fluorouracil has been researched along with Corneal Edema in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Corneal Edema: An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that there is greater risk of toxic anterior segment effects when mitomycin C is used as adjunctive therapy following filtration or pterygium surgery." | 1.29 | Ocular toxicity of mitomycin C and 5-fluorouracil in the rabbit. ( Feldman, F; Heathcote, JG; Ikeda-Douglas, JV; Morrow, GL; Stein, RM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, GL | 1 |
| Alexander, JL | 1 |
| Saeedi, OJ | 1 |
| Chalfin, S | 1 |
| Memmen, JE | 1 |
| Morrow, GL | 1 |
| Stein, RM | 1 |
| Heathcote, JG | 1 |
| Ikeda-Douglas, JV | 1 |
| Feldman, F | 1 |
| Mazey, BJ | 1 |
| Siegel, MJ | 1 |
| Siegel, LI | 1 |
| Dunn, SP | 1 |
4 other studies available for fluorouracil and Corneal Edema
| Article | Year |
|---|---|
Persistent Corneal Edema Associated With Subconjunctival 5-fluorouracil in an Infant With Primary Congenital Glaucoma.
Topics: Antimetabolites; Conjunctiva; Corneal Edema; Fluorouracil; Humans; Hydrophthalmos; Infant; Injection | 2016 |
Corneal endothelial toxic effect secondary to fluorouracil needle bleb revision.
Topics: Corneal Edema; Endothelium, Corneal; Fluorouracil; Glaucoma, Open-Angle; Humans; Needles; Reoperatio | 1995 |
Ocular toxicity of mitomycin C and 5-fluorouracil in the rabbit.
Topics: Animals; Corneal Edema; Corneal Neovascularization; Eye; Eyelids; Fluorouracil; Mitomycin; Necrosis; | 1994 |
Corneal endothelial toxic effect secondary to fluorouracil needle bleb revision.
Topics: Aged; Corneal Edema; Endothelium, Corneal; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Male; | 1994 |