fluorouracil has been researched along with Demyelinating Diseases in 16 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a patient who developed multifocal cerebral demyelination with the use of 5-fluorouracil, levamisole, and leucovorin as adjuvant treatment for intestinal adenocarcinoma." | 4.79 | Cerebral demyelination with 5-fluorouracil and levamisole. ( Fassas, AB; Gattani, AM; Morgello, S, 1994) |
| "The use of 5-fluorouracil (5-FU) and levamisole in patients with Stage III adenocarcinoma of the colon has now become standard." | 3.69 | Cerebral demyelination syndrome in a patient treated with 5-fluorouracil and levamisole. The use of thallium SPECT imaging to assist in noninvasive diagnosis--a case report. ( Gordon, J; Licho, R; Litofsky, NS; Ragland, R; Recht, L; Savarese, DM; Smith, TW, 1996) |
| "A cerebral demyelinating disease developed in 3 patients during adjuvant therapy with 5-fluorouracil and levamisole for adenocarcinoma of the colon." | 3.68 | Multifocal inflammatory leukoencephalopathy with 5-fluorouracil and levamisole. ( Forsyth, PA; Hook, CC; Kimmel, DW; Kvols, LK; Moertel, CG; Rodriguez, M; Rubin, J; Scheithauer, BW, 1992) |
| "Although the delayed demyelination induced by 5-FU in adult patients has been reported, the effect of 5-FU on oligodendrocyte myelination in adolescence is still unknown." | 1.40 | 5-Fluorouracil causes severe CNS demyelination by disruption of TCF7L2/HDAC1/HDAC2 complex in adolescent mice. ( He, Q; Shi, J; Tan, B; Wang, J; Weng, Q; Yang, B; Zhou, H, 2014) |
| "Inflammation or demyelination was not detected in brains or spinal cords of noninfected SJL mice treated with 5-FU and/or LE." | 1.30 | 5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus. ( Kimmel, DW; Lucchinetti, CF; Pavelko, K; Rodriguez, M, 1997) |
| "Pathology of the optic nerves revealed demyelination." | 1.29 | Ocular toxicity following high dose chemotherapy and autologous transplant. ( Elkordy, M; Hulette, C; Hussein, A; Jaffe, GJ; Khawly, JA; Peters, WP; Rubin, P; Vredenburgh, JJ, 1996) |
| "In a patient with akinetic mutism, extensive circumscribed bilateral lesions in the precentral part of the centrum semiovale, due to delayed necrotizing leucoencephalopathy after combined intravenous polychemotherapy and radiation, were found at autopsy." | 1.28 | Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings. ( Gütling, E; Kleihues, P; Landis, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 13 (81.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weng, Q | 1 |
| Tan, B | 1 |
| Wang, J | 2 |
| Zhou, H | 1 |
| Shi, J | 1 |
| He, Q | 1 |
| Yang, B | 1 |
| Enterline, DS | 1 |
| Davey, NC | 1 |
| Tien, RD | 1 |
| Critchley, P | 1 |
| Abbott, R | 1 |
| Madden, FJ | 1 |
| Fassas, AB | 1 |
| Gattani, AM | 1 |
| Morgello, S | 1 |
| Neu, IS | 1 |
| Savarese, DM | 1 |
| Gordon, J | 1 |
| Smith, TW | 1 |
| Litofsky, NS | 1 |
| Licho, R | 1 |
| Ragland, R | 1 |
| Recht, L | 1 |
| Matsumoto, S | 1 |
| Nishizawa, S | 1 |
| Murakami, M | 1 |
| Noma, S | 1 |
| Sano, A | 1 |
| Kuroda, Y | 1 |
| Rubin, P | 1 |
| Hulette, C | 1 |
| Khawly, JA | 1 |
| Elkordy, M | 1 |
| Hussein, A | 1 |
| Vredenburgh, JJ | 1 |
| Jaffe, GJ | 1 |
| Peters, WP | 1 |
| Lucchinetti, CF | 1 |
| Kimmel, DW | 2 |
| Pavelko, K | 1 |
| Rodriguez, M | 2 |
| Stein, ME | 1 |
| Drumea, K | 1 |
| Yarnitsky, D | 1 |
| Benny, A | 1 |
| Tzuk-Shina, T | 1 |
| Yeo, W | 1 |
| Tong, MM | 1 |
| Chan, YL | 1 |
| Israel, ZH | 1 |
| Lossos, A | 1 |
| Barak, V | 1 |
| Soffer, D | 1 |
