fluorouracil has been researched along with Diabetes Mellitus in 16 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glucose intolerance and hypokalemia may be rare but serious adverse effects during long-term chemotherapy with capecitabine." | 8.12 | Capecitabine-induced severe diabetes and hypokalemia: a case report. ( Chen, C; Ran, J; Yang, Q, 2022) |
| "Several reports have described hypertriglyceridemia (HTG) in cancer patients, including breast cancer patients treated with capecitabine (CAP)." | 7.79 | Hypertriglyceridemia in patients with metastatic breast cancer and treatment with capecitabine. ( Ariad, S; Geffen, DB; Geva, S; Lazarev, I, 2013) |
| "The aim of the study was to analyse the prevalence and characteristics of secondary diabetes induced by 5-fluorouracil (5-FU) based chemotherapy in non-diabetic patients with colorectal cancer (CRC)." | 7.79 | Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study. ( Fang, J; Feng, JP; Li, M; Lin, M; Luo, M; Xie, T; Ye, DW; Yuan, XL; Zhou, Y; Zhu, YM, 2013) |
| "Glucose intolerance and hypokalemia may be rare but serious adverse effects during long-term chemotherapy with capecitabine." | 4.12 | Capecitabine-induced severe diabetes and hypokalemia: a case report. ( Chen, C; Ran, J; Yang, Q, 2022) |
| "Several reports have described hypertriglyceridemia (HTG) in cancer patients, including breast cancer patients treated with capecitabine (CAP)." | 3.79 | Hypertriglyceridemia in patients with metastatic breast cancer and treatment with capecitabine. ( Ariad, S; Geffen, DB; Geva, S; Lazarev, I, 2013) |
| "The aim of the study was to analyse the prevalence and characteristics of secondary diabetes induced by 5-fluorouracil (5-FU) based chemotherapy in non-diabetic patients with colorectal cancer (CRC)." | 3.79 | Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study. ( Fang, J; Feng, JP; Li, M; Lin, M; Luo, M; Xie, T; Ye, DW; Yuan, XL; Zhou, Y; Zhu, YM, 2013) |
| "KRas is frequently mutated in pancreatic cancers." | 1.62 | GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals. ( Abrams, SL; Akula, SM; Candido, S; Cervello, M; Cocco, L; Duda, P; Falzone, L; Gizak, A; Libra, M; Martelli, AM; McCubrey, JA; Meher, AK; Montalto, G; Rakus, D; Ratti, S; Ruvolo, P; Steelman, LS, 2021) |
| " Neurological adverse effects were assessed by CTC v2." | 1.51 | Effect of diabetes on neurological adverse effects and chemotherapy induced peripheral neuropathy in advanced colorectal cancer patients treated with different FOLFOX regimens. ( Bano, N; Ikram, R, 2019) |
| "Thus, pancreatic cancer of the tail often presents late with a very poor prognosis." | 1.51 | The seemingly innocuous presentation of metastatic pancreatic tail cancer: a case report. ( Rahman, M; Washington, L, 2019) |
| "For further investigation, the human gastric cancer cell line SGC7901 was subjected to different glucose concentrations and the aforementioned proteins were detected using reverse transcription-quantitative polymerase chain reaction and western blot analysis." | 1.42 | High glucose promotes gastric cancer chemoresistance in vivo and in vitro. ( Che, XM; Chen, R; Fan, L; Li, L; Zhao, M; Zhao, W, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 4 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Q | 1 |
| Chen, C | 1 |
| Ran, J | 1 |
| Sharma, DS | 1 |
| Wadhwa, S | 1 |
| Gulati, M | 1 |
| Kumar, B | 1 |
| Chitranshi, N | 1 |
| Gupta, VK | 1 |
| Alrouji, M | 1 |
| Alhajlah, S | 1 |
| AlOmeir, O | 1 |
| Vishwas, S | 1 |
| Khursheed, R | 1 |
| Saini, S | 1 |
| Kumar, A | 1 |
| Parveen, SR | 1 |
| Gupta, G | 1 |
| Zacconi, F | 1 |
| Chellappan, DK | 1 |
| Morris, A | 1 |
| Loebenberg, R | 1 |
| Dua, K | 1 |
| Singh, SK | 1 |
| Laurent-Badr, Q | 1 |
| Barbe, C | 1 |
| Brugel, M | 1 |
| Hautefeuille, V | 1 |
| Volet, J | 1 |
| Grelet, S | 1 |
| Desot, E | 1 |
| Botsen, D | 1 |
| Deguelte, S | 1 |
| Pitta, A | 1 |
| Abdelli, N | 1 |
| Brasseur, M | 1 |
| De Mestier, L | 1 |
| Neuzillet, C | 1 |
| Bouché, O | 1 |
| Abrams, SL | 1 |
| Akula, SM | 1 |
| Meher, AK | 1 |
| Steelman, LS | 1 |
| Gizak, A | 1 |
| Duda, P | 1 |
| Rakus, D | 1 |
| Martelli, AM | 1 |
| Ratti, S | 1 |
| Cocco, L | 1 |
| Montalto, G | 1 |
| Cervello, M | 1 |
| Ruvolo, P | 1 |
| Libra, M | 1 |
| Falzone, L | 1 |
| Candido, S | 1 |
| McCubrey, JA | 1 |
| Abdel-Rahman, O | 1 |
