Page last updated: 2024-10-27

fluorouracil and Common Bile Duct Neoplasms

fluorouracil has been researched along with Common Bile Duct Neoplasms in 49 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.

Research Excerpts

ExcerptRelevanceReference
"From March 2009 through April 2012, 22 patients were treated with proton therapy and concomitant capecitabine (1000 mg PO twice daily) for resected (n = 5); marginally resectable (n = 5); and unresectable/inoperable (n = 12) biopsy-proven pancreatic and ampullary adenocarcinoma."3.79Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity. ( Asbun, HJ; Awad, ZT; George, TJ; Ho, MW; Hoppe, BS; Huh, S; Mendenhall, NP; Morris, CG; Nichols, RC; Zaiden, RA, 2013)
"Three patients with metastatic carcinoma of the ampulla of Vater received celiac artery infusion of 5-fluorouracil, adriamycin, mitomycin-C, and streptozotocin followed by intravenous administration of the same combination."3.67Combination chemotherapy for metastatic carcinoma of the ampulla of Vater--report of three cases. ( Bukowski, RM; Hermann, RE; Theodors, A, 1984)
"Nineteen patients with unresectable and metastatic adenocarcinoma of the pancreas and ampulla of Vater were treated with intermittent regional infusion of the celiac axis (CAI) with the combination of 5-fluorouracil, adriamycin, mitomycin-C, and streptozotocin (FAM-S)."3.66Intermittent regional infusion of chemotherapy for pancreatic adenocarcinoma. Phase I and II pilot study. ( Bukowski, RM; Hewlett, JS; Livingston, RB; Theodors, A; Weick, JK, 1982)
"In patients with pancreatic cancer, CAI/RT had no significant effect on local recurrence (log-rank P = 0."2.73Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. ( Hermans, JJ; Hop, WC; Incrocci, L; Jeekel, J; Kazemier, G; Morak, MJ; van Dekken, H; van der Gaast, A; van Eijck, CH, 2008)
"The role of adjuvant chemoradiation in pancreatic cancer remains unclear."2.73Long-term survival and metastatic pattern of pancreatic and periampullary cancer after adjuvant chemoradiation or observation: long-term results of EORTC trial 40891. ( Debois, M; Erdmann, J; Hop, WC; Jeekel, J; Klinkenbijl, JH; Smeenk, HG; Tran, KC; van Cutsem, E; van Dekken, H; van Eijck, CH, 2007)
"Pancreatic cancer has a dismal prognosis."1.38Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer. ( Dicheva, BM; Eggermont, AM; Hop, WC; Koning, GA; Seynhaeve, AL; Ten Hagen, TL; van Dekken, H; van der Zee, JA; van Eijck, CH, 2012)
"Nine of these 18 patients had bile duct cancer, seven had gallbladder cancer, and two had cancer of the papilla of Vater."1.32[Adjuvant arterial infusion chemotherapy for patients with biliary cancer]. ( Hasuike, Y; Kashiwazaki, M; Takeda, Y; Tsujinaka, T, 2004)
"Preoperative chemoradiation for pancreatic cancer is associated with low rates of hepatic toxicity and biliary stent-related complications."1.31Preoperative chemoradiation for patients with pancreatic cancer: toxicity of endobiliary stents. ( Abbruzzese, JL; Crane, CH; Evans, DB; Hudec, WA; Janjan, NA; Lahoti, S; Lee, JE; Lenzi, R; Pisters, PW; Raijman, I; Rich, TA; Wolff, RA, 2000)
" There were two EBRT dosage groups: Low EBRT, 23."1.30Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels. ( Abrams, RA; Cameron, JL; Chakravarthy, A; Grochow, LB; Haulk, TL; Hruban, RH; Lillemoe, KD; Ord, S; Pitt, HA; Sohn, TA; Yeo, CJ; Zahurak, ML, 1999)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19904 (8.16)18.7374
1990's3 (6.12)18.2507
2000's19 (38.78)29.6817
2010's21 (42.86)24.3611
2020's2 (4.08)2.80

