fluorouracil has been researched along with Cytomegalovirus in 15 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When we examine a patient with symptoms of acute enteritis in the course of chemotherapy with oral fluoropyrimidines such as uracil-tegafur (often referred to as UFT), we usually suspect 5-fluorouracil-induced enterocolitis." | 7.83 | Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur. ( Abe, N; Fujinaga, A; Hayashi, H; Hirata, K; Ito, K; Komatsu, Y; Matsuda, K; Uchida, T, 2016) |
| "The biological activities of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil (2'F-ara-FU), 1-(3'-deoxy-3'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil (3'F-ara-FU) and 1-beta-D-arabinofuranosylthymine (ara-T) were compared in human cytomegalovirus (HCMV)-infected and noninfected human fibroblasts." | 7.67 | A proposed mechanism for the selective inhibition of human cytomegalovirus replication by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil. ( Knaus, EE; Misra, HK; Suzuki, S; Tyrrell, DL; Wiebe, LI, 1987) |
| "When we examine a patient with symptoms of acute enteritis in the course of chemotherapy with oral fluoropyrimidines such as uracil-tegafur (often referred to as UFT), we usually suspect 5-fluorouracil-induced enterocolitis." | 3.83 | Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur. ( Abe, N; Fujinaga, A; Hayashi, H; Hirata, K; Ito, K; Komatsu, Y; Matsuda, K; Uchida, T, 2016) |
| " When evaluating their antiviral activity, the 3-deazapurine derivative of l-AA (3) exhibited the highest activity against both laboratory-adapted strains of human cytomegalovirus (HCMV) (AD-169 and Davis) with EC50 values comparable to those of the well-known anti-HCMV drug ganciclovir and without cytotoxic effects on normal human embryonal lung (HEL) cells." | 3.81 | Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations. ( Andrei, G; Kraljević Pavelić, S; Makuc, D; Martinović, T; Mintas, M; Pavelić, K; Plavec, J; Schols, D; Snoeck, R; Stipković Babić, M; Wittine, K, 2015) |
| "The biological activities of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil (2'F-ara-FU), 1-(3'-deoxy-3'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil (3'F-ara-FU) and 1-beta-D-arabinofuranosylthymine (ara-T) were compared in human cytomegalovirus (HCMV)-infected and noninfected human fibroblasts." | 3.67 | A proposed mechanism for the selective inhibition of human cytomegalovirus replication by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil. ( Knaus, EE; Misra, HK; Suzuki, S; Tyrrell, DL; Wiebe, LI, 1987) |
| "Human cytomegalovirus (CMV) DNA synthesis was studied in 5-fluorouracil (FU)-treated and untreated human embryonic lung cells, which differ greatly with respect to the number of cells in the culture synthesizing cellular DNA." | 3.65 | Replication of human cytomegalovirus DNA: lack of dependence on cell DNA synthesis. ( DeMarchi, JM; Kaplan, AS, 1976) |
| "We developed a recombinant defective adenovirus with an insert of gene encoding extracellular domain of mouse Flt3L (Ad-mFlt3L) under control of cytomegalovirus promoter to investigate the biological efficacy of Flt3L in combination with chemotherapeutical drug, 5-FU, in eliciting an effective anti-cancer immunity in mouse hepatoma and colon cancer model systems." | 1.34 | Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU. ( Dai, J; Fan, X; Guo, Y; Hou, S; Kou, G; Li, B; Li, J; Lin, B; Ma, J; Qian, W; Wang, H; Wu, M; Zhang, D; Zhao, J, 2007) |
| "The Ovcar-5 and Skov-3 ovarian cancer cell lines exposed to the Ad-Lp-CD adenoviral vector were much more sensitive to the prodrug 5-fluorocytosine (5FC), which is converted from the 5FC prodrug into the toxic chemical 5-fluorouracil, than was the CCD minimal deviation fibroblast cell line after exposure to the same vector." | 1.31 | The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. ( Crystal, R; Deisseroth, A; Fujii, T; Kacinski, B; Leavitt, J; Peng, XY; Pizzorno, G; Rutherford, T; Sapi, E; Schwartz, P; Won, JH; Zelterman, D, 2001) |
| " We applied the gene therapy strategy of toxin gene conversion of nontoxic prodrug to chemotherapeutic drug in combination with radiation therapy to the treatment of cholangiocarcinoma." | 1.30 | Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. ( Buchsbaum, DJ; Curiel, DT; Kancharla, SR; Mayo, MS; Pederson, LC; Stackhouse, MA; Vickers, SM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raić-Malić, S | 1 |
| Svedruzić, D | 1 |
| Gazivoda, T | 1 |
