Page last updated: 2024-10-27

fluorouracil and Conjunctival Diseases

fluorouracil has been researched along with Conjunctival Diseases in 13 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Conjunctival Diseases: Diseases involving the CONJUNCTIVA.

Research Excerpts

ExcerptRelevanceReference
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."7.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"The antimetabolite 5-fluorouracil (5-FU) has been used to inhibit fibroblastic growth to increase the success rate in glaucoma filtration surgery."7.67Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. ( Hersh, P; Kersten, D; Lee, DA; Melamed, S, 1987)
"The objective of this article was to study longitudinal changes in bleb morphology (presence of microcysts and bleb height and vascularity) in subjects enrolled in the Singapore 5-Fluorouracil (5-FU) trabeculectomy study."5.27Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy. ( Aung, T; Htoon, HM; Husain, R; Kumaran, A, 2018)
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."3.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"The antimetabolite 5-fluorouracil (5-FU) has been used to inhibit fibroblastic growth to increase the success rate in glaucoma filtration surgery."3.67Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery. ( Hersh, P; Kersten, D; Lee, DA; Melamed, S, 1987)
"Filtering bleb encapsulation may, in some cases, be a severe complication following filtering surgery."2.38Encapsulated filtering bleb. A selective review--new deductions. ( Ophir, A, 1992)
"The area and the height of the bleb in the conjunctivae with radial incision (Ain and Hin, respectively) were compared with the area and the height of the bleb in the conjunctivae without radial incision (Ano and Hno, respectively)."1.35Restricted post-trabeculectomy bleb formation by conjunctival scarring. ( Inatani, M; Iwao, K; Ogata-Iwao, M; Takihara, Y; Tanihara, H, 2009)
"Late bleb leaks may follow months to years after filtering surgery especially with the use of antimetabolites."1.31[Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps]. ( Ayed, T; Hamard, H; Hamard, P; Quesnot, S; Tazartes, M, 2001)
" In addition, toxic effects of 5-FU on existing fibroblasts, in rabbits and in vitro, were demonstrated."1.28Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy. ( Ophir, A; Ticho, U, 1992)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19903 (23.08)18.7374
1990's5 (38.46)18.2507
2000's4 (30.77)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kumaran, A1
Husain, R1
Htoon, HM1
Aung, T1
Iwao, K1
Inatani, M1
Ogata-Iwao, M1
Takihara, Y1
Tanihara, H1
McNaught, A1
Anand, N1
Arora, S1
Clowes, M1
Slezak, H1
Hwang, JM1
Chang, BL1
Hamard, P1
Tazartes, M1
Ayed, T1
Quesnot, S1
Hamard, H1
Ophir, A2
Ticho, U1
Hodge, W1
Saheb, N1
Balazsi, G1
Kasner, O1
Franks, WA1
Hitchings, RA1
de Keizer, RJ1
de Wolff-Rouendaal, D1
van Delft, JL1
Lee, DA1
Hersh, P1
Kersten, D1
Melamed, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489]Phase 470 participants Interventional2004-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Conjunctival Diseases

ArticleYear
Encapsulated filtering bleb. A selective review--new deductions.
    Eye (London, England), 1992, Volume: 6 ( Pt 4)

    Topics: Animals; Blister; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Post

1992

Trials

1 trial available for fluorouracil and Conjunctival Diseases

ArticleYear
Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy.
    Journal of glaucoma, 2018, Volume: 27, Issue:7

    Topics: Aged; Blister; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; Cysts; Female; Fluorou

2018

Other Studies

11 other studies available for fluorouracil and Conjunctival Diseases

ArticleYear
Restricted post-trabeculectomy bleb formation by conjunctival scarring.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2009, Volume: 247, Issue:8

    Topics: Antimetabolites; Blister; Cicatrix; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; C

2009
Loss of vision after phacotrabeculectomy.
    Journal of glaucoma, 2005, Volume: 14, Issue:4

    Topics: Antimetabolites; Blindness; Chemotherapy, Adjuvant; Conjunctival Diseases; Cysts; Diabetes Complicat

2005
Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks.
    The British journal of ophthalmology, 2006, Volume: 90, Issue:2

    Topics: Aged; Blister; Conjunctiva; Conjunctival Diseases; Female; Fluorouracil; Glaucoma; Humans; Intraocul

2006
[Drug-induced eye lesions in the aged].
    Aktuelle Gerontologie, 1983, Volume: 13, Issue:5

    Topics: Aged; Antipsychotic Agents; Aspirin; Cataract; Conjunctival Diseases; Corneal Diseases; Eye Diseases

1983
Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery.
    The British journal of ophthalmology, 1999, Volume: 83, Issue:7

    Topics: Adaptation, Physiological; Animals; Antimetabolites; Cellulose, Oxidized; Chondroitin; Chondroitin S

1999
[Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps].
    Journal francais d'ophtalmologie, 2001, Volume: 24, Issue:5

    Topics: Adult; Aged; Antimetabolites; Blister; Combined Modality Therapy; Conjunctival Diseases; Female; Flu

2001
Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy.
    Ophthalmic research, 1992, Volume: 24, Issue:5

    Topics: Adult; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Inclusion Bodie

1992
Treatment of encapsulated blebs with 30-gauge needling and injection of low-dose 5-fluorouracil.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1992, Volume: 27, Issue:5

    Topics: Adult; Aged; Conjunctival Diseases; Cysts; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma,

1992
Complications of 5--fluorouracil after trabeculectomy.
    Eye (London, England), 1991, Volume: 5 ( Pt 4)

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Conjunctiva; Conjunctival Diseases; Corneal Diseases; Fe

1991
Topical application of 5-fluorouracil in premalignant lesions of cornea, conjunctiva and eyelid.
    Documenta ophthalmologica. Advances in ophthalmology, 1986, Dec-30, Volume: 64, Issue:1

    Topics: Aged; Carcinoma in Situ; Conjunctival Diseases; Corneal Diseases; Drug Administration Schedule; Eyel

1986
Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery.
    Ophthalmic surgery, 1987, Volume: 18, Issue:3

    Topics: Aged; Aged, 80 and over; Conjunctiva; Conjunctival Diseases; Corneal Diseases; Fluorouracil; Glaucom

1987