Authors

AuthorsStudies
Kang, J1
Lee, W1
Shin, J1
Park, Y1
Kwon, JW1
Jun, E1
Song, KB1
Lee, JH1
Hwang, DW1
Park, SY1
Kim, SC1
Xu, H1
Chai, CP1
Miao, X1
Tang, H1
Hu, JJ1
Zhang, H1
Zhou, WC1
Jin, Z1
Hartgers, ML1
Sanhueza, CT1
Shubert, CR1
Alberts, SR1
Truty, MJ1
Muppa, P1
Nagorney, DM1
Smyrk, TC1
Hassan, M1
Mahipal, A1
Ecker, BL1
Vollmer, CM1
Behrman, SW1
Allegrini, V1
Aversa, J1
Ball, CG1
Barrows, CE1
Berger, AC2
Cagigas, MN1
Christein, JD1
Dixon, E1
Fisher, WE1
Freedman-Weiss, M1
Guzman-Pruneda, F1
Hollis, RH1
House, MG1
Kent, TS1
Kowalsky, SJ1
Malleo, G1
Salem, RR1
Salvia, R1
Schmidt, CR1
Seykora, TF1
Zheng, R1
Zureikat, AH1
Dickson, PV1
Nichols, RC1
George, TJ1
Zaiden, RA1
Awad, ZT1
Asbun, HJ1
Huh, S1
Ho, MW1
Mendenhall, NP1
Morris, CG1
Hoppe, BS1
Kim, HS1
Shin, SJ1
Kim, JH1
Kim, H1
Choi, HJ1
Gurzu, S1
Jung, I1
Comsulea, M1
Kadar, Z1
Azamfirei, L1
Molnar, C1
Shoji, H1
Morizane, C1
Hiraoka, N1
Kondo, S1
Ueno, H1
Ohno, I1
Shimizu, S1
Mitsunaga, S1
Ikeda, M1
Okusaka, T1
Kim, K4
Chie, EK4
Jang, JY5
Kim, SW4
Han, SW2
Oh, DY4
Im, SA4
Kim, TY4
Bang, YJ4
Ha, SW4
Senatore, FJ1
Ynson, ML1
Dasanu, CA1
Colussi, O1
Voron, T1
Pozet, A1
Hammel, P1
Sauvanet, A1
Bachet, JB1
Vaillant, JC1
Rougier, P1
Nordlinger, B1
Berger, A1
Coriat, R1
Dousset, B1
Malka, D1
André, T1
Paye, F1
Aparicio, T1
Locher, C1
Cojean Zeleck, D1
Tchinou, L1
Bonnetain, F1
Taieb, J1
Giuliani, J1
Piacentini, P1
Bonetti, A1
Morak, MJ1
van der Gaast, A1
Incrocci, L1
van Dekken, H3
Hermans, JJ1
Jeekel, J3
Hop, WC3
Kazemier, G1
van Eijck, CH3
Komatsu, S1
Sonoyama, T1
Ochiai, T1
Ichikawa, D1
Ikoma, H1
Okamura, H1
Otsuji, E1
Overman, MJ1
Varadhachary, GR1
Kopetz, S1
Adinin, R1
Lin, E1
Morris, JS1
Eng, C1
Abbruzzese, JL2
Wolff, RA3
Kim, ST1
Lee, J1
Lee, KT1
Lee, JK1
Lee, KH1
Choi, SH1
Heo, JS1
Choi, DW1
Park, SH1
Park, JO1
Lim, HY1
Park, YS1
Kang, WK1
Louvet, C1
Tournigand, C1
Yovino, S1
Poppe, M1
Jabbour, S1
David, V1
Garofalo, M1
Pandya, N1
Alexander, R1
Hanna, N1
Regine, WF1
Kang, SP1
Saif, MW1
Showalter, TN1
Zhan, T1
Anne, PR1
Chervoneva, I1
Mitchell, EP1
Yeo, CJ3
Rosato, EL1
Kennedy, EP1
Song, BJ1
Kwon, JH1
Kim, JJ1
Lee, JW1
Min, SY1
Lee, KB1
Ryu, JK1
Narang, AK1
Miller, RC2
Hsu, CC1
Bhatia, S3
Pawlik, TM1
Laheru, D1
Hruban, RH3
Zhou, J1
Winter, JM1
Haddock, MG2
Donohue, JH2
Schulick, RD1
Wolfgang, CL1
Cameron, JL3
Herman, JM1
van der Zee, JA1
Dicheva, BM1
Seynhaeve, AL1
Koning, GA1
Eggermont, AM1
Ten Hagen, TL1
Neoptolemos, JP1
Moore, MJ1
Cox, TF1
Valle, JW1
Palmer, DH1
McDonald, AC1
Carter, R1
Tebbutt, NC1
Dervenis, C1
Smith, D1
Glimelius, B1
Charnley, RM1
Lacaine, F1
Scarfe, AG1
Middleton, MR1
Anthoney, A1
Ghaneh, P1
Halloran, CM1
Lerch, MM1
Oláh, A1
Rawcliffe, CL1
Verbeke, CS1
Campbell, F1
Büchler, MW1
Takada, T1
Amano, H1
Yasuda, H1
Nimura, Y1
Matsushiro, T1
Kato, H1
Nagakawa, T1
Nakayama, T1
Nabeshima, S1
Kishihara, Y1
Nabeshima, A1
Yamaga, S1
Kinjo, M1
Kashiwagi, S1
Hayashi, J1
