fluorouracil has been researched along with Conus Medullaris Syndrome in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-five patients with stage D-2 prostate cancer refractory to orchiectomy have been entered in a controlled trial to test whether androgen priming enhances the efficacy of chemotherapy." | 2.66 | Androgen depletion and repletion as a means of potentiating the effect of cytotoxic chemotherapy in advanced prostate cancer. ( Boucher, AE; Drago, J; Gordon, R; Harvey, H; Lipton, A; Manni, A; Rohner, T; Santen, RJ; Simmonds, M; Wettlaufer, J, 1987) |
| "Patients with cancer commonly suffer neurologic disabilities." | 2.37 | Neurologic complications of systemic cancer. ( Patchell, RA; Posner, JB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasliwal, MK | 1 |
| Tan, LA | 1 |
| O'Toole, JE | 1 |
| Manni, A | 1 |
| Santen, RJ | 1 |
| Boucher, AE | 1 |
| Lipton, A | 1 |
| Harvey, H | 1 |
| Simmonds, M | 1 |
| Gordon, R | 1 |
| Rohner, T | 1 |
| Drago, J | 1 |
| Wettlaufer, J | 1 |
| Patchell, RA | 1 |
| Posner, JB | 1 |
1 review available for fluorouracil and Conus Medullaris Syndrome
| Article | Year |
|---|---|
Neurologic complications of systemic cancer.
Topics: Arachnoid; Bacterial Infections; Brain; Brain Neoplasms; Cerebrovascular Disorders; Cisplatin; Disse | 1985 |
1 trial available for fluorouracil and Conus Medullaris Syndrome
| Article | Year |
|---|---|
Androgen depletion and repletion as a means of potentiating the effect of cytotoxic chemotherapy in advanced prostate cancer.
Topics: Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Combined Modality | 1987 |
1 other study available for fluorouracil and Conus Medullaris Syndrome
| Article | Year |
|---|---|
Intradural tumor recurrence after resection of extradural metastasis: a rare but potential complication of intraoperative durotomy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Colorectal Neoplasms; C | 2014 |