fluorouracil has been researched along with Corneal Neovascularization in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Corneal Neovascularization: New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that there is greater risk of toxic anterior segment effects when mitomycin C is used as adjunctive therapy following filtration or pterygium surgery." | 1.29 | Ocular toxicity of mitomycin C and 5-fluorouracil in the rabbit. ( Feldman, F; Heathcote, JG; Ikeda-Douglas, JV; Morrow, GL; Stein, RM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrow, GL | 1 |
| Stein, RM | 1 |
| Heathcote, JG | 1 |
| Ikeda-Douglas, JV | 1 |
| Feldman, F | 1 |
1 other study available for fluorouracil and Corneal Neovascularization
| Article | Year |
|---|---|
Ocular toxicity of mitomycin C and 5-fluorouracil in the rabbit.
Topics: Animals; Corneal Edema; Corneal Neovascularization; Eye; Eyelids; Fluorouracil; Mitomycin; Necrosis; | 1994 |