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fluorouracil and Dementia, Vascular

fluorouracil has been researched along with Dementia, Vascular in 6 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Dementia, Vascular: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)

Research Excerpts

ExcerptRelevanceReference
"A 58-year-old man with hypopharyngeal cancer who developed 5-fluorouracil-induced leukoencephalopathy."3.73Reversible impairment of auditory callosal pathway in 5-fluorouracil-induced leukoencephalopathy: parallel changes in function and imaging. ( Fujimoto, C; Ito, K; Iwasaki, S; Nakao, K; Sugasawa, M, 2006)
"Patients with cerebrovascular accidents were excluded."1.35Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients. ( Baehring, JM; Fulbright, RK, 2008)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tha, KK1
Terae, S1
Sugiura, M1
Nishioka, T1
Oka, M1
Kudoh, K1
Kaneko, K1
Miyasaka, K1
Fujimoto, C1
Ito, K1
Iwasaki, S1
Nakao, K1
Sugasawa, M1
Allen, JA1
Adlakha, A1
Bergethon, PR1
Baehring, JM1
Fulbright, RK1
Israel, ZH1
Lossos, A1
Barak, V1
Soffer, D1
Siegal, T1
Mak, W1
Cheng, PW1
Cheung, RT1

Other Studies

6 other studies available for fluorouracil and Dementia, Vascular

ArticleYear
Diffusion-weighted magnetic resonance imaging in early stage of 5-fluorouracil-induced leukoencephalopathy.
    Acta neurologica Scandinavica, 2002, Volume: 106, Issue:6

    Topics: Adult; Antimetabolites, Antineoplastic; Brain; Dementia, Vascular; Diffusion Magnetic Resonance Imag

2002
Reversible impairment of auditory callosal pathway in 5-fluorouracil-induced leukoencephalopathy: parallel changes in function and imaging.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2006, Volume: 27, Issue:5

    Topics: Antimetabolites, Antineoplastic; Auditory Pathways; Corpus Callosum; Dementia, Vascular; Dichotic Li

2006
Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.
    Archives of neurology, 2006, Volume: 63, Issue:10

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C

2006
Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Brain; Brain Edema; Capecitabine; Dementia, Vascular; Deoxycytid

2008
Multifocal demyelinative leukoencephalopathy associated with 5-fluorouracil and levamisole.
    Acta oncologica (Stockholm, Sweden), 2000, Volume: 39, Issue:1

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dementia, Vascula

2000
Leukoencephalopathy following chemotherapy for colonic carcinoma.
    Clinical radiology, 2001, Volume: 56, Issue:4

    Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Co

2001