fluorouracil has been researched along with Disbacteriosis in 14 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The chemotherapeutic agent 5-fluorouracil (5-FU) causes intestinal mucositis with severe diarrhoea, but the pathogenesis is not fully understood." | 7.85 | Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice. ( Amagase, K; Hamouda, N; Higuchi, K; Kato, S; Matsumoto, K; Oikawa, Y; Ozaki, T; Sano, T; Shimakawa, M, 2017) |
| " 5-Fluorouracil (5-FU), widely used for cancer chemotherapy, is known to frequently induce intestinal mucositis accompanied by severe diarrhoea." | 7.85 | Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses. ( Amagase, K; Hamouda, N; Kano, Y; Kato, S; Matsumoto, K; Oikawa, Y; Shimakawa, M; Tanaka, Y, 2017) |
| "Colorectal cancer is one of the most frequently diagnosed cancers worldwide." | 5.48 | The influence of gut microbiota dysbiosis to the efficacy of 5-Fluorouracil treatment on colorectal cancer. ( An, C; Li, H; Mushtaq, N; Shi, Y; Ullah, S; Xu, J; Yang, F; Yuan, L; Zhang, S, 2018) |
| "The chemotherapeutic agent 5-fluorouracil (5-FU) causes intestinal mucositis with severe diarrhoea, but the pathogenesis is not fully understood." | 3.85 | Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice. ( Amagase, K; Hamouda, N; Higuchi, K; Kato, S; Matsumoto, K; Oikawa, Y; Ozaki, T; Sano, T; Shimakawa, M, 2017) |
| " 5-Fluorouracil (5-FU), widely used for cancer chemotherapy, is known to frequently induce intestinal mucositis accompanied by severe diarrhoea." | 3.85 | Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses. ( Amagase, K; Hamouda, N; Kano, Y; Kato, S; Matsumoto, K; Oikawa, Y; Shimakawa, M; Tanaka, Y, 2017) |
| "In a xenografted mouse model of cancer, HEP with 5-Fu significantly suppressed tumor growth, inhibited inflammatory markers such as interferon (IFN)-γ, interleukin (IL)-1β, IL-2, IL-6, tumor necrosis factor (TNF)-α, and lipopolysaccharide (LPS), and regulated the expression of Akt, CCDN1, CKD4, FOXM1, MMP7, MYC, PPAR-α, and PPAR-γ." | 1.56 | Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota. ( Chen, D; Li, H; Tang, X; Wang, D; Yizhen, X; Zhu, X, 2020) |
| "Colorectal cancer is one of the most frequently diagnosed cancers worldwide." | 1.48 | The influence of gut microbiota dysbiosis to the efficacy of 5-Fluorouracil treatment on colorectal cancer. ( An, C; Li, H; Mushtaq, N; Shi, Y; Ullah, S; Xu, J; Yang, F; Yuan, L; Zhang, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 8 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, L | 1 |
| Wen, XS | 1 |
| Xian, CJ | 1 |
| Li, C | 1 |
| Wang, Y | 2 |
| Liu, D | 1 |
| Wong, CC | 1 |
| Coker, OO | 1 |
| Zhang, X | 1 |
| Liu, C | 1 |
| Zhou, Y | 1 |
| Liu, Y | 1 |
| Kang, W | 1 |
| To, KF | 1 |
| Sung, JJ | 1 |
| Yu, J | 1 |
| Chen, KJ | 2 |
| Huang, YL | 1 |
| Kuo, LM | 2 |
| Chen, YT | 1 |
| Hung, CF | 1 |
| Hsieh, PW | 2 |
| Santana, AB | 1 |
| Souto, BS | 1 |
| Santos, NCM | 1 |
| Pereira, JA | 1 |
| Tagliati, CA | 1 |
| Novaes, RD | 1 |
| Corsetti, PP | 1 |
| de Almeida, LA | 1 |
| Sun, Z | 1 |
| Hu, Y | 1 |
| Feng, J | 1 |
| Dou, Y | 1 |
| Wang, D | 1 |
| Zhu, X | 1 |
| Tang, X | 1 |
| Li, H | 2 |
| Yizhen, X | 1 |
| Chen, D | 1 |
| Menezes-Garcia, Z | 1 |
| Do Nascimento Arifa, RD | 1 |
| Acúrcio, L | 1 |
| Brito, CB | 1 |
| Gouvea, JO | 1 |
| Lima, RL | 1 |
| Bastos, RW | 1 |
| Fialho Dias, AC | 1 |
| Antunes Dourado, LP | 1 |
| Bastos, LFS | 1 |
| Queiroz-Júnior, CM | 1 |
| Igídio, CED | 1 |
| Bezerra, RO | 1 |
| Vieira, LQ | 1 |
| Nicoli, JR | 1 |
| Teixeira, MM | 1 |
| Fagundes, CT | 1 |
| Souza, DG | 1 |
| Chen, YL | 1 |
