Page last updated: 2024-10-27

fluorouracil and Coronary Artery Vasospasm

fluorouracil has been researched along with Coronary Artery Vasospasm in 67 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Coronary vasospasm is a known side effect of 5-FU (fluorouracil) therapy."8.12The efficacy and safety of cardio-protective therapy in patients with 5-FU (Fluorouracil)-associated coronary vasospasm. ( Blaszkowsky, LS; Clark, JR; Clark, JW; Drobni, ZD; Gilman, HK; Gongora, CA; Hartmann, S; Jones-O'Connor, M; Lei, M; Lou, UY; Mahmood, A; Mosarla, R; Murphy, SP; Neilan, TG; Nipp, R; Quinaglia, T; Tavares, E; Weekes, CD; Zafar, A, 2022)
"5-Fluorouracil (5-FU), a known cardiotoxin, is the backbone for the treatment of colorectal cancer."8.12Managing life-threatening 5-fluorouracil cardiotoxicity. ( Boldig, K; Ganguly, A; Kadakia, M; Rohatgi, A, 2022)
"Coronary vasospasm associated with fluoropyrimidine (FP)-based chemotherapy is a potentially serious complication and reported to occur more often with infusional 5-fluorouracil (5-FU) or capecitabine than with bolus 5-FU."7.91Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5-FU or Capecitabine. ( Chakrabarti, S; Eiring, R; Finnes, H; Grothey, A; Halfdanarson, T; Hartgers, M; Lobo, R; Mitchell, J; Okano, A; Sara, J, 2019)
"Five patients with primary colorectal adenocarcinoma or anal squamous cell carcinoma were started on a 2-weeks-on, 1-week-off capecitabine dosing regimen in addition to other chemotherapeutic agents and/or radiation."7.78Capecitabine-induced chest pain relieved by diltiazem. ( Ambrosy, AP; Fisher, GA; Kunz, PL; Witteles, RM, 2012)
"A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed."7.715-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report. ( Campbell, NP; McGlinchey, PG; Webb, ST, 2001)
"Capecitabine has been shown to be much less cardiotoxic compared to 5-FU, with only a handful of cases reporting cardiotoxicity with capecitabine."5.43Capecitabine-induced coronary artery vasospasm in a patient who previously experienced a similar episode with fluorouracil therapy. ( Aladağ, E; Karakulak, UN; Maharjan, N; Övünç, K, 2016)
"Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion."5.38Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible. ( Celiker, E; Eren, M; Güvenç, TS; Ilhan, E; Ozcan, KS, 2012)
"Capecitabine is a member of the fluoropyrimidine family of chemotherapeutic agents that selectively delivers 5-fluorouracil (5-FU) to tumors."5.38Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm. ( Rather, A; Shah, A; Shah, NR, 2012)
"Capecitabine is a chemotherapeutic prodrug that is metabolised to 5-fluorouracil."5.35Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. ( Curzen, NP; Ferchow, L; Hobson, A; Scott, PA, 2008)
"Capecitabine (Xeloda) is an oral 5-fluorouracil pro-drug used in the treatment of two of the commonest cancers: breast and colorectal."5.35Capecitabine-associated coronary vasospasm: a case report. ( Papadopoulos, CA; Wilson, H, 2008)
"Coronary vasospasm is a known side effect of 5-FU (fluorouracil) therapy."4.12The efficacy and safety of cardio-protective therapy in patients with 5-FU (Fluorouracil)-associated coronary vasospasm. ( Blaszkowsky, LS; Clark, JR; Clark, JW; Drobni, ZD; Gilman, HK; Gongora, CA; Hartmann, S; Jones-O'Connor, M; Lei, M; Lou, UY; Mahmood, A; Mosarla, R; Murphy, SP; Neilan, TG; Nipp, R; Quinaglia, T; Tavares, E; Weekes, CD; Zafar, A, 2022)
"5-Fluorouracil (5-FU), a known cardiotoxin, is the backbone for the treatment of colorectal cancer."4.12Managing life-threatening 5-fluorouracil cardiotoxicity. ( Boldig, K; Ganguly, A; Kadakia, M; Rohatgi, A, 2022)
"Coronary vasospasm associated with fluoropyrimidine (FP)-based chemotherapy is a potentially serious complication and reported to occur more often with infusional 5-fluorouracil (5-FU) or capecitabine than with bolus 5-FU."3.91Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5-FU or Capecitabine. ( Chakrabarti, S; Eiring, R; Finnes, H; Grothey, A; Halfdanarson, T; Hartgers, M; Lobo, R; Mitchell, J; Okano, A; Sara, J, 2019)
"Five patients with primary colorectal adenocarcinoma or anal squamous cell carcinoma were started on a 2-weeks-on, 1-week-off capecitabine dosing regimen in addition to other chemotherapeutic agents and/or radiation."3.78Capecitabine-induced chest pain relieved by diltiazem. ( Ambrosy, AP; Fisher, GA; Kunz, PL; Witteles, RM, 2012)
"Capesitabine is a orally administered cytotoxic drug metabolized to 5-fluorouracil and is widely used in large intestine cancer and breast cancer therapy."3.75[Coronary artery disease attack caused by cytotoxic chemotherapy]. ( Eskola, M; Ilveskoski, E; Nikus, K; Tanner, M, 2009)
