and alters fecal microbiota in mice. ( Du, GH; Wang, L; Wang, R; Wang, SM; Wei, GY, 2020) |
| "5-Fluorouracil (5-Fu) is an effective anticarcinogenic agent, however, continuous use of 5-Fu may cause severe side effects." | 1.56 | Reduction of 5-fluorouracil-induced toxicity by Sarcodon aspratus polysaccharides in Lewis tumor-bearing mice. ( Chen, J; Chen, L; Chen, Y; Liu, JJ; Lu, YM; Mehmood, S; Pan, WJ; Wang, Y; Wu, QX; Yan, CC; Zhang, C; Zhang, WN, 2020) |
| "Glycine has been shown to protect livers from CTx-induced injury and oxidative stress, and it reduces platelet aggregation and improves microperfusion." | 1.56 | Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats. ( Bausys, A; Feldbacher, N; Hoefler, G; Kolb-Lenz, D; Leber, B; Maneikyte, J; Schemmer, P; Stiegler, P; Strupas, K, 2020) |
| "Patient-derived gastric cancer was established in nude mice from the patient' s surgical tumor specimen." | 1.56 | A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy. ( Bouvet, M; Higuchi, T; Hoffman, RM; Kawaguchi, K; Nishino, H; Park, JH; Sugisawa, N; Tashiro, Y; Unno, M; Yamamoto, J, 2020) |
| "Zinc sulfate has a beneficial role, decreasing the severity of gut mucosal injuries induced by 5-FU in Wistar rats." | 1.56 | Beneficial effect of oral administration of zinc sulfate on 5-fluorouracil-induced gastrointestinal mucositis in rats. ( Berce, C; Ciobanu, L; Meșter, A; Onica, S; Tanțău, M; Taulescu, M; Tefas, C; Toma, C, 2020) |
| "Taste disorders are common adverse effects of cancer chemotherapy that can reduce quality of life and impair nutritional status." | 1.56 | Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice. ( Hirayama, A; Hirose, F; Iwata, S; Kawabata, Y; Oike, A; Osaki, A; Sanematsu, K; Shigemura, N; Takai, S; Wada, N; Watanabe, Y; Yamada, Y; Yamazoe, J, 2020) |
| "Forty colon cancer primary tumor PDOX mouse models were divided into 4 groups of 10 mice each (total 40 mice) by measuring the tumor size." | 1.51 | Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model. ( Bouvet, M; Clary, B; Han, Q; Higuchi, T; Hoffman, RM; Park, JH; Singh, SR; Sugisawa, N; Sun, Y; Yamamoto, J; Zhao, M, 2019) |
| "Mucositis was induced by intraperitoneal injection of 5-FU (400 mg/kg)." | 1.51 | Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis. ( Choi, HS; Chun, HJ; Jeen, YT; Keum, B; Kim, CD; Kim, ES; Kim, SH; Lee, HS; Lee, JM; Seo, YS; Um, SH; Yoo, IK, 2019) |
| "Cancer chemotherapy is frequently accompanied by adverse effects, such as diarrhoea and leukopenia, which lead to malnutrition and a decrease in the patients' quality of life." | 1.51 | Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats. ( Ashida, K; Nakamura, K; Sasayama, A; Tonouchi, H; Yamaji, T, 2019) |
| "5-Fluorouracil treatment also accelerated the expression of the pro-apoptotic protein BAX and decelerated the expression of the anti-apoptotic protein Bcl-xL on melanoma cell line." | 1.51 | A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models. ( Choi, KC; Heo, JR; Hwang, KA; Kim, SU, 2019) |
| "Fatigue is a common symptom in many diseases and disorders and can reduce quality of life, yet lacks an adequate pharmacological intervention." | 1.51 | Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays. ( Cullen, MJ; Dougherty, JP; Gershengorn, MC; Springer, DA, 2019) |
| "Oral mucositis (OM) induced by cancer chemotherapy has a high incidence and serious symptoms, which often force chemotherapy to be stopped." | 1.51 | Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis. ( Makino, K; Shimamura, Y; Takeuchi, I; Terada, H, 2019) |
| "An orthotopic murine model of colon cancer expressing human uMUC1 peptide (MC38 MUC1) was created along with the control model devoid of the antigen (MC38 neo)." | 1.51 | uMUC1-Targeting Magnetic Resonance Imaging of Therapeutic Response in an Orthotropic Mouse Model of Colon Cancer. ( Moore, A; Mukherjee, P; Richardson, R; Talebloo, N; Wang, P; Zhao, H, 2019) |
| "The incidence rate of skin cancer has continuously increased over the past decades." | 1.48 | A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model. ( Ahn, JS; Cha-Molstad, H; Choi, TW; Han, HJ; Hong, JT; Hwang, J; Kim, BY; Kim, HJ; Kwon, YT; Lee, HG; Lee, KH; Lee, Y; Mun, J; Soung, NK, 2018) |
| "To observe changes in the growth of fluorescence-labelled tumour cells in nude mice using small animal in vivo imaging technology and to compare the anti-tumour effects of the administration of bevacizumab monoclonal antibodies combined with chemotherapy at different time sequences." | 1.48 | Effect of bevacizumab combined with chemotherapy at different sequences in the gastric-cancer-bearing nude mice. ( Chang, L; Liu, W; Liu, Y; Lv, Y; Song, L; Zhang, X, 2018) |
| "Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU." | 1.48 | Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model. ( Alvarez Leite, JI; Antunes Fernandes, SO; Cardoso, VN; Cassali, GD; da Gama, MAS; de Barros, PAV; de Sales E Souza, ÉL; de Vasconcelos Generoso, S; Dos Reis, DC; Dos Santos Martins, F; Lacerda Leocádio, PC; Mendes Miranda, SE; Rabelo Andrade, ME, 2018) |
| "Mucositis was induced by daily injections of 5-fluororacil (5-FU) after which mice were either given L." | 1.48 | Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice. ( de Moreno de LeBlanc, A; LeBlanc, JG; Levit, R; Savoy de Giori, G, 2018) |
| "Crocin was able to ameliorate the severe inflammation with mucosal ulcers and high-grade dysplastic crypts as detected by inflammation score, crypt loss, pathological changes and histology scores." | 1.48 | Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer. ( Amerizadeh, F; Avan, A; Boroumand, N; Ferns, GA; Fiuji, H; Ghayour-Mobarhan, M; Hassanian, SM; Khazaei, M; Moradi-Marjaneh, R; Nosrati-Tirkani, A; Rahmani, F; Rezaei, N, 2018) |
| "Drug-tolerant cancer cell subpopulations are responsible for relapse after chemotherapy." | 1.46 | Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil. ( Ishida, K; Ito, C; Iwaya, T; Kobunai, T; Koizumi, Y; Konta, A; Kume, K; Nishizuka, SS; Nukatsuka, M; Ohmori, Y; Sato, KA; Takechi, T, 2017) |
| "BACKGROUND Renal cell carcinoma (RCC) is among the most common malignant cancers of males worldwide." | 1.46 | Immunogenic Chemotherapy Sensitizes Renal Cancer to Immune Checkpoint Blockade Therapy in Preclinical Models. ( Cui, S, 2017) |
| "Fatigue affects most cancer patients and has numerous potential causes, including cancer itself and cancer treatment." | 1.46 | Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue. ( Cullen, MJ; Dougherty, JP; Gershengorn, MC; Saligan, LN; Wolff, BS, 2017) |
| "Liver fibrosis is characterized by the progressive accumulation of extracellular matrix (ECM) and is a strong predictor of hepatocellular carcinoma (HCC) development and progression." | 1.46 | A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells. ( Fukumitsu, K; Ishii, T; Katayama, H; Kawai, T; Kita, S; Kojima, H; Minami, T; Miyauchi, Y; Ogiso, S; Sasaki, N; Uemoto, S; Yamaoka, R; Yasuchika, K; Yasuda, K; Yoshitoshi-Uebayashi, EY, 2017) |
| "Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i." | 1.46 | Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil 1. ( Aragão, KS; Brito, GAC; Freire, GE; Freitas, MR; Leitão, RFC; Martins, CDS; Silva, VCD; Wanderley, CWS, 2017) |
| "Two human gastric cancer cell lines (AGS and SGC-7901) were xenografted into zebrafish embryos, their sensitivity to 5-FU were tested both in vitro and in vivo." | 1.46 | Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer. ( He, MF; Li, CY; Shen, LZ; Tan, AM; Wei, P; Wu, JQ; Zhai, J, 2017) |
| "Collectively, SGK1 promotes colorectal cancer development via regulation of CRC cell proliferation, migration and survival." | 1.46 | Therapeutic inhibition of SGK1 suppresses colorectal cancer. ( An, Y; Chen, T; Fu, W; Huang, Q; Jiao, G; Lan, C; Li, Y; Liang, X; Long, X; Wang, K; Xiao, J; Xu, B; Xu, J; Zhou, J, 2017) |
| "Apigenin treatment may enhance healing of OM induced by 5-fluorouracil, thus suggesting that more extensive research in this area may be useful to assess the role of agents of natural origin capable of preventing OM." | 1.46 | The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. ( Amaral Mendes, R; Gómez Garcia, F; Lopez-Jornet, P; Martinez Diaz, F; Molina Prats, P, 2017) |
| "Cotreatment with celecoxib and 5-FU partially blocked AKT phosphorylation, although no significant changes in total AKT protein levels were detected." | 1.46 | Celecoxib enhances the inhibitory effect of 5-FU on human squamous cell carcinoma proliferation by ROS production. ( Ahn, SH; Choi, JJ; Kim, YH; Kwon, SK; Lee, DY; Oh, SM; Park, SW; Shin, ES; Sung, MW, 2017) |
| "Distinct metastasis accounts for the leading cause of mortality among patients with gastric cancer." | 1.46 | Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis. ( Wu, J; Xu, Q; Zhou, Y; Zhu, X, 2017) |
| "Notably, REP1 is highly expressed in colon cancer tissues and cell lines, and silencing of REP1 sensitizes colon cancer cells to serum starvation- and 5-FU-induced apoptosis." | 1.46 | REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. ( Bae, DJ; Bae, YK; Cho, H; Chung, JY; Hibi, M; Hong, SM; Hong, SO; Kim, MG; Kim, SY; Kim, TW; Kim, YN; Lee, HJ; Oh, SJ; Rho, SB; Shim, J; Song, KH; Woo, SR, 2017) |
| "Chemotherapy-associated steatohepatitis is attracting increasing attention because it heralds an increased risk of morbidity and mortality in patients undergoing surgery because of liver metastases." | 1.46 | Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice. ( Bosserhoff, AK; Freese, K; Hellerbrand, C; Kuecuekoktay, FS; Mahli, A; Müller, M; Schiergens, TS; Sommer, J; Teufel, A; Thasler, WE, 2017) |
| " In vivo experiments confirmed the enhanced antitumor activity of the 5-FU + NaLV simultaneous combination with a good toxicity profile, whereas the sequential combination with CaLV failed to potentiate 5-FU activity." | 1.46 | Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo. ( Bocci, G; Danesi, R; Di Desidero, T; Di Paolo, A; Orlandi, P, 2017) |
| "5-FU-induced mucositis affects 80% of patients undergoing oncological treatment causing mucosal gut dysfunctions and great discomfort." | 1.46 | Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis. ( Azevedo, V; Bermúdez-Humarán, LG; Breyner, N; Carmona, D; Carvalho, RD; Chatel, JM; da Gloria Souza, D; de Azevedo, MS; de Faria, AM; Figueiredo, HC; Langella, P; Lemos, L; Maioli, TU; Menezes-Garcia, Z; Rodrigues, NM, 2017) |
| "Cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) possess tumor-initiating, metastatic, and drug resistance properties." | 1.43 | Comparative study of the effects of PEGylated interferon-α2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma. ( El-Boghdady, NA; El-Sayed, AM; Helmy, HS; Motawi, TK, 2016) |
| "Thus, magnetic 5-FU-IP is promising for breast cancer therapy with high efficacy." | 1.43 | Evaluation of magnetic nanoparticles coated by 5-fluorouracil imprinted polymer for controlled drug delivery in mouse breast cancer model. ( Hashemi-Moghaddam, H; Jamili, M; Kazemi-Bagsangani, S; Zavareh, S, 2016) |
| "Metastatic liver disease from colorectal cancer is a significant clinical problem." | 1.43 | The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis. ( Denys, A; Devun, F; Dutreix, M; Herath, NI; Herbette, A; Lienafa, MC; Sun, JS, 2016) |
| "Despite being the standard anti-colorectal cancer drug, 5-fluorouracil (5-FU) exhibits only limited therapeutic benefits." | 1.43 | Paricalcitol Enhances the Chemopreventive Efficacy of 5-Fluorouracil on an Intermediate-Term Model of Azoxymethane-Induced Colorectal Tumors in Rats. ( Ahmad, J; El-Shemi, AG; Idris, S; Kensara, OA; Mohamed, AM; Refaat, B, 2016) |
| " We found that cetuximab, in combination with chemotherapy, fostered ICD in CRC cells, which we measured via the endoplasmic reticulum (ER) stress response and an increase in phagocytosis by dendritic cells." | 1.43 | The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death. ( Bardelli, A; Bonaldi, T; Cancelliere, C; Conte, A; Cuomo, A; Di Fiore, PP; Magni, E; Penna, G; Pozzi, C; Ravenda, PS; Rescigno, M; Sigismund, S; Silvola, A; Spadoni, I; Zampino, MG, 2016) |
| "Mice harboring human HCT116 colon cancer xenografts were randomized to receive the control, or 4× or 12." | 1.43 | Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil. ( Croxford, R; Grin, A; Ishiguro, L; Kim, YI; Sohn, KJ; Streutker, CJ; Yang, M, 2016) |
| "Here we report that exposure of tumors to focused ultrasound after intravenous coinjection of cups and oncolytic vaccinia virus , leads to substantial and significant increases in activity." | 1.43 | Polymeric Cups for Cavitation-mediated Delivery of Oncolytic Vaccinia Virus. ( Balloul, JM; Carlisle, R; Coussios, C; Coviello, C; Crake, C; Erbs, P; Finn, S; Foloppe, J; Jackson, E; Kwan, J; Myers, R; Rowe, C; Story, C, 2016) |
| "Mucositis is a common and serious side-effect experienced by cancer patients during treatment with chemotherapeutic agents." | 1.42 | The assessment of general well-being using spontaneous burrowing behaviour in a short-term model of chemotherapy-induced mucositis in the rat. ( Howarth, GS; Lymn, KA; Nicholson, A; Whittaker, AL, 2015) |
| "INK-128 inhibited colorectal cancer cell growth and survival, and induced both apoptotic and non-apoptotic cancer cell death." | 1.42 | The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent. ( Chen, MB; Cui, JF; Li, C; Liu, CY; Liu, F; Lu, PH; Zhang, QD; Zou, J, 2015) |
| " Here, we investigated whether the IMD in combination with chemotherapy could prevent cancer cachexia in colon 26 tumor-bearing mice." | 1.42 | An Immune-Modulating Diet in Combination with Chemotherapy Prevents Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice. ( Nakamura, K; Sasayama, A; Takahashi, T; Yamaji, T, 2015) |
| "Using an orthotopic colon cancer mouse model, we demonstrated that tumor-infiltrating cytotoxic T lymphocytes are FasL(+) and that FasL-mediated cancer immune surveillance is essential for colon carcinoma growth control in vivo." | 1.42 | H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance. ( Bollag, WB; Choi, JH; Figueroa, M; Li, X; Liu, F; Liu, K; Lu, C; Nayak-Kapoor, A; Oberlies, NH; Paschall, AV; Pearce, C; Yang, D, 2015) |
