fluorouracil has been researched along with Dermatitis in 20 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Dermatitis: Any inflammation of the skin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the toxicity and efficacy of concurrent chemoirradiation with cisplatin followed by adjuvant ifosfamide, 5-fluorouracil and leucovorin in patients with stage IVb nasopharyngeal carcinoma (NPC) PATIENTS AND METHODS: Between October 1998 and August 2001, 35 Chinese patients with stage IVb NPC (N3a:12, N3b:23) were treated with by concurrent chemoirradiation using cisplatin 100 mg/m2 on days 1, 22, and 43 of radiotherapy, followed by adjuvant chemotherapy with 1." | 9.11 | A concurrent chemoirradiation with cisplatin followed by adjuvant chemotherapy with ifosfamide, 5-fluorouracil, and leucovorin for stage IV nasopharyngeal carcinoma. ( Au, GK; Chua, DT; Sham, JS, 2004) |
| "Elental reduced oral mucositis and dermatitis more effectively than dextrin in the animal model." | 5.48 | Elemental Diet Accelerates the Recovery From Oral Mucositis and Dermatitis Induced by 5-Fluorouracil Through the Induction of Fibroblast Growth Factor 2. ( Ferdous, T; Harada, K; Kobayashi, H; Ueyama, Y, 2018) |
| "To evaluate the toxicity and efficacy of concurrent chemoirradiation with cisplatin followed by adjuvant ifosfamide, 5-fluorouracil and leucovorin in patients with stage IVb nasopharyngeal carcinoma (NPC) PATIENTS AND METHODS: Between October 1998 and August 2001, 35 Chinese patients with stage IVb NPC (N3a:12, N3b:23) were treated with by concurrent chemoirradiation using cisplatin 100 mg/m2 on days 1, 22, and 43 of radiotherapy, followed by adjuvant chemotherapy with 1." | 5.11 | A concurrent chemoirradiation with cisplatin followed by adjuvant chemotherapy with ifosfamide, 5-fluorouracil, and leucovorin for stage IV nasopharyngeal carcinoma. ( Au, GK; Chua, DT; Sham, JS, 2004) |
| "Acute Grade 3 (G3) dysphagia was higher in DL2 (87% DL2 vs." | 2.77 | Dose-escalated intensity-modulated radiotherapy is feasible and may improve locoregional control and laryngeal preservation in laryngo-hypopharyngeal cancers. ( A'hern, R; Barbachano, Y; Bhide, SA; Bidmead, AM; Clark, C; Guerrero-Urbano, MT; Harrington, KJ; Hickey, J; Miah, AB; Newbold, KL; Nicol, R; Nutting, CM; St Rose, S; Tanay, M, 2012) |
| "Transforming growth factor-beta1 is related to adverse events in radiochemotherapy." | 2.77 | Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant. ( Becker, H; Beissbarth, T; Brockmöller, J; Christiansen, H; Conradi, LC; Gaedcke, J; Ghadimi, M; Hennies, S; Herrmann, MK; Hess, CF; Jo, P; Mergler, CP; Rave-Fränk, M; Schirmer, MA; Wolff, HA, 2012) |
| "Pursuant to this, the North Central Cancer Treatment Group has developed a series of clinical trials designed to study antidotes for these pathologic processes." | 2.39 | Alleviation of cytotoxic therapy-induced normal tissue damage. ( Foote, RL; Loprinzi, CL; Michalak, J, 1995) |
| "Elental reduced oral mucositis and dermatitis more effectively than dextrin in the animal model." | 1.48 | Elemental Diet Accelerates the Recovery From Oral Mucositis and Dermatitis Induced by 5-Fluorouracil Through the Induction of Fibroblast Growth Factor 2. ( Ferdous, T; Harada, K; Kobayashi, H; Ueyama, Y, 2018) |