"Among the various pathophysiologic mechanisms proposed to explain the 5-fluorouracil cardiotoxicity, coronary vasospasm, occurring most frequently after the completion of the second or third dose of the cycle, has gained wide acceptance."3.72Acute severe coronary spasm associated with initial first dose of 5-fluorouracil chemotherapy. ( Giaccon, G; Mariani, G; Mastore, M, 2003)
"A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed."3.715-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report. ( Campbell, NP; McGlinchey, PG; Webb, ST, 2001)
" Experimental studies revealed potential mechanisms of cardiotoxicity ranging from direct toxic effects on vascular endothelium involving endothelial NO synthase leading to coronary spasms and endothelium independent vasoconstriction via protein kinase C."2.43Cardiotoxicity of 5-fluorouracil. ( Alter, P; Herzum, M; Maisch, B; Schaefer, JR; Soufi, M, 2006)
" It has been shown experimentally that 5-FU has a direct toxic effect on the myocardium."2.38[Cardiotoxicity of 5-fluorouracil: coronary spasm? Apropos of 2 cases with normal coronarography]. ( Cristofini, P; Desnos, M; Funck, F; Guenot, O; Guerot, C; Hagege, A; Trotoux, J, 1989)
"Capecitabine has been shown to be much less cardiotoxic compared to 5-FU, with only a handful of cases reporting cardiotoxicity with capecitabine."1.43Capecitabine-induced coronary artery vasospasm in a patient who previously experienced a similar episode with fluorouracil therapy. ( Aladağ, E; Karakulak, UN; Maharjan, N; Övünç, K, 2016)
"Oral capecitabine is a prodrug of 5-fluorouracil that has been used into the management of multiple cancers because of the convenience of administration and efficacy at least comparable with 5-fluorouracil."1.40Acute coronary artery thrombosis and vasospasm following capecitabine in conjunction with oxaliplatin treatment for cancer. ( Cleator, S; Dzaye, O; Nihoyannopoulos, P, 2014)
"Capecitabine is a member of the fluoropyrimidine family of chemotherapeutic agents that selectively delivers 5-fluorouracil (5-FU) to tumors."1.38Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm. ( Rather, A; Shah, A; Shah, NR, 2012)
"Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion."1.38Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible. ( Celiker, E; Eren, M; Güvenç, TS; Ilhan, E; Ozcan, KS, 2012)
"The case of an 83-year-old man with colon cancer who developed chest pain during 5-FU infusion is presented."1.38A case of severe coronary spasm associated with 5-fluorouracil chemotherapy. ( Cho, WH; Choi, SK; Kim, SB; Kim, SM; Kwak, CH; Lee, B; Sir, JJ, 2012)
" We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided."1.36Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina. ( Pavlakis, N; Stewart, T; Ward, M, 2010)
" The most (even if not fully) effective strategy was reducing capecitabine dosage together with nitrates, calcium-channel blockers and trimetazidine therapy."1.36Capecitabine cardiac toxicity presenting as effort angina: a case report. ( Crivellari, D; Lestuzzi, C; Meneguzzo, N; Rigo, F; Viel, E, 2010)
"Capecitabine is a chemotherapeutic prodrug that is metabolised to 5-fluorouracil."1.35Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. ( Curzen, NP; Ferchow, L; Hobson, A; Scott, PA, 2008)
"Capecitabine (Xeloda) is an oral 5-fluorouracil pro-drug used in the treatment of two of the commonest cancers: breast and colorectal."1.35Capecitabine-associated coronary vasospasm: a case report. ( Papadopoulos, CA; Wilson, H, 2008)
"Capecitabine is an oral fluoropyrimidine that mimics the pharmaconkinetics of infusional 5-FU."1.34A case of capecitabine-induced coronary microspasm in a patient with rectal cancer. ( Arbea, L; Coma-Canella, I; García-Foncillas, J; Martinez-Monge, R, 2007)
"Capecitabine is a new chemotherapeutic agent considered highly specific for sensitive tumour cells, which convert the drug to 5-fluorouracil."1.33Coronary artery spasm induced by capecitabine. ( Barone, C; Cassano, A; Crea, F; Lanza, GA; Pozzo, C; Sestito, A; Sgueglia, GA, 2006)
"Coronary artery vasospasms have been postulated to be involved in the pathogenesis of this rare but serious problem."1.30Endothelin-1 and 5-fluorouracil-induced cardiotoxicity. ( Ferrari, S; Moroni, M; Nastasi, G; Porta, C, 1998)
"5-Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems."1.29Clinical cardiotoxicity of 5-fluorouracil. ( Keefe, DL; Pierri, MK; Roistacher, N, 1993)
"5-fluorouracil is a drug that is widely used in cancerology."1.27[Cardiotoxicity of 5-fluorouracil. Characteristics, mechanism, practical management]. ( Alexandre, JB; Escudier, B; Guyot, JM; Leclercq, B; Morin, P; Nitenberg, G, 1986)

