fluorouracil has been researched along with Dementia in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We observed leukoencephalopathy in 1 patient, and progressive dementia in another, during the administration of 5-fluorouracil (5-FU) and levamisole." | 7.69 | Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases. ( Dobranowski, J; Fawcet, SE; Figueredo, AT; Molloy, DW; Paulseth, JE, 1995) |
| "We observed leukoencephalopathy in 1 patient, and progressive dementia in another, during the administration of 5-fluorouracil (5-FU) and levamisole." | 3.69 | Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases. ( Dobranowski, J; Fawcet, SE; Figueredo, AT; Molloy, DW; Paulseth, JE, 1995) |
| "To estimate patterns of colon cancer presentation, diagnosis, and treatment according to history of dementia using National Cancer Institute (NCI) Surveillance, Epidemiology, and End-Result (SEER) Medicare data." | 1.32 | Patterns of presentation, diagnosis, and treatment in older patients with colon cancer and comorbid dementia. ( Gupta, SK; Lamont, EB, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ganno, H | 1 |
| Fujiya, K | 1 |
| Nakamura, M | 1 |
| Takasaki, J | 1 |
| Watayoh, Y | 1 |
| Amagasa, H | 1 |
| Kurokawa, T | 1 |
| Ami, K | 1 |
| Fukuda, A | 1 |
| Nagahama, T | 1 |
| Andoh, M | 1 |
| Arai, K | 1 |
| Stoff, BK | 1 |
| Seidler, A | 1 |
| Kinlaw, K | 1 |
| Gupta, SK | 1 |
| Lamont, EB | 1 |
| Figueredo, AT | 1 |
| Fawcet, SE | 1 |
| Molloy, DW | 1 |
| Dobranowski, J | 1 |
| Paulseth, JE | 1 |
4 other studies available for fluorouracil and Dementia
| Article | Year |
|---|---|
[A case of encephalopathy that was suspected to be caused by chemotherapy for colon cancer].
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2011 |
A patient with dementia: decision-making capacity and surrogate decision makers.
Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Dementia; Dermatology; | 2012 |
Patterns of presentation, diagnosis, and treatment in older patients with colon cancer and comorbid dementia.
Topics: Aged; Chemotherapy, Adjuvant; Colonic Neoplasms; Comorbidity; Confidence Intervals; Dementia; Female | 2004 |
Disabling encephalopathy during 5-fluorouracil and levamisole adjuvant therapy for resected colorectal cancer: a report of two cases.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Diseases; Chemoth | 1995 |