fluorouracil has been researched along with Dermatitis, Contact in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Keratoacanthomas (KAs) in 14 patients were treated with 20% fluorouracil ointment, two or three times daily, for two to four weeks." | 7.66 | Treatment of keratoacanthoma with topical application of fluorouracil. ( Arrott, JW; Diakon, NC; Goette, DK; Horn, RT; Odom, RB, 1982) |
| "An allergic contact dermatitis from fluorouracil developed in two patients 8 and 18 days respectively after institution of topical fluorouracil therapy." | 7.65 | Allergic contact dermatitis from topical fluorouracil. ( Goette, DK; Odom, RB; Owens, R, 1977) |
| "We designed a prospective and retrospective study to determine the incidence of allergic contact dermatitis to topical application of fluorouracil." | 7.65 | Allergic contact dermatitis to topical fluorouracil. ( Goette, DK; Odom, RB, 1977) |
| " 4% 5-FU qd q4wks recorded 65 adverse events and 30% application site skin irritation versus 71 events and 60% with 5% 5-FU bid q4wks." | 6.82 | Efficacy, Safety, and Tolerability of 4% 5-Fluorouracil Cream in a Novel Patented Aqueous Cream Containing Peanut Oil Once Daily Compared With 5% 5-Fluorouracil Cream Twice Daily: Meeting the Challenge in the Treatment of Actinic Keratosis. ( Dohil, MA, 2016) |
| "Keratoacanthomas (KAs) in 14 patients were treated with 20% fluorouracil ointment, two or three times daily, for two to four weeks." | 3.66 | Treatment of keratoacanthoma with topical application of fluorouracil. ( Arrott, JW; Diakon, NC; Goette, DK; Horn, RT; Odom, RB, 1982) |
| "An allergic contact dermatitis from fluorouracil developed in two patients 8 and 18 days respectively after institution of topical fluorouracil therapy." | 3.65 | Allergic contact dermatitis from topical fluorouracil. ( Goette, DK; Odom, RB; Owens, R, 1977) |
| "We designed a prospective and retrospective study to determine the incidence of allergic contact dermatitis to topical application of fluorouracil." | 3.65 | Allergic contact dermatitis to topical fluorouracil. ( Goette, DK; Odom, RB, 1977) |
| " 4% 5-FU qd q4wks recorded 65 adverse events and 30% application site skin irritation versus 71 events and 60% with 5% 5-FU bid q4wks." | 2.82 | Efficacy, Safety, and Tolerability of 4% 5-Fluorouracil Cream in a Novel Patented Aqueous Cream Containing Peanut Oil Once Daily Compared With 5% 5-Fluorouracil Cream Twice Daily: Meeting the Challenge in the Treatment of Actinic Keratosis. ( Dohil, MA, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Dohil, MA | 1 |
| Goette, DK | 4 |
| Odom, RB | 3 |
| Arrott, JW | 1 |
| Diakon, NC | 1 |
| Horn, RT | 1 |
| Epstein, E | 1 |
| Lubowe, II | 1 |
| Price, NM | 1 |
| Andersen, KE | 1 |
| Maibach, HI | 1 |
| Owens, R | 1 |
| Schuppli, R | 1 |
| de Berker, D | 1 |
| Marren, P | 1 |
| Powell, SM | 1 |
| Ryan, TJ | 1 |
| Claessen, AM | 1 |
| Valster, H | 1 |
| Bril, H | 1 |
| Meyer, S | 1 |
| Scheper, RJ | 1 |
| Shelley, WB | 1 |
| Shelley, ED | 1 |
| Sevadjian, CM | 1 |
| Griswold, DE | 2 |
| DiLorenzo, JA | 2 |
| Calabresi, P | 2 |
| Bareham, CR | 1 |
| Gonçalves, JC | 1 |
| Williams, AC | 1 |
| Klein, E | 1 |
1 review available for fluorouracil and Dermatitis, Contact
| Article | Year |
|---|---|
Topical chemotherapy with 5-fluorouracil. A review.
