fluorouracil has been researched along with Diabetic Retinopathy in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorouracil was administered in two series of five injections each, every second day in daily doses of 10 to 15 mg subconjunctivally." | 1.28 | Treatment of perimacular proliferations in diabetic ophthalmopathy with fluorouracil. ( Karhan, J; Rehák, J; Smecka, Z; Smecková, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, DS | 1 |
| Wadhwa, S | 1 |
| Gulati, M | 1 |
| Kumar, B | 1 |
| Chitranshi, N | 1 |
| Gupta, VK | 1 |
| Alrouji, M | 1 |
| Alhajlah, S | 1 |
| AlOmeir, O | 1 |
| Vishwas, S | 1 |
| Khursheed, R | 1 |
| Saini, S | 1 |
| Kumar, A | 1 |
| Parveen, SR | 1 |
| Gupta, G | 1 |
| Zacconi, F | 1 |
| Chellappan, DK | 1 |
| Morris, A | 1 |
| Loebenberg, R | 1 |
| Dua, K | 1 |
| Singh, SK | 1 |
| Lin, DY | 1 |
| Smecka, Z | 1 |
| Smecková, M | 1 |
| Karhan, J | 1 |
| Rehák, J | 1 |
| Wilson, CB | 1 |
| Winternitz, WW | 1 |
| Rush, BF | 1 |
| Walton, KN | 1 |
| Maddy, JA | 1 |
4 other studies available for fluorouracil and Diabetic Retinopathy
| Article | Year |
|---|---|
Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug.
Topics: Animals; Antineoplastic Agents; Chitosan; Diabetes Mellitus; Diabetic Retinopathy; Drug Carriers; Dr | 2023 |
Cox regression analysis of multivariate failure time data: the marginal approach.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bias; Clinical Trials as Topic; Cluster | 1994 |
Treatment of perimacular proliferations in diabetic ophthalmopathy with fluorouracil.
Topics: Diabetic Retinopathy; Fluorouracil; Humans; Macula Lutea | 1989 |
Cryohypophysectomy: indications, technic, and results.
Topics: Acromegaly; Adenoma, Chromophobe; Adult; Breast Neoplasms; Carcinoma; Castration; Cryosurgery; Cushi | 1967 |