fluorouracil has been researched along with Coronavirus Infections in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Coronavirus Infections: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The author here is proposing to test 5-FU in combination with a number of deoxynucleosides on animal models infected with this Covid-19." | 1.56 | 5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection. ( Ahmad, SI, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, Z | 1 |
| Zhao, Y | 1 |
| Sun, Y | 1 |
| Zhang, B | 1 |
| Wang, H | 1 |
| Wu, Y | 1 |
| Zhu, Y | 1 |
| Zhu, C | 1 |
| Hu, T | 1 |
| Du, X | 1 |
| Duan, Y | 1 |
| Yu, J | 1 |
| Yang, X | 2 |
| Yang, K | 1 |
| Liu, X | 1 |
| Guddat, LW | 1 |
| Xiao, G | 1 |
| Zhang, L | 1 |
| Yang, H | 1 |
| Rao, Z | 1 |
| Ahmad, SI | 1 |
| Vidra, R | 1 |
| Bodea, R | 1 |
| Mercea, V | 1 |
| Nemes, A | 1 |
| Parker, GA | 1 |
4 other studies available for fluorouracil and Coronavirus Infections
| Article | Year |
|---|---|
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Topics: Animals; Betacoronavirus; Chlorocebus aethiops; Coronavirus 3C Proteases; Coronavirus Infections; CO | 2020 |
5-Fluorouracil in combination with deoxyribonucleosides and deoxyribose as possible therapeutic options for the Coronavirus, COVID-19 infection.
Topics: Adenosine Monophosphate; Alanine; Betacoronavirus; Chloroquine; Clinical Trials as Topic; Coronaviru | 2020 |
Challenges of pancreatic cancer chemotherapy in the COVID-19 era.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Betacoronavirus; Capeci | 2020 |
Re: Article by Ewens et al. entitled, "Fluorouracil plus leucovorin induces submandibular salivary gland enlargement in rats".
Topics: Animals; Antidotes; Antimetabolites; Coronavirus Infections; Fluorouracil; Leucovorin; Rats; Salivar | 2005 |