fluorouracil has been researched along with Delayed Hypersensitivity in 30 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Furthermore, the delayed hypersensitivity response (DHR) against picryl chloride (PCl) was augmented by FD-1 but not by FT and FU if they were administrated for 3 days after PCl immunization." | 7.66 | Differential effects of 5-fluorouracil analogs on humoral and cell-mediated responses in mice: augmentation of delayed hypersensitivity response against picryl chloride by 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1), a new anti-tumor ( Miyauchi, S; Unemi, N; Yamada, Y, 1980) |
| "The relation between the induction of delayed hypersensitivity reactions to 5-FU following treatment with topical 5-FU and the cure rate for cutaneous neoplasms showed a trend toward correlation." | 5.25 | Delayed hypersensitivity to 5-fluorouracil following topical chemotherapy of cutaneous cancers. ( Ichinose, H; Krementz, ET; Litwin, MS; Mansell, PW, 1975) |
| " Furthermore, the delayed hypersensitivity response (DHR) against picryl chloride (PCl) was augmented by FD-1 but not by FT and FU if they were administrated for 3 days after PCl immunization." | 3.66 | Differential effects of 5-fluorouracil analogs on humoral and cell-mediated responses in mice: augmentation of delayed hypersensitivity response against picryl chloride by 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1), a new anti-tumor ( Miyauchi, S; Unemi, N; Yamada, Y, 1980) |
| "Stage III colon cancer patients receiving standard adjuvant oxaliplatin/capecitabine chemotherapy were vaccinated at the same time with keyhole limpet haemocyanin (KLH) and carcinoembryonic antigen (CEA)-peptide pulsed DCs." | 1.36 | A pilot study on the immunogenicity of dendritic cell vaccination during adjuvant oxaliplatin/capecitabine chemotherapy in colon cancer patients. ( Aarntzen, EA; Adema, GJ; de Boer, A; de Vries, IJ; Figdor, CG; Lesterhuis, WJ; Preijers, FW; Punt, CJ; Scharenborg, NM; van de Rakt, M; van Spronsen, DJ, 2010) |
| "Tests for delayed hypersensitivity to homologous tumor antigen before treatment were positive in 83." | 1.26 | Delayed hypersensitivity reactions in patients with breast cancer. ( Boeva, M; Christov, I; Donchev, T; Markova, R, 1978) |
| "The relation between the induction of delayed hypersensitivity reactions to 5-FU following treatment with topical 5-FU and the cure rate for cutaneous neoplasms showed a trend toward correlation." | 1.25 | Delayed hypersensitivity to 5-fluorouracil following topical chemotherapy of cutaneous cancers. ( Ichinose, H; Krementz, ET; Litwin, MS; Mansell, PW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (70.00) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lesterhuis, WJ | 1 |
| de Vries, IJ | 1 |
| Aarntzen, EA | 1 |
| de Boer, A | 1 |
| Scharenborg, NM | 1 |
| van de Rakt, M | 1 |
| van Spronsen, DJ | 1 |
| Preijers, FW | 1 |
| Figdor, CG | 1 |
| Adema, GJ | 1 |
| Punt, CJ | 1 |
| Shaw, HS | 1 |
| Hobbs, KB | 1 |
| Kroll, DJ | 1 |
| Seewaldt, VL | 1 |
| Noronha, V | 1 |
| Burtness, B | 1 |
| Murren, J | 1 |
| Duffy, TP | 1 |
| Ohta, Y | 1 |
| Sueki, K | 1 |
| Kitta, K | 1 |
| Takemoto, K | 1 |
| Ishitsuka, H | 1 |
| Yagi, Y | 1 |
| Yamada, Y | 1 |
| Miyauchi, S | 1 |
| Unemi, N | 1 |
| Itoh, H | 1 |
| Ito, H | 1 |
| Amano, H | 1 |
| Noda, H | 1 |
| Sakamoto, O | 2 |
| Mori, H | 3 |
| Kitaichi, K | 1 |
| Koda, A | 3 |
| Duley, JA | 1 |
| Nethersell, AB | 1 |
| Baars, A | 1 |
| Claessen, AM | 1 |
| Wagstaff, J | 1 |
| Giaccone, G | 1 |
| Scheper, RJ | 1 |
| Meijer, S | 1 |
