fluorouracil has been researched along with Dermatosclerosis in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 72-year-old patient with esophageal carcinoma developed a severe hand-foot syndrome during second-line therapy with the oral fluoropyrimidine capecitabine." | 7.74 | [Hand-foot syndrome with capecitabine therapy]. ( Hengge, UR; Marini, A, 2007) |
| "A 72-year-old patient with esophageal carcinoma developed a severe hand-foot syndrome during second-line therapy with the oral fluoropyrimidine capecitabine." | 3.74 | [Hand-foot syndrome with capecitabine therapy]. ( Hengge, UR; Marini, A, 2007) |
| " HFS manifests as acral erythema, with swelling and dysesthesia of the palms and plantar aspects of the feet, which in the absence of dosage reduction or drug cessation, progresses to moist desquamation and ulceration, resulting in serious infections and loss of function." | 1.34 | Hand-foot syndrome with scleroderma-like change induced by the oral capecitabine: a case report. ( Hwang, SJ; Kim, BS; Kim, HJ; Kim, YJ; Lee, SD; Nam, SH, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marini, A | 1 |
| Hengge, UR | 1 |
| Sroa, N | 1 |
| Bartholomew, DA | 1 |
| Magro, CM | 1 |
| Lee, SD | 1 |
| Kim, HJ | 1 |
| Hwang, SJ | 1 |
| Kim, YJ | 1 |
| Nam, SH | 1 |
| Kim, BS | 1 |
| Trindade, F | 1 |
| Haro, R | 1 |
| Fariña, MC | 1 |
| Requena, L | 1 |
1 review available for fluorouracil and Dermatosclerosis
| Article | Year |
|---|---|
Lipodermatosclerosis as a form of vascular compromise-associated radiation recall dermatitis: case report and a review of literature.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Cisplatin; | 2006 |
3 other studies available for fluorouracil and Dermatosclerosis
| Article | Year |
|---|---|
[Hand-foot syndrome with capecitabine therapy].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Esophageal Neopl | 2007 |
Hand-foot syndrome with scleroderma-like change induced by the oral capecitabine: a case report.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorourac | 2007 |
Hand-foot syndrome with sclerodactyly-like changes in a patient treated with capecitabine.
Topics: Adenocarcinoma; Administration, Oral; Biopsy, Needle; Capecitabine; Deoxycytidine; Dose-Response Rel | 2008 |