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fluorouracil and Complications of Diabetes Mellitus

fluorouracil has been researched along with Complications of Diabetes Mellitus in 14 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"We previously reported a 35% overall response rate (ORR) with biweekly 5-fluorouracil (5-FU) continuous infusion (TTD [Spanish Cooperative Group for Digestive Tumour Therapy] schedule) plus irinotecan as first-line therapy in elderly patients with metastatic colorectal cancer (mCRC)."9.16Oxaliplatin in combination with infusional 5-fluorouracil as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumors. ( Alfaro, J; Aparicio, J; Aranda, E; Benavides, M; Cabrera, E; Campos, JM; Carrato, A; Dueñas, R; Etxeberría, A; Gil-Calle, S; Gómez, A; Gómez, MJ; González-Flores, E; Guasch, I; Marcuello, E; Massutí, B; Pericay, C; Queralt, B; Reina, JJ; Valladares-Ayerbes, M, 2012)
"Treatment with fluconazole was ineffective, but amphotericin B was curative."5.29Candida albicans osteomyelitis of the zygomatic bone. A distinctive case with a possible peculiar mechanism of infection and therapeutic failure with fluconazole. ( Arranz-Caso, JA; García-Altozano, J; Gomez-Herruz, P; Lopez-Pizarro, VM; Martinez-Martinez, J, 1996)
"We previously reported a 35% overall response rate (ORR) with biweekly 5-fluorouracil (5-FU) continuous infusion (TTD [Spanish Cooperative Group for Digestive Tumour Therapy] schedule) plus irinotecan as first-line therapy in elderly patients with metastatic colorectal cancer (mCRC)."5.16Oxaliplatin in combination with infusional 5-fluorouracil as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumors. ( Alfaro, J; Aparicio, J; Aranda, E; Benavides, M; Cabrera, E; Campos, JM; Carrato, A; Dueñas, R; Etxeberría, A; Gil-Calle, S; Gómez, A; Gómez, MJ; González-Flores, E; Guasch, I; Marcuello, E; Massutí, B; Pericay, C; Queralt, B; Reina, JJ; Valladares-Ayerbes, M, 2012)
"Treatment with fluconazole was ineffective, but amphotericin B was curative."1.29Candida albicans osteomyelitis of the zygomatic bone. A distinctive case with a possible peculiar mechanism of infection and therapeutic failure with fluconazole. ( Arranz-Caso, JA; García-Altozano, J; Gomez-Herruz, P; Lopez-Pizarro, VM; Martinez-Martinez, J, 1996)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's4 (28.57)18.2507
2000's3 (21.43)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, L1
Gao, HY1
Baba, M1
Okada, Y1
Okuyama, T1
Wu, LJ1
Zhan, LB1
Russolillo, N1
Ratti, F1
Viganò, L1
Langella, S1
Cipriani, F1
Aldrighetti, L1
Ferrero, A1
Benavides, M1
Pericay, C1
Valladares-Ayerbes, M1
Gil-Calle, S1
Massutí, B1
Aparicio, J1
Dueñas, R1
González-Flores, E1
Carrato, A1
Marcuello, E1
Gómez, A1
Cabrera, E1
Queralt, B1
Gómez, MJ1
Guasch, I1
Etxeberría, A1
Alfaro, J1
Campos, JM1
Reina, JJ1
Aranda, E1
McNaught, A1
Lemperle, G1
Rullan, PP1
Gauthier-Hazan, N1
Vokes, EE1
Ratain, MJ1
Mick, R1
McEvilly, JM1
Haraf, D1
Kozloff, M1
Hamasaki, V1
Weichselbaum, RR1
Panje, WR1
Wenig, B1
Arranz-Caso, JA1
Lopez-Pizarro, VM1
Gomez-Herruz, P1
García-Altozano, J1
Martinez-Martinez, J1
Khalil, A1
Chammas, M1
Shamseddine, A1
Seoud, M1
Sadoff, L1
Lehmann, OJ1
Bunce, C1
Matheson, MM1
Maurino, V1
Khaw, PT1
Wormald, R1
Barton, K1
Chihara, E1
Hayashida, T1
Yamamoto, A1
Torii, H1
Nakamura, A1
Yoshida, S1
Sawada, A1
Pearson, LH1
Smith, JG1
Chalker, DK1
Lokich, JJ1
Skarin, AT1
Hermann, J1
Plenert, W1