| "Intestinal mucositis is a frequently encountered side effect in oncology patients undergoing chemotherapy." | 1.42 | Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model. ( Chan, WT; Chang, SW; Cheng, ML; Chiang Chiau, JS; Jiang, CB; Lee, HC; Liu, CY; Yeung, CY, 2015) |
| "The recurrence of colorectal cancer after chemotherapy is the leading cause of its high mortality." | 1.42 | CXCL4 mediates tumor regrowth after chemotherapy by suppression of antitumor immunity. ( Deng, S; Gao, J; Guan, W; Han, W; Wang, X; Wu, M; Ye, H; Yu, Y; Zhang, Y; Zhu, S, 2015) |
| "5-Fluorouracil (5FU) was chosen as reference drug and was administered intraperitoneally weekly for 7 weeks (from the 21st week of experiment) at the dose of 45 mg/kg." | 1.42 | Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer. ( Kotlyar, IP; Kuznietsova, HM; Luzhenetska, VK; Rybalchenko, VK, 2015) |
| "In hNSC-breast cancer co-cultures the viability of breast cancer cells which were significantly reduced by HB1." | 1.40 | Selective antitumor effect of neural stem cells expressing cytosine deaminase and interferon-beta against ductal breast cancer cells in cellular and xenograft models. ( Aboody, KS; Choi, KC; Hwang, KA; Jeung, EB; Kim, SU; Yi, BR, 2014) |
| "Whether simvastatin can sensitize the gastric cancer to the antitumor effects of capecitabine in vitro and in vivo was investigated." | 1.40 | Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. ( Ahn, KS; Chen, L; Kumar, AP; Li, F; Manu, KA; Sethi, G; Shanmugam, MK; Siveen, KS, 2014) |
| "Hydroxyproline levels were higher in group M than in group C." | 1.40 | The use of collagen content as determined by spectral domain polarization-sensitive optical coherence tomography to assess colon anastomosis healing in a rat model. ( Ahn, CB; Jeong, HW; Jung, WW; Kim, BM; Kim, HS; Kim, KT; Lee, SH; Lee, SK; Park, KY; Son, KH, 2014) |
| "The recovery stage of oral mucositis was evaluated through daily weighing, measurements of the ulcer area, histopathologic analysis, and a myeloperoxidase activity assay." | 1.40 | Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters. ( Horii, K; Kanayama, T; Kohgo, T; Miyamoto, H; Shigetomi, T; Tsuchimochi, T; Yokoi, M, 2014) |
| "The treatment of colorectal cancer (CRC) might be improved by the identification of a signalling pathway that could be targeted with novel therapeutics." | 1.40 | Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer. ( Matsumura, Y; Yasunaga, M, 2014) |
| "Human colon cancer xenografts propagated in NSG and NRG mice maintain structural fidelity while replacing human stromal cells with murine stromal cells." | 1.40 | NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. ( Greiner, DL; Houghton, J; Li, H; Liu, JH; Maykel, J; Shultz, LD, 2014) |
| " In this study, we investigated the efficiency of transgene delivery and the cytotoxic effects of alphaviral vector in combination with 5-fluorouracil (5-FU) in a mouse mammary tumor model (4 T1)." | 1.40 | High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model. ( Kozlovska, T; Plotniece, A; Skrastina, D; Spaks, A; Vasilevska, J; Zajakina, A; Zhulenkovs, D, 2014) |
| "Irinotecan is a water-soluble camptothecin derivative with clinical activity against colorectal and small cell lung cancers and is currently a standard of care therapeutic in the treatment of colorectal cancer in combination with 5-fluorouracil." | 1.40 | Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities. ( Anantha, M; Bally, MB; Harasym, N; Manisali, I; Masin, D; Osooly, M; Ostlund, C; Santos, ND; Strutt, D; Sutherland, BW; Waterhouse, DN; Webb, MS; Wehbe, M, 2014) |
| "Genistein is a soy-derived isoflavone with pleiotropic biological effects that can enhance the antitumor effect of chemotherapeutic agents." | 1.40 | Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells. ( Fleming, JB; Kang, Y; Li, X; Roife, D; Suzuki, R; Zhang, R, 2014) |
| "Oral mucositis was induced in male hamsters by two intraperitoneal administrations of 5-FU on the first and second days of the experiment (60 and 40 mg/kg, respectively) followed by mechanical trauma on the fourth day." | 1.40 | S-nitrosoglutathione accelerates recovery from 5-fluorouracil-induced oral mucositis. ( Baldim, V; Braga, CM; Brito, GA; Cavalcante, MM; Colombo, AP; de Oliveira, MG; Holanda-Afonso, RC; Leitão, RF; Moura-Neto, V; Ribeiro, RA; Silva-Boghossian, CM; Skeff, MA, 2014) |
| "Gastric samples from patients with gastric cancer were further analyzed for levels of a specifically downregulated lncRNA (termed as LEIGC)." | 1.40 | LEIGC long non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition. ( Chen, J; Chen, Z; Gao, S; Han, Y; Huang, J; Wu, D; Wu, P; Ye, J, 2014) |
| "Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC)." | 1.39 | Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer. ( Bapiro, TE; Bramhall, JL; Cook, N; Courtin, A; Jodrell, DI; Krippendorff, BF; Neesse, A; Richards, FM; Tuveson, DA, 2013) |
| "It has been reported that oral mucositis can reduce quality of life, as well as increasing the incidence of mortality." | 1.39 | Alteration of the redox state with reactive oxygen species for 5-fluorouracil-induced oral mucositis in hamsters. ( Lee, MC; Nakajima, A; Takahashi, SS; Wada-Takahashi, S; Yoshida, A; Yoshino, F, 2013) |
| "Human colon cancer cell lines, transfected with human chorionic gonadotropin and luciferase, were injected orthotopically into the caecal wall of severe combined immunodeficient mice, intrasplenically or subcutaneously." | 1.39 | Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models. ( Francia, G; Hackl, C; Kerbel, RS; Man, S; Milsom, C; Xu, P, 2013) |
| "Oral formulations of 5-fluorouracil (5-FU) with enhanced bioavailability were developed using microemulsion as a drug carrier system." | 1.38 | Development and evaluation of novel microemulsion based oral formulations of 5-fluorouracil using non-everted rat intestine sac model. ( Maheshwari, M, 2012) |
| " Survival benefit is dose dependent for both vector and 5-FC, and as few as 4 cycles of 5-FC dosing after Toca 511 therapy provides significant survival advantage." | 1.38 | Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector. ( Amundson, KK; Buckley, T; Burnett, R; Chen, CI; Daublebsky, V; Galvão da Silva, AP; Gruber, HE; Gunzburg, W; Hlavaty, J; Ibañez, CE; Jolly, DJ; Kasahara, N; Lin, AH; Lopez Espinoza, F; Martin, B; Ostertag, D; Perez, OD; Pettersson, PL; Robbins, JM; Valenta, DT, 2012) |
| "Mouse and human pancreatic cancer cells, irradiated in vitro by alpha particles with or without chemotherapy, were evaluated for cell growth inhibition." | 1.38 | Local control of experimental malignant pancreatic tumors by treatment with a combination of chemotherapy and intratumoral 224radium-loaded wires releasing alpha-emitting atoms. ( Arazi, L; Bittan, H; Cooks, T; Efrati, M; Horev-Drori, G; Keisari, Y; Kelson, I; Lazarov, E; Schmidt, M, 2012) |
| "Superficial bladder cancer is often multifocal, has high recurrences after surgical resection and recurs after intravesical live Bacillus Calmette-Guérin." | 1.38 | Combination of a fusogenic glycoprotein, pro-drug activation and oncolytic HSV as an intravesical therapy for superficial bladder cancer. ( Annels, NE; Coffin, RS; Harrington, KJ; Horvath, A; Melcher, AA; Metcalf, S; Mostafid, H; Pandha, HS; Pencavel, T; Peschard, P; Price, T; Seth, R; Simpson, GR, 2012) |
| "Whether γ-tocotrienol can sensitize gastric cancer to capecitabine in vitro and in a xenograft mouse model was investigated." | 1.38 | First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. ( Fong, CW; Kumar, AP; Li, F; Manu, KA; Ramachandran, L; Sethi, G; Shanmugam, MK; Tan, P, 2012) |
| "Intestinal mucositis is one of the major troublesome side effects of anticancer chemotherapy leading to poor patient compliance." | 1.38 | Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. ( Araújo, CV; Azevedo, OG; Costa, TB; Guerrant, RL; Lima, AÂ; Lima, RC; Lucena, HB; Oliveira, BC; Oliveira, RA; Oriá, RB; Ribeiro, RA; Vitek, MP; Warren, CA; Wong, DV; Zaja-Milatovic, S, 2012) |
| " The paper aims to study whether mood disorder alters drug metabolism process through the pharmacokinetic research on some clinically important anticancer drugs in depression model rats." | 1.38 | Pharmacokinetics of 5-fluorouracil and cyclophosphamide in depression rats. ( Chen, X; Duan, JJ; Wang, Y; Wen, YG; Xu, F; Zhou, T, 2012) |
| "Oral mucositis is an important dose-limiting and costly side effect of cancer chemotherapy." | 1.38 | Protein fraction of Calotropis procera latex protects against 5-fluorouracil-induced oral mucositis associated with downregulation of pivotal pro-inflammatory mediators. ( Bitencourt, FS; Brito, GA; de Alencar, NM; Freitas, AP; Lima-Júnior, RC; Ramos, MV; Ribeiro, RA; Vale, ML, 2012) |
| " We also observed bioavailability of ursolic acid in the serum and tissue of animals." | 1.38 | Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. ( Aggarwal, BB; Baladandayuthapani, V; Deorukhkar, A; Diagaradjane, P; Guha, S; Kannappan, R; Krishnan, S; Prasad, S; Reuter, S; Sung, B; Wei, C; Yadav, VR, 2012) |
| " Pharmacokinetics of (188)Re-liposome showed the properties of high circulation time and high bioavailability (mean residence time [MRT]=18." | 1.38 | Comparative therapeutic efficacy of rhenium-188 radiolabeled-liposome and 5-fluorouracil in LS-174T human colon carcinoma solid tumor xenografts. ( Chang, CH; Chang, YJ; Chen, LC; Hsu, CW; Lan, KL; Lee, TW; Ting, G, 2012) |
| "Human colon cancer HT-29 cells were transduced with a pLPCX expression retroviral vector containing green fluorescent protein and neomycin resistance genes." | 1.37 | A superficial colon tumor model involving subcutaneous colon translocation and orthotopic transplantation of green fluorescent protein-expressing human colon tumor. ( Ding, Y; Jin, H; Sun, Y; Wang, J; Yang, Z; Zhang, S, 2011) |
| "Multiorgan metastasis of drug-resistant 4T1 breast tumors was totally resistant to doxorubicin treatment." | 1.37 | Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model. ( Bao, L; Dash, S; Haque, A; Hazari, S; Jackson, K; Jetly, R; Moroz, K, 2011) |
| "Microsatellite instability was observed in all VCMsh2 strains and limited to the intestinal mucosa." | 1.36 | An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. ( Bronson, RT; Clark, AB; Edelmann, W; Fan, K; Hou, H; Jelicks, L; Kucherlapati, MH; Kucherlapati, R; Kunkel, TA; Lee, K; Li, H; Lipkin, M; Nguyen, AA; Rosulek, A; Yang, K, 2010) |
| " immediately after each dosing of 5-FU significantly reversed the delay in healing by 5-FU, and this effect was attenuated by the chemical ablation of capsaicin-sensitive afferent neurons." | 1.35 | Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons. ( Amagase, K; Hayashi, S; Komatsu, Y; Kotani, T; Murashima, Y; Nakagiri, A; Takeuchi, K, 2009) |
| "The human colon cancer cell line LoVo was injected subcutaneously into the necks of five mice to generate a solid tumor." | 1.35 | A simple colostomy implantation model for evaluating colon cancer. ( Ding, Y; Jin, H; Li, VK; Liu, F; Liu, X; Ni, M; Song, Y; Yun, S; Zhou, S, 2009) |
| " The life prolongation rate, toxic reactions of chemotherapy, WBC count, the body weight, tumor weight, thymus index and spleen index, and phagocytic function of intra-abdominal macrophages were investigated in the H22 tumor-bearing mice." | 1.35 | The effect-enhancing and toxicity-reducing action of the extract of herba Scutellariae barbatae for chemotherapy in hepatoma H22 tumor-bearing mice. ( Dai, Z; Diao, Y; Ji, Z; Kang, H; Liu, L; Liu, X; Wang, X, 2008) |
| "In this study, we generated a dual cancer-specific targeting vector system by using PEGylation and the telomere reverse transcriptase (TERT) promoter and attempted to treat experimental metastases through systemic administration of the vectors." | 1.35 | Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis. ( Eto, Y; Mizuguchi, H; Morishige, T; Mukai, Y; Nakagawa, S; Okada, N; Okada, Y; Watanabe, H; Yao, X; Yoshioka, Y, 2009) |
| "Intestinal mucositis is a common and debilitating side-effect of chemotherapy, associated with severe small intestinal inflammation." | 1.35 | Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis. ( Butler, RN; Geier, MS; Howarth, GS; Smith, CL; Tooley, KL; Torres, DM, 2008) |
| " Here, it was tried to evaluate the antiangiogenic effect of IFN-alpha in combination with chemotherapy." | 1.35 | Interferon-alpha in combination with chemotherapy has potent antiangiogenic properties in an orthotopic mouse model for pancreatic adenocarcinoma. ( Büchler, MW; Hackert, T; Jäger, D; Märten, A; Ryschich, E; Schmidt, J; Tibensky, I; Zhu, Y, 2008) |
| "A non-invasive orthotopic hepatocellular carcinoma (HCC) model was created with human HCC cells (HepG-Luc) constitutively expressing luciferase (Luc) in nude mice." | 1.34 | Bioluminescent imaging of hepatocellular carcinoma in live mice. ( Peng, J; Sun, Z; Wang, Y; Zhan, L, 2007) |
| "Capecitabine is a tumor selective pro-drug of 5-fluorouracil, indicated for the therapy of colorectal cancer." | 1.34 | Histological evaluation of colonic anastomotic healing, during perioperative Capecitabine administration. Experimental study in rats. ( Demertzidis, CI; Economou, LD; Konstantinidis, HD; Mpallas, KD; Pissanidou, TT; Sioga, AC, 2007) |
| "Recent studies on polychemotherapy of head and neck cancer showed an improved remission rate on adding taxanes to the standard cytotoxic drugs cisplatin and 5-fluorouracil (5-FU)." | 1.33 | EGFR-antibody-supplemented TPF chemotherapy. Preclinical investigations to a novel approach for head and neck cancer induction treatment. ( Baghi, M; Gstöttner, W; Hambek, M; Knecht, R; Peters, S; Solbach, C, 2005) |
| "The therapeutic efficacy of G207, a replication-competent herpes simplex virus, for malignancies is increased when combined with certain chemotherapies, but the mechanism is unclear and the interaction between G207 and surgical resection has not been extensively studied." | 1.33 | Enhanced efficacy of conditionally replicating herpes simplex virus (G207) combined with 5-fluorouracil and surgical resection in peritoneal cancer dissemination models. ( Cohen, JB; Glorioso, JC; Kuroki, S; Nakano, K; Tanaka, M; Todo, T; Yamaguchi, K; Zhao, G, 2005) |