Sorio, C1
Moore, PS1
Ennas, MG1
Tecchio, C1
Bonora, A1
Sartoris, S1
Balzarini, P1
Grigolato, P1
Scarpa, A1
Takeda, Y1
Hasuike, Y1
Kashiwazaki, M1
Tsujinaka, T1
Sikora, SS1
Balachandran, P1
Dimri, K1
Rastogi, N1
Kumar, A1
Saxena, R1
Kapoor, VK1
O'Connor, JK1
Sause, WT1
Hazard, LJ1
Belnap, LP1
Noyes, RD1
Chang, PY1
Chao, TY1
Dai, MS1
Krishnan, S2
Hughes, MA1
Frassica, DA1
Riall, TS1
Lillemoe, KD2
Donehower, RC1
Laheru, DA1
Abrams, RA2
Smeenk, HG1
Erdmann, J1
Tran, KC1
Debois, M1
van Cutsem, E1
Klinkenbijl, JH1
Noda, T1
Ohigashi, H1
Ishikawa, O1
Eguchi, H1
Yamada, T1
Sasaki, Y1
Yano, M1
Imaoka, S1
Rana, V1
Evans, DB2
Varadhachary, G1
Das, P1
Delclos, ME1
Janjan, NA2
Crane, CH2
Pisters, PW2
Theodors, A2
Bukowski, RM2
Hewlett, JS1
Livingston, RB1
Weick, JK1
Hermann, RE1
Recchia, F1
Recchia, G1
Tempesti, M1
Venditti, A1
Ishikawa, T1
Ishikawa, N2
Oota, H1
Yoshida, T1
Honma, A1
Kamimura, T1
Takeda, K1
Ozaki, T1
Grochow, LB1
Chakravarthy, A1
Sohn, TA1
Zahurak, ML1
Haulk, TL1
Ord, S1
Pitt, HA1
Hudec, WA1
Lee, JE1
Raijman, I1
Lahoti, S1
Rich, TA1
Lenzi, R1
Mehta, VK1
Fisher, GA1
Ford, JM1
Poen, JC1
Vierra, MA1
Oberhelman, HA1
Bastidas, AJ1
Bouras, N1
Caudry, M1
Saric, J1
Bonnel, C1
Rullier, E1
Trouette, R1
Demeaux, H1
Maire, JP1
Suda, Y1
Akazawa, S1
Splinter, TA1
Obertop, H1
Kok, TC1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Study of Capecitabine and Oxaliplatin (XELOX) in Adenocarcinoma of the Small Bowel and Ampulla of Vater[NCT00354887]Phase 231 participants (Actual)Interventional2004-11-30Completed
The ADAPTA Study: ADjuvant chemotherAPy After Curative Intent resecTion of Ampullary Cancer. A Pan-European Prospective Multicenter Double Single Arm Cohort Study.[NCT06068023]400 participants (Anticipated)Observational2023-07-01Recruiting
A Multi-center, II Phase,Randomized Controlled Clinical Study of Capecitabine Metronomic Chemotherapy After Gemcitabine Plus Capecitabine Standard Adjuvant Therapy for Stage II/III Pancreatic Cancer[NCT03959150]Phase 2/Phase 3231 participants (Anticipated)Interventional2020-01-05Recruiting
European Study Group For Pancreatic Cancer - Trial 3[NCT00058201]Phase 31,030 participants (Anticipated)Interventional2001-07-31Completed
Randomized Phase 2 Study of Capecitabine vs Gemcistabine Plus Cisplatin in Patients With Resected Extrahepatic Cholangiocarcinoma With Regional Lymph Node Metastasis[NCT03079427]Phase 2101 participants (Actual)Interventional2017-05-15Completed
Randomized Controlled Trial Comparing Adjuvant Chemotherapy Vs. no Chemotherapy for Patients With Carcinoma of Gallbladder Undergoing Curative Resection.[NCT02778308]100 participants (Actual)Interventional2012-01-31Completed
A Study of Preoperative FOLFIRINOX For Potentially Curable Pancreatic Cancer[NCT03167112]Phase 220 participants (Anticipated)Interventional2017-07-03Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Overall Response