| Marunović, A | 1 |
| Hergold-Brundić, A | 1 |
| Nagl, A | 1 |
| Balzarini, J | 1 |
| De Clercq, E | 1 |
| Mintas, M | 2 |
| Kokosza, K | 1 |
| Andrei, G | 2 |
| Schols, D | 2 |
| Snoeck, R | 2 |
| Piotrowska, DG | 1 |
| Stipković Babić, M | 1 |
| Makuc, D | 1 |
| Plavec, J | 1 |
| Martinović, T | 1 |
| Kraljević Pavelić, S | 1 |
| Pavelić, K | 1 |
| Wittine, K | 1 |
| Nishio-Nagai, M | 1 |
| Suzuki, S | 3 |
| Yoshikawa, K | 1 |
| Ueda, R | 1 |
| Kazaoka, Y | 1 |
| Hayashi, H | 1 |
| Komatsu, Y | 1 |
| Uchida, T | 1 |
| Abe, N | 1 |
| Ito, K | 1 |
| Hirata, K | 1 |
| Matsuda, K | 1 |
| Fujinaga, A | 1 |
| Bezborodova, OA | 1 |
| Nemtsova, ER | 1 |
| Gevorkov, AR | 1 |
| Boyko, AV | 1 |
| Venediktova, JB | 1 |
| Alekseenko, IV | 1 |
| Kostina, MB | 1 |
| Monastyrskaya, GS | 1 |
| Sverdlov, ED | 1 |
| Khmelevskiy, EV | 1 |
| Yakubovskaya, RI | 1 |
| Hou, S | 1 |
| Kou, G | 1 |
| Fan, X | 1 |
| Wang, H | 1 |
| Qian, W | 1 |
| Zhang, D | 1 |
| Li, B | 1 |
| Dai, J | 1 |
| Zhao, J | 1 |
| Ma, J | 1 |
| Li, J | 1 |
| Lin, B | 1 |
| Wu, M | 1 |
| Guo, Y | 1 |
| Guo, X | 1 |
| Evans, TR | 1 |
| Somanath, S | 1 |
| Armesilla, AL | 1 |
| Darling, JL | 1 |
| Schatzlein, A | 1 |
| Cassidy, J | 1 |
| Wang, W | 1 |
| Avni, A | 1 |
| Haikin, H | 1 |
| Feuchtwanger, MM | 1 |
| Sacks, M | 1 |
| Naggan, L | 1 |
| Sarov, B | 1 |
| Sarov, I | 1 |
| Pederson, LC | 1 |
| Buchsbaum, DJ | 1 |
| Vickers, SM | 1 |
| Kancharla, SR | 1 |
| Mayo, MS | 1 |
| Curiel, DT | 1 |
| Stackhouse, MA | 1 |
| Peng, XY | 1 |
| Won, JH | 1 |
| Rutherford, T | 1 |
| Fujii, T | 1 |
| Zelterman, D | 1 |
| Pizzorno, G | 1 |
| Sapi, E | 1 |
| Leavitt, J | 1 |
| Kacinski, B | 1 |
| Crystal, R | 1 |
| Schwartz, P | 1 |
| Deisseroth, A | 1 |
| DeMarchi, JM | 2 |
| Kaplan, AS | 2 |
| Saneyoshi, M | 1 |
| Nakayama, C | 1 |
| Nishiyama, Y | 1 |
| Yoshida, S | 1 |
| Misra, HK | 1 |
| Wiebe, LI | 1 |
| Knaus, EE | 1 |
| Tyrrell, DL | 1 |
15 other studies available for fluorouracil and Cytomegalovirus
| Article | Year |
|---|---|
Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6- dideoxy-L-ascorbic acid.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line; Crystallography, X-Ray; | 2000 |
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
Topics: Acrylamides; Adenine; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Survival; Cycl | 2015 |
Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line; Cell Proliferation; Cyto | 2015 |
Adoptive immunotherapy combined with FP treatment for head and neck cancer: An in vitro study.
Topics: Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Prolifera | 2017 |
Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemot | 2016 |
Antitumor efficacy of combined gene and radiotherapy in animals.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; Combi | 2016 |
Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU.
Topics: Adenoviridae; Adoptive Transfer; Animals; Antimetabolites, Antineoplastic; Bone Marrow; Carcinoma, H | 2007 |
In vitro evaluation of cancer-specific NF-kappaB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines.
Topics: Blotting, Western; Carcinoembryonic Antigen; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplas | 2007 |
Antibody pattern to human cytomegalovirus in patients with adenocarcinoma of the colon.
Topics: Adenocarcinoma; Adult; Aged; Antibodies, Viral; Colonic Neoplasms; Cytomegalovirus; Fluorouracil; He | 1981 |
Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Bile Duct Neoplasms; Bile Ducts, Intrahepati | 1997 |
The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines.
Topics: Adenoviridae; Animals; Cytomegalovirus; Cytosine Deaminase; Female; Flucytosine; Fluorouracil; Gene | 2001 |
Replication of human cytomegalovirus DNA: lack of dependence on cell DNA synthesis.
Topics: Antigens, Viral; Culture Techniques; Cytomegalovirus; DNA; DNA Replication; DNA, Viral; Fluorouracil | 1976 |
Physiological state of human embryonic lung cells affects their response to human cytomegalovirus.
Topics: Antigens, Viral; Cell Line; Cytomegalovirus; DNA; DNA, Viral; Fluorouracil; Herpesvirus 1, Suid; Hum | 1977 |
Mechanism of selective inhibition of human cytomegalovirus replication by 1-beta-D-arabinofuranosyl-5-fluorouracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Arabinonucleotides; Cytomegalovirus; D | 1985 |
A proposed mechanism for the selective inhibition of human cytomegalovirus replication by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Arabinonucleotides; Cell Line; Cell Su | 1987 |