fluorouracil has been researched along with Coronary Thrombosis in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion." | 5.38 | Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible. ( Celiker, E; Eren, M; Güvenç, TS; Ilhan, E; Ozcan, KS, 2012) |
| "5-fluorouracil (5FU) is a largely employed antimetabolite, responsible for several well-known toxicities like hand-foot syndrome, diarrhoea, mucositis or leucopenia." | 2.42 | [Cardiotoxicity of 5-fluorouracil]. ( Barry, S; Cohen, A; Debourdeau, P; Teixeira, L; Tournigand, C, 2004) |
| "Oral capecitabine is a prodrug of 5-fluorouracil that has been used into the management of multiple cancers because of the convenience of administration and efficacy at least comparable with 5-fluorouracil." | 1.40 | Acute coronary artery thrombosis and vasospasm following capecitabine in conjunction with oxaliplatin treatment for cancer. ( Cleator, S; Dzaye, O; Nihoyannopoulos, P, 2014) |
| "Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion." | 1.38 | Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible. ( Celiker, E; Eren, M; Güvenç, TS; Ilhan, E; Ozcan, KS, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dzaye, O | 1 |
| Cleator, S | 1 |
| Nihoyannopoulos, P | 1 |
| Güvenç, TS | 1 |
| Celiker, E | 1 |
| Ozcan, KS | 1 |
| Ilhan, E | 1 |
| Eren, M | 1 |
| Teixeira, L | 1 |
| Barry, S | 1 |
| Debourdeau, P | 1 |
| Cohen, A | 1 |
| Tournigand, C | 1 |
| Roncalli, J | 1 |
| Delord, JP | 1 |
| Galinier, M | 1 |
| Massabuau, P | 1 |
| Lescure, M | 1 |
| Fauvel, JM | 1 |
| Azria, D | 1 |
1 review available for fluorouracil and Coronary Thrombosis
| Article | Year |
|---|---|
[Cardiotoxicity of 5-fluorouracil].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Coronary Thrombosis; Coronary Vessels; Deoxycytidine; | 2004 |
3 other studies available for fluorouracil and Coronary Thrombosis
| Article | Year |
|---|---|
Acute coronary artery thrombosis and vasospasm following capecitabine in conjunction with oxaliplatin treatment for cancer.
Topics: Adult; Antineoplastic Agents; Capecitabine; Colonic Neoplasms; Coronary Angiography; Coronary Thromb | 2014 |
Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible.
Topics: Capecitabine; Coronary Thrombosis; Coronary Vasospasm; Deoxycytidine; Female; Fluorouracil; Humans; | 2012 |
Bevacizumab in metastatic colorectal cancer: a left intracardiac thrombotic event.
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopl | 2006 |