| "With these fluorescent tools, tumors and metastasis in host organs can be externally imaged down to the single-cell level." | 1.33 | Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. ( Hoffman, RM, 2005) |
| "Oral mucositis is a frequent side-effect of cancer therapy." | 1.33 | Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. ( Augusto, RF; Brito, GA; Cunha, FQ; Falcão, BA; Leitão, BT; Lima, V; Rebouças, CG; Ribeiro, RA; Souza, ML, 2005) |
| " Furthermore, the efficacy of immunotherapy combined with either 5-fluorouracil or irinotecan was similar to that of immunotherapy alone." | 1.33 | Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer. ( Beck, S; Bourquin, C; Endres, S; Hartmann, G; Schreiber, S, 2006) |
| "Microsatellite instability is a recognised pathway of colorectal carcinogenesis responsible for about 15% of all sporadic colorectal cancers." | 1.33 | 5-fluorouracil (5FU) treatment does not influence invasion and metastasis in microsatellite unstable (MSI-H) colorectal cancer. ( Kaufman, A; Ramanathan, P; Robinson, BG; Schnitzler, M; Warusavitarne, J, 2006) |
| "thioTEPA was found to yield a pronounced dose-related inhibition in cell proliferation, while 5-fluorouracil did not." | 1.33 | Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA. ( Mignone, RG; Weber, ET, 2006) |
| "Human gastric cancer cells (MKN-45) were injected into the peritoneal cavity of nude mice." | 1.32 | Prevention of peritoneal metastasis of human gastric cancer cells in nude mice by S-1, a novel oral derivative of 5-Fluorouracil. ( Fujiwara, Y; Monden, M; Mori, T; Takiguchi, S; Tamura, S; Yano, M; Yasuda, T, 2003) |
| "1/mIL-12 combined with 5-fluoro-uracilum (5-FU) in treatment of tumor-burdened mice." | 1.32 | [Subcutaneous transplantation of microencapsulated Chinese hamster ovary (CHO) cells/pcDNA 3.1/mIL-12 and subcutaneous transplantation of microencapsulated CHO/pcDNA3.1/mIL-12 combined with 5-fluoro-uracil in treatment of tumor-burdened mice]. ( Cao, J; Pan, YL; Xiao, ZX; Yao, HP; Zheng, S, 2003) |
| " Since clinical studies have demonstrated that bisphosphonates (BPs), specific inhibitors of osteoclastic bone resorption, are beneficial for breast cancer patients with bone metastases, we next examined the effects of UFT combined with the BP zoledronic acid (ZOL) on established bone metastases." | 1.32 | Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer. ( Hata, K; Hiraga, T; Ikeda, F; Tamura, D; Ueda, A; Williams, PJ; Yoneda, T, 2003) |
| "The murine AT-84 orthotopic model of oral cancer was assessed to find how similar it is to human oral cancer." | 1.32 | Clinical and pathological features of the murine AT-84 orthotopic model of oral cancer. ( Hutchison, R; Kellman, RM; Lou, E; Shillitoe, EJ, 2003) |
| "The human bladder cancer cell line T24 was transfected with human CDD2 cDNA by the lipofectin method." | 1.32 | Forced expression of cytidine deaminase confers sensitivity to capecitabine. ( Kurokawa, S; Matsuzaki, A; Morita, T; Tokue, A, 2003) |
| "Infiltrating squamous cell carcinomas of the URT occurred in 92% of the controls and were reduced by 50% in animals receiving DFMO (P = 0." | 1.32 | Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil. ( Estensen, RD; Wattenberg, LW; Wiedmann, TS, 2004) |
| "Human colon cancer cells were implanted s." | 1.32 | Comparison between triple therapy with octreotide, galanin and serotonin, 5-fluorouracil/leucovorin, and sequential treatment with both, on human colon cancer. ( El-Salhy, M, 2004) |
| "5-fluorouracil (5-FU) has been combined in the past with other drugs for the combination chemotherapy for cancers of the breast, ovary, and colon." | 1.32 | Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms. ( Akbulut, H; Deisseroth, A; Maynard, J; Pizzorno, G; Tang, Y; Zhang, L, 2004) |
| " This study was designed to investigate the effects of angiogenesis inhibitor TNP-470 in combination with 5-fluorouracil (5-FU) on the growth of human colon cancer cell line, LOVO, in vitro and in vivo." | 1.31 | [Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer]. ( Fan, YF; Huang, ZH; Nie, J, 2002) |
| "Systemic immunosuppressives are used to treat sensorineural hearing loss due to inflammation (autoimmune, bacterial, viral), which in animal models causes hearing loss." | 1.31 | Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss. ( Harris, JP; Keithley, EM; Song, HT; Yang, GS, 2000) |
| "5-FU combined with busulfan could impair the hematopoietic stem cells and resulted in an irreversible aplastic anemia in rats, making a rat aplastic anemia model with hematopoietic stem cell failure." | 1.31 | [A novel rat aplastic anemia model induced by 5-fluorouracil combined with busulfan]. ( Chu, J; Ding, S; Liu, A; Wang, S; Xu, S; Zhao, J, 2001) |
| "Mitomycin C suppository was significantly less toxic compared with intravenous delivery, and higher rectal tissue concentrations were observed from 10 to 30 minutes (P < 0." | 1.30 | Suppository administration of chemotherapeutic drugs with concomitant radiation for rectal cancer. ( Ackerman, D; Galandiuk, S; Hofmeister, A; LaRocca, R; Lewis, RK; Myers, SR; Paris, KJ; Pokorny, RM; Wrightson, WR, 1997) |
| " Animals in Groups III and IV received the same drug dosage for six weeks and were operated at different intervals: Group III at one week and Group IV at two weeks after completion of chemotherapy." | 1.29 | Effect of 5-fluorouracil and leucovorin on the integrity of colonic anastomoses in the rat. ( Gordon, PH; Hananel, N, 1995) |
| "Oral mucositis was induced in male Golden Syrian hamsters with 5-fluorouracil 60 mg/kg intraperitoneal, days 0 and 2." | 1.29 | IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology. ( Albert, L; Keith, JC; Pfeiffer, CJ; Schaub, RG; Sonis, ST, 1994) |
| "levamisole/5-FU) treatment." | 1.29 | Enhancement of antitumor effects of combined chemoimmunotherapy. ( Fowler, WC; Gerçel-Taylor, C; Taylor, DD; Weese, JL, 1993) |
| "Pancreatic cancer is a disease with essentially no effective treatment." | 1.29 | A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice. ( Furukawa, T; Hoffman, RM; Kitajima, M; Kubota, T; Watanabe, M, 1993) |
| "This metastatic model of human stomach cancer shows that locally growing and metastatic tumors may have different chemosensitivities, and provides the opportunity to test both with various treatment regimens." | 1.29 | Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice. ( Furukawa, T; Hoffman, RM; Kitajima, M; Kubota, T; Kuo, TH; Watanabe, M, 1993) |
| " Subsequent dosing with 5-FU induced lethal septicaemia caused by the inoculated strains in most of these mice, whereas CY did not regularly induce septicaemia." | 1.29 | Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice. ( Furuya, N; Hirakata, Y; Matsumoto, T; Tateda, K; Yamaguchi, K, 1996) |
| "Mitomycin C was estimated to be at least 125 times as potent as 5-FU in inhibiting corneal epithelial healing." | 1.28 | Inhibition of corneal epithelial wound healing. A comparative study of mitomycin C and 5-fluorouracil. ( Ando, H; Ido, T; Kawai, Y; Kitazawa, Y; Yamamoto, T, 1992) |
| "Eighty-three rats with isolated colon cancer underwent total colectomy; 40 of these rats with no metastases were randomized into two groups: surgery alone or surgery plus 5-FU (5 mg/kg body weight/day) for 5 days after surgery." | 1.28 | Experimental model of colon cancer: recurrences after surgery alone or associated with intraperitoneal 5-fluorouracil chemotherapy. ( Ballet, F; Delelo, R; Herve, JP; Nordlinger, B; Panis, Y; Puts, JP, 1991) |
| "Two cohorts of rats, 240 with colon cancer and 150 controls, were assessed clinically and immunologically for their response to tumour and its management which was either by surgical excision alone or by surgical excision combined with either adjuvant chemotherapy or immunotherapy." | 1.27 | Clinical and in vivo response following surgery or surgery plus adjuvant chemotherapy or immunotherapy for colorectal carcinoma in a rat model. ( House, AK; Maley, MA, 1983) |
| "A combination chemotherapy regimen for brain tumors was developed, based on investigations of the survival of animals harboring the intracerebral 9L rat brain-tumor model and on analyses of their clonogenic tumor cells." | 1.27 | Improved treatment of a brain-tumor model. Part 2: Sequential therapy with BCNU and 5-fluorouracil. ( Dougherty, DV; Gerosa, MA; Rosenblum, ML; Wilson, CB, 1983) |
| "5-Fluorouracil was administered intraperitoneally in maximally tolerated doses from week 26 onwards and failed to influence significantly the development of either benign or malignant tumours." | 1.27 | Chemotherapy of chemically-induced colorectal tumours. ( Gilbert, JM; Kark, AE; Slavin, G; Thompson, EM, 1983) |
| " Fifty-one rats with hepatic tumors of colonic origin were randomly assigned to one of three dosage groups (20, 40, or 80 mg/kg) receiving 5-FU by ILP, hepatic artery infusion (HAI), or jugular vein infusion (JVI)." | 1.27 | In vivo isolated liver perfusion technique in a rat hepatic metastasis model: 5-fluorouracil concentrations in tumor tissue. ( Bell, AV; de Brauw, LM; de Bruijn, EA; Hermans, J; Tjaden, UR; van de Velde, CJ; Zwaveling, A, 1988) |
| "Pre-treatment with colchicine or 5-fluorouracil to reduce cell accumulation was not found to effect the modified PGE2 response." | 1.27 | Studies of eicosanoid production in the air pouch model of synovial inflammation. ( Lees, P; Sedgwick, AD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (11.76) | 18.7374 |
| 1990's | 45 (9.13) | 18.2507 |
| 2000's | 97 (19.68) | 29.6817 |
| 2010's | 223 (45.23) | 24.3611 |
| 2020's | 70 (14.20) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 12 |
| Jiang, J | 3 |
| Jiang, X | 1 |
| Cai, S | 2 |
| Han, H | 1 |
| Li, L | 3 |
| Tian, Z | 1 |
| Jiang, W | 1 |
| Zhang, Z | 6 |
| Xiao, Y | 2 |
| Wright, SC | 1 |
| Larrick, JW | 1 |
| Vendramini-Costa, DB | 1 |
| de Castro, IB | 1 |
| Ruiz, AL | 1 |
| Marquissolo, C | 1 |
| Pilli, RA | 1 |
| de Carvalho, JE | 1 |
| Liu, W | 2 |
| Zhou, J | 2 |
| Zhang, T | 1 |
| Zhu, H | 1 |
| Qian, H | 1 |
| Zhang, H | 5 |
| Huang, W | 2 |
| Gust, R | 1 |
| Ovais, S | 1 |
| Javed, K | 1 |
| Yaseen, S | 1 |
| Bashir, R | 1 |
| Rathore, P | 1 |
| Yaseen, R | 1 |
| Hameed, AD | 1 |
| Samim, M | 1 |
| Zhu, P | 1 |
| Liu, J | 4 |
| Lin, Y | 2 |
| Yao, H | 1 |
| Ye, W | 1 |
| Wu, X | 4 |
| Xu, J | 3 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Chang, CK | 1 |
| Chiu, PF | 1 |
| Yang, HY | 1 |
| Juang, YP | 1 |
| Lai, YH | 1 |
| Lin, TS | 1 |
| Hsu, LC | 1 |
| Yu, LC | 1 |
| Liang, PH | 1 |
| Takeuchi, I | 4 |
| Tanaka, K | 2 |
| Makino, K | 4 |
| Chen, G | 1 |
| Zeng, H | 1 |
| Li, X | 7 |
| Li, Z | 2 |
| Xu, R | 1 |
| Ma, Y | 3 |
| Liu, C | 4 |
| Xue, B | 1 |
| Monirujjaman, M | 1 |
| Pant, A | 1 |
| Nelson, R | 1 |
| Bathe, O | 1 |
| Jacobs, R | 1 |
| Mazurak, VC | 2 |
| Deng, S | 2 |
| Wu, D | 2 |
| Li, J | 4 |
| Xu, Y | 2 |
| Abulizi, A | 1 |
| Ran, J | 1 |
| Ye, Y | 2 |
| An, Y | 2 |
| Zhang, Y | 8 |
| Huang, Z | 1 |
| Lin, S | 1 |
| Zhou, H | 2 |
| Lin, D | 2 |
| Wang, L | 5 |
| Lin, Z | 1 |
| Li, M | 4 |
| Yang, B | 2 |
| Yoneda, J | 1 |
| Nishikawa, S | 1 |
| Kurihara, S | 1 |
| El-Sherbiny, M | 1 |
| Fahmy, EK | 1 |
| Eisa, NH | 1 |
| Said, E | 1 |
| Elkattawy, HA | 1 |
| Ebrahim, HA | 1 |
| Elsherbiny, NM | 1 |
| Ghoneim, FM | 1 |
| Shehatta, NH | 1 |
| Okda, TM | 1 |
| Omran, GA | 1 |
| Abd-Alhaseeb, MM | 1 |
| Dong, S | 1 |
| Liang, S | 1 |
| Cheng, Z | 1 |
| Zhang, X | 5 |
| Luo, L | 1 |
| Zhang, W | 4 |
| Li, S | 2 |
| Xu, Q | 2 |
| Zhong, M | 1 |
| Zhu, J | 3 |
| Zhang, G | 1 |
| Hu, S | 1 |
| Cao, YN | 1 |
| Zhang, L | 4 |
| Hou, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chemotherapy and Irreversible Electroporation (IRE) in the Treatment of Advanced Pancreatic Adenocarcinoma[NCT03484299] | Phase 1 | 20 participants (Anticipated) | Interventional | 2018-05-30 | Recruiting | ||
| The Effectiveness of Topical Oral Vitamin D Gel in Prevention of Radiation-induced Oral Mucositis[NCT04308161] | Phase 2 | 45 participants (Anticipated) | Interventional | 2019-11-02 | Recruiting | ||
| The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis[NCT03833570] | Phase 2 | 40 participants (Actual) | Interventional | 2018-01-12 | Completed | ||
| Efficacy and Safety of Trabeculectomy With Subconjunctival Bevacizumab Versus Trabeculectomy With Mitomycin C.[NCT01310764] | 36 participants (Actual) | Interventional | 2009-04-30 | Completed | |||
| A Phase 1 Ascending Dose Trial of the Safety and Tolerability of Toca 511 in Patients With Recurrent High Grade Glioma[NCT01156584] | Phase 1 | 54 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| A Phase 1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG & Followed by Treatment With Extende[NCT01985256] | Phase 1 | 17 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| A Phase 1 Ascending Dose Trial of Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered to Subjects at the Time of Resection for Recurrent High Grade Glioma & Followed by Treatment With Toca FC, Extended-Release 5-FC[NCT01470794] | Phase 1 | 58 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Candidate Gene Polymorphisms and Response to Rituximab-CHOP in Patients With Diffuse Large Cell Lymphoma[NCT00590941] | 52 participants (Actual) | Interventional | 2005-02-28 | Completed | |||
| A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420] | Phase 1 | 4 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489] | Phase 4 | 70 participants | Interventional | 2004-09-30 | Completed | ||
| Phase II Study of an All-Oral Combination of Capecitabine (X) and Cyclophosphamide (C) in Patients With Anthracycline- and Taxane-Pretreated Metastatic Breast Cancer[NCT00589901] | Phase 2 | 60 participants (Anticipated) | Interventional | 2006-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for fluorouracil and Disease Models, Animal
| Article | Year |
|---|---|
Combination of 5-Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis
Topics: Aminolevulinic Acid; Animals; Biomarkers; Disease Models, Animal; Fluorouracil; Immunity; Keratosis, | 2023 |
Dihydropyrimidine dehydrogenase in the metabolism of the anticancer drugs.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dihydrouracil Dehydrogenase (NADP); Disease | 2019 |
Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal.
