fluorouracil has been researched along with Coronary Disease in 22 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three cases of cardiotoxicity manifested by chest pain, tachycardia, respiratory distress, and electrocardiographic changes simulating acute myocardial infarction or ischemia were observed during the course of combination chemotherapy with etoposide, cisplatin, and continuous infusion of 5-fluorouracil in patients with advanced non-small cell lung cancer." | 7.68 | Electrocardiographic changes simulating acute myocardial infarction or ischemia associated with combination chemotherapy with etoposide, cisplatin, and 5-fluorouracil. ( Kim, SH; Lee, JS; Lee, KH, 1990) |
| "Coronary artery spasm has been postulated to be involved in the mechanism of this incident Patients may present with angina, myocardial infarction, arrhythmias and/or even sudden death." | 5.31 | A case of coronary spasm induced by 5-fluorouracil. ( Celik, S; Gorgulu, S; Tezel, T, 2002) |
| " She underwent recent chemotherapy with fluorouracil for metastatic colorectal cancer." | 3.75 | 5 flourouracil-induced apical ballooning syndrome: a case report. ( Dentali, F; Gianni, M; Lonn, E, 2009) |
| " Nine patients had symptoms resembling myocardial ischemia, one patient died due to assumed myocardial infarction related closely to fluorouracil treatment, four patients had supraventricular arrhythmia, and one patient had congestive heart failure." | 3.68 | Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer. ( Bokemeyer, C; Harstrick, A; Hiddemann, W; Köhne-Wömpner, CH; Mügge, A; Papageorgiou, E; Poliwoda, H; Schöber, C; Stahl, M; Wilke, H, 1993) |
| "Three cases of cardiotoxicity manifested by chest pain, tachycardia, respiratory distress, and electrocardiographic changes simulating acute myocardial infarction or ischemia were observed during the course of combination chemotherapy with etoposide, cisplatin, and continuous infusion of 5-fluorouracil in patients with advanced non-small cell lung cancer." | 3.68 | Electrocardiographic changes simulating acute myocardial infarction or ischemia associated with combination chemotherapy with etoposide, cisplatin, and 5-fluorouracil. ( Kim, SH; Lee, JS; Lee, KH, 1990) |
| "The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent." | 1.33 | Cardiotoxicity of de Gramont's regimen: incidence, clinical characteristics and long-term follow-up. ( Alakavuklar, MN; Barutca, S; Kundak, I; Meydan, N; Oztop, I; Yavuzsen, T; Yilmaz, U, 2005) |
| "Coronary artery spasm has been postulated to be involved in the mechanism of this incident Patients may present with angina, myocardial infarction, arrhythmias and/or even sudden death." | 1.31 | A case of coronary spasm induced by 5-fluorouracil. ( Celik, S; Gorgulu, S; Tezel, T, 2002) |
| "5-fluorouracil is a drug that is widely used in cancerology." | 1.27 | [Cardiotoxicity of 5-fluorouracil. Characteristics, mechanism, practical management]. ( Alexandre, JB; Escudier, B; Guyot, JM; Leclercq, B; Morin, P; Nitenberg, G, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (50.00) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gianni, M | 1 |
| Dentali, F | 1 |
| Lonn, E | 1 |
| Atar, A | 1 |
| Korkmaz, ME | 1 |
| Ozin, B | 1 |
| Gorgulu, S | 1 |
| Celik, S | 1 |
| Tezel, T | 1 |
| Meydan, N | 1 |
| Kundak, I | 1 |
| Yavuzsen, T | 1 |
| Oztop, I | 1 |
| Barutca, S | 1 |
| Yilmaz, U | 1 |
| Alakavuklar, MN | 1 |
| Wijesinghe, N | 1 |
| Thompson, PI | 1 |
| McAlister, H | 1 |
| Tsibiribi, P | 1 |
| Bui-Xuan, C | 1 |
| Bui-Xuan, B | 1 |
| Lombard-Bohas, C | 1 |
| Duperret, S | 1 |
| Belkhiria, M | 1 |
| Tabib, A | 1 |
| Maujean, G | 1 |
| Descotes, J | 1 |
| Timour, Q | 1 |
| Pinelli, G | 1 |
| Lusa, AM | 1 |
| Salvarani, R | 1 |
| Di Pasquale, G | 1 |
| Roncuzzi, R | 1 |
| Coluccini, M | 1 |
| Sacks, H | 1 |
| Chalmers, TC | 1 |
| Smith, H | 1 |
| Manente, P | 1 |
| Buchberger, R | 1 |
| Valmachino, G | 1 |
| Fioretti, D | 1 |
| Lo Giudice, C | 1 |
| Gasparoni, P | 1 |
| Conte, N | 1 |
| Schöber, C | 1 |
| Papageorgiou, E | 1 |
| Harstrick, A | 1 |
| Bokemeyer, C | 1 |
| Mügge, A | 1 |
| Stahl, M | 1 |
| Wilke, H | 1 |
| Poliwoda, H | 1 |
| Hiddemann, W | 1 |
| Köhne-Wömpner, CH | 1 |
| Prunier, F | 1 |
| Monségu, J | 1 |
| Coutant, G | 1 |
| Ollivier, JP | 1 |
| Pottage, A | 1 |
| Holt, S | 1 |
| Ludgate, S | 1 |
| Langlands, AO | 1 |
| Kaye, SB | 1 |
| Ikram, H | 1 |
| Ferrari, E | 1 |
| Taillan, B | 1 |
| Tibi, T | 1 |
| Darmon, JP | 1 |
| Gibelin, P | 1 |
| Chichmanian, RM | 1 |
| Dujardin, P | 1 |
| Morand, P | 1 |
| Climent, MA | 1 |
| López Pousa, A | 1 |
| de Andrés, L | 1 |
| Carrió, I | 1 |
| Lee, KH | 1 |
| Lee, JS | 1 |
| Kim, SH | 1 |
| Rezkalla, S | 1 |
| Kloner, RA | 2 |
| Ensley, J | 2 |
| al-Sarraf, M | 3 |
| Revels, S | 1 |
| Olivenstein, A | 1 |
| Bhasin, S | 1 |
| Kerpel-Fronious, S | 1 |
| Turi, ZG | 1 |
| Ensley, JF | 1 |
| Patel, B | 2 |
| Kloner, R | 1 |
| Kish, JA | 1 |
| Wynne, J | 2 |
| Escudier, B | 2 |
| Alexandre, JB | 1 |
| Leclercq, B | 2 |
| Morin, P | 1 |
| Guyot, JM | 1 |
| Nitenberg, G | 2 |
| Monk, MR | 1 |
| Sanchez, JD | 1 |
| Phelps, CD | 1 |
| Miller, DM | 1 |
| Kish, J | 1 |
| Conscience, G | 1 |
| Nkam, M | 1 |
| Rougier, P | 1 |
22 other studies available for fluorouracil and Coronary Disease
| Article | Year |
|---|---|
5 flourouracil-induced apical ballooning syndrome: a case report.
