fluorouracil has been researched along with Colonic Diseases in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intussusception is relatively rare in adults, particularly in portions of the colon fixed to the retroperitoneum, such as the descending colon." | 2.53 | [A Case of Intussusception Caused by Descending Colon Cancer]. ( Hashimoto, Y; Hotta, S; Iwaki, T; Kameyama, H; Kobayashi, T; Oyamatsu, M; Sakata, J; Sato, K; Sato, Y; Shimada, Y; Wakai, T, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (36.84) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akyuz, C | 1 |
| Yasar, NF | 1 |
| Uzun, O | 1 |
| Peker, KD | 1 |
| Sunamak, O | 1 |
| Duman, M | 1 |
| Sehirli, AO | 1 |
| Yol, S | 1 |
| Soldini, D | 1 |
| Gaspert, A | 1 |
| Montani, M | 1 |
| Reineke, T | 1 |
| Rogler, G | 1 |
| Odze, R | 1 |
| Weber, A | 1 |
| van den Berg, MW | 1 |
| Sloothaak, DA | 1 |
| Dijkgraaf, MG | 1 |
| van der Zaag, ES | 1 |
| Bemelman, WA | 1 |
| Tanis, PJ | 1 |
| Bosker, RJ | 1 |
| Fockens, P | 1 |
| ter Borg, F | 1 |
| van Hooft, JE | 1 |
| Kalaitzakis, E | 1 |
| Havre, RF | 1 |
| Willemoe, GL | 1 |
| Meisner, S | 1 |
| Hotta, S | 1 |
| Kameyama, H | 1 |
| Sato, K | 1 |
| Oyamatsu, M | 1 |
| Hashimoto, Y | 1 |
| Sato, Y | 1 |
| Iwaki, T | 1 |
| Shimada, Y | 1 |
| Sakata, J | 1 |
| Kobayashi, T | 1 |
| Wakai, T | 1 |
| Verburg, RJ | 1 |
| Meijssen, MA | 1 |
| Fuccio, L | 1 |
| Cennamo, V | 1 |
| Kempin, S | 1 |
| Gutierrez, J | 1 |
| Wilson, E | 1 |
| Lowery, C | 1 |
| Diasio, R | 1 |
| REITEMEIER, RJ | 1 |
| MOERTEL, CG | 1 |
| Colucci, G | 1 |
| Thaler, W | 1 |
| Dejaco, H | 1 |
| Marsoner, H | 1 |
| Grones, A | 1 |
| Kuebler, JP | 1 |
| Colangelo, L | 1 |
| O'Connell, MJ | 1 |
| Smith, RE | 1 |
| Yothers, G | 1 |
| Begovic, M | 1 |
| Robinson, B | 1 |
| Seay, TE | 1 |
| Wolmark, N | 1 |
| Fuhrman, GM | 1 |
| Ota, DM | 1 |
| El-Malt, M | 1 |
| Ceelen, W | 1 |
| van den Broecke, C | 1 |
| Cuvelier, C | 1 |
| Van Belle, S | 1 |
| De Neve, W | 1 |
| de Hemptinne, B | 1 |
| Pattyn, P | 1 |
| Danjoux, CE | 1 |
| Catton, GE | 1 |
| Classen, JN | 1 |
| Martin, RE | 1 |
| Sabagal, J | 1 |
| Holt, RW | 1 |
| Petrilli, ES | 1 |
| Evans, SR | 1 |
| Ahlgren, JD | 1 |
| Saeed, W | 1 |
| Kim, S | 1 |
| Burch, BH | 1 |
| Donaldson, GA | 1 |
| Welch, JP | 1 |
| Shook, R | 1 |
| Windschitl, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Clinical Trial Comparing 5-Fluorouracil (5-FU) Plus Leucovorin (LV) and Oxaliplatin With 5-FU Plus LV for the Treatment of Patients With Stages II and III Carcinoma of the Colon[NCT00004931] | Phase 3 | 2,472 participants (Anticipated) | Interventional | 2000-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluorouracil and Colonic Diseases
| Article | Year |
|---|---|
[A Case of Intussusception Caused by Descending Colon Cancer].
