fluorouracil has been researched along with Crohn Disease in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 47-year-old man who was diagnosed as Crohn's disease at the age of 27 became aware of a mass on the forehead." | 2.45 | [Modified FOLFOX6 was effective for advanced adenocarcinoma with unknown origin in a patient with Crohn's disease]. ( Hayashi, N; Hayashi, Y; Hiramatsu, N; Iijima, H; Ito, H; Kondo, J; Nishida, T; Takehara, T; Tsuji, S; Tsujii, M; Tsutsui, S; Yamamoto, K, 2009) |
| "Eighteen cases of stage IV CAC (7 ulcerative colitis, 11 Crohn disease) and 18 CRC were identified." | 1.56 | Systemic Chemotherapy for Metastatic Colitis-Associated Cancer Has a Worse Outcome Than Sporadic Colorectal Cancer: Matched Case Cohort Analysis. ( Bates, DDB; Capanu, M; Chatila, W; Chou, J; Hersch, J; Kelsen, D; Paroder, V; Schultz, N; Tang, L; Yaeger, R, 2020) |
| "Rectovaginal fistula in long-standing Crohn's disease is possibly associated with malignant transformation to mucinous adenocarcinoma of the vagina." | 1.35 | Vulvar mucinous adenocarcinoma associated with Crohn's disease: report of two cases. ( Chi, DS; Eno, ML; Im, DD; Matsuo, K; Rosenshein, NB, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Yaeger, R | 1 |
| Paroder, V | 1 |
| Bates, DDB | 1 |
| Capanu, M | 1 |
| Chou, J | 1 |
| Tang, L | 1 |
| Chatila, W | 1 |
| Schultz, N | 1 |
| Hersch, J | 1 |
| Kelsen, D | 1 |
| Hashash, JG | 1 |
| Proksell, S | 1 |
| Regueiro, MD | 1 |
| Hayashi, Y | 1 |
| Nishida, T | 1 |
| Kondo, J | 1 |
| Yamamoto, K | 1 |
| Iijima, H | 1 |
| Tsutsui, S | 1 |
| Hiramatsu, N | 1 |
| Tsujii, M | 1 |
| Tsuji, S | 1 |
| Ito, H | 1 |
| Takehara, T | 1 |
| Hayashi, N | 1 |
| Yri, OE | 1 |
| Vig, J | 1 |
| Hegstad, E | 1 |
| Hovde, O | 1 |
| Pignon, I | 1 |
| Jynge, P | 1 |
| Matsuo, K | 1 |
| Chi, DS | 1 |
| Eno, ML | 1 |
| Im, DD | 1 |
| Rosenshein, NB | 1 |
| Welch, CE | 1 |
| Saeed, W | 1 |
| Kim, S | 1 |
| Burch, BH | 1 |
| Gear, EV | 1 |
3 reviews available for fluorouracil and Crohn Disease
| Article | Year |
|---|---|
[Modified FOLFOX6 was effective for advanced adenocarcinoma with unknown origin in a patient with Crohn's disease].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Crohn Disease; Fluorouracil; Humans; | 2009 |
Abdominal surgery (second of three parts).
Topics: Abdomen; Acute Disease; Anus Diseases; Appendectomy; Appendicitis; Appendix; Carcinoembryonic Antige | 1975 |
Dobbins WO 3d,+DOBBINS WO III: Rectal biopsy. A review of its diagnostic usefulness.
Topics: Amyloidosis; Biopsy; Colitis, Ulcerative; Crohn Disease; Cystic Fibrosis; Cysts; Deficiency Diseases | 1968 |
5 other studies available for fluorouracil and Crohn Disease
| Article | Year |
|---|---|
Systemic Chemotherapy for Metastatic Colitis-Associated Cancer Has a Worse Outcome Than Sporadic Colorectal Cancer: Matched Case Cohort Analysis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Case-C | 2020 |
Crohn's disease with worsening symptoms.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Colectomy; Colorectal Neoplasms; Combined Mo | 2013 |
Mangafodipir as a cytoprotective adjunct to chemotherapy--a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cholangitis, Sclerosing; Col | 2009 |
Vulvar mucinous adenocarcinoma associated with Crohn's disease: report of two cases.
Topics: Adenocarcinoma, Mucinous; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineop | 2009 |
Development of carcinoma in regional enteritis.
Topics: Adenocarcinoma, Mucinous; Barium Sulfate; Cecum; Colon; Colonic Diseases; Crohn Disease; Enema; Fluo | 1974 |