fluorouracil has been researched along with Depression in 15 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The paper aims to study whether mood disorder alters drug metabolism process through the pharmacokinetic research on some clinically important anticancer drugs in depression model rats." | 5.38 | Pharmacokinetics of 5-fluorouracil and cyclophosphamide in depression rats. ( Chen, X; Duan, JJ; Wang, Y; Wen, YG; Xu, F; Zhou, T, 2012) |
| "Goserelin was most burdensome and resulted in similar symptom levels as those of CMF, whereas the side effects of tamoxifen alone were milder." | 2.71 | Side effects of adjuvant endocrine treatment in premenopausal breast cancer patients: a prospective randomized study. ( Berglund, G; Bolund, C; Fornander, T; Nystedt, M; Rutqvist, LE, 2003) |
| "From a randomized study in high-risk breast cancer patients on the efficacy of high-dose versus standard-dose adjuvant chemotherapy, late effects on cognitive functioning were analyzed by neuropsychological tests." | 2.70 | Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function. ( Boogerd, W; Hamburger, HL; Muller, MJ; Schagen, SB; van Dam, FS, 2001) |
| "Thirty-nine breast carcinoma patients who had been treated with adjuvant CMF (6 courses) followed (n = 20) by 3 years of tamoxifen 20 mg daily or not (n = 19) were examined with neuropsychologic tests and interviews." | 2.69 | Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. ( Boogerd, W; Bruning, PF; Lindeboom, J; Muller, MJ; Schagen, SB; van Dam, FS, 1999) |
| "Treatment with uridine triacetate was arranged in the emergency department." | 1.46 | The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV/AIDS with uridine triacetate. ( Geller, RJ; Morgan, BW; Santos, C, 2017) |
| "Depression was directly affected by fatigue (β=." | 1.43 | [Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer]. ( Lee, JR; Oh, PJ, 2016) |
| "Twenty women undergoing CT for breast cancer completed the Pittsburgh Sleep Quality Index (PSQI) 1 h prior to a CT infusion." | 1.40 | Ecological momentary assessment of sleep, symptoms, and mood during chemotherapy for breast cancer. ( Arun, B; Cohen, L; Lam, CY; Ratcliff, CG; Valero, V, 2014) |
| " The paper aims to study whether mood disorder alters drug metabolism process through the pharmacokinetic research on some clinically important anticancer drugs in depression model rats." | 1.38 | Pharmacokinetics of 5-fluorouracil and cyclophosphamide in depression rats. ( Chen, X; Duan, JJ; Wang, Y; Wen, YG; Xu, F; Zhou, T, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, F | 1 |
| Chen, H | 1 |
| Zhang, R | 1 |
| Liu, Y | 1 |
| Kong, N | 1 |
| Guo, Y | 1 |
| Xu, M | 1 |
| Likhacheva, A | 1 |
| Jhingran, A | 1 |
| Bodurka, DC | 1 |
| Sun, C | 1 |
| Sam, M | 1 |
| Eifel, PJ | 1 |
| Hamaker, ME | 1 |
| Seynaeve, C | 1 |
| Wymenga, AN | 1 |
| van Tinteren, H | 1 |
| Nortier, JW | 1 |
| Maartense, E | 1 |
| de Graaf, H | 1 |
| de Jongh, FE | 1 |
| Braun, JJ | 1 |
| Los, M | 1 |
| Schrama, JG | 1 |
| van Leeuwen-Stok, AE | 1 |
| de Groot, SM | 1 |
| Smorenburg, CH | 1 |
| Ratcliff, CG | 1 |
| Lam, CY | 1 |
| Arun, B | 1 |
| Valero, V | 1 |
| Cohen, L | 1 |
| Oh, PJ | 1 |
| Lee, JR | 1 |
| Santos, C | 1 |
| Morgan, BW | 1 |
| Geller, RJ | 1 |
| Duan, JJ | 1 |
| Zhou, T | 1 |
| Chen, X | 1 |
| Wang, Y | 1 |
| Wen, YG | 1 |
| Xu, F | 1 |
| Nystedt, M | 1 |
| Berglund, G | 1 |
| Bolund, C | 1 |
| Fornander, T | 1 |
| Rutqvist, LE | 1 |
| de Jong, N | 1 |
| Candel, MJ | 1 |
| Schouten, HC | 1 |
| Abu-Saad, HH | 1 |
| Courtens, AM | 1 |
| Fortner, BV | 1 |
| Houts, AC | 1 |
| Schwartzberg, LS | 1 |
| Milstein, HG | 1 |
| Palmer, KR | 1 |
| Kerr, M | 1 |
| Knowles, G | 1 |
| Cull, A | 1 |
| Carter, DC | 1 |
| Leonard, RC | 1 |
| Schagen, SB | 2 |
| van Dam, FS | 2 |
| Muller, MJ | 2 |
| Boogerd, W | 2 |
| Lindeboom, J | 1 |
| Bruning, PF | 1 |
| Colleoni, M | 1 |
| Mandala, M | 1 |
| Peruzzotti, G | 1 |
| Robertson, C | 1 |
| Bredart, A | 1 |
