fluorouracil has been researched along with Cystitis in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cystitis: Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stage II and III rectal cancer patients received, after total mesorectal excision, 2 cycles of XELOX regimen (oxaliplatin 130 mg/m(2) on day 1; capecitabine 1000 mg/m(2) bid on day 1 to 14, q21), followed by capecitabine (800 mg/m(2) bid daily; 20% dose at 12:00 AM and 80% dose at 12:00 PM) administered continuously during pelvic radiation (total 50." | 2.79 | Chronomodulated capecitabine and adjuvant radiation in intermediate-risk to high-risk rectal cancer: a phase II study. ( Bajetta, E; Biondani, P; Buzzoni, R; Di Bartolomeo, M; Dotti, KF; Ferrario, E; Formisano, B; Gevorgyan, A; Grassi, P; Mariani, L; Pietrantonio, F; Valvo, F, 2014) |
| "Transforming growth factor-beta1 is related to adverse events in radiochemotherapy." | 2.77 | Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant. ( Becker, H; Beissbarth, T; Brockmöller, J; Christiansen, H; Conradi, LC; Gaedcke, J; Ghadimi, M; Hennies, S; Herrmann, MK; Hess, CF; Jo, P; Mergler, CP; Rave-Fränk, M; Schirmer, MA; Wolff, HA, 2012) |
| "To investigate the association between polymorphisms of DNA repair genes and xenobiotic with acute adverse effects in locally advanced rectal cancer patients treated with neoadjuvant radiochemotherapy." | 1.46 | Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy. ( Agolli, L; Borro, M; Bracci, S; De Sanctis, V; Di Nardo, F; Enrici, RM; Falco, T; Gentile, G; Maglio, M; Minniti, G; Nicosia, L; Osti, MF; Simmaco, M; Valeriani, M, 2017) |
| "Totally 197 patients with primary cervical cancer in our hospital from 2000 to 2006 were studied." | 1.34 | [Retrospective study of chemoradiotherapy based on cisplatin compared with radiotherapy alone for cervical cancer]. ( Han, C; Kong, WM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bajetta, E | 1 |
| Pietrantonio, F | 1 |
| Buzzoni, R | 1 |
| Ferrario, E | 1 |
| Valvo, F | 1 |
| Mariani, L | 1 |
| Dotti, KF | 1 |
| Biondani, P | 1 |
| Formisano, B | 1 |
| Gevorgyan, A | 1 |
| Grassi, P | 1 |
| Di Bartolomeo, M | 1 |
| Osti, MF | 1 |
| Nicosia, L | 1 |
| Agolli, L | 1 |
| Gentile, G | 1 |
| Falco, T | 1 |
| Bracci, S | 1 |
| Di Nardo, F | 1 |
| Minniti, G | 1 |
| De Sanctis, V | 1 |
| Valeriani, M | 1 |
| Maglio, M | 1 |
| Borro, M | 1 |
| Simmaco, M | 1 |
| Enrici, RM | 1 |
| Wolff, HA | 3 |
| Gaedcke, J | 2 |
| Jung, K | 2 |
| Hermann, RM | 1 |
| Rothe, H | 1 |
| Schirmer, M | 1 |
| Liersch, T | 1 |
| Herrmann, MKA | 1 |
| Hennies, S | 3 |
| Rave-Fränk, M | 2 |
| Hess, CF | 3 |
| Christiansen, H | 3 |
| Raus, I | 1 |
| Schüler, P | 1 |
| Herrmann, MK | 2 |
| Vorwerk, H | 1 |
| Hille, A | 1 |
| Schirmer, MA | 1 |
| Mergler, CP | 1 |
| Conradi, LC | 1 |
| Jo, P | 1 |
| Beissbarth, T | 1 |
| Becker, H | 1 |
| Ghadimi, M | 1 |
| Brockmöller, J | 1 |
| Han, C | 1 |
| Kong, WM | 1 |
| Imoto, S | 1 |
| Ernst, H | 1 |
| Stolle, E | 1 |
| Weber, P | 1 |
| Scheffler, A | 1 |
| Riedel, B | 2 |
| Giai, M | 1 |
| De Fabiani, E | 1 |
| Lamberto, A | 1 |
| Cortese, P | 1 |
| Giardina, G | 1 |
| Pavone-Macaluso, M | 1 |
| Brosig, W | 1 |
| Nagel, R | 1 |
| Pust, R | 1 |
| Piro, AJ | 1 |
| Wilson, RE | 1 |
| Nevinny, HB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Translational Validation Study to Examine KFO179-1 Biomarker Scores for the Prediction and Prognosis of Advanced Primary Resectable Rectal Cancer Stages UICC II-IV, With a 5-FU-based Standard Radiochemotherapy Followed by Total Mesorectal Excision.[NCT03034473] | 200 participants (Actual) | Interventional | 2011-08-31 | Active, not recruiting | |||
| Prospective Randomised Multicenter Phase-III-study: Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil Plus Oxaliplatin Versus Preoperative Radiochemotherapy and Adjuvant Chemotherapy With 5-Fluorouracil for Locally Advanced Rect[NCT00349076] | Phase 3 | 1,256 participants (Actual) | Interventional | 2006-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for fluorouracil and Cystitis
| Article | Year |
|---|---|
Chronomodulated capecitabine and adjuvant radiation in intermediate-risk to high-risk rectal cancer: a phase II study.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy P | 2014 |
Acute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variant.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; C | 2012 |
10 other studies available for fluorouracil and Cystitis
| Article | Year |
|---|---|
Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Capecitabine; Chemoradiothera | 2017 |
High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathologic tumor regression in multimodal treatment of locally advanced rectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap | 2010 |
High-grade acute organ toxicity as a positive prognostic factor in primary radiochemotherapy for anal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols | 2011 |
[Retrospective study of chemoradiotherapy based on cisplatin compared with radiotherapy alone for cervical cancer].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 2007 |
Feasibility of adjuvant chemotherapy for breast cancer patients.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemo | 1997 |
[Preoperative radiotherapy of bladder cancer].
Topics: Bone Marrow Diseases; Colitis; Cystitis; Elementary Particles; Fluorouracil; Humans; Mitosis; Preope | 1975 |
[Secondary effects of adjuvant therapy].
Topics: Alopecia; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophospha | 1985 |
Chemotherapy of vesical and prostatic tumours.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Cobalt Isotopes; Cystitis; Daunorubic | 1971 |
[Preoperative treatment of the carcinoma of the urinary bladder (author's transl)].
Topics: Bone Marrow; Cystitis; Diarrhea; Fluorouracil; Humans; Precancerous Conditions; Preoperative Care; R | 1974 |
Cyclophosphamide therapy in patients with advancing breast cancer following adrenalectomy and 5-fluorouracil.
Topics: Adrenal Insufficiency; Adrenalectomy; Adult; Aged; Alopecia; Breast Neoplasms; Cortisone; Cyclophosp | 1971 |