Overall response rate defined as Complete Response (CR), disappearance of all target lesions; or Partial Response (PR), at least a 30% decrease in sum of longest diameter (LD) of target lesions, taking as reference the baseline sum LD, assessed by Response Evaluation Criteria in Solid Tumors (RECIST) Committee [JNCI 92(3):205-216, 2000]. In addition to a baseline scan, confirmatory scans for those deemed to have achieved a PR or CR. (NCT00354887)
Timeframe: Every 9 weeks from treatment initiation and confirmatory images 6 weeks or more after initial responses

Interventionparticipants (Number)
Participants with CRParticipants with PR
Oxaliplatin + Capecitabine312

Reviews

1 review available for fluorouracil and Common Bile Duct Neoplasms

ArticleYear
Adenocarcinoma of the ampulla of Vater: what treatment options are available?
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2015, Volume: 21, Issue:5

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2015

Trials

7 trials available for fluorouracil and Common Bile Duct Neoplasms

ArticleYear
Better outcome of XELOX chemotherapy in patients with advanced intestinal-type adenocarcinoma of the ampulla of Vater.
    The Tohoku journal of experimental medicine, 2013, Volume: 231, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Agents; Antineoplastic Combined Chemot

2013
Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial.
    Annals of surgery, 2008, Volume: 248, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemo

2008
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jun-01, Volume: 27, Issue:16

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec

2009
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jun-01, Volume: 27, Issue:16

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec

2009
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jun-01, Volume: 27, Issue:16

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec

2009
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jun-01, Volume: 27, Issue:16

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec

2009
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
    JAMA, 2012, Jul-11, Volume: 308, Issue:2

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy

2012
Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma.
    Cancer, 2002, Oct-15, Volume: 95, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Chemotherapy, Adju

2002
Long-term survival and metastatic pattern of pancreatic and periampullary cancer after adjuvant chemoradiation or observation: long-term results of EORTC trial 40891.
    Annals of surgery, 2007, Volume: 246, Issue:5

    Topics: Adult; Aged; Ampulla of Vater; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Common Bile

2007
Adjuvant chemoradiotherapy for "unfavorable" carcinoma of the ampulla of Vater: preliminary report.
    Archives of surgery (Chicago, Ill. : 1960), 2001, Volume: 136, Issue:1

    Topics: Actuarial Analysis; Ampulla of Vater; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chola

2001

Other Studies

41 other studies available for fluorouracil and Common Bile Duct Neoplasms

ArticleYear
Controversial benefit of 5-fluorouracil/leucovorin-based adjuvant chemotherapy for ampullary cancer: a propensity score-matched analysis.
    Langenbeck's archives of surgery, 2022, Volume: 407, Issue:3

    Topics: Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Common Bil

2022
Establishment and characterization of a new human ampullary carcinoma cell line, DPC-X1.
    World journal of gastroenterology, 2023, May-07, Volume: 29, Issue:17

