Page last updated: 2024-10-27

fluorouracil and Dementia

fluorouracil has been researched along with Dementia in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

ExcerptRelevanceReference
"We observed leukoencephalopathy in 1 patient, and progressive dementia in another, during the administration of 5-fluorouracil (5-FU) and levamisole."7.69Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases. ( Dobranowski, J; Fawcet, SE; Figueredo, AT; Molloy, DW; Paulseth, JE, 1995)
"We observed leukoencephalopathy in 1 patient, and progressive dementia in another, during the administration of 5-fluorouracil (5-FU) and levamisole."3.69Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases. ( Dobranowski, J; Fawcet, SE; Figueredo, AT; Molloy, DW; Paulseth, JE, 1995)
"To estimate patterns of colon cancer presentation, diagnosis, and treatment according to history of dementia using National Cancer Institute (NCI) Surveillance, Epidemiology, and End-Result (SEER) Medicare data."1.32Patterns of presentation, diagnosis, and treatment in older patients with colon cancer and comorbid dementia. ( Gupta, SK; Lamont, EB, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ganno, H1
Fujiya, K1
Nakamura, M1
Takasaki, J1
Watayoh, Y1
Amagasa, H1
Kurokawa, T1
Ami, K1
Fukuda, A1
Nagahama, T1
Andoh, M1
Arai, K1
Stoff, BK1
Seidler, A1
Kinlaw, K1
Gupta, SK1
Lamont, EB1
Figueredo, AT1
Fawcet, SE1
Molloy, DW1
Dobranowski, J1
Paulseth, JE1

Other Studies

4 other studies available for fluorouracil and Dementia

ArticleYear
[A case of encephalopathy that was suspected to be caused by chemotherapy for colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:12

    Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera

2011
A patient with dementia: decision-making capacity and surrogate decision makers.
    Journal of the American Academy of Dermatology, 2012, Volume: 67, Issue:4

    Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Dementia; Dermatology;

2012
Patterns of presentation, diagnosis, and treatment in older patients with colon cancer and comorbid dementia.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:10

    Topics: Aged; Chemotherapy, Adjuvant; Colonic Neoplasms; Comorbidity; Confidence Intervals; Dementia; Female

2004
Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases.
    Cancer investigation, 1995, Volume: 13, Issue:6

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Diseases; Chemoth

1995