fluorouracil has been researched along with Coma in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer." | 5.33 | 5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma. ( Chua, YJ; Cunningham, D; Formica, V; Leary, A, 2006) |
| "Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer." | 1.33 | 5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma. ( Chua, YJ; Cunningham, D; Formica, V; Leary, A, 2006) |
| "We report here the case of a coma with a favorable outcome following 5FU chemotherapy." | 1.33 | [Coma following chemotherapy: is 5FU implicated? Discussion about on case-report]. ( Heluwaert, F; Hilleret, MN; Martin, C; Martin, D; Santre, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boilève, A | 1 |
| Osman, D | 1 |
| Marthey, L | 1 |
| Carbonnel, F | 1 |
| Jozwiak, M | 1 |
| Formica, V | 1 |
| Leary, A | 1 |
| Cunningham, D | 1 |
| Chua, YJ | 1 |
| Heluwaert, F | 1 |
| Santre, C | 1 |
| Martin, C | 1 |
| Hilleret, MN | 1 |
| Martin, D | 1 |
| Yeh, KH | 2 |
| Cheng, AL | 2 |
| Arsac, M | 1 |
| Bonnet, G | 1 |
| Mouzon, M | 1 |
6 other studies available for fluorouracil and Coma
| Article | Year |
|---|---|
Drug-induced coma after chemotherapy in intensive care unit: How to make the right diagnosis?
Topics: Adenosine Triphosphate; Adult; Antineoplastic Combined Chemotherapy Protocols; Coma; Esophageal Neop | 2018 |
5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma.
Topics: Antineoplastic Agents; Blood-Brain Barrier; Capecitabine; Central Nervous System Diseases; Coma; Deo | 2006 |
[Coma following chemotherapy: is 5FU implicated? Discussion about on case-report].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cecal Neoplasms; Cecum; Coma; Fluorouracil; Humans; | 2006 |
Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.
Topics: Acute Disease; Brain Diseases; Coma; Confusion; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 1994 |
High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy.
Topics: Acidosis; Ammonia; Antimetabolites, Antineoplastic; Brain Diseases; Coma; Diagnosis, Differential; E | 1997 |
[Cancer of the body of the pancreas with hepatic metastases].
Topics: Abdomen; Blindness; Catheterization; Cholangiography; Coma; Diagnosis, Differential; Fluorouracil; H | 1968 |