    Topics: Ampulla of Vater; Animals; Carcinoembryonic Antigen; Cell Line; Cell Line, Tumor; Common Bile Duct N

2023
Prognostic factors and benefits of adjuvant therapy after pancreatoduodenectomy for ampullary adenocarcinoma: Mayo Clinic experience.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2018, Volume: 44, Issue:5

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Antimetabolites, Antin

2018
Role of Adjuvant Multimodality Therapy After Curative-Intent Resection of Ampullary Carcinoma.
    JAMA surgery, 2019, 08-01, Volume: 154, Issue:8

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antimetabolites, Antineoplastic; Chemoradiotherapy, Adjuvant

2019
Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity.
    Acta oncologica (Stockholm, Sweden), 2013, Volume: 52, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Aged; Ampulla of Vater; Capecitabine; Chemoradiotherapy; Commo

2013
Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman.
    Diagnostic pathology, 2013, Sep-16, Volume: 8

    Topics: Acute Disease; Adenocarcinoma; Adult; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protoco

2013
Twenty-six cases of advanced ampullary adenocarcinoma treated with systemic chemotherapy.
    Japanese journal of clinical oncology, 2014, Volume: 44, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Cispl

2014
Prognostic Significance of Nodal Ratio in Patients Undergoing Adjuvant Chemoradiotherapy After Curative Resection for Ampullary Cancer.
    American journal of clinical oncology, 2016, Volume: 39, Issue:4

    Topics: Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Ad

2016
Prognostic score for recurrence after Whipple's pancreaticoduodenectomy for ampullary carcinomas; results of an AGEO retrospective multicenter cohort.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2015, Volume: 41, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Ampulla of Vater; Antineoplastic Combined Chemotherapy

2015
Ampulla of Vater carcinoma in real-world clinical practice: a case series.
    Tumori, 2015, Jun-25, Volume: 101, Issue:3

    Topics: Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecit

2015
Long-term complete response of multiple hepatic metastases from carcinoma of the papilla of Vater using intrahepatic infusion of 5-FU with low-dose cisplatin following pancreaticoduodenectomy.
    International journal of clinical oncology, 2008, Volume: 13, Issue:6

    Topics: Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Thera

2008
Role of adjuvant chemoradiotherapy for ampulla of Vater cancer.
    International journal of radiation oncology, biology, physics, 2009, Oct-01, Volume: 75, Issue:2

    Topics: Adult; Age Factors; Aged; Ampulla of Vater; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant;

2009
The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater.
    Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec

2010
Is duodenal invasion a relevant prognosticator in patients undergoing adjuvant chemoradiotherapy for distal common bile duct cancer?
    International journal of radiation oncology, biology, physics, 2010, Jul-15, Volume: 77, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Chemotherapy, Ad

2010
Time to move to targeted drugs in biliary tract cancer?
    Onkologie, 2010, Volume: 33, Issue:1-2

    Topics: Adenocarcinoma; Ampulla of Vater; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineo

2010
Intensity-modulated radiation therapy significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancers.
    International journal of radiation oncology, biology, physics, 2011, Jan-01, Volume: 79, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Antineoplastic Combined Chemothera

2011
Ampullary and periampullary tumors: translational efforts to meet a challenge in diagnosis and treatment. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011.
    JOP : Journal of the pancreas, 2011, Mar-09, Volume: 12, Issue:2

    Topics: Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Common Bile Duct Neoplasms; Deoxyc

2011
The influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2011, Volume: 15, Issue:8

    Topics: Age Factors; Aged; Ampulla of Vater; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma; Chemo

2011
[A case of primary mucoepidermoid carcinoma arising from the common bile duct].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2011, May-25, Volume: 57, Issue:5

    Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma, Mucoepidermoid; Cholangiopancreatography, Endoscop

2011
Evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study.
    Radiation oncology (London, England), 2011, Sep-28, Volume: 6

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Antineoplastic Agents; Chemoradiot

2011
Prognostic significance of tumour location after adjuvant chemoradiotherapy for periampullary adenocarcinoma.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2012, Volume: 14, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antimetabolites, Antineoplastic; Chemoradiotherapy, A

2012
Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2012, Volume: 38, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Antimetabolites, Antineoplastic; B