Topics: Adenocarcinoma, Mucinous; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colon, Desce | 2016 |
Colonic rupture in a patient on combination chemotherapy for metastasized carcinoma of the esophagogastric junction. Case report and review of the literature.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cecal Diseases; Cisplatin; Colonic D | 2005 |
Iatrogenic lesions of the colon and rectum.
Topics: Adult; Aged; Angiography; Barium Sulfate; Cathartics; Colon; Colonic Diseases; Cyclophosphamide; Ele | 1975 |
Management of cancer of the colon.
Topics: Colitis, Ulcerative; Colon; Colonic Diseases; Colonic Neoplasms; Diagnostic Errors; Fluorouracil; Hu | 1974 |
1 trial available for fluorouracil and Colonic Diseases
| Article | Year |
|---|---|
Severe enteropathy among patients with stage II/III colon cancer treated on a randomized trial of bolus 5-fluorouracil/leucovorin plus or minus oxaliplatin: a prospective analysis.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Diseases; Colonic Neop | 2007 |
14 other studies available for fluorouracil and Colonic Diseases
| Article | Year |
|---|---|
Effects of melatonin on colonic anastomosis healing following chemotherapy in rats.
Topics: Anastomosis, Surgical; Animals; Antineoplastic Agents; Colon; Colonic Diseases; Disease Models, Anim | 2018 |
Apoptotic enteropathy caused by antimetabolites and TNF-α antagonists.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Apoptosis; Biopsy | 2014 |
Bridge-to-surgery stent placement versus emergency surgery for acute malignant colonic obstruction.
Topics: Aged; Anastomosis, Surgical; Antineoplastic Combined Chemotherapy Protocols; Colonic Diseases; Color | 2014 |
Colonic perforation following endoscopic mucosal resection in a patient on bevacizumab treatment.
Topics: Adenocarcinoma; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camp | 2016 |
Late colonic stent perforation following chemotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Diseases; Fluorouracil; Humans; Intest | 2009 |
Bevacizumab-based therapy and complication risk after colonic stent placement: is it time for a warning?
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C | 2010 |
Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Colonic Diseases; D | 2002 |
Comparison of rapid and slow intravenous administration of 5-fluorouracil in treating patients with advanced carcinoma of the large intestine.
Topics: Adenocarcinoma; Administration, Intravenous; Colonic Diseases; Fluorouracil; Humans; Intestinal Neop | 1962 |
Laparoscopic intestinal stomas.
Topics: Adenocarcinoma; Adult; Aged; Anus Neoplasms; Carcinoma, Squamous Cell; Colonic Diseases; Colostomy; | 1994 |
Healing of experimental colonic anastomoses: effects of combined preoperative high-dose radiotherapy and intraperitoneal 5-fluorouracil.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Body Weight; Colon; Colonic Disease | 2001 |
Delayed complications in colo-rectal carcinoma treated by combination radiotherapy and 5-fluorouracil--Eastern Cooperative Oncology Group (E.C.O.G.) pilot study.
Topics: Aged; Colonic Diseases; Colonic Neoplasms; Connective Tissue; Constriction, Pathologic; Female; Fluo | 1979 |
Intraperitoneal chemotherapy complicated by erosion of a Tenckhoff catheter into the colon.
Topics: Catheters, Indwelling; Cecal Neoplasms; Colonic Diseases; Female; Fluorouracil; Humans; Infusions, P | 1989 |
Development of carcinoma in regional enteritis.
Topics: Adenocarcinoma, Mucinous; Barium Sulfate; Cecum; Colon; Colonic Diseases; Crohn Disease; Enema; Fluo | 1974 |
Gardners syndrome.
Topics: Adult; Colonic Diseases; Colonic Neoplasms; Female; Fluorouracil; Humans; Polyps | 1965 |