| Schakel, MJ | 1 |
| Gall, HE | 1 |
| Meijer, CJ | 1 |
| Vermorken, JB | 1 |
| Pinedo, HM | 1 |
| van den Eertwegh, AJ | 1 |
| Boeva, M | 1 |
| Donchev, T | 1 |
| Markova, R | 1 |
| Christov, I | 1 |
| Salamon, T | 1 |
| Stojaković, M | 1 |
| Bogdanović, B | 1 |
| Mansell, PW | 1 |
| Litwin, MS | 1 |
| Ichinose, H | 1 |
| Krementz, ET | 2 |
| Ottolenghi, F | 1 |
| Andreassi, L | 1 |
| Sbano, E | 1 |
| Fimiani, M | 1 |
| Tsuru, S | 1 |
| Shinomiya, N | 1 |
| Katsura, Y | 1 |
| Gotoh, M | 1 |
| Noritake, M | 1 |
| Nomoto, K | 2 |
| Kurimoto, Y | 1 |
| Xu, QA | 2 |
| Kobayashi, H | 1 |
| Komuro, T | 1 |
| Furue, H | 1 |
| Tokuda, N | 1 |
| Mayumi, H | 1 |
| Himeno, K | 1 |
| Gondo, H | 1 |
| Fan, JL | 1 |
| Uesugi, Y | 1 |
| Ono, Y | 1 |
| Nishioka, I | 1 |
| Ryan, RF | 1 |
| Truesdale, GL | 1 |
| Liebman, IM | 1 |
| Maguire, HC | 1 |
| Blomgren, SE | 1 |
| Wolberg, WH | 1 |
| Kisken, WA | 1 |
| Heppner, GH | 1 |
| Griswold, DE | 1 |
| Di Lorenzo, J | 1 |
| Poplin, EA | 1 |
| Calabresi, P | 1 |
| Hattori, T | 1 |
| Weintraub, I | 1 |
| Lagasse, LD | 1 |
| Klein, E | 3 |
| Cavins, JA | 1 |
| Schwartz, SH | 1 |
| Bardos, TJ | 1 |
| Burgess, GH | 1 |
| Williams, AC | 1 |
| Al-Sarraf, M | 1 |
| Wong, P | 1 |
| Sardesai, S | 1 |
| Vaitkevicius, VK | 1 |
| Mitchell, MS | 1 |
| DeConti, RC | 1 |
2 reviews available for fluorouracil and Delayed Hypersensitivity
| Article | Year |
|---|---|
Oxaliplatin induces a delayed immune-mediated hemolytic anemia: a case report and review of the literature.
Topics: Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; | 2005 |
[A review of clinical tumor immunology. An approach to immunochemotherapy].
Topics: Animals; Antibiotics, Antineoplastic; BCG Vaccine; Cytarabine; Drug Therapy, Combination; Fluorourac | 1974 |
1 trial available for fluorouracil and Delayed Hypersensitivity
| Article | Year |
|---|---|
A phase II study of active specific immunotherapy and 5-FU/Leucovorin as adjuvant therapy for stage III colon carcinoma.
Topics: Adult; Aged; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Humans; Hypersensitivi | 2002 |
27 other studies available for fluorouracil and Delayed Hypersensitivity
| Article | Year |
|---|---|
A pilot study on the immunogenicity of dendritic cell vaccination during adjuvant oxaliplatin/capecitabine chemotherapy in colon cancer patients.
Topics: Aged; Antibody Formation; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Cancer Vacc | 2010 |
Delayed-type hypersensitivity reaction with iscador M given in combination with cytotoxic chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Deoxycytid | 2004 |
Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil.
Topics: Animals; Antibody Formation; Erythrocytes; Female; Floxuridine; Fluorouracil; Graft Rejection; Hyper | 1980 |
Differential effects of 5-fluorouracil analogs on humoral and cell-mediated responses in mice: augmentation of delayed hypersensitivity response against picryl chloride by 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione (FD-1), a new anti-tumor
Topics: Animals; Antibody Formation; Drug Hypersensitivity; Fluorouracil; Graft Rejection; Hypersensitivity, | 1980 |
Inhibitory action of a (1-->6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Meth A fibrosarcoma-bearing mice and its antitumor mechanism.
Topics: Agaricus; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Synergism; Erythrocytes; Fema | 1994 |
Novel low immunosuppressive derivatives of the antitumor drug fluoropyrimidine, UK-21 and UK-25: effect on delayed type hypersensitivity and tumor immunity.