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-199011 (16.42)18.7374
1990's7 (10.45)18.2507
2000's27 (40.30)29.6817
2010's20 (29.85)24.3611
2020's2 (2.99)2.80

Authors

AuthorsStudies
Zafar, A1
Drobni, ZD1
Lei, M1
Gongora, CA1
Quinaglia, T1
Lou, UY1
Mosarla, R1
Murphy, SP1
Jones-O'Connor, M1
Mahmood, A1
Hartmann, S1
Gilman, HK1
Weekes, CD1
Nipp, R1
Clark, JR2
Clark, JW1
Blaszkowsky, LS1
Tavares, E1
Neilan, TG1
Boldig, K1
Ganguly, A1
Kadakia, M1
Rohatgi, A1
Kounis, NG2
Koniari, I1
Patsouras, N1
Koutsogiannis, N1
Velissaris, D1
Soufras, G1
Hahalis, G1
Mukhopadhyay, A1
Faridi, KF1
Asnani, A1
Osborn, EA1
Yang, JX1
Phillips, CT1
York, M1
Chakrabarti, S1
Sara, J1
Lobo, R1
Eiring, R1
Finnes, H1
Mitchell, J1
Hartgers, M1
Okano, A1
Halfdanarson, T1
Grothey, A1
Fradley, MG1
Barrett, CD1
Francis, SA1
Klag, T1
Cantara, G1
Ong, P1
Kaufmann, M1
Sechtem, U1
Athanasiadis, A1
Dzaye, O1
Cleator, S1
Nihoyannopoulos, P1
Vargo, CA1
Blazer, M1
Reardon, J1
Gulati, M1
Bekaii-Saab, T1
Karakulak, UN1
Aladağ, E1
Maharjan, N1
Övünç, K1
Ben-Yakov, M1
Mattu, A1
Brady, WJ1
Dubbs, SB1
Goldsmith, YB1
Roistacher, N2
Baum, MS1
Scott, PA1
Ferchow, L1
Hobson, A1
Curzen, NP1
Cerny, J1
Hassan, A1
Smith, C1
Piperdi, B1
Dalzell, JR1
Samuel, LM1
Ilveskoski, E1
Nikus, K1
Tanner, M1
Eskola, M1
Bathina, JD1
Yusuf, SW1
Farina, A1
Malafronte, C1
Valsecchi, MA1
Achilli, F1
Lestuzzi, C2
Crivellari, D1
Rigo, F1
Viel, E2
Meneguzzo, N2
Stewart, T1
Pavlakis, N1
Ward, M1
Atar, A1
Korkmaz, ME1
Ozin, B1
Shah, NR1
Shah, A1
Rather, A1
Karabay, CY1
Gecmen, C1
Aung, SM1
Guler, A1
Candan, O1
Batgerel, U1
Kalayci, A1
Kirma, C1
Tsigkas, GG1
Almpanis, G1
Mazarakis, A1
Connolly, S1
Scott, P1
Cochrane, D1
Harte, R1
Ambrosy, AP1
Kunz, PL1
Fisher, GA1
Witteles, RM1
Güvenç, TS1
Celiker, E1
Ozcan, KS1
Ilhan, E1
Eren, M1
Kim, SM1
Kwak, CH1
Lee, B1
Kim, SB1
Sir, JJ1
Cho, WH1
Choi, SK1
Mariani, G1
Giaccon, G1
Mastore, M1
Suresh, V1
Khavandi, A1
Hancock, H1
Ceyhan, C1
Meydan, N1
Barutca, S1
Tekten, T1
Onbasili, AO1
Ozturk, B1
Unal, S1
Bayrak, I1
Karadag, O1
Babaoglu, MO1
Altundag, K1