Topics: Adaptive Immunity; Animals; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemothera | 2020 |
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplas | 2014 |
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplas | 2014 |
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplas | 2014 |
Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Death; Colorectal Neoplas | 2014 |
Small bowel adenocarcinoma.
Topics: Adenocarcinoma; Age of Onset; Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Fema | 2008 |
Cancer pharmacogenomics: current and future applications.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Dihydrour | 2003 |
Development of and clinical experience with capecitabine (Xeloda) in the treatment of solid tumours.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Clin | 2004 |
Preclinical investigations with epothilones in breast cancer models.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Capecitabine; Cell Line, Tumor; Cl | 2008 |
Docetaxel in combination with fluorouracil for advanced solid tumors.
Topics: Adult; Aged; Animals; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplas | 1997 |
[Discovery and development of novel anticancer drug capecitabine].
Topics: Animals; Antineoplastic Agents; Biological Availability; Bridged-Ring Compounds; Capecitabine; Cyclo | 1999 |
Recent advances in the use of radiosensitizing nucleosides.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Dis | 2001 |
Chemotherapy in the treatment of malignant brain tumors.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphami | 1975 |
[Experimental models for hepatic metastases from colorectal tumors].
Topics: Animals; Azoxymethane; Colectomy; Colorectal Neoplasms; Cyclosporins; Disease Models, Animal; Fluoro | 1991 |
In vivo potentiation of 5-fluorouracil by leucovorin in murine colon carcinoma.
Topics: Adenocarcinoma; Animals; Carcinoma; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; Femal | 1988 |
[Prevention of eye scarring by 5-fluorouracil].
Topics: Animals; Cicatrix; Disease Models, Animal; Eye; Fluorouracil; Glaucoma; Humans; Postoperative Compli | 1987 |
Chemotherapy of bronchial carcinoma.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Blood Cell Count; Bone Marrow Diseases; Bronchial N | 1973 |
4 trials available for fluorouracil and Disease Models, Animal
| Article | Year |
|---|---|
Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycyti | 2020 |
Molecular Analyses Support the Safety and Activity of Retroviral Replicating Vector Toca 511 in Patients.
Topics: Aged; Animals; Autopsy; Cell Line, Tumor; Cytosine Deaminase; Disease Models, Animal; Female; Flucyt | 2018 |
Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celeco | 2007 |
The use of bioerodible polymers and 5-fluorouracil in glaucoma filtration surgery.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Double-Blind Method; Fluorouracil; Glauco | 1988 |
473 other studies available for fluorouracil and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; Duocarmycins; | 2008 |
Effect of goniothalamin on the development of Ehrlich solid tumor in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carrageenan; Cel | 2010 |
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L | 2012 |
Synthesis, antiproliferative and anti-inflammatory activities of some novel 6-aryl-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-ones.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Line, Tumor; Cell Prolif | 2013 |
Synthesis, in vitro and in vivo antitumor activity of pyrazole-fused 23-hydroxybetulinic acid derivatives.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, | 2015 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-Fluorouracil.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Disease Model | 2021 |
Therapeutic Effects of GGsTop
Topics: Aminobutyrates; Animals; Antimetabolites, Antineoplastic; Body Weight; Collagen; Disease Models, Ani | 2021 |
Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Proliferation; Cytoprotection; Disease Mo | 2021 |
Alterations in hepatic fatty acids reveal depletion of total polyunsaturated fatty acids following irinotecan plus 5-fluorouracil treatment in an animal model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal | 2021 |
TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2.
Topics: Animals; Cell Death; Cell Line; Cytokines; Diarrhea; Disease Models, Animal; Epithelial Cells; Ferro | 2021 |
Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice.
Topics: Animals; Antineoplastic Agents; Cognitive Dysfunction; Disease Models, Animal; Fluorouracil; Male; M | 2021 |
Oral administration of cystine and theanine attenuates 5-fluorouracil-induced intestinal mucositis and diarrhea by suppressing both glutathione level decrease and ROS production in the small intestine of mucositis mouse model.
Topics: Animals; Cystine; Diarrhea; Disease Models, Animal; Drug Therapy, Combination; Fluorouracil; Glutama | 2021 |
Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS.
Topics: Animals; Disease Models, Animal; Fluorouracil; gamma-Glutamylcyclotransferase; Gold; Heme Oxygenase | 2021 |
Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in Ehrlich solid tumor.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease Models, Animal; D | 2022 |
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Topics: Animals; beta Catenin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Fluorouracil; | 2022 |
Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Endoplasmic Reticulum Stress; Fluorouracil; | 2022 |
Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.
Topics: Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, An | 2022 |
Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil-induced intestinal mucositis: Impact on inflammation and gut microbiota dysbiosis.
Topics: Animals; Disease Models, Animal; Dysbiosis; Fluorouracil; Gastrointestinal Diseases; Gastrointestina | 2022 |
Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Carbon-Sulfur Lyases; Dise | 2022 |
Rapamycin Liposomes Combined with 5-Fluorouracil Inhibits Angiogenesis and Tumor Growth of APC
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Fluor | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo.
Topics: Animals; Cell Movement; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Epithelial-Me | 2022 |
Quercetin Improved Muscle Mass and Mitochondrial Content in a Murine Model of Cancer and Chemotherapy-Induced Cachexia.
Topics: Animals; Antineoplastic Agents; Cachexia; Disease Models, Animal; Fluorouracil; Mice; Mitochondria; | 2022 |
Characterization of a novel dual murine model of chemotherapy-induced oral and intestinal mucositis.
Topics: Animals; Antimetabolites, Antineoplastic; Diarrhea; Disease Models, Animal; Fluorouracil; Intestinal | 2023 |
Theabrownin from Fu Brick Tea Improves Ulcerative Colitis by Shaping the Gut Microbiota and Modulating the Tryptophan Metabolism.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Fluorouracil; | 2023 |
Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Drug Re | 2023 |
Konjac glucomannan enhances 5-FU-induced cytotoxicity of hepatocellular carcinoma cells via TLR4/PERK/CHOP signaling to induce endoplasmic reticulum stress.
Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Endoplasmic Reticulum Stress; Fluorourac | 2022 |
KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer.
Topics: Animals; Autophagosomes; Autophagy; Colonic Neoplasms; Disease Models, Animal; Fluorouracil; Humans; | 2023 |
Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CCAAT-Enhancer-Binding Protein-beta; Cell L | 2019 |
Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols | 2019 |
Bio-mediated synthesis of 5-FU based nanoparticles employing orange fruit juice: a novel drug delivery system to treat skin fibrosarcoma in model animals.
Topics: Animals; Antineoplastic Agents; Apoptosis; Calorimetry, Differential Scanning; Caspase 9; Citrus sin | 2019 |
Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; | 2019 |
5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Bacterial Agents; Cefepime; Convulsants; Disease Models, Animal; Fluorouracil; Kindlin | 2019 |
Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carbon-Sul | 2019 |
Crinamine Induces Apoptosis and Inhibits Proliferation, Migration, and Angiogenesis in Cervical Cancer SiHa Cells.
Topics: Amaryllidaceae Alkaloids; Angiogenesis Inhibitors; Animals; Carboplatin; Cell Line, Tumor; Cell Move | 2019 |
Evaluation of a new histological grading system for assessing the response to chemotherapy of peritoneal metastases from colorectal cancer: A mouse model study.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Models, Anima | 2020 |
Pharmacokinetic and toxicodynamic evaluation of 5-fluorouracil administration after major hepatectomy in a rat model.
Topics: Animals; Antineoplastic Agents; Dihydrouracil Dehydrogenase (NADP); Disease Models, Animal; Female; | 2020 |
Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Cytokines; Diarrhea; Disease Mode | 2019 |
Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; CA1 Region, Hippocampal; | 2020 |
Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Body Weight; Diarrhea; Dipeptidyl Pe | 2019 |
Modulations of probiotics on gut microbiota in a 5-fluorouracil-induced mouse model of mucositis.
Topics: Animals; Antimetabolites, Antineoplastic; Dietary Supplements; Disease Models, Animal; Fluorouracil; | 2020 |
Combination of Trabectedin With Oxaliplatinum and 5-Fluorouracil Arrests a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Body Weight; Cell Proliferation; | 2019 |
Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Aspirin; Cell Line, Tumor; Disease Models, Anim | 2019 |
Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats.
Topics: Animals; Body Weight; Cultured Milk Products; Dietary Supplements; Disease Models, Animal; Eating; E | 2019 |
Characterization of CD44-positive Cancer Stem-like Cells in COLO 201 Cells.
Topics: Animals; Biomarkers; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Cell Transformation, Neopla | 2020 |
Over-expression of EGFR regulated by RARA contributes to 5-FU resistance in colon cancer.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; | 2020 |
Runx2 Deficiency in Osteoblasts Promotes Myeloma Progression by Altering the Bone Microenvironment at New Bone Sites.
Topics: Animals; Bone and Bones; Bone Marrow; Bone Neoplasms; Cell Line, Tumor; Core Binding Factor Alpha 1 | 2020 |
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Colorectal Neo | 2020 |
Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model.
Topics: Animals; Child; Cricetinae; Culture Media, Conditioned; Disease Models, Animal; Female; Fluorouracil | 2020 |
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.
Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Lin | 2020 |
Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colorectal Neoplasms; Disease Models, A | 2020 |
Lactobacillus rhamnosus FLRH93 protects against intestinal damage in mice induced by 5-fluorouracil.
Topics: Animals; Disease Models, Animal; Female; Fluorouracil; Ileum; Interleukin-1beta; Intestinal Diseases | 2020 |
Protective effect of Andrographolide on 5-Fu induced intestinal mucositis by regulating p38 MAPK signaling pathway.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; | 2020 |
Comparing the intra-tumoral distribution of Gemcitabine, 5-Fluorouracil, and Capecitabine in a murine model of pancreatic ductal adenocarcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Pancreatic Ductal; Cell Hypoxia; | 2020 |
A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments.
Topics: Animals; Antineoplastic Agents; Body Weight; Disease Models, Animal; Fluorouracil; Leukocyte Count; | 2020 |
Cannabidiol on 5-FU-induced oral mucositis in mice.
Topics: Animals; Cannabidiol; Disease Models, Animal; Fluorouracil; Intestinal Mucosa; Mice; Mucositis; Stom | 2020 |
Dihydrotanshinone attenuates chemotherapy-induced intestinal mucositis and alters fecal microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Bacteria; Colon; Diglycerides; Disease Mod | 2020 |
Reduction of 5-fluorouracil-induced toxicity by Sarcodon aspratus polysaccharides in Lewis tumor-bearing mice.
Topics: Animals; Basidiomycota; Carcinoma, Lewis Lung; Cell Line, Tumor; Disease Models, Animal; Drug Antago | 2020 |
5-Fluorouracil induced dysregulation of the microbiome-gut-brain axis manifesting as depressive like behaviors in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Colorectal Neoplasms; Depression; Diseas | 2020 |
CO
Topics: Animals; Cicatrix, Hypertrophic; Collagen Type I; Disease Models, Animal; Fluorouracil; Lasers, Gas; | 2021 |
Melatonin Administered before or after a Cytotoxic Drug Increases Mammary Cancer Stabilization Rates in HER2/Neu Mice.
Topics: Anemia; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cyclophosphamide; Diseas | 2020 |
Immunogenic chemotherapy in two mouse colon cancer models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CD8-Positive T-Lymphocytes; Cell Line, Tumo | 2020 |
Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms | 2020 |
A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Fluo | 2020 |
Comments on "Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma".
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Ele | 2020 |
Loganetin and 5-fluorouracil synergistically inhibit the carcinogenesis of gastric cancer cells via down-regulation of the Wnt/β-catenin pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; beta Catenin; Biomarkers; Cell Line, Tumor; Cell Surviva | 2020 |
Evaluation of vitamin-producing and immunomodulatory lactic acid bacteria as a potential co-adjuvant for cancer therapy in a mouse model.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Cell Line; C | 2021 |
Jianpi Yangwei decoction promotes apoptosis and suppresses proliferation of 5-fluorouracil resistant gastric cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Ani | 2020 |
Combined chemotherapy of platinum and fluorouracil promotes T cell-mediated antitumor immunity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CD4-Positive T-Lymphocytes; CD8-Positive T- | 2021 |
Beneficial effect of oral administration of zinc sulfate on 5-fluorouracil-induced gastrointestinal mucositis in rats.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Female; Fluo | 2020 |
Prophylactic and therapeutic supplementation using fructo-oligosaccharide improves the intestinal homeostasis after mucositis induced by 5- fluorouracil.
Topics: Acetates; Animals; Bacteria; Bacterial Translocation; Butyrates; Disease Models, Animal; Fatty Acids | 2021 |
Drinking Ice-Cold Water Reduces the Severity of Anticancer Drug-Induced Taste Dysfunction in Mice.
Topics: Animals; Cell Proliferation; Cisplatin; Disease Models, Animal; Docetaxel; Fluorouracil; Head and Ne | 2020 |
Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis.
Topics: Animals; Cell Line; Cytokines; Disease Models, Animal; Dysbiosis; Fluorouracil; Gastrointestinal Mic | 2021 |
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Carcinoma, Hepatocellular; C | 2021 |
Antitumor Effects of the Novel Quinazolinone Holu-12: Induction of Mitotic Arrest and Apoptosis in Human Oral Squamous Cell Carcinoma CAL27 Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Cycle Checkpoi | 2021 |
Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis.
Topics: Animals; Apoptosis; Chemoprevention; Colon; Disease Models, Animal; Drug Liberation; Fluorouracil; K | 2021 |
Anti-inflammatory effects of Radix Aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Body Weight; Cytokines; Diarrhea; Disease Models, Ani | 2021 |
Combination of tumor cell anti-adhesion and anti-tumor effect to prevent recurrence after cytoreductive surgery in a mice model.
Topics: Animals; Antineoplastic Agents; Biological Availability; Colorectal Neoplasms; Combined Modality The | 2021 |
Targeting stanniocalcin-1-expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer.
Topics: A549 Cells; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferatio | 2021 |
Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.
Topics: Amino Acid Transport System y+; Animals; Cell Line, Tumor; Colonic Neoplasms; Cysteine; Deubiquitina | 2021 |
Anacardic Acids from
Topics: Anacardiaceae; Anacardic Acids; Animals; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Carbop | 2021 |
Intravital Whole-Process Monitoring Thermo-Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long-Term Microscopic Precise Imaging Strategy.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Disease Models, Animal; Fluorouracil; Gli | 2021 |
Amelioration of 5-fluorouracil-induced intestinal mucositis by Streptococcus thermophilus ST4 in a mouse model.