| "The most common metastatic sites from gastric cancer are the liver, intra-abdominal lymph nodes, ovary and peritoneal cavity." | 1.34 | Cutaneous metastasis resembling acute dermatitis in patient with advanced gastric cancer. ( Chang, HM; Jung, JY; Kang, YK; Kim, TW; Koo, DH; Lee, JL; Lee, JS; Ryu, MH; Song, JH; Song, JS; Yook, JH, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Citrin, D | 1 |
| Valle, L | 1 |
| Camphausen, K | 1 |
| Cooley-Zgela, T | 1 |
| Smart, D | 1 |
| Yao, M | 1 |
| Mitchell, JB | 1 |
| Thompson, W | 1 |
| Sereti, I | 1 |
| Uldrick, T | 1 |
| Sakamoto, S | 1 |
| Tagai, N | 1 |
| Shimada, M | 1 |
| Kurebayashi, H | 1 |
| Sawai, K | 1 |
| Morikawa, M | 1 |
| Koneri, K | 1 |
| Tamaki, M | 1 |
| Murakami, M | 1 |
| Hirono, Y | 1 |
| Goi, T | 1 |
| Lukovic, J | 3 |
| Hosni, A | 3 |
| Liu, A | 3 |
| Chen, J | 3 |
| Tadic, T | 3 |
| Patel, T | 3 |
| Li, K | 3 |
| Han, K | 3 |
| Lindsay, P | 3 |
| Craig, T | 3 |
| Brierley, J | 3 |
| Barry, A | 3 |
| Wong, R | 3 |
| Ringash, J | 3 |
| Dawson, LA | 3 |
| Kim, JJ | 3 |
| Searle, T | 1 |
| Al-Niaimi, F | 1 |
| Ali, FR | 1 |
| Harada, K | 1 |
| Ferdous, T | 1 |
| Kobayashi, H | 1 |
| Ueyama, Y | 1 |
| Nakata, Y | 1 |
| Ijichi, K | 1 |
| Hanai, N | 1 |
| Nishikawa, D | 1 |
| Suzuki, H | 1 |
| Hirakawa, H | 1 |
| Kodaira, T | 1 |
| Fujimoto, Y | 1 |
| Fujii, T | 1 |
| Miyazaki, T | 1 |
| Shimizu, T | 1 |
| Hasegawa, Y | 1 |
| Miah, AB | 1 |
| Bhide, SA | 1 |
| Guerrero-Urbano, MT | 1 |
| Clark, C | 1 |
| Bidmead, AM | 1 |
| St Rose, S | 1 |
| Barbachano, Y | 1 |
| A'hern, R | 1 |
| Tanay, M | 1 |
| Hickey, J | 1 |
| Nicol, R | 1 |
| Newbold, KL | 1 |
| Harrington, KJ | 1 |
| Nutting, CM | 1 |
| Schirmer, MA | 1 |
| Mergler, CP | 1 |
| Rave-Fränk, M | 1 |
| Herrmann, MK | 1 |
| Hennies, S | 1 |
| Gaedcke, J | 1 |
| Conradi, LC | 1 |
| Jo, P | 1 |
| Beissbarth, T | 1 |
| Hess, CF | 1 |
| Becker, H | 2 |
| Ghadimi, M | 1 |
| Brockmöller, J | 1 |
| Christiansen, H | 1 |
| Wolff, HA | 1 |
| Partl, R | 1 |
| Richtig, E | 1 |
| Kapp, KS | 1 |
| Masters, SL | 1 |
| Gerlic, M | 1 |
| Metcalf, D | 1 |
| Preston, S | 1 |
| Pellegrini, M | 1 |
| O'Donnell, JA | 1 |
| McArthur, K | 1 |
| Baldwin, TM | 1 |
| Chevrier, S | 1 |
| Nowell, CJ | 1 |
| Cengia, LH | 1 |
| Henley, KJ | 1 |
| Collinge, JE | 1 |
| Kastner, DL | 1 |
| Feigenbaum, L | 1 |
| Hilton, DJ | 1 |
| Alexander, WS | 1 |
| Kile, BT | 1 |
| Croker, BA | 1 |
| Schneider, HB | 1 |
| Chua, DT | 1 |
| Sham, JS | 1 |
| Au, GK | 1 |
| Koo, DH | 1 |
| Chang, HM | 1 |
| Jung, JY | 1 |
| Song, JH | 1 |
| Lee, JL | 1 |
| Ryu, MH | 1 |
| Kim, TW | 1 |
| Yook, JH | 1 |
| Song, JS | 1 |
| Lee, JS | 1 |
| Kang, YK | 1 |
| Carter, DM | 1 |
| Balin, AK | 1 |
| Loprinzi, CL | 1 |
| Foote, RL | 1 |
| Michalak, J | 1 |
| Epstein, E | 1 |
| Schaefer, U | 1 |
| Micke, O | 1 |
| Schueller, P | 1 |
| Willich, N | 1 |
| Miller, E | 1 |
| Klein, E | 2 |
| Stoll, HL | 1 |
| Milgrom, H | 1 |
| Helm, F | 1 |
| Walker, MJ | 1 |
| Williams, AC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Randomised Multicenter Phase-III-study: Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil Plus Oxaliplatin Versus Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil for Locally Advanced Rect[NCT00349076] | Phase 3 | 1,256 participants (Actual) | Interventional | 2006-07-31 | Completed | ||
| trūFreeze® Spray Cryotherapy Patient Registry[NCT01802203] | 275 participants (Actual) | Observational [Patient Registry] | 2013-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for fluorouracil and Dermatitis
| Article | Year |
|---|---|
5-Fluorouracil in Dermatology: The Diverse Uses Beyond Malignant and Premalignant Skin Disease.