Elkiran, T1
Yasar, U1
Bozkurt, A1
Pop, C1
Nica, R1
Vlaicu, R1
Vinereanu, D1
Alter, P2
Herzum, M2
Schaefer, JR2
Maisch, B2
Aksoy, S1
Karaca, B1
Dinçer, M1
Yalçin, S1
Duran, S1
Bulur, S1
Sozen, SB1
Bilir, C1
Uyan, C1
Akdemir, R1
Soufi, M1
Sestito, A1
Sgueglia, GA1
Pozzo, C1
Cassano, A1
Barone, C1
Crea, F1
Lanza, GA1
Spencker, S1
Schmittel, A1
Westermann, D1
Marek, A1
Schultheiss, HP1
Witzenbichler, B1
Arbea, L1
Coma-Canella, I1
Martinez-Monge, R1
García-Foncillas, J1
Coughlin, S1
Das, S1
Lee, J1
Cooper, J1
Papadopoulos, CA1
Wilson, H1
Shapira, I1
Miller, HI1
Braun, S1
Laniado, S1
Mizuno, Y1
Hokamura, Y1
Kimura, T1
Kimura, Y1
Kaikita, K1
Yasue, H1
Unverdorben, M1
Birkenhake, S1
Kunkel, B1
Dunst, J1
Keefe, DL1
Pierri, MK1
Porta, C1
Moroni, M1
Ferrari, S1
Nastasi, G1
Martínez Sellés, M1
Pérez Castellano, N1
Bueno Zamora, H1
González Torrecilla, E1
Abeytua Jiménez, M1
Delcán Domínguez, JL1
Heib, C1
Schmidt, HJ1
Heib, T1
Lüer, B1
Stasche, N1
Schnetzler, B1
Popova, N1
Collao Lamb, C1
Sappino, AP1
Picano, E1
Maseri, A1
Lanza, G1
Sucker, C1
Scheffold, N1
McGlinchey, PG1
Webb, ST1
Campbell, NP1
Labianca, R1
Luporini, G1
Luwaert, RJ1
Descamps, O1
Majois, F1
Chaudron, JM1
Beauduin, M1
Perreau, P1
Jaulmes, H1
Bokowy, C1
Demaldent, JE1
Mazoyer, G1
Assouline, D1
Fourchard, V1
Kalb, JC1
Cristofini, P1
Desnos, M1
Guenot, O1
Funck, F1
Hagege, A1
Trotoux, J1
Guerot, C1
Fournier, C1
Benahmed, M1
Blondeau, M1
Spain, M1
McPherson, D1
Escudier, B1
Alexandre, JB1
Leclercq, B1
Morin, P1
Guyot, JM1
Nitenberg, G1
Nakagawa, Y1
Ogawa, N1
Suzuki, H1
Miki, H1
Tominaga, M1
Takahashi, M1
Oleksowicz, L1
Bruckner, HW1
Burger, AJ1
Mannino, S1
Thyss, A1
Falewee, MN1
Leborgne, L1
Viens, P1
Schneider, M1
Demard, F1
Kleiman, NS1
Lehane, DE1
Geyer, CE1
Pratt, CM1
Young, JB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Microvascular Function in Patients Undergoing 5-Fluorouracil Chemotherapy[NCT04042298]106 participants (Anticipated)Observational2019-06-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for fluorouracil and Coronary Artery Vasospasm