Topics: Animals; Body Weight; Disease Models, Animal; Eating; Fluorouracil; Intestinal Mucosa; Male; Mice; M | 2021 |
RNA-seq and
Topics: Animals; Cell Line; Curcumin; Disease Models, Animal; Epithelial Cells; Fluorouracil; Gene Expressio | 2021 |
Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death.
Topics: Animals; Biosynthetic Pathways; Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cell Prolife | 2017 |
KU32 prevents 5-fluorouracil induced cognitive impairment.
Topics: Analysis of Variance; Animals; Cognition Disorders; Disease Models, Animal; Fluorouracil; Immunosupp | 2017 |
Mulberry leaf extract fermented with Lactobacillus acidophilus A4 ameliorates 5-fluorouracil-induced intestinal mucositis in rats.
Topics: Acetamides; Animals; Cytokines; Disease Models, Animal; Fermentation; Fluorouracil; Intestinal Mucos | 2017 |
Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; ATPases Associated with Diverse Cellular Activities; Color | 2017 |
Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.
Topics: Amino Acid Substitution; Animals; Antigens, Viral; Antiviral Agents; Cells, Cultured; Cricetinae; Di | 2017 |
Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidyl | 2017 |
Actinic keratosis modelling in mice: A translational study.
Topics: Animals; Dermoscopy; Disease Models, Animal; Fluorouracil; Humans; Immunosuppressive Agents; Keratos | 2017 |
Immunogenic Chemotherapy Sensitizes Renal Cancer to Immune Checkpoint Blockade Therapy in Preclinical Models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Carcinoma, Renal Cell; Cell | 2017 |
Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Anima | 2017 |
The novel gene HA117 promotes in vitro and in vivo drug resistance in mouse colon tumor cells.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Disease Models, A | 2017 |
Evaluation of cytotoxic and antitumoral properties of Tessaria absinthioides (Hook & Arn) DC, "pájaro bobo", aqueous extract.
Topics: Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Cell Line, Tumor; Colorectal Neoplasms; Dise | 2017 |
Bifidobacterium Infantis Ameliorates Chemotherapy-Induced Intestinal Mucositis Via Regulating T Cell Immunity in Colorectal Cancer Rats.
Topics: Animals; Antineoplastic Agents; Bifidobacterium longum subspecies infantis; Cell Line; Colorectal Ne | 2017 |
A novel three-dimensional culture system maintaining the physiological extracellular matrix of fibrotic model livers accelerates progression of hepatocellular carcinoma cells.
Topics: Animals; Biopsy; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line, Tumor; Cell Prolifer | 2017 |
ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells.
Topics: ADAM12 Protein; Animals; Antimetabolites, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Line, Tu | 2017 |
A novel vascular-targeting peptide for gastric cancer delivers low-dose TNFα to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, A | 2017 |
Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil 1.
Topics: Animals; Cricetinae; Cysteine; Cytokines; Disease Models, Animal; Fluorouracil; Immunohistochemistry | 2017 |
A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin.
Topics: Administration, Oral; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Fluorouracil; Human | 2017 |
Neurobiological Mechanisms of Chemotherapy-induced Cognitive Impairment in a Transgenic Model of Breast Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognitive Dysfunct | 2018 |
Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer.
Topics: Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; China; Di | 2017 |
Therapeutic inhibition of SGK1 suppresses colorectal cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colo | 2017 |
Active Ingredients of Hange-shashin-to, Baicalelin and 6-Gingerol, Inhibit 5-Fluorouracil-Induced Upregulation of CXCL1 in the Colon to Attenuate Diarrhea Development.
Topics: Animals; Antimetabolites, Antineoplastic; Catechols; Chemokine CXCL1; Colon; Diarrhea; Disease Model | 2017 |
Therapeutic effect of andiroba oil (Carapa guianensis Aubl.) against oral mucositis: an experimental study in golden Syrian hamsters.
Topics: Animals; Disease Models, Animal; Fluorouracil; Male; Meliaceae; Mesocricetus; Plant Oils; Random All | 2018 |
Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer.
Topics: Adipocytes; Adipose Tissue; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; C | 2017 |
A Mouse Model for Oral Mucositis Induced by Cancer Chemotherapy.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Disease Models, Animal; Fluor | 2018 |
The effects of concurrent chemoradiation therapy to the base of tongue in a preclinical model.
Topics: Animals; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Disease Models, Animal; Dose Fractiona | 2018 |
PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats.
Topics: Animals; Antineoplastic Agents; Cognitive Dysfunction; Dentate Gyrus; Discrimination Learning; Disea | 2018 |
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Benzofurans; Carcinogene | 2018 |
Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Antibiotics, Antineoplastic; Carbazoles; Carvedilol; Chemical and Drug | 2018 |
Effects of melatonin on colonic anastomosis healing following chemotherapy in rats.
Topics: Anastomosis, Surgical; Animals; Antineoplastic Agents; Colon; Colonic Diseases; Disease Models, Anim | 2018 |
Effect of bevacizumab combined with chemotherapy at different sequences in the gastric-cancer-bearing nude mice.
Topics: Animals; Antineoplastic Agents, Immunological; Bevacizumab; Biomarkers; Cisplatin; Disease Models, A | 2018 |
A Judgement Bias Test to Assess Affective State and Potential Therapeutics in a Rat Model of Chemotherapy-Induced Mucositis.
Topics: Affect; Analgesics, Opioid; Animals; Antineoplastic Agents; Buprenorphine; Disease Models, Animal; D | 2018 |
Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.
Topics: Animals; Bacterial Translocation; Body Weight; Chemokines; Disease Models, Animal; Feeding Behavior; | 2018 |
Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy.
Topics: Adenocarcinoma; Allografts; Animals; Antineoplastic Combined Chemotherapy Protocols; Autografts; Car | 2018 |
Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice.
Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Culture Techniques; Disease Models, Animal; Femal | 2018 |
Improving the Subcutaneous Mouse Tumor Model by Effective Manipulation of Magnetic Nanoparticles-Treated Implanted Cancer Cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Disease Models, Animal; Fluorouracil; Ma | 2018 |
Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Behavior, Animal; Cell Cycle Checkpoints; Di | 2018 |
Crocin synergistically enhances the antiproliferative activity of 5-flurouracil through Wnt/PI3K pathway in a mouse model of colitis-associated colorectal cancer.
Topics: Animals; Antioxidants; Carotenoids; Cell Proliferation; Colitis; Colorectal Neoplasms; Dextran Sulfa | 2018 |
SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy.
Topics: Animals; Cytokines; Disease Models, Animal; Fluorouracil; Intestinal Mucosa; Male; Mice; Mice, Inbre | 2019 |
Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-β1 expression in hepatocellular carcinoma-induced in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Disease Models, Ani | 2018 |
A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Epi | 2019 |
Effects of simvastatin on 5-fluorouracil-induced gastrointestinal mucositis in rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Disease Models, Animal; Fluorouracil; Interleukin-1be | 2018 |
Multiple aPDT sessions on periodontitis in rats treated with chemotherapy: histomorphometrical, immunohistochemical, immunological and microbiological analyses.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Dental Scaling; Disease Models, | 2019 |
Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Body Weight; Centr | 2019 |
Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.
Topics: Aminobutyrates; Animals; Disease Models, Animal; Fluorouracil; gamma-Glutamyltransferase; Humans; Mi | 2019 |
Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer.
Topics: Adult; Aged; Animals; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Cell Line, Tumor; Cell | 2019 |
Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antimetabolites, Antineoplastic; Bone Marrow Cells; Disease | 2019 |
Lipophilic 5-fluorouracil prodrug encapsulated xylan-stearic acid conjugates nanoparticles for colon cancer therapy.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Colonic Neoplasms; Disease Models, Ani | 2019 |
Bmi1 marks gastric stem cells located in the isthmus in mice.
Topics: Acetic Acid; Animals; Biomarkers; Cell Differentiation; Cell Lineage; Cell Proliferation; Disease Mo | 2019 |
uMUC1-Targeting Magnetic Resonance Imaging of Therapeutic Response in an Orthotropic Mouse Model of Colon Cancer.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Fluorouracil; Glycosylation; M | 2019 |
Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Dis | 2019 |
Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation.
Topics: Amifostine; Animals; Cricetinae; Disease Models, Animal; Fluorouracil; Inflammation; Male; Protectiv | 2019 |
Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection.
Topics: Animals; Antimetabolites; Candida albicans; Candidiasis, Oral; Disease Models, Animal; Dysbiosis; Fe | 2019 |
Establishment and Characterization of 5-Fluorouracil-Resistant Human Colorectal Cancer Stem-Like Cells: Tumor Dynamics under Selection Pressure.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers; Cell Cycle; Cell Line, Tumor; Color | 2019 |
Treatment with selenium-enriched Saccharomyces cerevisiae UFMG A-905 partially ameliorates mucositis induced by 5-fluorouracil in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Disease Models, Animal; Female; Fluorouracil | 2019 |
MicroRNA-552 deficiency mediates 5-fluorouracil resistance by targeting SMAD2 signaling in DNA-mismatch-repair-deficient colorectal cancer.
Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; DNA Mismatch Repair; Fluorouracil; Humans; Mi | 2019 |
PI3 kinase alpha and delta promote hematopoietic stem cell activation.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Cycle; Class I Phosphatidylinositol 3-Kinases; Dis | 2019 |
Vorinostat Potentiates 5-Fluorouracil/Cisplatin Combination by Inhibiting Chemotherapy-Induced EGFR Nuclear Translocation and Increasing Cisplatin Uptake.
Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tu | 2019 |
l-arginine minimizes immunosuppression and prothrombin time and enhances the genotoxicity of 5-fluorouracil in rats.
Topics: Animals; Arginine; Disease Models, Animal; DNA Damage; Female; Fluorouracil; Immunosuppression Thera | 2019 |
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Topics: Active Transport, Cell Nucleus; Adult; Aged; Animals; beta Karyopherins; Carrier Proteins; Cell Line | 2019 |
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Disease Models, Animal; Female; Fluorouracil; | 2019 |
Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Cell Cycle; Colorectal Neopla | 2013 |
Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil.
Topics: Animals; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Combinat | 2013 |
Effects of laser irradiation at different wavelengths (660, 810, 980, and 1,064 nm) on mucositis in an animal model of wound healing.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Fibroblast Growth Factor 2; Fibroblasts; Fluoro | 2014 |
KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion.
Topics: Animals; Cell Growth Processes; Disease Models, Animal; Erythroid Cells; Female; Fluorouracil; Hemat | 2013 |
Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.
Topics: Animals; Autocrine Communication; Disease Models, Animal; Fluorouracil; Jejunal Diseases; Macrophage | 2013 |
A bioengineered metastatic pancreatic tumor model for mechanistic investigation of chemotherapeutic drugs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bioengineering; Camp | 2013 |
Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Disease Models, Animal; | 2013 |
Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; | 2013 |
Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Pancreatic Ductal; | 2013 |
Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Models, Animal; Disease Prog | 2013 |
Selective antitumor effect of neural stem cells expressing cytosine deaminase and interferon-beta against ductal breast cancer cells in cellular and xenograft models.
Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cell- a | 2014 |
Ultrasound-activated agents comprised of 5FU-bearing nanoparticles bonded to microbubbles inhibit solid tumor growth and improve survival.
Topics: Administration, Intravenous; Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug | 2014 |
The effect of bevacizumab on wound healing modulation in an experimental trabeculectomy model.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Disease Models, An | 2014 |
A preclinical murine model for the detection of circulating human tumor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Disease | 2013 |
Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Capecitabine; Cell Line, Tumor; Cell Proliferation; Deoxycyti | 2014 |
Alteration of the redox state with reactive oxygen species for 5-fluorouracil-induced oral mucositis in hamsters.
Topics: Animals; Cyclic N-Oxides; Disease Models, Animal; Fluorouracil; Kinetics; Male; Malondialdehyde; Mes | 2013 |
Efficacy of Salmonella typhimurium A1-R versus chemotherapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX).
Topics: Animals; Antimetabolites, Antineoplastic; Cisplatin; Deoxycytidine; Disease Models, Animal; Fluorour | 2014 |
The use of collagen content as determined by spectral domain polarization-sensitive optical coherence tomography to assess colon anastomosis healing in a rat model.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Antineoplastic Agents; Collagen; Collagen Type I; | 2014 |
Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters.
Topics: Administration, Topical; Animals; Blood Platelets; Cricetinae; Disease Models, Animal; Fibrin; Fluor | 2014 |
Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.
Topics: Albuminuria; Animals; Antimetabolites; Cytosine Deaminase; Diabetic Nephropathies; Disease Models, A | 2014 |
Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Disease Models, Animal; Doxorub | 2014 |
3'-Deoxy-3'-[18F]fluorothymidine positron emission tomography imaging of thymidine kinase 1 activity after 5-fluorouracil treatment in a mouse tumor model.
Topics: Animals; Colonic Neoplasms; Dideoxynucleosides; Disease Models, Animal; Fluorouracil; Heterografts; | 2014 |
Dietary quercetin reduces chemotherapy-induced fatigue in mice.
Topics: Anemia; Animals; Antimetabolites, Antineoplastic; Chemokine CCL2; Dietary Supplements; Disease Model | 2014 |
Efficacy of 5-fluorouracil in inhibition of unintended bone formation in spinal surgery: a histological evaluation on a rat model of spontaneous spinal fusion.
Topics: Animals; Antimetabolites; Disease Models, Animal; Fluorouracil; Organic Chemicals; Osteogenesis; Rat | 2014 |
Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model.
Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Dietary Fib | 2014 |
The effects of 5-fluorouracil on severe acute pancreatitis-inducing apoptosis of macrophages.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Cells, C | 2014 |
Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2014 |
NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Topics: Aged; Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Disease Models, Animal; Female; F | 2014 |
Thymidine phosphorylase is both a therapeutic and a suicide gene in a murine model of mitochondrial neurogastrointestinal encephalomyopathy.
Topics: Animals; Capecitabine; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine; Disease Models, A | 2014 |
Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cyclin-Depe | 2015 |
High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model.
Topics: Alphavirus; Animals; Cell Line; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; | 2014 |
Deletion of Dicer in late erythroid cells results in impaired stress erythropoiesis in mice.
Topics: Anemia, Hemolytic; Animals; Argonaute Proteins; Colony-Forming Units Assay; DEAD-box RNA Helicases; | 2014 |
Sphere-forming-like cells (squamospheres) with cancer stem-like cell traits from VX2 rabbit buccal squamous cell carcinoma.
Topics: AC133 Antigen; Aldehyde Dehydrogenase 1 Family; Animals; Antigens, CD; Antineoplastic Agents; Carcin | 2014 |
Effect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit model.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Collagen; Disease | 2014 |
Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cholester | 2014 |
The assessment of general well-being using spontaneous burrowing behaviour in a short-term model of chemotherapy-induced mucositis in the rat.
Topics: Animal Welfare; Animals; Disease Models, Animal; Drug Therapy; Fluorouracil; Inflammation; Injection | 2015 |
Ablation of experimental colon cancer by intratumoral 224Radium-loaded wires is mediated by alpha particles released from atoms which spread in the tumor and can be augmented by chemotherapy.
