fluorouracil has been researched along with Dehydration in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Dehydration: The condition that results from excessive loss of water from a living organism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among 13 patients with advanced colorectal cancer, 10 required dose reductions of irinotecan and 5-FU because of dehydration, diarrhoea, and neutropenia, seven of whom required hospitalisation, three with neutropenic fever." | 6.71 | A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer. ( Berlin, J; Davis, L; Giantonio, B; Haller, DG; O'Dwyer, PJ; Shults, J; Sun, W; Veronese, ML, 2005) |
| "Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients." | 5.30 | Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999) |
| "Among 13 patients with advanced colorectal cancer, 10 required dose reductions of irinotecan and 5-FU because of dehydration, diarrhoea, and neutropenia, seven of whom required hospitalisation, three with neutropenic fever." | 2.71 | A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer. ( Berlin, J; Davis, L; Giantonio, B; Haller, DG; O'Dwyer, PJ; Shults, J; Sun, W; Veronese, ML, 2005) |
| "Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients." | 1.30 | Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999) |
| "These two cases suggest that dehydration and electrolyte disturbance from high stomal output could be a serious problem following chemoradiation therapy in patients with an ileostomy." | 1.29 | Ileostomy dysfunction with adjuvant chemoradiation for rectal carcinoma requiring in-hospital management: a cause for concern. ( Chen, FC; Mackay, JR; Woods, RJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chakravarty, T | 1 |
| Crane, CH | 1 |
| Ajani, JA | 1 |
| Mansfield, PF | 1 |
| Briere, TM | 1 |
| Beddar, AS | 1 |
| Mok, H | 1 |
| Reed, VK | 1 |
| Krishnan, S | 1 |
| Delclos, ME | 1 |
| Das, P | 1 |
| Veronese, ML | 1 |
| Sun, W | 1 |
| Giantonio, B | 1 |
| Berlin, J | 1 |
| Shults, J | 1 |
| Davis, L | 1 |
| Haller, DG | 1 |
| O'Dwyer, PJ | 1 |
| Wisinski, K | 1 |
| Benson, A | 2 |
| Punt, CJ | 1 |
| Koopman, M | 1 |
| Minsky, BD | 1 |
| Neuberg, D | 1 |
| Kelsen, DP | 1 |
| Pisansky, TM | 1 |
| Ginsberg, R | 1 |
| Chen, FC | 1 |
| Mackay, JR | 1 |
| Woods, RJ | 1 |
| Liaw, CC | 1 |
| Wang, HM | 1 |
| Wang, CH | 1 |
| Yang, TS | 1 |
| Chen, JS | 1 |
| Chang, HK | 1 |
| Lin, YC | 1 |
| Liaw, SJ | 1 |
| Yeh, CT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Definitive Concurrent Chemoradiotherapy With Docetaxel Plus Cisplatin Versus 5-fluorouracil Plus Cisplatin in Patients With Esophageal Squamous Cell Carcinoma: a Phase II Randomized Controlled Trial[NCT02969473] | Phase 2 | 120 participants (Anticipated) | Interventional | 2010-10-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for fluorouracil and Dehydration
| Article | Year |
|---|---|
A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neopl | 2005 |
Neoadjuvant chemotherapy plus concurrent chemotherapy and high-dose radiation for squamous cell carcinoma of the esophagus: a preliminary analysis of the phase II intergroup trial 0122.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Co | 1996 |
5 other studies available for fluorouracil and Dehydration
| Article | Year |
|---|---|
Intensity-modulated radiation therapy with concurrent chemotherapy as preoperative treatment for localized gastric adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; | 2012 |
Chemotherapy-induced mucositis: focusing on diarrhea.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Budesonide; Camptothecin; Dehydration; Diar | 2007 |
Capecitabine and irinotecan as first-line treatment of advanced colorectal cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; | 2008 |
Ileostomy dysfunction with adjuvant chemoradiation for rectal carcinoma requiring in-hospital management: a cause for concern.
Topics: Antimetabolites, Antineoplastic; Carcinoma; Chemotherapy, Adjuvant; Dehydration; Fluorouracil; Hospi | 1996 |
Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Bacterial Infections; Brain Diseases; Dehydration; Fem | 1999 |