ArticleYear
Coronary vasospasm with myocardial stunning in a patient with colon cancer receiving adjuvant chemotherapy with FOLFOX regimen.
    Clinical colorectal cancer, 2009, Volume: 8, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Coronary

2009
The spectrum of 5-fluorouracil cardiotoxicity.
    Anti-cancer drugs, 2009, Volume: 20, Issue:1

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arr

2009
Kounis syndrome is likely culprit of coronary vasospasm induced by capecitabine.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2012, Volume: 18, Issue:2

    Topics: Antimetabolites, Antineoplastic; Coronary Vasospasm; Deoxycytidine; Fluorouracil; Humans; Male; Vent

2012
Cardiotoxicity of 5-fluorouracil.
    Cardiovascular & hematological agents in medicinal chemistry, 2006, Volume: 4, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Coronary Vasospasm; Endothelium, Vascular; Fluorouracil; H

2006
[Cardiac toxicity of 5-fluorouracil. Reflections on a case].
    Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1990, Volume: 107, Issue:8

    Topics: Coronary Vasospasm; Fluorouracil; France; Humans; Male; Middle Aged

1990
[Cardiotoxicity of 5-fluorouracil: coronary spasm? Apropos of 2 cases with normal coronarography].
    Annales de medecine interne, 1989, Volume: 140, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart

1989

Other Studies

61 other studies available for fluorouracil and Coronary Artery Vasospasm

ArticleYear
The efficacy and safety of cardio-protective therapy in patients with 5-FU (Fluorouracil)-associated coronary vasospasm.
    PloS one, 2022, Volume: 17, Issue:4

    Topics: Calcium Channel Blockers; Coronary Vasospasm; Fluorouracil; Humans; Neoplasms; Nitrates; Retrospecti

2022
Managing life-threatening 5-fluorouracil cardiotoxicity.
    BMJ case reports, 2022, Oct-17, Volume: 15, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Calcium Channel Blockers; Camptothecin; Cardiotoxici

2022
Coronary vasospasm associated with 5-fluorouracil chemotherapy: Cardiac toxicity or cardiac hypersensitivity?
    The American journal of emergency medicine, 2017, Volume: 35, Issue:11

    Topics: Acute Coronary Syndrome; Cardiotoxicity; Coronary Vasospasm; Drug Hypersensitivity; Fluorouracil; Hu

2017
Chest Pain During Chemotherapy: A Case of Severe Myocardial Bridging.
    The Journal of invasive cardiology, 2018, Volume: 30, Issue:7

    Topics: Antimetabolites, Antineoplastic; Coronary Angiography; Coronary Vasospasm; Drug Substitution; Electr

2018
Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe and Well Tolerated in Patients Who Experienced Coronary Vasospasm With Infusional 5-FU or Capecitabine.
    Clinical colorectal cancer, 2019, Volume: 18, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cardiotox

2019
Ventricular fibrillation cardiac arrest due to 5-fluorouracil cardiotoxicity.
    Texas Heart Institute journal, 2013, Volume: 40, Issue:4

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Coronary Angiography; Coronary Vasospasm; Defibrill

2013
Epicardial coronary artery spasm as cause of capecitabine-induced tako tsubo cardiomyopathy.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2014, Volume: 103, Issue:3

    Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Coronary Angiogr

2014
Acute coronary artery thrombosis and vasospasm following capecitabine in conjunction with oxaliplatin treatment for cancer.
    BMJ case reports, 2014, 09-22, Volume: 2014

    Topics: Adult; Antineoplastic Agents; Capecitabine; Colonic Neoplasms; Coronary Angiography; Coronary Thromb