Topics: Animals; Antineoplastic Agents; Erythrocytes; Female; Fluorouracil; Glycine; Hypersensitivity, Delay | 1993 |
Delayed hypersensitivity to 5-fluorouracil associated with reduced dihydropyrimidine dehydrogenase (DPD) activity.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Creatinine; Dihydrouracil Dehydrogenase (NADP | 1998 |
Delayed hypersensitivity reactions in patients with breast cancer.
Topics: Adult; Antigens, Neoplasm; Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Humans; Hyperse | 1978 |
Delayed hypersensitivity in xeroderma pigmentosum.
Topics: Carcinoma, Squamous Cell; Child; Child, Preschool; Eye Diseases; Female; Fluorouracil; Humans; Hyper | 1975 |
Delayed hypersensitivity to 5-fluorouracil following topical chemotherapy of cutaneous cancers.
Topics: Administration, Topical; Biopsy; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Basosquamous; | 1975 |
[Diffuse chronic mucocutaneous candidiasis: Effects of antimycotics in vitro].
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis, Cutaneous; Candidiasis, Oral; Child; Chroni | 1975 |
Effects of combined therapies with protein-bound polysaccharide (PSK, Krestin) and fluorinated pyrimidine derivatives on experimental liver metastases and on the immunologic capacities of the hosts.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antineoplastic Combined Chemotherapy Protocols; | 1991 |
Effect of a non-protein fraction from an extract of the inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin) on Meth A-induced delayed type hypersensitivity.
Topics: Animals; Fluorouracil; Hypersensitivity, Delayed; Mice; Mice, Inbred BALB C; Polysaccharides; Rabbit | 1990 |
[Effect of combination immunochemotherapy with an organogermanium compound, Ge-132, and antitumor agents on C57BL/6 mice bearing Lewis lung carcinoma (3LL)].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Fluoroura | 1986 |
Drug-induced in vitro tolerance to allogeneic antigens. II. Further analysis of in vitro-tolerized spleen cells in a fully allogeneic murine combination.
Topics: Animals; Animals, Newborn; Crosses, Genetic; Cytotoxicity, Immunologic; Fluorouracil; Graft vs Host | 1988 |
Immunological mechanisms of antitumor activity of some kinds of Chinese herbs: Meth A-induced delayed type hypersensitivity.
Topics: Animals; Cyclophosphamide; Female; Fluorouracil; Hypersensitivity, Delayed; Lipopolysaccharides; Mal | 1988 |
Salvage of stage IV intraoral squamous cell carcinomas with preoperative 5-fluorouracil.
Topics: Administration, Topical; Adult; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; F | 1986 |
Maintenance of delayed hypersensitivity reactions in patients receiving cancer chemotherapy.
Topics: Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Hypersensitivity, Delayed; Immunity; Ma | 1968 |
Effect of fluoropyrimidines on delayed cutaneous hypersensitivity.
Topics: Floxuridine; Fluorouracil; Humans; Hypersensitivity, Delayed; Neoplasms; Pyrimidines; Skin Tests | 1965 |
Selective immunosuppression by drugs in balanced immune responses.
Topics: Animals; Antibody Formation; Cell Division; Clone Cells; Cytarabine; Cytotoxicity Tests, Immunologic | 1974 |
Reversibility of vulvar atypia by DNCB-induced delayed hypersensitivity.
Topics: Adult; Biopsy; Carcinoma in Situ; Carcinoma, Squamous Cell; Chlorine; Female; Fluorouracil; Humans; | 1973 |
Proceedings: Chemotherapy and immunotherapy for cancer involving the skin.
Topics: Administration, Topical; Antigens, Bacterial; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinom | 1972 |
Review of a 3-year experience with topical chemotherapy and immunotherapy of superficial cutaneous neoplasms.
Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chlorine; Facial Neoplasms; | 1971 |
Cytostatic and immunologic activity of 5-mercaptouracil desoxyriboside in the management of multiple superficial basal cell epitheliomas.
Topics: Antimetabolites; Carcinoma, Basal Cell; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Humans; Hypersens | 1970 |
Experiences with local chemotherapy and immunotherapy in premalignant and malignant skin lesions.
Topics: Antigen-Antibody Reactions; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Dermatitis, | 1970 |
Clinical immunologic responsiveness in malignant disease. I. Delayed hypersensitivity reaction and the effect of cytotoxic drugs.
Topics: Adolescent; Adult; Aged; Antigens; Antineoplastic Agents; Breast Neoplasms; Candida; Child; Child, P | 1970 |
Immunosuppression by 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Aged; Antibody Formation; Antigens; Blood Bactericidal Activity; Blood Platel | 1970 |