fluorouracil has been researched along with Delayed Effects, Prenatal Exposure in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) is a cytostatic anti-tumor drug which is known to have immunosuppressive activities." | 5.31 | Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice. ( Horii, I; Inoue, T, 2002) |
| "Between 1992 and 2010, 81 pregnant patients with breast cancer were treated in a single-arm, institutional review board-approved study with 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) in the adjuvant or neoadjuvant setting." | 3.80 | Outcomes of children exposed in utero to chemotherapy for breast cancer. ( Barnett, CM; Hodge, S; Hortobagyi, GN; Litton, JK; Milbourne, A; Murthy, RK; Ramirez, MM; Rimes, SA; Theriault, RL; Valero, V, 2014) |
| "5-Fluorouracil (5-FU) is a cytostatic anti-tumor drug which is known to have immunosuppressive activities." | 1.31 | Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice. ( Horii, I; Inoue, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murthy, RK | 1 |
| Theriault, RL | 1 |
| Barnett, CM | 1 |
| Hodge, S | 1 |
| Ramirez, MM | 1 |
| Milbourne, A | 1 |
| Rimes, SA | 1 |
| Hortobagyi, GN | 1 |
| Valero, V | 1 |
| Litton, JK | 1 |
| Mathelin, C | 1 |
| Annane, K | 1 |
| Dufour, P | 1 |
| Liegeois, P | 1 |
| Bergerat, JP | 1 |
| Inoue, T | 1 |
| Horii, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multimodality Treatment of Primary Breast Cancer Occurring Concomitant With Pregnancy[NCT00510367] | Early Phase 1 | 61 participants (Actual) | Interventional | 2001-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for fluorouracil and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Outcomes of children exposed in utero to chemotherapy for breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clubfoot; Congenital | 2014 |
Chemotherapy for breast cancer during pregnancy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; | 2005 |
Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice.
Topics: Animals; Animals, Newborn; Body Weight; Female; Flow Cytometry; Fluorouracil; Immune System; Immunos | 2002 |