Page last updated: 2024-10-27

fluorouracil and Delayed Effects, Prenatal Exposure

fluorouracil has been researched along with Delayed Effects, Prenatal Exposure in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"5-Fluorouracil (5-FU) is a cytostatic anti-tumor drug which is known to have immunosuppressive activities."5.31Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice. ( Horii, I; Inoue, T, 2002)
"Between 1992 and 2010, 81 pregnant patients with breast cancer were treated in a single-arm, institutional review board-approved study with 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) in the adjuvant or neoadjuvant setting."3.80Outcomes of children exposed in utero to chemotherapy for breast cancer. ( Barnett, CM; Hodge, S; Hortobagyi, GN; Litton, JK; Milbourne, A; Murthy, RK; Ramirez, MM; Rimes, SA; Theriault, RL; Valero, V, 2014)
"5-Fluorouracil (5-FU) is a cytostatic anti-tumor drug which is known to have immunosuppressive activities."1.31Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice. ( Horii, I; Inoue, T, 2002)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Murthy, RK1
Theriault, RL1
Barnett, CM1
Hodge, S1
Ramirez, MM1
Milbourne, A1
Rimes, SA1
Hortobagyi, GN1
Valero, V1
Litton, JK1
Mathelin, C1
Annane, K1
Dufour, P1
Liegeois, P1
Bergerat, JP1
Inoue, T1
Horii, I1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multimodality Treatment of Primary Breast Cancer Occurring Concomitant With Pregnancy[NCT00510367]Early Phase 161 participants (Actual)Interventional2001-08-07Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for fluorouracil and Delayed Effects, Prenatal Exposure

ArticleYear
Outcomes of children exposed in utero to chemotherapy for breast cancer.
    Breast cancer research : BCR, 2014, Dec-30, Volume: 16, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clubfoot; Congenital

2014
Chemotherapy for breast cancer during pregnancy.
    European journal of obstetrics, gynecology, and reproductive biology, 2005, Dec-01, Volume: 123, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast;

2005
Effects on fetal thymocyte populations and postnatal T-cell-dependent immune functions after maternal exposure to 5-fluorouracil during pregnancy in mice.
    The Journal of toxicological sciences, 2002, Volume: 27, Issue:2

    Topics: Animals; Animals, Newborn; Body Weight; Female; Flow Cytometry; Fluorouracil; Immune System; Immunos

2002