| Siegal, T | 1 |
| Gütling, E | 1 |
| Landis, T | 1 |
| Kleihues, P | 1 |
| Hook, CC | 1 |
| Kvols, LK | 1 |
| Scheithauer, BW | 1 |
| Forsyth, PA | 1 |
| Rubin, J | 1 |
| Moertel, CG | 1 |
| Koenig, H | 1 |
1 review available for fluorouracil and Demyelinating Diseases
| Article | Year |
|---|---|
Cerebral demyelination with 5-fluorouracil and levamisole.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Colorec | 1994 |
15 other studies available for fluorouracil and Demyelinating Diseases
| Article | Year |
|---|---|
5-Fluorouracil causes severe CNS demyelination by disruption of TCF7L2/HDAC1/HDAC2 complex in adolescent mice.
Topics: Age Factors; Animals; Antimetabolites, Antineoplastic; Brain; Cell Death; Cells, Cultured; Demyelina | 2014 |
Neuroradiology case of the day. Multifocal inflammatory leukoencephalopathy due to treatment with 5-fluorouracil and levamisole.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Colonic Neoplasms; Demyelinating Dis | 1995 |
Multifocal inflammatory leukoencephalopathy developing in a patient receiving 5-fluorouracil and levamisole.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Chemotherapy, Adjuvant; Colonic Neopla | 1994 |
Multifocal inflammatory leukencephalopathy caused by adjuvant therapy with 5-fluorouracil and levamisole after resection for an adenocarcinoma of the colon.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neop | 1993 |
Cerebral demyelination syndrome in a patient treated with 5-fluorouracil and levamisole. The use of thallium SPECT imaging to assist in noninvasive diagnosis--a case report.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Brain Diseases; Colonic Neoplasms; Demyelinati | 1996 |
Carmofur-induced leukoencephalopathy: MRI.
Topics: Antineoplastic Agents; Brain; Brain Damage, Chronic; Breast Neoplasms; Chemotherapy, Adjuvant; Demye | 1995 |
Ocular toxicity following high dose chemotherapy and autologous transplant.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Cispl | 1996 |
5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus.
Topics: Adjuvants, Immunologic; Animals; Antimetabolites, Antineoplastic; Demyelinating Diseases; Female; Fl | 1997 |
A rare event of 5-fluorouracil-associated peripheral neuropathy: a report of two patients.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Combined Modality Therapy; Demyelinating Diseases; Female; | 1998 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1999. Neurologic disorder in a 65-year-old man after treatment of colon cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Diseases; Cogniti | 1999 |
Multifocal cerebral demyelination secondary to fluorouracil and levamisole therapy.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Brain; Demyelinating Diseases; Fluorouracil | 1999 |
Multifocal demyelinative leukoencephalopathy associated with 5-fluorouracil and levamisole.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dementia, Vascula | 2000 |
Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings.
Topics: Adult; Afferent Pathways; Akinetic Mutism; Alpha Rhythm; Antineoplastic Combined Chemotherapy Protoc | 1992 |
Multifocal inflammatory leukoencephalopathy with 5-fluorouracil and levamisole.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Biopsy; Brain; Chemoth | 1992 |
Some observations on the experimental production of acute neuroaxonal and synaptosomal dystrophy.
Topics: Animals; Axons; Brain; Cats; Citrates; Citric Acid Cycle; Cyanides; Demyelinating Diseases; Fluorine | 1971 |