| Ueng, SH | 1 |
| Hwang, TL | 1 |
| Hamouda, N | 2 |
| Sano, T | 1 |
| Oikawa, Y | 2 |
| Ozaki, T | 1 |
| Shimakawa, M | 2 |
| Matsumoto, K | 2 |
| Amagase, K | 2 |
| Higuchi, K | 1 |
| Kato, S | 2 |
| Kano, Y | 1 |
| Tanaka, Y | 1 |
| Yuan, L | 1 |
| Zhang, S | 1 |
| Yang, F | 1 |
| Mushtaq, N | 1 |
| Ullah, S | 1 |
| Shi, Y | 1 |
| An, C | 1 |
| Xu, J | 1 |
| Bertolini, M | 1 |
| Ranjan, A | 1 |
| Thompson, A | 2 |
| Diaz, PI | 2 |
| Sobue, T | 2 |
| Maas, K | 1 |
| Dongari-Bagtzoglou, A | 2 |
| Hong, BY | 1 |
| Choquette, L | 1 |
| Dupuy, AK | 1 |
| Burleson, JA | 1 |
| Salner, AL | 1 |
| Schauer, PK | 1 |
| Joshi, P | 1 |
| Fox, E | 1 |
| Shin, DG | 1 |
| Weinstock, GM | 1 |
| Strausbaugh, LD | 1 |
| Peterson, DE | 1 |
| Tang, Y | 1 |
| Wu, Y | 1 |
| Huang, Z | 1 |
| Dong, W | 1 |
| Deng, Y | 1 |
| Wang, F | 1 |
| Li, M | 1 |
| Yuan, J | 1 |
1 review available for fluorouracil and Disbacteriosis
| Article | Year |
|---|---|
Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; Drug Therapy; Drug-Related Side Effects and Adverse React | 2021 |
13 other studies available for fluorouracil and Disbacteriosis
| Article | Year |
|---|---|
Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogenesis; Cell Proliferation; Cholesterol; Colore | 2022 |
Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil-induced intestinal mucositis: Impact on inflammation and gut microbiota dysbiosis.
Topics: Animals; Disease Models, Animal; Dysbiosis; Fluorouracil; Gastrointestinal Diseases; Gastrointestina | 2022 |
Murine response to the opportunistic bacterium Pseudomonas aeruginosa infection in gut dysbiosis caused by 5-fluorouracil chemotherapy-induced mucositis.
Topics: Animals; Antineoplastic Agents; Bacteria; Dysbiosis; Fluorouracil; Intestinal Mucosa; Mice; Mice, In | 2022 |
Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway.
Topics: Animals; Dysbiosis; Fluorouracil; Forkhead Transcription Factors; Gene Expression Regulation; Intest | 2020 |
Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota.
Topics: Animals; Antineoplastic Agents; Bacteria; Basidiomycota; Dysbiosis; Fluorouracil; Fungal Proteins; G | 2020 |
Colonization by
Topics: Animals; Antineoplastic Agents; Bacteria; Corticosterone; Dysbiosis; Enterobacteriaceae; Fluorouraci | 2020 |
Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil-induced intestinal mucositis.
Topics: Animals; Cell Line; Cytokines; Disease Models, Animal; Dysbiosis; Fluorouracil; Gastrointestinal Mic | 2021 |
Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice.
Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Apoptosis; Cell Proliferation; Cyto | 2017 |
Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses.
Topics: Animals; Apoptosis; Bifidobacterium bifidum; Body Weight; Diarrhea; Dysbiosis; Fluorouracil; Inflamm | 2017 |
The influence of gut microbiota dysbiosis to the efficacy of 5-Fluorouracil treatment on colorectal cancer.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Biodiversity; Cell Line, Tumor; Colorectal Ne | 2018 |
Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection.
Topics: Animals; Antimetabolites; Candida albicans; Candidiasis, Oral; Disease Models, Animal; Dysbiosis; Fe | 2019 |
Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis.
Topics: Antineoplastic Agents; Bacteria; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Dysb | 2019 |
Administration of probiotic mixture DM#1 ameliorated 5-fluorouracil-induced intestinal mucositis and dysbiosis in rats.
Topics: Animals; Cytokines; Dysbiosis; Fluorouracil; Gastrointestinal Microbiome; Ileum; Inflammation; Inter | 2017 |