Topics: Ablation Techniques; Alpha Particles; Animals; Antineoplastic Agents; Brachytherapy; Cell Line, Tumo | 2015 |
Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Disease Models, Animal; Drug | 2014 |
Overcoming 5-Fu resistance in human non-small cell lung cancer cells by the combination of 5-Fu and cisplatin through the inhibition of glucose metabolism.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Disease Models, Animal; Drug R | 2014 |
Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cytosine Deaminase; Disease Models, Animal; Dose-Response | 2014 |
The chemokine CXCL9 exacerbates chemotherapy-induced acute intestinal damage through inhibition of mucosal restitution.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Proliferation; Chemokine CXCL9; Disease Mo | 2015 |
Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Survival; Dis | 2015 |
S-nitrosoglutathione accelerates recovery from 5-fluorouracil-induced oral mucositis.
Topics: Administration, Topical; Animals; Cricetinae; Disease Models, Animal; Fluorouracil; Gene Expression | 2014 |
Natural products and chemotherapeutic agents on cancer: prevention vs. treatment.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biological Availability; Biologic | 2014 |
LEIGC long non-coding RNA acts as a tumor suppressor in gastric carcinoma by inhibiting the epithelial-to-mesenchymal transition.
Topics: Adult; Aged; Aged, 80 and over; Animals; Base Sequence; Cell Line, Tumor; Cell Movement; Cell Prolif | 2014 |
Enhanced in vivo delivery of 5-fluorouracil by ethosomal gels in rabbit ear hypertrophic scar model.
Topics: Administration, Cutaneous; Animals; Antimetabolites; Cell Line; Chemistry, Pharmaceutical; Cicatrix, | 2014 |
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
Topics: Aberrant Crypt Foci; Animals; Antibodies, Blocking; Antineoplastic Combined Chemotherapy Protocols; | 2014 |
Integrinβ6-targeted immunoliposomes mediate tumor-specific drug delivery and enhance therapeutic efficacy in colon carcinoma.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Ca | 2015 |
Dopamine is a safe antiangiogenic drug which can also prevent 5-fluorouracil induced neutropenia.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Blood Pressure; Cell Line, Tumor; | 2015 |
Pretreatment With L-Citrulline Positively Affects the Mucosal Architecture and Permeability of the Small Intestine in a Murine Mucositis Model.
Topics: Animals; Citrulline; Dietary Supplements; Disease Models, Animal; Fluorouracil; Intestinal Mucosa; M | 2016 |
Myelotoxicity of carboplatin is increased in vivo in db/db mice, the animal model of obesity-associated diabetes mellitus.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Carboplatin; Diabetes Mellitus, Experimental; | 2015 |
Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined | 2015 |
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Chemoembolization, Therapeutic; Disea | 2015 |
Gastrointestinal toxicities of 5-fluorouracil increase the proportion of regulatory T cells in intestinal tract: advantages of alternate-day S-1 administration.
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Drug Combinations; Fluorouracil; G | 2015 |
The Combination of the PARP Inhibitor Rucaparib and 5FU Is an Effective Strategy for Treating Acute Leukemias.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Models | 2015 |
A Novel Therapy for Laryngotracheal Stenosis: Treatment With Ethosomes Containing 5-Fluorouracil.
Topics: Animals; Disease Models, Animal; Female; Fluorouracil; Immunosuppressive Agents; Laryngostenosis; Li | 2015 |
The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazoles; Cadherins; Carrier Proteins; Cell Line, Tum | 2015 |
Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model.
Topics: Alanine; Animals; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Apoptosis; Disease Models, Ani | 2015 |
The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination.
Topics: Animals; Apoptosis; Benzophenones; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferatio | 2015 |
Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats.
Topics: Administration, Intravenous; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain Injuries | 2015 |
An Immune-Modulating Diet in Combination with Chemotherapy Prevents Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice.
Topics: Animals; Antineoplastic Agents; Blood Glucose; Cachexia; Cell Line, Tumor; Colon; Colonic Neoplasms; | 2015 |
H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.
Topics: Animals; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; DNA Methylation; Dr | 2015 |
Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury.
Topics: Animals; Antineoplastic Agents; Calcium; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Mo | 2015 |
Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer.
Topics: Animals; beta Catenin; Cholecalciferol; Colonic Neoplasms; Disease Models, Animal; Fluorouracil; Hum | 2015 |
Neuroprotective effects of intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats on ischemic stroke.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain; Brain Ischemia; Cell Survival; Disea | 2016 |
Comparative study of the effects of PEGylated interferon-α2a versus 5-fluorouracil on cancer stem cells in a rat model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Disease Models, Animal | 2016 |
Influence of an elemental diet on 5-fluorouracil-induced morphological changes in the mouse salivary gland and colon.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Colon; Diarrhea; Disease Models, Anim | 2016 |
Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model.
Topics: Administration, Oral; Animals; Bifidobacterium; Cytokines; Diarrhea; Disease Models, Animal; Fluorou | 2015 |
Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model.
Topics: Animals; CD8-Positive T-Lymphocytes; Clinical Protocols; Disease Models, Animal; Drug Dosage Calcula | 2015 |
CXCL4 mediates tumor regrowth after chemotherapy by suppression of antitumor immunity.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferati | 2015 |
Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferat | 2016 |
Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Colon; Colonic Neoplasms; Digestive System; Disease | 2015 |
Evaluation of magnetic nanoparticles coated by 5-fluorouracil imprinted polymer for controlled drug delivery in mouse breast cancer model.
Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal | 2016 |
The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cholesterol; Colorectal Neoplasms; Disease Models, | 2016 |
Fancb deficiency impairs hematopoietic stem cell function.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cell P | 2015 |
The over-expression of FGFR4 could influence the features of gastric cancer cells and inhibit the efficacy of PD173074 and 5-fluorouracil towards gastric cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Flu | 2016 |
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil.
Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C | 2016 |
Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Bifidobacterium; | 2016 |
Paricalcitol Enhances the Chemopreventive Efficacy of 5-Fluorouracil on an Intermediate-Term Model of Azoxymethane-Induced Colorectal Tumors in Rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azoxymethane; Blotting, Western; Carcinogen | 2016 |
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoco | 2016 |
Folic Acid Supplementation Adversely Affects Chemosensitivity of Colon Cancer Cells to 5-fluorouracil.
Topics: Animals; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Drug In | 2016 |
Protective effect and potential mechanisms of Wei-Chang-An pill on high-dose 5-fluorouracil-induced intestinal mucositis in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Biomarkers; Cell Proliferation; Chromatogra | 2016 |
[Protective Effects of Acupuncture Intervention Against Damage of Intestinal Mucosal Barrier Induced by 5-Fluorouracil in Rats].
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Antineoplastic Agents; Disease Models, Animal; Fem | 2016 |
Environmental enrichment protects against cognitive impairment following chemotherapy in an animal model.
Topics: Animals; Antimetabolites, Antineoplastic; Cognition Disorders; Disease Models, Animal; Drug Therapy; | 2016 |
Intravoxel incoherent motion diffusion-weighted imaging for monitoring chemotherapeutic efficacy in gastric cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Diffusion Magnet | 2016 |
Polymeric Cups for Cavitation-mediated Delivery of Oncolytic Vaccinia Virus.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Fluorouracil; Gene Transfer Techniques; Genetic V | 2016 |
The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model.
Topics: Animals; Anti-Inflammatory Agents; Apigenin; Dexamethasone; Disease Models, Animal; Fluorouracil; Ma | 2017 |
Protective effect of Bu-zhong-yi-qi decoction, the water extract of Chinese traditional herbal medicine, on 5-fluorouracil-induced renal injury in mice.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal | 2016 |
Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Disease Models, | 2016 |
Neuroprotection by intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats in a model of ischemic stroke.
Topics: Analysis of Variance; Animals; Antigens, CD; Brain Ischemia; Chemokine CXCL12; Cytokines; Disease Mo | 2016 |
Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Colonic Neoplasms; Disease Model | 2016 |
miR-221 Mediates Chemoresistance of Esophageal Adenocarcinoma by Direct Targeting of DKK2 Expression.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Culture Techniques; Disease Models, A | 2016 |
miRNA-24-3p promotes cell proliferation and regulates chemosensitivity in head and neck squamous cell carcinoma by targeting CHD5.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2016 |
Celecoxib enhances the inhibitory effect of 5-FU on human squamous cell carcinoma proliferation by ROS production.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Celeco | 2017 |
Use of 5-Fluorouracil Loaded Micelles and Cisplatin in Thermosensitive Chitosan Hydrogel as an Efficient Therapy against Colorectal Peritoneal Carcinomatosis.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmac | 2017 |
Repurposing the anticancer drug mitomycin C for the treatment of persistent Acinetobacter baumannii infections.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Antibiotics, Anti | 2017 |
Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chemokine CXCL12; Disease Models, Animal; Drug | 2017 |
REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Sur | 2017 |
Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice.
Topics: Acyl-CoA Oxidase; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Cells, Cultured; Dise | 2017 |
Reduction of carcinomatosis risk using icodextrin as a carrier solution of intraperitoneal oxaliplatin chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cell Line, Tumor; Cell Movement; | 2017 |
Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Ani | 2017 |
Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis.
Topics: Animals; Antibiosis; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Enterococcus fae | 2017 |
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.
Topics: Acetamides; Animals; Antimetabolites, Antineoplastic; Capsaicin; Cell Line; Cell Movement; Cell Prol | 2009 |
[Effect of 5-fluorouracil on modulation of immunity-associated cytokine during severe sepsis in rat].
Topics: Animals; Cytokines; Disease Models, Animal; Female; Fluorouracil; Interleukin-10; Interleukin-6; Lun | 2008 |
Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice.
Topics: Adenoviridae; alpha-Fetoproteins; Animals; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellula | 2008 |
A simple colostomy implantation model for evaluating colon cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; Colostomy; Disease Mo | 2009 |
Light-emitting diode therapy in chemotherapy-induced mucositis.
Topics: Animals; Antineoplastic Agents; Cheek; Cricetinae; Disease Models, Animal; Fluorouracil; Male; Mesoc | 2008 |
The effect-enhancing and toxicity-reducing action of the extract of herba Scutellariae barbatae for chemotherapy in hepatoma H22 tumor-bearing mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined | 2008 |
Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice.
Topics: Animals; Anorexia; Antimetabolites, Antineoplastic; Appetite Stimulants; Body Weight; Cachexia; Cell | 2008 |
Effects of oxaliplatin and 5-fluorouracil on the healing of colon anastomoses.
Topics: Anastomosis, Surgical; Animals; Antineoplastic Agents; Colonic Neoplasms; Disease Models, Animal; Fe | 2009 |
Pectin/Kollicoat SR30D isolated films for colonic delivery [I]: a comparison of normal and colitis-induced models to assess the efficiency of microbially triggered drug delivery.
Topics: Animals; Cecum; Colitis; Colon; Disease Models, Animal; Drug Delivery Systems; Fluorouracil; Glass; | 2009 |
Postoperative use of bevacizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbit.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimet | 2009 |
Early effects of FOLFOX treatment of colorectal tumour in an animal model: assessment of changes in gene expression and FDG kinetics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colorectal Neoplasms; Dis | 2009 |
Expression of the bifunctional suicide gene CDUPRT increases radiosensitization and bystander effect of 5-FC in prostate cancer cells.
Topics: Animals; Blotting, Western; Bystander Effect; Cell Line, Tumor; Coculture Techniques; Cytosine Deami | 2009 |
Fluorescence lifetime imaging microscopy of chemotherapy-induced apoptosis resistance in a syngenic mouse tumor model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Caspase 3; Colorectal Neoplasms; Disease M | 2010 |
Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Combined Modality Therapy; Disease Models, Animal; Flu | 2009 |
Minocycline attenuates 5-fluorouracil-induced small intestinal mucositis in mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Apoptosis; Cell P | 2009 |
Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.
Topics: Analysis of Variance; Animals; Cell Proliferation; Disease Models, Animal; Exploratory Behavior; Flu | 2010 |
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Topics: Adenocarcinoma; Adenoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2010 |
Anticancer drug 5-fluorouracil induces reproductive and developmental defects in Caenorhabditis elegans.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Caenorhabditis elegans; Caenorhabditis elegans | 2010 |
The combination of 5-FU, leucovorin and CPT-11 (FOLFIRI) prolongs survival through inhibition of metastasis in an orthotopic model of colon cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neo | 2010 |
Comparative evaluation of preclinical in vivo models for the assessment of replicating retroviral vectors for the treatment of glioblastoma.
Topics: Animals; Brain Neoplasms; Bystander Effect; Cytosine Deaminase; Disease Models, Animal; Drug Evaluat | 2011 |
Chemotherapy-induced myelotoxicity and incidence of lung metastasis in an animal model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Cisplatin; Colonic Ne | 2011 |
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Topics: Actins; Acute Disease; Animals; Bone Marrow Cells; Cell Movement; Cell Proliferation; Cell Survival; | 2010 |
Interleukin-1 receptor antagonist reduced apoptosis and attenuated intestinal mucositis in a 5-fluorouracil chemotherapy model in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Benzimidazoles; Diarrhea; Disease Models, Anima | 2011 |
Interleukin 1 receptor antagonist reduces lethality and intestinal toxicity of 5-fluorouracil in a mouse mucositis model.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Body Weight; Diarrhea; Disease M | 2010 |
[Comparison of glucan and galactomannan tests with real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model].
Topics: Animals; Antigens, Fungal; Aspergillus fumigatus; beta-Glucans; Bronchoalveolar Lavage Fluid; Diseas | 2010 |
A superficial colon tumor model involving subcutaneous colon translocation and orthotopic transplantation of green fluorescent protein-expressing human colon tumor.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cecum; Cell Proliferation; Colonic Neoplas | 2011 |
Role of bone marrow-derived monocytes/macrophages in the repair of mucosal damage caused by irradiation and/or anticancer drugs in colitis model.
Topics: Acetic Acid; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biomarkers; Bone Marro | 2010 |
Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, T | 2011 |
Interleukin 1 receptor antagonist reduces lethality and intestinal toxicity of 5-Fluorouracil in a mouse mucositis model.
Topics: Animals; Body Weight; Diarrhea; Disease Models, Animal; Drug Interactions; Female; Fluorouracil; Gen | 2011 |
Multidrug resistance reversal effect of DMC derived from buds of Cleistocalyx operculatus in human hepatocellular tumor xenograft model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3 | 2012 |
Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model.
Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Cognition Disorders; | 2011 |
Development and evaluation of novel microemulsion based oral formulations of 5-fluorouracil using non-everted rat intestine sac model.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Benzo(a)pyrene; Biological Availabil | 2012 |
Regeneration of dopaminergic neurons after 6-hydroxydopamine-induced lesion in planarian brain.
Topics: Analysis of Variance; Animals; Brain Injuries; Bromodeoxyuridine; Cell Cycle; Cell Movement; Cell Pr | 2011 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Topics: Animals; Brain Neoplasms; Combined Modality Therapy; Disease Models, Animal; Female; Flucytosine; Fl | 2012 |
Microscopic comparison of topical use of Mitomycin C and Fluorouracil on cold knife myringotomy.
Topics: Administration, Topical; Animals; Disease Models, Animal; Female; Fluorouracil; Immunohistochemistry | 2012 |
Antitumor activity of chemoendocrine therapy in premenopausal and postmenopausal models with human breast cancer xenografts.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase; | 2012 |
Local control of experimental malignant pancreatic tumors by treatment with a combination of chemotherapy and intratumoral 224radium-loaded wires releasing alpha-emitting atoms.
