fluorouracil has been researched along with Dehiscence, Surgical Wound in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Postoperative complications were graded according to the Clavien-Dindo classification." | 1.40 | Prognostic factors for postoperative morbidity and tumour response after neoadjuvant chemoradiation followed by resection for rectal cancer. ( Berkel, AE; Klaase, JM; van der Palen, J; Woutersen, DP, 2014) |
| "Malondialdehyde levels were significantly higher in the 5-FU groups than in the 5-FU + AM groups." | 1.36 | Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing. ( Citgez, B; Ipcioglu, OM; Isgor, A; Kartal, A; Ozcan, O; Ozdilli, K; Polat, N; Torun, P; Uludag, M; Yetkin, G, 2010) |
| "Gastrointestinal perforation is a known risk factor of unknown etiology associated with the use of bevacizumab." | 1.35 | [Ischemic anastomotic bowel perforation during treatment with bevacizumab 10 months after surgery]. ( Abbrederis, K; Kremer, M; Schuhmacher, C, 2008) |
| "The hydroxyproline levels were higher in the IGF-I and the IGF-I +5-FU groups as a result of the stimulating act of IGF-I." | 1.35 | Effect of IGF-I on healing of colonic anastomoses in rats under 5-FU treatment. ( Betsis, D; Demetriades, H; Kanellos, I; Koliakos, G; Lambrou, I; Pramateftakis, MG; Zacharakis, E; Zaraboukas, T, 2008) |
| "Capecitabine is a fluoropyrimidine carbamate with antineoplasmatic activity, recommended for the treatment of colorectal cancer." | 1.34 | The effect of capecitabine on the healing of colonic anastomoses in rats. ( Athanasiadou, ZS; Ballas, KD; Demertzidis, CI; Economou, LD; Konstantinidis, HD; Pissanidou, TT; Sakadamis, AK; Sioga, AC; Slavakis, AP, 2007) |
| "Hydroxyproline levels were significantly increased with the use of HBO2 in rats, independent of chemotherapy administration." | 1.32 | Effect of hyperbaric oxygen on anastomoses created under the influence of 5-FU. ( Akin, ML; Celenk, T; Emeksiz, S; Erenoğlu, C; Foley, E; Uluutku, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berkel, AE | 1 |
| Woutersen, DP | 1 |
| van der Palen, J | 1 |
| Klaase, JM | 1 |
| Ersoy, E | 1 |
| Akbulut, H | 1 |
| Moray, G | 1 |
| Crane, CH | 1 |
| Eng, C | 1 |
| Feig, BW | 1 |
| Das, P | 1 |
| Skibber, JM | 1 |
| Chang, GJ | 1 |
| Wolff, RA | 1 |
| Krishnan, S | 1 |
| Hamilton, S | 1 |
| Janjan, NA | 1 |
| Maru, DM | 1 |
| Ellis, LM | 1 |
| Rodriguez-Bigas, MA | 1 |
| Tsikitis, VL | 1 |
| Larson, DW | 1 |
| Poola, VP | 1 |
| Nelson, H | 1 |
| Wolff, BG | 1 |
| Pemberton, JH | 1 |
| Cima, RR | 1 |
| Uludag, M | 1 |
| Ozdilli, K | 1 |
| Citgez, B | 1 |
| Yetkin, G | 1 |
| Ipcioglu, OM | 1 |
| Ozcan, O | 1 |
| Polat, N | 1 |
| Kartal, A | 1 |
| Torun, P | 1 |
| Isgor, A | 1 |
| Garant, A | 1 |
| Des Groseilliers, S | 1 |
| Martin, L | 1 |
| Ferland, É | 1 |
| Vuong, T | 1 |
| Erenoğlu, C | 1 |
| Uluutku, H | 1 |
| Emeksiz, S | 1 |
| Akin, ML | 1 |
| Foley, E | 1 |
| Celenk, T | 1 |
| Konstantinidis, HD | 1 |
| Slavakis, AP | 1 |
| Ballas, KD | 1 |
| Sioga, AC | 1 |
| Economou, LD | 1 |
| Demertzidis, CI | 1 |
| Pissanidou, TT | 1 |
| Athanasiadou, ZS | 1 |
| Sakadamis, AK | 1 |
| Abbrederis, K | 1 |
| Kremer, M | 1 |
| Schuhmacher, C | 1 |
| Zacharakis, E | 2 |
| Demetriades, H | 1 |
| Pramateftakis, MG | 1 |
| Lambrou, I | 1 |
| Zaraboukas, T | 2 |
| Koliakos, G | 1 |
| Kanellos, I | 2 |
| Betsis, D | 1 |
| de Waard, JW | 1 |
| Wobbes, T | 1 |
| van der Linden, CJ | 1 |
| Hendriks, T | 1 |
| Kavouni, A | 1 |
| Odisseos, C | 1 |
| Galovatsea, K | 1 |
| Dadoukis, I | 1 |
| Kuzu, MA | 1 |
| Köksoy, C | 1 |
| Kale, T | 1 |
| Demirpençe, E | 1 |
| Renda, N | 1 |
| Fukuchi, SG | 1 |
| Seeburger, JL | 1 |
| Parquet, G | 1 |
| Rolandelli, RH | 1 |
| Morris, T | 1 |
| Welch, CE | 1 |
| Liss, RP | 1 |
| Scholes, GN | 1 |
| Crandall, AS | 1 |
| Salm, R | 1 |
| Wullich, B | 1 |
| Kiefer, G | 1 |
| Fiebig, HH | 1 |
| Farthmann, EH | 1 |
| Cohn, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Continuous Dosing of Sunitinib in Non GIST Sarcomas With Concomitant Radiotherapy[NCT01308034] | Phase 1 | 25 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Dehiscence, Surgical Wound
| Article | Year |
|---|---|
Abdominal surgery (second of three parts).