2012
Poorly differentiated adenocarcinoma with signet-ring cells of the Vater's ampulla, without jaundice but with disseminated carcinomatosis.
    Fukuoka igaku zasshi = Hukuoka acta medica, 2003, Volume: 94, Issue:7

    Topics: Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Carcinoma,

2003
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma.
    Virchows Archiv : an international journal of pathology, 2004, Volume: 444, Issue:3

    Topics: Adenocarcinoma; Ampulla of Vater; Animals; Cell Adhesion; Common Bile Duct Neoplasms; Deoxycytidine;

2004
[Adjuvant arterial infusion chemotherapy for patients with biliary cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Ampulla of Vater; Bile Duct Neoplasms; Biliary Tract Neoplasms; Chem

2004
Adjuvant chemo-radiotherapy in ampullary cancers.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2005, Volume: 31, Issue:2

    Topics: Adult; Ampulla of Vater; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Common Bile Duct N

2005
Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma.
    International journal of radiation oncology, biology, physics, 2005, Nov-15, Volume: 63, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Chemotherapy, Adjuvant; Combined M

2005
Early occurrence of chylothorax related to thoracic irradiation and concomitant chemotherapy.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2005, Volume: 17, Issue:4

    Topics: Adenocarcinoma; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Chylothorax; Cispl

2005
Adjuvant therapy for ampullary carcinomas: the Mayo Clinic experience.
    International journal of radiation oncology, biology, physics, 2006, Oct-01, Volume: 66, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Ampulla of Vater; Analysis of Variance; Antimetabolites, Antineoplas

2006
Adjuvant concurrent chemoradiation for adenocarcinoma of the distal common bile duct.
    International journal of radiation oncology, biology, physics, 2007, May-01, Volume: 68, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antimetabolites, Antineoplasti

2007
Liver perfusion chemotherapy for selected patients at a high-risk of liver metastasis after resection of duodenal and ampullary cancers.
    Annals of surgery, 2007, Volume: 246, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Ampulla of Vater; Antimetabolites, Antineoplastic; Chemotherapy, Adj

2007
Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater.
    International journal of radiation oncology, biology, physics, 2008, Mar-01, Volume: 70, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Ampulla of Vater; Analysis of Variance; Antineoplastic Combined Chem

2008
Intermittent regional infusion of chemotherapy for pancreatic adenocarcinoma. Phase I and II pilot study.
    American journal of clinical oncology, 1982, Volume: 5, Issue:5

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineop

1982
Combination chemotherapy for metastatic carcinoma of the ampulla of Vater--report of three cases.
    Journal of surgical oncology, 1984, Volume: 25, Issue:4

    Topics: Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Common Bile Duct

1984
[Indications and technic of percutaneous external biliary drainage].
    Minerva chirurgica, 1981, Jun-30, Volume: 36, Issue:12

    Topics: Antineoplastic Agents; Bile; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Cholestasis,

1981
[A case of common bile duct cancer responding to MMC leucovorin, 5-FU, and UFT combination chemotherapy and radiation].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Common Bile Duct Ne

1996
Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels.
    International journal of radiation oncology, biology, physics, 1999, Jul-15, Volume: 44, Issue:5

    Topics: Adenocarcinoma; Aged; Ampulla of Vater; Antimetabolites, Antineoplastic; Biomarkers, Tumor; CA-19-9

1999
Preoperative chemoradiation for patients with pancreatic cancer: toxicity of endobiliary stents.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Ampulla of Vater; Antimetabolites, Antineoplastic; A

2000
[Conformal therapy of locally advanced cholangiocarcinoma of the main bile ducts].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2002, Volume: 6, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemoth

2002
[Biliary and pancreatic excretion of methotrexate (MTX) and 5-FU on the MTX/5-FU sequential therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bile; Common Bile Duct Neoplasms; Drug Admini

1990
Adjuvant chemotherapy after resection of adenocarcinoma of the periampullary region and the head of the pancreas. A non-randomized pilot study.
    Journal of cancer research and clinical oncology, 1989, Volume: 115, Issue:2

    Topics: Activities of Daily Living; Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemothe

1989