2014
Successful Completion of Adjuvant Chemotherapy in a Patient With Colon Cancer Experiencing 5-Fluorouracil-Induced Cardiac Vasospasm.
    Clinical colorectal cancer, 2016, Volume: 15, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cardiotoxicit

2016
Capecitabine-induced coronary artery vasospasm in a patient who previously experienced a similar episode with fluorouracil therapy.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2016, Volume: 44, Issue:1

    Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Coronary Vasospasm; Fluorouracil; Humans;

2016
Prinzmetal angina (Coronary vasospasm) associated with 5-fluorouracil chemotherapy.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:7

    Topics: Administration, Sublingual; Antineoplastic Combined Chemotherapy Protocols; Chest Pain; Coronary Ang

2017
Capecitabine-induced coronary vasospasm.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Aug-01, Volume: 26, Issue:22

    Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; C

2008
Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction.
    Emergency medicine journal : EMJ, 2008, Volume: 25, Issue:10

    Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Chest Pain; Colorectal Neoplasms; Coronary Vaso

2008
[Coronary artery disease attack caused by cytotoxic chemotherapy].
    Duodecim; laaketieteellinen aikakauskirja, 2009, Volume: 125, Issue:9

    Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Chest Pain; Coronary Vasospas

2009
5-Fluorouracil-induced coronary vasospasm.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2010, Volume: 11, Issue:4

    Topics: Aged; Antimetabolites, Antineoplastic; Cardiotoxins; Coronary Vasospasm; Female; Fluorouracil; Human

2010
Capecitabine-induced cardiotoxicity: when to suspect? How to manage? A case report.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2009, Volume: 10, Issue:9

    Topics: Angina Pectoris; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvant; Colonic Neop

2009
Capecitabine cardiac toxicity presenting as effort angina: a case report.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2010, Volume: 11, Issue:9

    Topics: Angina Pectoris; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Cardiovascular Age

2010
Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina.
    Internal medicine journal, 2010, Volume: 40, Issue:4

    Topics: Aged; Aged, 80 and over; Angina, Unstable; Capecitabine; Cardiotoxins; Cardiovascular Diseases; Coro

2010
Two cases of coronary vasospasm induced by 5-fluorouracil.
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2010, Volume: 10, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Adult; Antimetabolites, Antineoplastic; Cecal Neoplasms; Coron

2010
Ventricular fibrillation as a likely consequence of capecitabine-induced coronary vasospasm.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2012, Volume: 18, Issue:1

    Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Coronary Vasospasm; Defi

2012
Is 5-fluorouracil-induced vasospasm a Kounis syndrome? A diagnostic challenge.
    Perfusion, 2011, Volume: 26, Issue:6

    Topics: Antimetabolites, Antineoplastic; Carcinoma, Signet Ring Cell; Coronary Vasospasm; Electrocardiograph

2011
A case report of 5-fluorouracil-induced coronary artery vasospasm.
    The Ulster medical journal, 2010, Volume: 79, Issue:3

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Coronary Vasospasm; Coronary Vessels; Fluorou

2010
Capecitabine-induced chest pain relieved by diltiazem.
    The American journal of cardiology, 2012, Dec-01, Volume: 110, Issue:11

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Anus Neoplasms; Calcium Channel Blockers; Cap

2012
Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible.
    Chinese medical journal, 2012, Volume: 125, Issue:18

    Topics: Capecitabine; Coronary Thrombosis; Coronary Vasospasm; Deoxycytidine; Female; Fluorouracil; Humans;

2012
A case of severe coronary spasm associated with 5-fluorouracil chemotherapy.
    The Korean journal of internal medicine, 2012, Volume: 27, Issue:3

    Topics: Aged, 80 and over; Angina Pectoris; Antineoplastic Combined Chemotherapy Protocols; Calcium Channel

2012
Acute severe coronary spasm associated with initial first dose of 5-fluorouracil chemotherapy.
    Italian heart journal : official journal of the Italian Federation of Cardiology, 2003, Volume: 4, Issue:8

    Topics: Acute Disease; Adenocarcinoma; Chemotherapy, Adjuvant; Colonic Neoplasms; Coronary Angiography; Coro