Topics: Abdomen; Acute Disease; Anus Diseases; Appendectomy; Appendicitis; Appendix; Carcinoembryonic Antige | 1975 |
2 trials available for fluorouracil and Dehiscence, Surgical Wound
| Article | Year |
|---|---|
Phase II trial of neoadjuvant bevacizumab, capecitabine, and radiotherapy for locally advanced rectal cancer.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chem | 2010 |
Complications and toxic manifestations of surgical adjuvant chemotherapy for breast cancer.
Topics: Adult; Aged; Blood Cell Count; Blood Platelets; Blood Transfusion; Breast Neoplasms; Clinical Trials | 1968 |
16 other studies available for fluorouracil and Dehiscence, Surgical Wound
| Article | Year |
|---|---|
Prognostic factors for postoperative morbidity and tumour response after neoadjuvant chemoradiation followed by resection for rectal cancer.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Anastomotic Leak; Antimetabolites, Anti | 2014 |
Effects of oxaliplatin and 5-fluorouracil on the healing of colon anastomoses.
Topics: Anastomosis, Surgical; Animals; Antineoplastic Agents; Colonic Neoplasms; Disease Models, Animal; Fe | 2009 |
Postoperative morbidity with diversion after low anterior resection in the era of neoadjuvant therapy: a single institution experience.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Anastomosis, Surgical; Antimetabolites, | 2009 |
Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Biological Dressings; Body Weight; | 2010 |
Late anastomotic dehiscence during bevacizumab therapy for patients with colorectal cancer.
Topics: Adenocarcinoma; Anastomotic Leak; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemoth | 2011 |
Effect of hyperbaric oxygen on anastomoses created under the influence of 5-FU.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Colon; Fluorouracil; Hydroxyproline | 2003 |
The effect of capecitabine on the healing of colonic anastomoses in rats.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Capecitabine; Colon; Deoxycytidine; | 2007 |
[Ischemic anastomotic bowel perforation during treatment with bevacizumab 10 months after surgery].
Topics: Anastomosis, Surgical; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Huma | 2008 |
Effect of IGF-I on healing of colonic anastomoses in rats under 5-FU treatment.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Collagen; Colon; Colonic Neoplasms; | 2008 |
Retinol may promote fluorouracil-suppressed healing of experimental intestinal anastomoses.
Topics: Anastomosis, Surgical; Animals; Collagen; Fluorouracil; Intestinal Mucosa; Intestines; Male; Random | 1995 |
Influence of intraperitoneal 5-fluorouracil plus folinic acid on the healing of colonic anastomoses in rats.
Topics: Anastomosis, Surgical; Animals; Colon; Drug Combinations; Fluorouracil; Incidence; Injections, Intra | 1996 |
Experimental study of the effect of preoperative 5-fluorouracil on the integrity of colonic anastomoses.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Colon; Fluorouracil; Hemoglobins; M | 1998 |
Influence of 5-fluorouracil on colonic healing and expression of transforming growth factor-beta 1.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Colon; Fluorouracil; Incidence; Mal | 1999 |
Retardation of healing of large-bowel anastomoses by 5-fluorouracil.
Topics: Animals; Fluorouracil; Intestine, Large; Male; Rats; Surgical Wound Dehiscence | 1979 |
Glaucoma filtration surgery: new horizontal mattress closure of conjunctival incision.
Topics: Cataract Extraction; Conjunctiva; Fluorouracil; Glaucoma; Humans; Surgical Wound Dehiscence; Suture | 1991 |
Effects of a three-drug antineoplastic protocol of wound healing in rats: a biomechanical and histologic study on gastrointestinal anastomoses and laparotomy wounds.
Topics: Anastomosis, Surgical; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Doxorub | 1991 |