Topics: Alpha Particles; Animals; Antimetabolites, Antineoplastic; Brachytherapy; Cell Line, Tumor; Cell Pro | 2012 |
Combination of a fusogenic glycoprotein, pro-drug activation and oncolytic HSV as an intravesical therapy for superficial bladder cancer.
Topics: Administration, Intravesical; Animals; Apoptosis; Carcinoma, Transitional Cell; Cell Line, Tumor; Cr | 2012 |
Potently immunosuppressive 5-fluorouracil-resistant mesenchymal stromal cells completely remit an experimental autoimmune disease.
Topics: Animals; Cell Differentiation; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Down-R | 2012 |
Murine retroviral bone marrow transplantation models for the study of human myeloproliferative disorders.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow Cells; Bone Marrow Transplantation; Culture Me | 2008 |
A WKYMVm-containing combination elicits potent anti-tumor activity in heterotopic cancer animal model.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Antineoplastic Agents; Apoptosis; Cancer Vaccines; | 2012 |
First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Capecitabine; Cel | 2012 |
The effects of chemotherapy on cognitive function in a mouse model: a prospective study.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cognition; Disease Models, Animal; Female; | 2012 |
Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis.
Topics: Animals; Apolipoproteins E; Apoptosis; Biomimetic Materials; Cell Movement; Cell Proliferation; Cell | 2012 |
Efficient inhibition of colorectal peritoneal carcinomatosis by drug loaded micelles in thermosensitive hydrogel composites.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; | 2012 |
Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models.
Topics: Administration, Metronomic; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Prot | 2013 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
Pharmacokinetics of 5-fluorouracil and cyclophosphamide in depression rats.
Topics: Affect; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Behavior, Anima | 2012 |
Protein fraction of Calotropis procera latex protects against 5-fluorouracil-induced oral mucositis associated with downregulation of pivotal pro-inflammatory mediators.
Topics: Animals; Antimetabolites, Antineoplastic; Calotropis; Cricetinae; Cyclooxygenase 2; Cytokines; Disea | 2012 |
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
Topics: Adenosine; Animals; Cell Line; Cell Line, Tumor; Disease Models, Animal; Fibrosarcoma; Fluorouracil; | 2012 |
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2012 |
[Effects of myxoma virus on gliomas of rats models in vivo].
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Female; Fluorouracil; Glioma; Male; Myxoma virus; | 2012 |
Comparative therapeutic efficacy of rhenium-188 radiolabeled-liposome and 5-fluorouracil in LS-174T human colon carcinoma solid tumor xenografts.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Fluorouracil; Humans; Liposome | 2012 |
Hedgehog signaling displays a biphasic expression pattern during intestinal injury and repair.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Down-Regulation; Female; Fluo | 2012 |
Therapeutic efficacy of 188Re-liposome in a C26 murine colon carcinoma solid tumor model.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; | 2013 |
Skin cancer treatment by albumin/5-Fu loaded magnetic nanocomposite spheres in a mouse model.
Topics: Albumins; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Drug Carriers; Fluorouracil; Ma | 2013 |
Anti-tumor efficacy of a novel antisense anti-MDM2 mixed-backbone oligonucleotide in human colon cancer models: p53-dependent and p53-independent mechanisms.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Colorectal Neoplasms; | 2002 |
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy.
Topics: Animals; Antimetabolites; Bystander Effect; Cell Survival; Cytosine Deaminase; Disease Models, Anima | 2002 |
[Double promoters induct suicide gene target killing of 5-FU drug-fast cancer cells].
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Drug Delivery Systems; Fluorouraci | 2002 |
[Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer].
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Cyclohexanes; Disease Models, Animal; Drug C | 2002 |
Prevention of peritoneal metastasis of human gastric cancer cells in nude mice by S-1, a novel oral derivative of 5-Fluorouracil.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Drug Combina | 2003 |
[Influence of combination of low dosage 131I-labeled anti-carcinoembryonic antigen antibody C50 and 5-fluorouracil on tumor growth of colorectal cancer xenografts in nude mice].
Topics: Animals; Antibodies; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colorectal Neoplasms | 2003 |
[Subcutaneous transplantation of microencapsulated Chinese hamster ovary (CHO) cells/pcDNA 3.1/mIL-12 and subcutaneous transplantation of microencapsulated CHO/pcDNA3.1/mIL-12 combined with 5-fluoro-uracil in treatment of tumor-burdened mice].
Topics: Animals; Antimetabolites, Antineoplastic; CHO Cells; Cricetinae; Disease Models, Animal; Drug Compou | 2003 |
Experimental study to evaluate the usefulness of S-1 in a model of peritoneal dissemination of gastric cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Disease Models, Animal; Drug Combinations; Ea | 2003 |
[Nonbiodegradable drug-sustained capsular ring for prevention of secondary cataract. Part II: In vivo evaluation].
Topics: Animals; Antimetabolites; Biocompatible Materials; Capsules; Cataract; Delayed-Action Preparations; | 2003 |
Kinetic modeling of 5-fluorouracil anabolism in colorectal adenocarcinoma: a positron emission tomography study in rats.
Topics: Adenocarcinoma; Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Fluorine Radioisotope | 2003 |
Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Bo | 2003 |
Pharmacokinetics of 5-fluorouracil following hepatic intra-arterial infusion in a VX2 hepatic metastasis model.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Models, Animal; Drug Adminis | 2003 |
Antitumor effect of a splenic injection of 5-fluorouracil on metastatic liver cancer in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Fluorouracil; Injections; Interleu | 2004 |
[Combined treatment with fluorinated pyrimidines and selective cyclooxygenase-2 inhibitors for liver metastasis of colon cancer].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; Cyclooxyg | 2003 |
Clinical and pathological features of the murine AT-84 orthotopic model of oral cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models | 2003 |
Forced expression of cytidine deaminase confers sensitivity to capecitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Survival; Cytidine Deaminase; Deoxycyti | 2003 |
Combined 5-fluorouracil/systemic interferon-beta gene therapy results in long-term survival in mice with established colorectal liver metastases.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Colorectal Neop | 2004 |
Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Aorta, Thoracic; Colonic Neoplasms; Deoxyr | 2004 |
Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil.
Topics: Administration, Inhalation; Aerosols; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squa | 2004 |
Chemoembolization of rat liver metastasis with microspheres and gemcitabine followed by evaluation of tumor cell load by chemiluminescence.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Chemoembolization, Therapeutic; Colonic | 2004 |
Comparison between triple therapy with octreotide, galanin and serotonin, 5-fluorouracil/leucovorin, and sequential treatment with both, on human colon cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Division; C | 2004 |
An intravitreal biodegradable sustained release naproxen and 5-fluorouracil system for the treatment of experimental post-traumatic proliferative vitreoretinopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Disease Models, Ani | 2004 |
Schedule-dependent synergism of vinorelbine and 5-fluorouracil/UFT against non-small cell lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Carcinoma, Non-Small-Cel | 2004 |
Water-soluble extracts from Angelica acutiloba Kitagawa enhance hematopoiesis by activating immature erythroid cells in mice with 5-fluorouracil-induced anemia.
Topics: Anemia; Angelica; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eryt | 2004 |
Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Camptothecin; Carboxylesterase; Cell Line, T | 2004 |
EGFR-antibody-supplemented TPF chemotherapy. Preclinical investigations to a novel approach for head and neck cancer induction treatment.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; | 2005 |
Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Topics: Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cystadenocarcinoma, Mucinous; Disease Models | 2005 |
CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antimetabolites, Antineoplastic; Cell Proliferat | 2005 |
Enhanced efficacy of conditionally replicating herpes simplex virus (G207) combined with 5-fluorouracil and surgical resection in peritoneal cancer dissemination models.
Topics: Animals; Antibodies, Viral; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality | 2005 |
Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Camptothecin; Cisplatin; Colonic Neoplasms; | 2005 |
Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters.
Topics: Abscess; Animals; Antimetabolites, Antineoplastic; Cricetinae; Disease Models, Animal; Edema; Erythe | 2005 |
Improvement in 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) concentration by 5-fluorouracil-polyethylene-glycol-liposomes in abdominal stop-flow: treatment of VX2 liver-tumor-bearing rabbits.
Topics: Animals; Biological Availability; Blood Flow Velocity; Chromatography, High Pressure Liquid; Disease | 2005 |
Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; CpG Island | 2006 |
Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches.
Topics: Administration, Topical; Animals; Anti-Ulcer Agents; Biomarkers; Cricetinae; Disease Models, Animal; | 2006 |
Therapy with ribozyme to the proliferating cell nuclear antigen-ribozyme and 5-fluorouracil of experimental choroidal neovascularization in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Choroidal Neovascularization; Combined Modality Therapy; D | 2006 |
5-fluorouracil (5FU) treatment does not influence invasion and metastasis in microsatellite unstable (MSI-H) colorectal cancer.
Topics: Animals; Cell Count; Cell Survival; Colorectal Neoplasms; Disease Models, Animal; Flow Cytometry; Fl | 2006 |
Carbogen breathing differentially enhances blood plasma volume and 5-fluorouracil uptake in two murine colon tumor models with a distinct vascular structure.
Topics: Animals; Antimetabolites, Antineoplastic; Carbon Dioxide; Cell Line, Tumor; Colonic Neoplasms; Disea | 2006 |
Development of an orogastrointestinal mucosal model of candidiasis with dissemination to visceral organs.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Colony Count, Microbial; Disease Models, | 2006 |
Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Ce | 2006 |
Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Atrasentan; Cell Prolife | 2006 |
[The effect of topical application of 5-fluorouracil on patency times after incisional myringotomy of guinea pig tympanic membrane].
Topics: Administration, Topical; Animals; Antimetabolites; Disease Models, Animal; Fluorouracil; Guinea Pigs | 2006 |
Probiotic effects on 5-fluorouracil-induced mucositis assessed by the sucrose breath test in rats.
Topics: Animals; Bifidobacterium; Breath Tests; Disease Models, Animal; Female; Fluorouracil; Ileum; Immunos | 2007 |
A combination of 5-fluorouracil and membrane-bound antibody inhibits B-cell lymphoma growth in a mouse model system.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; CD40 Antigens; Cell Membrane; Comb | 2007 |
Macroscopic and microscopic effects of GaAIAs diode laser and dexamethasone therapies on oral mucositis induced by fluorouracil in rats.
Topics: Aluminum; Animals; Anti-Inflammatory Agents; Antimetabolites; Arsenicals; Biofilms; Dexamethasone; D | 2007 |
In vivo imaging of oral mucositis in an animal model using optical coherence tomography and optical Doppler tomography.
Topics: Animals; Blood Flow Velocity; Cricetinae; Disease Models, Animal; Fluorouracil; Mesocricetus; Mouth | 2007 |
Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
Topics: Animals; Colorectal Neoplasms; Cytosine Deaminase; Disease Models, Animal; Female; Flucytosine; Fluo | 2007 |
Effect of hydroxyapatite nanoparticles on the growth and p53/c-Myc protein expression of implanted hepatic VX2 tumor in rabbits by intravenous injection.
Topics: Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; Cell Proliferation; Disease Model | 2007 |
Bioluminescent imaging of hepatocellular carcinoma in live mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, | 2007 |
Histological evaluation of colonic anastomotic healing, during perioperative Capecitabine administration. Experimental study in rats.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvan | 2007 |
[Study of the immunological mechanism of anti-tumor effects of 5-FU by establishing EL4 tumor-bearing mouse models].
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship | 2007 |
Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis.
Topics: Animals; Antimetabolites, Antineoplastic; Breath Tests; Disease Models, Animal; Dose-Response Relati | 2008 |
Effects of endogenous nitric oxide induced by 5-fluorouracil and L-Arg on liver carcinoma in nude mice.
Topics: Animals; Antimetabolites; Apoptosis; Arginine; bcl-2-Associated X Protein; Carcinoma, Hepatocellular | 2007 |
Effects of locally applied 5-fluorouracil on the prevention of postmastectomy seromas in a rat model.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Female; Fluorour | 2008 |
Interferon-alpha in combination with chemotherapy has potent antiangiogenic properties in an orthotopic mouse model for pancreatic adenocarcinoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Cel | 2008 |
Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined | 2008 |
[Relationships between tumor shrinkage and peripheral blood cell changes during tumor-rejection induced by a high dose of 5-FU in C57BL/6 mice].
Topics: Animals; Antimetabolites, Antineoplastic; Blood Platelets; Cell Line, Tumor; Disease Models, Animal; | 2008 |
Defining the optimal schedule of drug administration: art or science?
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Top | 2008 |
Myelophil, a mixture of Astragali Radix and Salviae Radix extract, moderates toxic side effects of fluorouracil in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Bone Marrow; Bone Marrow Diseases; Cell | 2008 |
Symbrachydactyly: pathogenesis of 5-fluorouracil induced model in mice.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Fluorouracil; Mice; Pregnancy; | 1980 |
Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. Monotherapy with 5-fluorouracil, methyl-CCNU, mitomycin C, adriamycin, and cytosine arabinoside, and combination therapy with respective two-drug combina
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Disease Models, Animal; Dox | 1983 |
Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Doxorubicin; Eye Diseases; Female; Fibroblas | 1984 |
16-16 dimethyl prostaglandin E2 reduces 5-fluorouracil-induced and mitomycin C-induced gastric mucosal injury in the dog.
Topics: Animals; Disease Models, Animal; Dogs; Female; Fluorouracil; Gastric Acid; Gastric Mucosa; Infusions | 1984 |
[Combination chemotherapy and radiotherapy. Differential effect, on the intestinal syndrome, of fractionated irradiation with fractionated drug administration].
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Female; Fluorouracil; Intestinal Dise | 1982 |
[Combination chemotherapy and radiotherapy. Differential effect, on the medullary syndrome, of fractionated irradiation with fractionated drug administration].
Topics: Animals; Brain Diseases; Disease Models, Animal; Drug Administration Schedule; Female; Fluorouracil; | 1982 |
Clinical and in vivo response following surgery or surgery plus adjuvant chemotherapy or immunotherapy for colorectal carcinoma in a rat model.
Topics: Animals; Colonic Neoplasms; Combined Modality Therapy; Disease Models, Animal; Fluorouracil; Levamis | 1983 |
Chemotherapy of pancreatic adenocarcinoma: initial report on two transplantable models in the Syrian hamster.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cricetinae; Cyclophosphamide; Disease Models, Animal | 1982 |
Improved treatment of a brain-tumor model. Part 2: Sequential therapy with BCNU and 5-fluorouracil.
Topics: Animals; Brain Neoplasms; Carmustine; Clone Cells; Disease Models, Animal; Drug Therapy, Combination | 1983 |
Chemotherapy of chemically-induced colorectal tumours.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Female; Fluorouracil; Neopla | 1983 |
Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy.
Topics: Animals; Autoradiography; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Eye | 1983 |
The cause of neural tube defects: some experiments and a hypothesis.
Topics: Animals; Disease Models, Animal; DNA; Female; Fluorouracil; Gestational Age; Hydroxyurea; Mice; Mice | 1983 |
Castration--chemotherapy treatment of prostate cancer model.
Topics: Animals; Carmustine; Castration; Cell Transformation, Neoplastic; Cisplatin; Cyclophosphamide; Disea | 1981 |
An experimental model for treatment of mesothelioma.
