fluorouracil has been researched along with Deficiency, Folic Acid in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years." | 5.31 | Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. ( Berger, FG; Bunni, MA; Davis, C; Kitchens, ME; Priest, DG; Spencer, HT; Tucker, JM, 2002) |
| "Folate was identified as an essential micronutrient early in the twentieth century and anti-folate chemotherapy such as 5-fluorouracil (5-FU) has been central to the medical management of solid tumours including colorectal cancer for more than five decades." | 4.91 | How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy. ( Jennings, BA; Willis, G, 2015) |
| "5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years." | 1.31 | Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. ( Berger, FG; Bunni, MA; Davis, C; Kitchens, ME; Priest, DG; Spencer, HT; Tucker, JM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jennings, BA | 1 |
| Willis, G | 1 |
| Tucker, JM | 1 |
| Davis, C | 1 |
| Kitchens, ME | 1 |
| Bunni, MA | 1 |
| Priest, DG | 3 |
| Spencer, HT | 1 |
| Berger, FG | 1 |
| Wickramasinghe, SN | 1 |
| Raghunathan, K | 2 |
| Schmitz, JC | 1 |
| Branda, RF | 1 |
| Nigels, E | 1 |
| Lafayette, AR | 1 |
| Hacker, M | 1 |
| Hooton, JW | 2 |
| Hoffbrand, AV | 2 |
| Friedkin, M | 1 |
3 reviews available for fluorouracil and Deficiency, Folic Acid
| Article | Year |
|---|---|
How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy.
Topics: Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Folic Acid; Folic Acid Antagonists; | 2015 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deox | 1981 |
Thymidylate synthetase.
Topics: Animals; Binding Sites; Deoxyuridine; Drug Stability; Escherichia coli; Fluorouracil; Folic Acid Def | 1973 |
6 other studies available for fluorouracil and Deficiency, Folic Acid
| Article | Year |
|---|---|
Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice.
Topics: Animals; Antimetabolites, Antineoplastic; Diet; DNA Primers; Fluorouracil; Folic Acid; Folic Acid De | 2002 |
Impact of schedule on leucovorin potentiation of fluorouracil antitumor activity in dietary folic acid deplete mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Diet; Drug Synergism; Fluor | 1997 |
Nutritional folate status influences the efficacy and toxicity of chemotherapy in rats.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkyla | 1998 |
Modulation of fluorouracil antitumor activity by folic acid in a murine model system.
Topics: Animals; Antidotes; Antimetabolites, Antineoplastic; Diet; Disease Models, Animal; Drug Synergism; F | 1999 |
DNA synthesis in isolated lymphocyte nuclei. Effects of megaloblastic anaemia due to folate or vitamin B-12 deficiency or antimetabolite drugs.
Topics: Adenosine Triphosphate; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Cell Nucleus; Cytara | 1977 |
Thymidine kinase in megaloblastic anaemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; | 1976 |