2003
5-flurouracil induced coronary artery vasospasm.
    Heart (British Cardiac Society), 2004, Volume: 90, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Colonic Neoplasms; Coronary Vasospasm; Electrocardiography;

2004
Influence of high-dose leucovorin and 5-fluorouracil chemotherapy regimen on P wave duration and dispersion.
    Journal of clinical pharmacy and therapeutics, 2004, Volume: 29, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Carcinoma; Colorectal Neoplas

2004
5-Fluorouracil-induced coronary spasm: may inhibition of hyperpolarization factors produced by CYP2C enzymes be the cause?
    Oncology, 2004, Volume: 66, Issue:6

    Topics: Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Coronary Vasospasm; Cytochrome P-450

2004
Vasospastic angina caused by 5-fluorouracil. A case report.
    Romanian journal of internal medicine = Revue roumaine de medecine interne, 2003, Volume: 41, Issue:4

    Topics: Adenocarcinoma; Aged; Angina Pectoris; Antimetabolites, Antineoplastic; Colonic Neoplasms; Coronary

2003
Coronary artery spasm induced by 5-fluorouracil.
    Zeitschrift fur Kardiologie, 2005, Volume: 94, Issue:1

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Coronary Angiograph

2005
Common etiology of capecitabine and fluorouracil-induced coronary vasospasm in a colon cancer patient.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:3

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; Coronary Vasospasm

2005
Images in emergency medicine: Acute severe coronary spasm associated with 5-fluorouracil chemotherapy.
    Emergency medicine journal : EMJ, 2006, Volume: 23, Issue:1

    Topics: Acute Disease; Antimetabolites, Antineoplastic; Coronary Vasospasm; Electrocardiography; Emergencies

2006
Coronary artery spasm induced by capecitabine.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2006, Volume: 7, Issue:2

    Topics: Adult; Angina Pectoris; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma,

2006
[Angina pectoris and ST-elevation after chemotherapy with 5-fluorouracil].
    Der Internist, 2007, Volume: 48, Issue:1

    Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Antineoplastic Combined Chemotherapy Protocols; Carc

2007
A case of capecitabine-induced coronary microspasm in a patient with rectal cancer.
    World journal of gastroenterology, 2007, Apr-14, Volume: 13, Issue:14

    Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Coronary Vasospasm; Deoxycytidine; Dihydrouraci

2007
Capecitabine induced vasospastic angina.
    International journal of cardiology, 2008, Oct-30, Volume: 130, Issue:1

    Topics: Angina Pectoris; Antimetabolites, Antineoplastic; Capecitabine; Coronary Vasospasm; Deoxycytidine; F

2008
Capecitabine-associated coronary vasospasm: a case report.
    Emergency medicine journal : EMJ, 2008, Volume: 25, Issue:5

    Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Capecitabine; Coronary Vasospasm; Deoxycytid

2008
[5-fluorouracil cardiotoxicity].
    Harefuah, 1982, Volume: 103, Issue:12

    Topics: Adult; Aged; Coronary Vasospasm; Exercise Test; Female; Fluorouracil; Humans; Male; Middle Aged; Rad

1982
A case of 5-fluorouracil cardiotoxicity simulating acute myocardial infarction.
    Japanese circulation journal, 1995, Volume: 59, Issue:5

    Topics: Aged; Breast Neoplasms; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diagnosis, Differentia

1995
[Extended reversible global left ventricular contraction dysfunction with symptomless coronary system as effect of cytostatic therapy with 5-fluorouracil].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1994, Volume: 170, Issue:8

    Topics: Anus Neoplasms; Combined Modality Therapy; Coronary Angiography; Coronary Vasospasm; Diagnosis, Diff

1994
Clinical cardiotoxicity of 5-fluorouracil.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:11

    Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart Arr

1993
Endothelin-1 and 5-fluorouracil-induced cardiotoxicity.
    Neoplasma, 1998, Volume: 45, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Coronary Vasospasm; Endothelin-1; Female; Fluorouracil; Heart

1998
[Vasospasm following chemotherapy with 5-fluorouracil].
    Anales de medicina interna (Madrid, Spain : 1984), 2001, Volume: 18, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Coronary Vasospasm; Female; Fluorouracil; Humans