| Jiménez Gordo, AM | 1 |
| López Gómez, M | 1 |
| Bano, N | 1 |
| Ikram, R | 1 |
| Rahman, M | 1 |
| Washington, L | 1 |
| Geva, S | 1 |
| Lazarev, I | 1 |
| Geffen, DB | 1 |
| Ariad, S | 1 |
| Zhao, W | 1 |
| Chen, R | 1 |
| Zhao, M | 1 |
| Li, L | 1 |
| Fan, L | 1 |
| Che, XM | 1 |
| Njiaju, UO | 1 |
| Truica, CI | 1 |
| Michie, CO | 1 |
| Sakala, M | 1 |
| Rivans, I | 1 |
| Strachan, MW | 1 |
| Clive, S | 1 |
| Feng, JP | 1 |
| Yuan, XL | 1 |
| Li, M | 1 |
| Fang, J | 1 |
| Xie, T | 1 |
| Zhou, Y | 1 |
| Zhu, YM | 1 |
| Luo, M | 1 |
| Lin, M | 1 |
| Ye, DW | 1 |
| Altimari, AF | 1 |
| Bhoopalam, N | 1 |
| O'Dorsio, T | 1 |
| Lange, CL | 1 |
| Sandberg, L | 1 |
| Prinz, RA | 1 |
| Zarowitz, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Surveillance of Metabolic Parameters in Patients Who Will Receive Chemotherapy After Surgical Resection of Colorectal Cancer: KBSMC Colon Cancer Cohort[NCT02700555] | 23 participants (Actual) | Observational [Patient Registry] | 2016-02-29 | Terminated (stopped due to The patient's study enrollment was too low.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Diabetes Mellitus
| Article | Year |
|---|---|
Nowadays pancreatic cancer prognosis.
Topics: Aged; Aged, 80 and over; Albumin-Bound Paclitaxel; Antineoplastic Combined Chemotherapy Protocols; C | 2019 |
15 other studies available for fluorouracil and Diabetes Mellitus
| Article | Year |
|---|---|
Capecitabine-induced severe diabetes and hypokalemia: a case report.
Topics: Blood Glucose; Breast Neoplasms; Capecitabine; Diabetes Mellitus; Female; Fluorouracil; Humans; Hypo | 2022 |
Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug.
Topics: Animals; Antineoplastic Agents; Chitosan; Diabetes Mellitus; Diabetic Retinopathy; Drug Carriers; Dr | 2023 |
Time intervals to diagnosis and chemotherapy do not influence survival outcome in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Diabetes Mellitus; Female; Flu | 2020 |
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals.
Topics: Adenocarcinoma; Adenylate Kinase; Antineoplastic Agents; bcl-X Protein; Berberine; Biphenyl Compound | 2021 |
Impact of diabetes comorbidity on the efficacy and safety of FOLFOX first-line chemotherapy among patients with metastatic colorectal cancer: a pooled analysis of two phase-III studies.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Colorecta | 2019 |
Effect of diabetes on neurological adverse effects and chemotherapy induced peripheral neuropathy in advanced colorectal cancer patients treated with different FOLFOX regimens.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuva | 2019 |
The seemingly innocuous presentation of metastatic pancreatic tail cancer: a case report.
Topics: Abdominal Pain; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Diabe | 2019 |
Hypertriglyceridemia in patients with metastatic breast cancer and treatment with capecitabine.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast | 2013 |
High glucose promotes gastric cancer chemoresistance in vivo and in vitro.
Topics: Adult; Aged; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, | 2015 |
Pancreatic cancer: the stealth cancer. Pancreatic cancer is hard to detect and highly resistant to chemotherapy; new research reveals possible resolutions.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers; Diabetes Mellitus; DNA Mismatch Repair; Fluoro | 2009 |
Metastatic prostatic adenocarcinoma mimicking inflammatory breast carcinoma: a case report.
Topics: Adenocarcinoma; Aged; Anilides; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms, Ma | 2010 |
The frequency and severity of capecitabine-induced hypertriglyceridaemia in routine clinical practice: a prospective study.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Diabetes Mellitus; Dyslip | 2010 |
Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study.
Topics: Aged; Analysis of Variance; Antimetabolites, Antineoplastic; C-Peptide; Colorectal Neoplasms; Diabet | 2013 |
Use of a somatostatin analog (SMS 201-995) in the glucagonoma syndrome.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dacarbaz | 1986 |
Postpancreatectomy insulin-resistant diabetes mellitus. Improvement after prednisone and 5-fluorouracil.
Topics: Diabetes Mellitus; Female; Fluorouracil; Humans; Insulin Resistance; Middle Aged; Pancreatectomy; Pa | 1972 |