Reviews

2 reviews available for fluorouracil and Complications of Diabetes Mellitus

ArticleYear
Avoiding and treating dermal filler complications.
    Plastic and reconstructive surgery, 2006, Volume: 118, Issue:3 Suppl

    Topics: Adipose Tissue; Adrenal Cortex Hormones; Animals; Autoimmune Diseases; Biocompatible Materials; Catt

2006
[Generalized candida mycoses].
    Kinderarztliche Praxis, 1974, Volume: 42, Issue:4

    Topics: Amphotericin B; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Burns; Candida albicans; Candidi

1974

Trials

3 trials available for fluorouracil and Complications of Diabetes Mellitus

ArticleYear
Oxaliplatin in combination with infusional 5-fluorouracil as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumors.
    Clinical colorectal cancer, 2012, Volume: 11, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diabe

2012
Cisplatin, fluorouracil, and leucovorin augmented by interferon alfa-2b in head and neck cancer: a clinical and pharmacologic analysis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diabetes Complic

1993
Combination therapy with 5-fluorouracil (5-FU; NSC-19893) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) for disseminated gastrointestinal carcinoma.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:5

    Topics: Adult; Aged; Anemia, Aplastic; Blood Cell Count; Carcinoma; Clinical Trials as Topic; Colonic Neopla

1972

Other Studies

9 other studies available for fluorouracil and Complications of Diabetes Mellitus

ArticleYear
Extracts and compounds with anti-diabetic complications and anti-cancer activity from Castanea mollissina Blume (Chinese chestnut).
    BMC complementary and alternative medicine, 2014, Oct-28, Volume: 14

    Topics: Aldehyde Reductase; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Diabete

2014
The Influence of Aging on Hepatic Regeneration and Early Outcome after Portal Vein Occlusion: A Case-Control Study.
    Annals of surgical oncology, 2015, Volume: 22, Issue:12

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Antineoplastic Combined Chemotherapy Protocols;

2015
Loss of vision after phacotrabeculectomy.
    Journal of glaucoma, 2005, Volume: 14, Issue:4

    Topics: Antimetabolites; Blindness; Chemotherapy, Adjuvant; Conjunctival Diseases; Cysts; Diabetes Complicat

2005
Candida albicans osteomyelitis of the zygomatic bone. A distinctive case with a possible peculiar mechanism of infection and therapeutic failure with fluconazole.
    Diagnostic microbiology and infectious disease, 1996, Volume: 24, Issue:3

    Topics: Administration, Inhalation; Amphotericin B; Biopsy; Candidiasis; Candidiasis, Oral; Diabetes Complic

1996
Fatal acute tumor lysis syndrome following treatment of vulvar carcinoma: case report.
    European journal of gynaecological oncology, 1998, Volume: 19, Issue:4

    Topics: Aged; Carcinoma, Squamous Cell; Cisplatin; Diabetes Complications; Fatal Outcome; Female; Fluorourac

1998
Overwhelming 5-fluorouracil toxicity in patients whose diabetes is poorly controlled.
    American journal of clinical oncology, 1998, Volume: 21, Issue:6

    Topics: Aged; Antimetabolites, Antineoplastic; Diabetes Complications; Female; Fluorouracil; Humans; Hypergl

1998
Risk factors for development of post-trabeculectomy endophthalmitis.
    The British journal of ophthalmology, 2000, Volume: 84, Issue:12

    Topics: Aged; Antimetabolites; Case-Control Studies; Diabetes Complications; Endophthalmitis; Female; Fluoro

2000
[Treatment of neovascular glaucoma by seton and 5-FU].
    Nippon Ganka Gakkai zasshi, 1987, Volume: 91, Issue:11

    Topics: Combined Modality Therapy; Diabetes Complications; Fluorouracil; Glaucoma; Humans; Male; Methods; Mi

1987
Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review.
    Journal of the American Academy of Dermatology, 1987, Volume: 16, Issue:1 Pt 2

    Topics: Administration, Cutaneous; Diabetes Complications; Fluorouracil; Humans; Keratosis; Male; Middle Age

1987