fluorouracil has been researched along with Cystic Fibrosis of Pancreas in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients." | 3.74 | Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus. ( Besier, S; Brade, V; Dehghani, F; Loitsch, S; Saum, SH; Wichelhaus, TA; Zander, J, 2008) |
| "To investigate the therapeutical effect and side-effect of docetaxel combined with cisplatin (DDP) on the treatment of local advanced esophageal cancer with concomitant radiation therapy." | 2.75 | [Efficacy and side-effects of docetaxel combined with cisplatin on the treatment of local advanced esophageal cancer with concomitant radiation therapy]. ( Gu, XW; Pan, YK; Xu, X; Zhang, TR; Zhao, T, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 1 |
| Di Bonaventura, G | 2 |
| Lupetti, V | 2 |
| De Fabritiis, S | 1 |
| Piccirilli, A | 2 |
| Porreca, A | 1 |
| Di Nicola, M | 1 |
| Pompilio, A | 2 |
| Di Giulio, A | 1 |
| Muzzi, M | 1 |
| Cariani, L | 1 |
| Hough, NE | 1 |
| Chapman, SJ | 1 |
| Flight, WG | 1 |
| Neely, D | 1 |
| Ong, J | 1 |
| Patterson, J | 1 |
| Kirkpatrick, D | 1 |
| Skelly, R | 1 |
| Zhang, TR | 1 |
| Zhao, T | 1 |
| Xu, X | 1 |
| Gu, XW | 1 |
| Pan, YK | 1 |
| Ibele, AR | 1 |
| Koplin, SA | 1 |
| Slaughenhoupt, BL | 1 |
| Kryger, JV | 1 |
| Friedl, A | 1 |
| Lund, DP | 1 |
| Zander, J | 1 |
| Besier, S | 1 |
| Saum, SH | 1 |
| Dehghani, F | 1 |
| Loitsch, S | 1 |
| Brade, V | 1 |
| Wichelhaus, TA | 1 |
| Gear, EV | 1 |
3 reviews available for fluorouracil and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Gastrointestinal malignancy in cystic fibrosis.
Topics: Adenocarcinoma, Clear Cell; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; C | 2020 |
Small intestinal adenocarcinoma: rarely considered, often missed?
Topics: Adenocarcinoma; Aged; Capsule Endoscopy; Celiac Disease; Chemotherapy, Adjuvant; Cystic Fibrosis; Do | 2013 |
Dobbins WO 3d,+DOBBINS WO III: Rectal biopsy. A review of its diagnostic usefulness.
Topics: Amyloidosis; Biopsy; Colitis, Ulcerative; Crohn Disease; Cystic Fibrosis; Cysts; Deficiency Diseases | 1968 |
1 trial available for fluorouracil and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
[Efficacy and side-effects of docetaxel combined with cisplatin on the treatment of local advanced esophageal cancer with concomitant radiation therapy].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; C | 2010 |
5 other studies available for fluorouracil and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Giving Drugs a Second Chance: Antibacterial and Antibiofilm Effects of Ciclopirox and Ribavirin against Cystic Fibrosis
Topics: Anti-Bacterial Agents; Biofilms; Ciclopirox; Cystic Fibrosis; Dactinomycin; Drug Repositioning; Extr | 2022 |
Repurposing High-Throughput Screening Identifies Unconventional Drugs with Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa under Experimental Conditions Relevant to Cystic Fibrosis.
Topics: Anti-Bacterial Agents; Biofilms; Cystic Fibrosis; Drug Repositioning; Fluorouracil; High-Throughput | 2023 |
Colonic adenocarcinoma in a 13-year-old with cystic fibrosis.
Topics: Adenocarcinoma; Adolescent; Air; Anastomosis, Surgical; Antineoplastic Combined Chemotherapy Protoco | 2007 |
Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Dihydropteroate Synthase; Fluorouracil; Folic Aci | 2008 |