fluorouracil has been researched along with Diabetic Glomerulosclerosis in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose 5-fluorouracil (5-FU) containing chemotherapy occasionally causes hyperammonemia and can be lethal." | 7.85 | Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia. ( Funakoshi, T; Horimatsu, T; Matsubara, K; Matsubara, T; Miyamoto, S; Muto, M; Nakagawa, S; Nishikawa, Y; Yanagita, M; Yonezawa, A, 2017) |
| "High-dose 5-fluorouracil (5-FU) containing chemotherapy occasionally causes hyperammonemia and can be lethal." | 3.85 | Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia. ( Funakoshi, T; Horimatsu, T; Matsubara, K; Matsubara, T; Miyamoto, S; Muto, M; Nakagawa, S; Nishikawa, Y; Yanagita, M; Yonezawa, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 1 |
| Tang, Y | 1 |
| Eisner, W | 1 |
| Sparks, MA | 1 |
| Buckley, AF | 1 |
| Spurney, RF | 1 |
| Nishikawa, Y | 1 |
| Funakoshi, T | 1 |
| Horimatsu, T | 1 |
| Miyamoto, S | 1 |
| Matsubara, T | 1 |
| Yanagita, M | 1 |
| Nakagawa, S | 1 |
| Yonezawa, A | 1 |
| Matsubara, K | 1 |
| Muto, M | 1 |
2 other studies available for fluorouracil and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.
Topics: Albuminuria; Animals; Antimetabolites; Cytosine Deaminase; Diabetic Nephropathies; Disease Models, A | 2014 |
Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia.
Topics: Aged; Ammonia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta | 2017 |