fluorouracil has been researched along with Colon Diverticula in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colon cancer was located in the rectosigmoid in 46." | 2.72 | Diverticular disease in patients with colon cancer: subgroup analysis of national surgical adjuvant breast and bowel project protocol C-06. ( Harlak, A; Lembersky, BC; Nesbitt, L; O'Connell, MJ; Soran, A; Wienad, HS; Wilson, JW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soran, A | 1 |
| Harlak, A | 1 |
| Wilson, JW | 1 |
| Nesbitt, L | 1 |
| Lembersky, BC | 1 |
| Wienad, HS | 1 |
| O'Connell, MJ | 1 |
| Welch, CE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Clinical Trial Comparing Oral Uracil/Ftorafur (UFT) Plus Leucovorin (LV) With 5-Fluorouracil (5-FU) Plus LV in the Treatment of Patients With Stages II And III Carcinoma of the Colon[NCT00378716] | Phase 3 | 1,608 participants (Actual) | Interventional | 1997-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Colon Diverticula
| Article | Year |
|---|---|
Abdominal surgery (second of three parts).
Topics: Abdomen; Acute Disease; Anus Diseases; Appendectomy; Appendicitis; Appendix; Carcinoembryonic Antige | 1975 |
1 trial available for fluorouracil and Colon Diverticula
| Article | Year |
|---|---|
Diverticular disease in patients with colon cancer: subgroup analysis of national surgical adjuvant breast and bowel project protocol C-06.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Cohort Studies; Colonic Neoplasms; Diverticulum, Colon; | 2006 |