fluorouracil has been researched along with Dementia, Vascular in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Dementia, Vascular: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 58-year-old man with hypopharyngeal cancer who developed 5-fluorouracil-induced leukoencephalopathy." | 3.73 | Reversible impairment of auditory callosal pathway in 5-fluorouracil-induced leukoencephalopathy: parallel changes in function and imaging. ( Fujimoto, C; Ito, K; Iwasaki, S; Nakao, K; Sugasawa, M, 2006) |
| "Patients with cerebrovascular accidents were excluded." | 1.35 | Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients. ( Baehring, JM; Fulbright, RK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tha, KK | 1 |
| Terae, S | 1 |
| Sugiura, M | 1 |
| Nishioka, T | 1 |
| Oka, M | 1 |
| Kudoh, K | 1 |
| Kaneko, K | 1 |
| Miyasaka, K | 1 |
| Fujimoto, C | 1 |
| Ito, K | 1 |
| Iwasaki, S | 1 |
| Nakao, K | 1 |
| Sugasawa, M | 1 |
| Allen, JA | 1 |
| Adlakha, A | 1 |
| Bergethon, PR | 1 |
| Baehring, JM | 1 |
| Fulbright, RK | 1 |
| Israel, ZH | 1 |
| Lossos, A | 1 |
| Barak, V | 1 |
| Soffer, D | 1 |
| Siegal, T | 1 |
| Mak, W | 1 |
| Cheng, PW | 1 |
| Cheung, RT | 1 |
6 other studies available for fluorouracil and Dementia, Vascular
| Article | Year |
|---|---|
Diffusion-weighted magnetic resonance imaging in early stage of 5-fluorouracil-induced leukoencephalopathy.
Topics: Adult; Antimetabolites, Antineoplastic; Brain; Dementia, Vascular; Diffusion Magnetic Resonance Imag | 2002 |
Reversible impairment of auditory callosal pathway in 5-fluorouracil-induced leukoencephalopathy: parallel changes in function and imaging.
Topics: Antimetabolites, Antineoplastic; Auditory Pathways; Corpus Callosum; Dementia, Vascular; Dichotic Li | 2006 |
Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C | 2006 |
Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
Topics: Adult; Aged; Antineoplastic Agents; Brain; Brain Edema; Capecitabine; Dementia, Vascular; Deoxycytid | 2008 |
Multifocal demyelinative leukoencephalopathy associated with 5-fluorouracil and levamisole.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dementia, Vascula | 2000 |
Leukoencephalopathy following chemotherapy for colonic carcinoma.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Co | 2001 |