2001
[Cardiotoxicity of 5-fluorouracil. Clinical relevance of palliative radiochemotherapy of malignant head-neck tumors].
    Laryngo- rhino- otologie, 2001, Volume: 80, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Coronary Vasospasm; Fluor

2001
Coronary spasm induced by capecitabine.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:5

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C

2001
Coronary vasospasm as a cause of effort-related myocardial ischemia during low-dose chronic continuous infusion of 5-fluorouracil.
    The American journal of medicine, 2001, Volume: 111, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols;

2001
Fluorouracil-induced coronary artery spasm.
    The American journal of medicine, 2001, Volume: 111, Issue:4

    Topics: Angina Pectoris; Antimetabolites, Antineoplastic; Coronary Vasospasm; Exercise Test; Fluorouracil; H

2001
[Coronary vasospasm during 5-fluorouracil chemotherapy].
    Deutsche medizinische Wochenschrift (1946), 2001, Nov-16, Volume: 126, Issue:46

    Topics: Antimetabolites, Antineoplastic; Coronary Vasospasm; Diagnosis, Differential; Electrocardiography; F

2001
5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.
    BMC cardiovascular disorders, 2001, Volume: 1

    Topics: Aged; Antimetabolites, Antineoplastic; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diagnos

2001
5-fluorouracil cardiotoxicity: the risk of rechallenge.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2, Issue:5

    Topics: Angina Pectoris; Coronary Vasospasm; Fluorouracil; Humans; Myocardial Infarction; Recurrence

1991
Coronary artery spasm induced by 5-fluorouracil.
    European heart journal, 1991, Volume: 12, Issue:3

    Topics: Aged; Coronary Angiography; Coronary Vasospasm; Fluorouracil; Humans; Male

1991
[Cardiotoxicity of 5 fluoro-uracil. Apropos of a case].
    Revue des maladies respiratoires, 1989, Volume: 6, Issue:6

    Topics: Coronary Vasospasm; Electrocardiography; Fluorouracil; Humans; Male; Middle Aged

1989
[Cardiac toxicity of 5-fluorouracil].
    Annales de cardiologie et d'angeiologie, 1989, Volume: 38, Issue:2

    Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Fluorouracil; Humans; Laryngeal Neoplasms; Male; Voc

1989
5-Fluorouracil-induced angina.
    The Journal of the Oklahoma State Medical Association, 1989, Volume: 82, Issue:8

    Topics: Aged; Angina Pectoris; Coronary Vasospasm; Female; Fluorouracil; Humans; Liver Neoplasms; Platelet A

1989
[Cardiotoxicity of 5-fluorouracil. Characteristics, mechanism, practical management].
    Presse medicale (Paris, France : 1983), 1986, Oct-18, Volume: 15, Issue:36

    Topics: Coronary Disease; Coronary Vasospasm; Female; Fluorouracil; Heart Diseases; Humans; Male; Middle Age

1986
[A case of variant angina induced by 5-fluorouracil and Tegafur].
    Kokyu to junkan. Respiration & circulation, 1988, Volume: 36, Issue:11

    Topics: Adenocarcinoma; Angina Pectoris, Variant; Coronary Vasospasm; Electrocardiography; Fluorouracil; Hum

1988
Prophylaxis of 5-fluorouracil-induced coronary vasospasm with calcium channel blockers.
    The American journal of medicine, 1988, Volume: 85, Issue:5

    Topics: Aged; Angina Pectoris; Coronary Vasospasm; Female; Fluorouracil; Humans; Nifedipine

1988
5-Fluorouracil-induced coronary vasospasm.
    American heart journal, 1987, Volume: 114, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Coronary Vasospas

1987
[Cardiotoxicity of 5-fluorouracil. Spasm or direct myocardial toxicity?].
    Bulletin du cancer, 1987, Volume: 74, Issue:4

    Topics: Aged; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart; Humans; Male; Middle Age

1987
Prinzmetal's angina during 5-fluorouracil chemotherapy.
    The American journal of medicine, 1987, Volume: 82, Issue:3

    Topics: Angina Pectoris, Variant; Coronary Vasospasm; Electrocardiography; Fluorouracil; Humans; Injections,

1987