Topics: Adrenal Cortex Hormones; Cicatrix; Combined Modality Therapy; Cosmetic Techniques; Dermatitis; Derma | 2021 |
Impact of dihydropyrimidine dehydrogenase on 5-fluorouracil treatment in cancer patients.
Topics: Antimetabolites, Antineoplastic; Dermatitis; Diarrhea; Dihydropyrimidine Dehydrogenase Deficiency; D | 2003 |
Dermatological aspects of aging.
Topics: Adult; Aged; Aging; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Female; Fl | 1983 |
Alleviation of cytotoxic therapy-induced normal tissue damage.
Topics: Chlorhexidine; Clinical Trials as Topic; Cryotherapy; Dermatitis; Esophagitis; Eye Diseases; Fluorou | 1995 |
The metabolism and pharmacology of 5-fluorouracil.
Topics: Adenocarcinoma; Alopecia; Animals; Breast Neoplasms; Carbon Isotopes; Cell Division; Chromosome Aber | 1971 |
5 trials available for fluorouracil and Dermatitis
| Article | Year |
|---|---|
Pilot trial of topical MTS‑01 application to reduce dermatitis in patients receiving chemoradiotherapy for stage I‑III carcinoma of the anal canal.
Topics: Anal Canal; Anus Neoplasms; Carcinoma, Squamous Cell; Chemoradiotherapy; Dermatitis; Fluorouracil; H | 2022 |
Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemoradiotherapy; C | 2017 |
Dose-escalated intensity-modulated radiotherapy is feasible and may improve locoregional control and laryngeal preservation in laryngo-hypopharyngeal cancers.
Topics: Adult; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; | 2012 |
Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; C | 2012 |
A concurrent chemoirradiation with cisplatin followed by adjuvant chemotherapy with ifosfamide, 5-fluorouracil, and leucovorin for stage IV nasopharyngeal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chemotherapy, Adjuvant; Cisp | 2004 |
10 other studies available for fluorouracil and Dermatitis
| Article | Year |
|---|---|
[A Case of BRAF V600E-Mutant Colorectal Cancer Treated Effectively by Encorafenib, Binimetinib, and Cetuximab Triple Therapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cetuximab; Colorectal Neoplasms; | 2022 |
Evaluation of dosimetric predictors of toxicity after IMRT with concurrent chemotherapy for anal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Chemoradiotherapy; Dermatitis; Diarr | 2023 |
Evaluation of dosimetric predictors of toxicity after IMRT with concurrent chemotherapy for anal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Chemoradiotherapy; Dermatitis; Diarr | 2023 |
Evaluation of dosimetric predictors of toxicity after IMRT with concurrent chemotherapy for anal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Chemoradiotherapy; Dermatitis; Diarr | 2023 |
Evaluation of dosimetric predictors of toxicity after IMRT with concurrent chemotherapy for anal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Chemoradiotherapy; Dermatitis; Diarr | 2023 |
Elemental Diet Accelerates the Recovery From Oral Mucositis and Dermatitis Induced by 5-Fluorouracil Through the Induction of Fibroblast Growth Factor 2.
Topics: Animals; Dermatitis; Female; Fibroblast Growth Factor 2; Fluorouracil; Food, Formulated; Glutamine; | 2018 |
Calling attention to radiation recall reactions. Simultaneous occurrence of a Recall Dermatitis after CMF application in two separate sites irradiated 10 years apart.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cycloph | 2012 |
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; CARD Signal | 2012 |
Cutaneous metastasis resembling acute dermatitis in patient with advanced gastric cancer.
Topics: Antineoplastic Agents; Capecitabine; Cisplatin; Deoxycytidine; Dermatitis; Diagnosis, Differential; | 2007 |
Does intermittent "pulse" topical 5-fluorouracil therapy allow destruction of actinic keratoses without significant inflammation?
Topics: Administration, Cutaneous; Antimetabolites; Dermatitis; Drug Administration Schedule; Drug Eruptions | 1998 |
Recurrent head and neck cancer: retreatment of previously irradiated areas with combined chemotherapy and radiation therapy-results of a prospective study.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy P | 2000 |
Tumors of the skin. XII. Topical 5-Fluorouracil for epidermal neoplasms.
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Esthetics; Female; Fluorouracil; Humans | 1971 |
Experiences with local chemotherapy and immunotherapy in premalignant and malignant skin lesions.
Topics: Antigen-Antibody Reactions; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Dermatitis, | 1970 |