Topics: Animals; Asbestos; Body Weight; Cricetinae; Cyclophosphamide; Disease Models, Animal; Doxorubicin; F | 1981 |
Uptake of 5-fluorouracil during isolated perfusion of the canine liver.
Topics: Animals; Disease Models, Animal; Dogs; Fluorouracil; Liver; Liver Neoplasms; Perfusion | 1980 |
Raloxifene (LY156758) produces antimetastatic responses and extends survival in the PAIII rat prostatic adenocarcinoma model.
Topics: Adenocarcinoma; Adrenal Glands; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Dis | 1995 |
Antitumour effects of pure diastereoisomers of 5-formyltetrahydrofolate in hepatic transplants of a rodent colon carcinoma model.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Divis | 1995 |
[Establishment and application of transplantable models of human esophageal carcinoma in nude mice].
Topics: Animals; Bleomycin; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; Disease Models, Animal; Esop | 1993 |
Effect of 5-fluorouracil and leucovorin on the integrity of colonic anastomoses in the rat.
Topics: Anastomosis, Surgical; Animals; Colectomy; Colon; Disease Models, Animal; Fluorouracil; Injections, | 1995 |
IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.
Topics: Acetates; Acetic Acid; Animals; Animals, Genetically Modified; beta 2-Microglobulin; Colitis; Cricet | 1994 |
Inhibitory action of a (1-->6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Meth A fibrosarcoma-bearing mice and its antitumor mechanism.
Topics: Agaricus; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Synergism; Erythrocytes; Fema | 1994 |
Oral administration of BOF-A2 to rats with lung transplanted tumors results in increased 5-fluorouracil levels.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Combinations; Dru | 1994 |
Enhancement of antitumor effects of combined chemoimmunotherapy.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; CD4-Positive T-Lymphocytes; Chemotherapy, Adjuvant; | 1993 |
Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3.
Topics: Animals; Cell Cycle; Cell Division; CHO Cells; Cricetinae; Disease Models, Animal; DNA; Epithelial C | 1994 |
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil.
Topics: Animals; Biodegradation, Environmental; Chromatography, High Pressure Liquid; Delayed-Action Prepara | 1994 |
A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice.
Topics: Animals; Disease Models, Animal; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neopl | 1993 |
Treatment of gamma radiation-induced transplanted leukemia in ICRC mice by liposomally encapsulated 5-fluoro uracil.
Topics: Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Stability; Female; F | 1993 |
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorour | 1993 |
Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C.
Topics: Animals; Biopsy; Conjunctiva; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Flu | 1993 |
Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Combined Modali | 1993 |
Suppression of experimental proliferative vitreoretinopathy by sustained intraocular delivery of 5-FU.
Topics: Animals; Antimetabolites; Biocompatible Materials; Biodegradation, Environmental; Delayed-Action Pre | 1995 |
Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice.
Topics: Ampicillin; Animals; Bacteremia; Ceftazidime; Cephalosporins; Cyclophosphamide; Disease Models, Anim | 1996 |
A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies.
Topics: Administration, Topical; Animals; Antibiotics, Antineoplastic; Conjunctiva; Cornea; Delayed-Action P | 1996 |
Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy.
Topics: Animals; Antimetabolites; Delayed-Action Preparations; Dexamethasone; Disease Models, Animal; Drug C | 1996 |
Colonic healing after early intraperitoneal administration of 5-fluorouracil and interferon in rats.
Topics: Anastomosis, Surgical; Animals; Colon; Disease Models, Animal; Drug Administration Schedule; Drug Th | 1997 |
The action of 5-fluorouracil on human HT29 colon cancer cells grown in SCID mice: mitosis, apoptosis and cell differentiation.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Body Weight; Carbohydrate Sequence; Cell Differ | 1997 |
Suppository administration of chemotherapeutic drugs with concomitant radiation for rectal cancer.
Topics: Adenocarcinoma; Administration, Rectal; Animals; Antibiotics, Antineoplastic; Chromatography, High P | 1997 |
An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy.
Topics: Animals; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Disease Models, Animal; | 1998 |
Vasopressin selectively increases 5-fluorouracil uptake by colorectal liver metastases following hepatic artery bolus infusion.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Models, Animal; Dose-Respons | 1998 |
Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Colorectal Neoplasms; Disease Models, Animal; Drug Combin | 1999 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxur | 1999 |
Modulation of fluorouracil antitumor activity by folic acid in a murine model system.
Topics: Animals; Antidotes; Antimetabolites, Antineoplastic; Diet; Disease Models, Animal; Drug Synergism; F | 1999 |
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemother | 1999 |
Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder.
Topics: Animals; Antimetabolites, Antineoplastic; B-Lymphocytes; Base Sequence; Bone Marrow Transplantation; | 2000 |
Sphingomyelin potentiates chemotherapy of human cancer xenografts.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; | 2000 |
Effects of 5-fluorouracil on flexor tendon repair.
Topics: Administration, Topical; Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Biomechanic | 2000 |
Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss.
Topics: Animals; Anti-Inflammatory Agents; Cyclosporine; Dexamethasone; Disease Models, Animal; Drug Evaluat | 2000 |
Validation of fluorouracil metabolite analysis in excised tumor. Lability of anabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease Models, Animal; Female; Fluo | 2000 |
Electrochemotherapy for colorectal cancer with commonly used chemotherapeutic agents in a mouse model.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cisplatin; Colorectal Neoplasms; Disease Models, Animal; | 2000 |
Modulation of the formation of adhesions during the healing of injured tendons.
Topics: Animals; Cell Count; Disease Models, Animal; Fibroblasts; Fluorouracil; Hindlimb; Immunosuppressive | 2000 |
An experimental model of tumor dormancy therapy for advanced head and neck carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antioxidan | 2000 |
A novel weekday-on/weekend-off UFT schedule.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 2000 |
Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Renal Cell; Cell Survival; Deoxyc | 2001 |
Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidi | 2001 |
A preclinical model for experimental chemotherapy of human head and neck cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Body Weight; Carboplatin; | 2001 |
Beyond hydroxyurea.
Topics: Animals; Antiviral Agents; Benzamidines; Dipyridamole; Disease Models, Animal; Floxuridine; Fluorour | 1995 |
Thrombocytopenic c-mpl(-/-) mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response.
Topics: Age Factors; Animals; Blood Platelets; Bone Marrow Cells; Disease Models, Animal; Fluorouracil; Mega | 2001 |
Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Camptothecin; Cisplatin; Colonic | 2002 |
Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Bystander Effect; Colonic Neoplasms; Cytosine Deaminase; D | 2002 |
[A novel rat aplastic anemia model induced by 5-fluorouracil combined with busulfan].
Topics: Anemia, Aplastic; Animals; Blood Cell Count; Busulfan; Disease Models, Animal; Female; Fluorouracil; | 2001 |
Naked DNA injection for liver metastases treatment in rats.
Topics: Animals; Antimetabolites; Colonic Neoplasms; Cytosine Deaminase; Disease Models, Animal; Flucytosine | 2002 |
A study of trace and minor elements in the solid tumor model 3924A hepatoma before and after treatment with t-fluorouracil.
Topics: Animals; Carcinoma, Hepatocellular; Cattle; Disease Models, Animal; Female; Fluorouracil; Liver; Liv | 1975 |
Effect of immunosuppressive agents on the course of experimental syphilis in rabbits.
Topics: Animals; Antibody Formation; Cyclophosphamide; Disease Models, Animal; Female; Fluorouracil; Immunit | 1979 |
Chemotherapy of Nb rat adenocarcinoma of the prostate heterotransplanted into congenitally athymic (nude) mice: report of 5-fluorouracil and cyclophosphamide.
Topics: Adenocarcinoma; Animals; Cyclophosphamide; Disease Models, Animal; Fluorouracil; Male; Mice; Mice, N | 1979 |
Solid tumor models for the assessment of different treatment modalities: VIII. The scheduling of treatment for a chemotherapeutically resistant experimental solid tumor.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cyclophosphamide; Disease Models, Animal; DNA; Doxorubi | 1979 |
Solid tumor models for the assessment of different treatment modalities. XII. Combined chemotherapy-radiotherapy: variation of time interval between time of administration of 5-fluorouracil and radiation and its effect on the control of tumor growth.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radia | 1979 |
Prostate adenocarcinoma model: Nb rat chemotherapy.
Topics: Adenocarcinoma; Animals; Castration; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Doxorub | 1979 |
[Possibilities and limits of pre-therapeutic neoplasm sensitivity cytostatics tests under short-term conditions].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cyclophosphamide; Dactinomycin; D | 1975 |
An animal model for screening topical and systemic drugs for potential use in the treatment of psoriasis.
Topics: Administration, Topical; Animals; Cyclophosphamide; Disease Models, Animal; DNA; Drug Evaluation, Pr | 1975 |
Single and combination chemotherapy for primary murine bladder cancer.
Topics: Animals; Carcinoma, Transitional Cell; Cisplatin; Cyclophosphamide; Dactinomycin; Disease Models, An | 1975 |
Antibacterial effect of bovine milk antibody against Escherichia coli in a mouse indigenous infection model.
Topics: Animals; Antibodies, Bacterial; Cattle; Cecum; Disease Models, Animal; Escherichia coli; Escherichia | 1992 |
Inhibition of corneal epithelial wound healing. A comparative study of mitomycin C and 5-fluorouracil.
Topics: Animals; Cell Division; Cornea; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelium | 1992 |
Comparison of intra-arterial versus intravenous 5-fluorouracil administration on epidermal squamous cell carcinoma in sheep.
Topics: Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Drug Administration Schedule; Ear Neoplas | 1992 |
Fatal systemic candidiasis of gastrointestinal origin: an experimental model in mice compromised by anti-cancer treatment.
Topics: Animals; Candida albicans; Candidiasis; Cecum; Chemotherapy, Adjuvant; Disease Models, Animal; Esoph | 1992 |
[The action of 5-fluorouracil in DMH-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Drug Evalua | 1992 |
Evaluation of the wap-ras transgenic mouse as a model system for testing anticancer drugs.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Disease Models, Animal; Fluorouracil; Genes, ras; | 1992 |
Evaluation of drug treatments for proliferative vitreoretinopathy using vitreous microtensiometry.
Topics: Aminopropionitrile; Animals; Cattle; Disease Models, Animal; Drug Combinations; Equipment Design; Ev | 1991 |
Experimental model of colon cancer: recurrences after surgery alone or associated with intraperitoneal 5-fluorouracil chemotherapy.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Dise | 1991 |
Anti-tumor effect of L-methionine-deprived total parenteral nutrition with 5-fluorouracil administration on Yoshida sarcoma-bearing rats.
Topics: Animals; Body Weight; Cause of Death; Combined Modality Therapy; Disease Models, Animal; Evaluation | 1991 |
The therapeutic impact of dipyridamole: chemopotentiation of the cytotoxic combination 5-fluorouracil/cisplatin in an animal model of human bladder cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cisplatin; Dipyridamole; Disease | 1991 |
Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil.
Topics: Animals; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Follow-Up Studies; Rabbits | 1991 |
An animal model for mucositis induced by cancer chemotherapy.
Topics: Animals; Cricetinae; Disease Models, Animal; Epithelium; Fluorouracil; Leukopenia; Male; Mesocricetu | 1990 |
Prolonged thrombocytosis in mice after 5-fluorouracil results from failure to down-regulate megakaryocyte concentration. An experimental model that dissociates regulation of megakaryocyte size and DNA content from megakaryocyte concentration.
Topics: Animals; Disease Models, Animal; DNA; Down-Regulation; Female; Fluorouracil; Megakaryocytes; Mice; M | 1990 |
Effect of 5-fluorouracil on "primitive" hematopoietic stem cells that reconstitute whole erythropoiesis of genetically anemic W/Wv mice.
Topics: Anemia; Animals; Bone Marrow Transplantation; Disease Models, Animal; Erythrocytes; Erythropoiesis; | 1989 |
Effect of concentration and time of drug exposure on clonal growth of murine bladder cancer.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Line; Cisplatin; Colony-Forming Units Assay; Disease | 1985 |
Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Disea | 1989 |
Corneal endothelial wound closure in vitro. Effects of EGF and/or indomethacin.
Topics: Animals; Cell Count; Cell Division; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothel | 1989 |
In vivo isolated liver perfusion technique in a rat hepatic metastasis model: 5-fluorouracil concentrations in tumor tissue.
Topics: Animals; Chemotherapy, Cancer, Regional Perfusion; Chromatography, High Pressure Liquid; Colonic Neo | 1988 |
Studies of eicosanoid production in the air pouch model of synovial inflammation.
Topics: 6-Ketoprostaglandin F1 alpha; Air; Animals; Carrageenan; Colchicine; Dinoprostone; Disease Models, A | 1986 |
Experimental combination chemotherapy of ACNU and 5-FU against cultured glioma model (spheroid) and subcutaneous rat glioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colony-Forming Units Assay; Di | 1987 |
Temporary blood flow stasis with degradable starch microspheres (DSM) for liver metastases in a rat model.
Topics: Animals; Disease Models, Animal; Drug Carriers; Fluorouracil; Hemostasis; Hepatic Artery; Injections | 1987 |
Stability of the in vivo P388 leukemia model in evaluation of antitumor activity of natural products.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Evaluation Stu | 1985 |
[Intraductal therapy of acute pancreatitis with 5-fluorouracil].
Topics: Acute Disease; Adult; Animals; Antibody Formation; Disease Models, Animal; Dogs; Drug Evaluation; Dr | 1985 |
Intra-arterial infusion chemotherapy in head and neck cancer. A clinical and experimental study.
Topics: Animals; Carotid Artery, External; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Diseas | 1973 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides | 1974 |
The growth of human tumours in immunosuppressed mice and their response to chemotherapy.
Topics: Animals; Chlorambucil; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; | 1974 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; N | 1970 |
Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymom | 1971 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; | 1969 |
A re-examination of the renal blastema graft model for Wilms tumor production.
Topics: Animals; Autopsy; Cell Differentiation; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Drug | 1974 |
The chemotherapy of large-bowel cancer. Present status and future prospects.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Cricetinae; Culture Techniques; Cyclohexanes; Cyc | 1974 |
ICRF-159 in treatment of germinal testicular tumor in animals.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Dogs; Drug T | 1974 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, | 1974 |
Intra-articular 5-fluorouracil (5-FU) in antigen-induced arthritis: effect of timing on response.
Topics: Animals; Antigens; Arthritis, Rheumatoid; Disease Models, Animal; Fluorouracil; Freund's Adjuvant; H | 1973 |
Age cohort variation of tumor cells.
Topics: Animals; Cell Division; Disease Models, Animal; DNA, Neoplasm; Fluorouracil; Hydroxyurea; Lymphoma; | 1973 |
Proceedings: Rationale and results of primary endocrine therapy in patients with prostatic cancer.
Topics: Androgen Antagonists; Animals; Arginase; Body Weight; Castration; Cyclophosphamide; Cyproterone; Dis | 1973 |
Effect of chemotherapeutic agents on bladder cancer: a new animal model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Cyclophosphamide; Dactinomycin; Diamin | 1973 |
The effect of chemotherapy on germinal testicular tumors in mice.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluo | 1970 |
Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Disease Mo | 1970 |
Differential effects of anti-tumour drugs on human tumour and spleen DNA synthesis in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Culture Techniques; Disease Model | 1971 |
Intra-articular 5-fluorouracil in antigen-induced arthritis.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Fluorouracil; Knee Joint; Ovalbumin; Rabbits | 1971 |