fluorouracil has been researched along with Conjunctival Diseases in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Conjunctival Diseases: Diseases involving the CONJUNCTIVA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery." | 7.73 | Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006) |
| "The antimetabolite 5-fluorouracil (5-FU) has been used to inhibit fibroblastic growth to increase the success rate in glaucoma filtration surgery." | 7.67 | Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. ( Hersh, P; Kersten, D; Lee, DA; Melamed, S, 1987) |
| "The objective of this article was to study longitudinal changes in bleb morphology (presence of microcysts and bleb height and vascularity) in subjects enrolled in the Singapore 5-Fluorouracil (5-FU) trabeculectomy study." | 5.27 | Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy. ( Aung, T; Htoon, HM; Husain, R; Kumaran, A, 2018) |
| "To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery." | 3.73 | Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006) |
| "The antimetabolite 5-fluorouracil (5-FU) has been used to inhibit fibroblastic growth to increase the success rate in glaucoma filtration surgery." | 3.67 | Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. ( Hersh, P; Kersten, D; Lee, DA; Melamed, S, 1987) |
| "Filtering bleb encapsulation may, in some cases, be a severe complication following filtering surgery." | 2.38 | Encapsulated filtering bleb. A selective review--new deductions. ( Ophir, A, 1992) |
| "The area and the height of the bleb in the conjunctivae with radial incision (Ain and Hin, respectively) were compared with the area and the height of the bleb in the conjunctivae without radial incision (Ano and Hno, respectively)." | 1.35 | Restricted post-trabeculectomy bleb formation by conjunctival scarring. ( Inatani, M; Iwao, K; Ogata-Iwao, M; Takihara, Y; Tanihara, H, 2009) |
| "Late bleb leaks may follow months to years after filtering surgery especially with the use of antimetabolites." | 1.31 | [Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps]. ( Ayed, T; Hamard, H; Hamard, P; Quesnot, S; Tazartes, M, 2001) |
| " In addition, toxic effects of 5-FU on existing fibroblasts, in rabbits and in vitro, were demonstrated." | 1.28 | Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy. ( Ophir, A; Ticho, U, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumaran, A | 1 |
| Husain, R | 1 |
| Htoon, HM | 1 |
| Aung, T | 1 |
| Iwao, K | 1 |
| Inatani, M | 1 |
| Ogata-Iwao, M | 1 |
| Takihara, Y | 1 |
| Tanihara, H | 1 |
| McNaught, A | 1 |
| Anand, N | 1 |
| Arora, S | 1 |
| Clowes, M | 1 |
| Slezak, H | 1 |
| Hwang, JM | 1 |
| Chang, BL | 1 |
| Hamard, P | 1 |
| Tazartes, M | 1 |
| Ayed, T | 1 |
| Quesnot, S | 1 |
| Hamard, H | 1 |
| Ophir, A | 2 |
| Ticho, U | 1 |
| Hodge, W | 1 |
| Saheb, N | 1 |
| Balazsi, G | 1 |
| Kasner, O | 1 |
| Franks, WA | 1 |
| Hitchings, RA | 1 |
| de Keizer, RJ | 1 |
| de Wolff-Rouendaal, D | 1 |
| van Delft, JL | 1 |
| Lee, DA | 1 |
| Hersh, P | 1 |
| Kersten, D | 1 |
| Melamed, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489] | Phase 4 | 70 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Conjunctival Diseases
| Article | Year |
|---|---|
Encapsulated filtering bleb. A selective review--new deductions.
Topics: Animals; Blister; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Post | 1992 |
1 trial available for fluorouracil and Conjunctival Diseases
| Article | Year |
|---|---|
Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy.
Topics: Aged; Blister; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; Cysts; Female; Fluorou | 2018 |
11 other studies available for fluorouracil and Conjunctival Diseases
| Article | Year |
|---|---|
Restricted post-trabeculectomy bleb formation by conjunctival scarring.
Topics: Antimetabolites; Blister; Cicatrix; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; C | 2009 |
Loss of vision after phacotrabeculectomy.
Topics: Antimetabolites; Blindness; Chemotherapy, Adjuvant; Conjunctival Diseases; Cysts; Diabetes Complicat | 2005 |
Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks.
Topics: Aged; Blister; Conjunctiva; Conjunctival Diseases; Female; Fluorouracil; Glaucoma; Humans; Intraocul | 2006 |
[Drug-induced eye lesions in the aged].
Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases | 1983 |
Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery.
Topics: Adaptation, Physiological; Animals; Antimetabolites; Cellulose, Oxidized; Chondroitin; Chondroitin S | 1999 |
[Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps].
Topics: Adult; Aged; Antimetabolites; Blister; Combined Modality Therapy; Conjunctival Diseases; Female; Flu | 2001 |
Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy.
Topics: Adult; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Inclusion Bodie | 1992 |
Treatment of encapsulated blebs with 30-gauge needling and injection of low-dose 5-fluorouracil.
Topics: Adult; Aged; Conjunctival Diseases; Cysts; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma, | 1992 |
Complications of 5--fluorouracil after trabeculectomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Conjunctiva; Conjunctival Diseases; Corneal Diseases; Fe | 1991 |
Topical application of 5-fluorouracil in premalignant lesions of cornea, conjunctiva and eyelid.
Topics: Aged; Carcinoma in Situ; Conjunctival Diseases; Corneal Diseases; Drug Administration Schedule; Eyel | 1986 |
Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery.
Topics: Aged; Aged, 80 and over; Conjunctiva; Conjunctival Diseases; Corneal Diseases; Fluorouracil; Glaucom | 1987 |