Topics: Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Coronary Disease; Female; Fluorouracil; | 2009 |
Two cases of coronary vasospasm induced by 5-fluorouracil.
Topics: Adenocarcinoma; Administration, Oral; Adult; Antimetabolites, Antineoplastic; Cecal Neoplasms; Coron | 2010 |
A case of coronary spasm induced by 5-fluorouracil.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Chest Pain; Colonic Neoplasms; Coronary Angiography; | 2002 |
Cardiotoxicity of de Gramont's regimen: incidence, clinical characteristics and long-term follow-up.
Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Atrial Fibri | 2005 |
Acute coronary syndrome induced by capecitabine therapy.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; Coronary Angiography; Coronary Dis | 2006 |
Cardiac lesions induced by 5-fluorouracil in the rabbit.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cardiomyopathies; Coronary Disease; Electrocard | 2006 |
[Does 5-fluorouracil cardiotoxicity exist? Presentation of 2 cases with acute manifestations and clinico-instrumental study of 12 cases in chronic treatment with 5-fluorouracil].
Topics: Adult; Aged; Coronary Disease; Electrocardiography; Female; Fluorouracil; Heart Diseases; Humans; Ma | 1984 |
Randomized versus historical controls for clinical trials.
Topics: Abortion, Habitual; Anticoagulants; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Corona | 1982 |
[Cardiotoxicity induced by 5-fluorouracil. A case report].
Topics: Adult; Coronary Disease; Fluorouracil; Humans; Intestinal Neoplasms | 1980 |
Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Coronary Disease; | 1993 |
[Emergency coronary angioplasty following treatment with 5-fluorouracil].
Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Antimetabolites, Antineoplastic; Coronary Di | 2000 |
Fluorouracil cardiotoxicity.
Topics: Adult; Aged; Coronary Disease; Electrocardiography; Female; Fluorouracil; Humans; Male; Middle Aged; | 1978 |
Acute cardiac pain and electrocardiographic changes following cytotoxic treatment for metastatic carcinoma.
Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Breast Neoplasms; Coronary Disease; Cyclophosphamide; | 1976 |
[Cardiac toxicity of fluoro-uracil. Typical and atypical aspects. Apropos of 8 cases].
Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiomyopathies; Coronary Disease; Fluorouracil; Heart Diseases; | 1992 |
[Toxicity from 5-fluorouracil].
Topics: Coronary Disease; Fluorouracil; Humans; Male; Middle Aged | 1991 |
Electrocardiographic changes simulating acute myocardial infarction or ischemia associated with combination chemotherapy with etoposide, cisplatin, and 5-fluorouracil.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Coronary Disease; Diagnosis, | 1990 |
Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study.
Topics: Adult; Aged; Cardiac Complexes, Premature; Cohort Studies; Coronary Disease; Electrocardiography; Fe | 1989 |
The clinical syndrome of 5-fluorouracil cardiotoxicity.
Topics: Adult; Aged; Coronary Disease; Death, Sudden; Electrocardiography; Female; Fluorouracil; Heart Disea | 1989 |
[Cardiotoxicity of 5-fluorouracil. Characteristics, mechanism, practical management].
Topics: Coronary Disease; Coronary Vasospasm; Female; Fluorouracil; Heart Diseases; Humans; Male; Middle Age | 1986 |
Myocardial ischemia with fluorouracil and floxuridine therapy.
Topics: Adenocarcinoma; Aged; Colonic Neoplasms; Coronary Disease; Electrocardiography; Floxuridine; Fluorou | 1987 |
5-Fluorouracil cardiotoxicity: left ventricular dysfunction and effect of coronary vasodilators.
Topics: Aged; Coronary Disease; Echocardiography; Electrocardiography; Female; Fluorouracil; Heart; Heart Ve | 1987 |
[Cardiotoxicity of 5-fluorouracil. Apropos of a new case].
Topics: Coronary Disease; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged | 1985 |