Topics: Administration, Topical; Chemical Phenomena; Chemistry; Dermatitis, Atopic; Dermatitis, Contact; Fem | 1981 |
1 trial available for fluorouracil and Dermatitis, Contact
| Article | Year |
|---|---|
Efficacy, Safety, and Tolerability of 4% 5-Fluorouracil Cream in a Novel Patented Aqueous Cream Containing Peanut Oil Once Daily Compared With 5% 5-Fluorouracil Cream Twice Daily: Meeting the Challenge in the Treatment of Actinic Keratosis.
Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Dermatitis, Contact; Double-Blind Me | 2016 |
17 other studies available for fluorouracil and Dermatitis, Contact
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Treatment of keratoacanthoma with topical application of fluorouracil.
Topics: Administration, Topical; Adult; Aged; Dermatitis, Contact; Female; Fluorouracil; Humans; Keratoacant | 1982 |
Contact dermatitis to 5-fluorouracil with false negative patch tests.
Topics: Dermatitis, Contact; False Negative Reactions; Female; Fluorouracil; Humans; Middle Aged; Patch Test | 1980 |
Fluorouracil for skin blemishes and lines.
Topics: Dermatitis, Contact; Drug Eruptions; Fluorouracil; Humans | 1977 |
Actinic keratoses treated with a combination of topical 5-fluorouracil and dinitrochlorobenzene.
Topics: Administration, Topical; Arm; Dermatitis, Contact; Dinitrochlorobenzene; Drug Evaluation; Drug Thera | 1979 |
Predictive testing with 5-fluorouracil.
Topics: Animals; Dermatitis, Contact; Fluorouracil; Guinea Pigs; Humans; Ointments; Skin Tests | 1979 |
Allergic contact dermatitis from topical fluorouracil.
Topics: Administration, Topical; Dermatitis, Atopic; Dermatitis, Contact; Female; Fluorouracil; Humans; Kera | 1977 |
Allergic contact dermatitis to topical fluorouracil.
Topics: California; Dermatitis, Atopic; Dermatitis, Contact; Fluorouracil; Keratosis; Prospective Studies; R | 1977 |
[In vitro and in vivo experiments on the immunosuppressive properties of cytostatic substances (author's transl)].
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dermatitis, Contact; Fluorouracil; Guinea Pigs; Im | 1976 |
Contact sensitivity to the stearyl alcohol in Efudix cream (5-fluorouracil).
Topics: Aged; Dermatitis, Contact; Drug Eruptions; Fatty Alcohols; Female; Fluorouracil; Humans; Keratosis | 1992 |
Cell-mediated immunity is enhanced by cytostatic drugs continuously released at the site of antigenic stimulation.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Cyclophosphamide; Dermatitis, Contact; Dose- | 1989 |
Scrotal dermatitis caused by 5-fluorouracil (Efudex).
Topics: Adolescent; Adult; Condylomata Acuminata; Dermatitis, Contact; Drug Eruptions; Fluorouracil; Genital | 1988 |
Pustular contact hypersensitivity to fluorouracil with rosacealike sequelae.
Topics: Administration, Topical; Dermatitis, Contact; Drug Hypersensitivity; Facial Dermatoses; Female; Fluo | 1985 |
Quantification and pharmacological dissection of oxazolone-induced contact sensitivity in the mouse.
Topics: Animals; Antigens; Cyclophosphamide; Cytarabine; Dermatitis, Contact; Female; Fluorouracil; Immuniza | 1974 |
Selective alteration of immunocompetence with methotrexate and 5-fluorouracil.
Topics: Animals; Antibody Formation; Antigen-Antibody Complex; Dermatitis, Contact; Female; Fluorouracil; Gr | 1974 |
Fluorouracil ointment treatment of porokeratosis of Mibelli.
Topics: Adult; Dermatitis, Contact; Female; Fluorouracil; Humans; Keratosis; Male; Middle Aged; Ointments; R | 1973 |
Experiences with local chemotherapy and immunotherapy in premalignant and malignant skin lesions.
Topics: Antigen-Antibody Reactions; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Dermatitis, | 1970 |