| Goldhirsch, A | 1 |
| Hamburger, HL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment, A Pilot Study[NCT00387062] | Phase 1 | 50 participants (Anticipated) | Interventional | 2006-10-31 | Completed | ||
| Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774] | 400 participants (Anticipated) | Interventional | 2022-04-30 | Not yet recruiting | |||
| Transcranial Magnetic Stimulation for Psychological Distress in Patients With Advanced Illness: A Phase 2a/2b Dose-finding and Feasibility Clinical Trial[NCT04257227] | 15 participants (Anticipated) | Interventional | 2020-11-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for fluorouracil and Depression
| Article | Year |
|---|---|
Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: results from the OMEGA study of the Dutch breast cancer trialists' group.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Antineoplastic Agents; Body Mass Index; Breast | 2014 |
Side effects of adjuvant endocrine treatment in premenopausal breast cancer patients: a prospective randomized study.
Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Anxiety; Bre | 2003 |
Chemotherapy prolongs survival in inoperable pancreatic carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Anxiety; Depression; | 1994 |
Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Attention; Breast Neoplasms; Chemotherapy, Ad | 1999 |
Neurophysiological evaluation of late effects of adjuvant high-dose chemotherapy on cognitive function.
Topics: Alpha Rhythm; Antineoplastic Combined Chemotherapy Protocols; Anxiety; Breast Neoplasms; Carboplatin | 2001 |
10 other studies available for fluorouracil and Depression
| Article | Year |
|---|---|
5-Fluorouracil induced dysregulation of the microbiome-gut-brain axis manifesting as depressive like behaviors in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Colorectal Neoplasms; Depression; Diseas | 2020 |
Prospective study of symptom assessment among patients with cervical cancer during concurrent chemoradiotherapy with weekly cisplatin or every-3-week cisplatin and 5-fluorouracil.
Topics: Adult; Aged; Anorexia; Antimetabolites, Antineoplastic; Anxiety; Carcinoma; Chemoradiotherapy; Cispl | 2013 |
Ecological momentary assessment of sleep, symptoms, and mood during chemotherapy for breast cancer.
Topics: Adult; Affect; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Anxiety; | 2014 |
[Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer].
Topics: Adult; Aged; Anemia; Antineoplastic Agents; Anxiety; Camptothecin; Cognitive Dysfunction; Depression | 2016 |
The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV/AIDS with uridine triacetate.
Topics: Acetates; Antimetabolites, Antineoplastic; Anus Neoplasms; Depression; Drug Overdose; Emergency Medi | 2017 |
Pharmacokinetics of 5-fluorouracil and cyclophosphamide in depression rats.
Topics: Affect; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Behavior, Anima | 2012 |
Course of mental fatigue and motivation in breast cancer patients receiving adjuvant chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cognition Disorders; | 2005 |
A prospective investigation of chemotherapy-induced neutropenia and quality of life.
Topics: Adaptation, Psychological; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Prot | 2006 |
Mental depression secondary to fluorouracil therapy for actinic keratoses.
Topics: Depression; Female; Fluorouracil; Humans; Keratosis; Middle Aged | 1980 |
Depression and degree of acceptance of adjuvant cytotoxic drugs.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; | 2000 |
Depression and degree of acceptance of adjuvant cytotoxic drugs.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; | 2000 |
Depression and degree of acceptance of adjuvant cytotoxic drugs.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; | 2000 |
Depression and degree of acceptance of adjuvant cytotoxic drugs.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; | 2000 |