fluorouracil has been researched along with Colon Cancer, Familial Nonpolyposis in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Microsatellite instability is the consequence of a deficient mismatch repair system." | 2.49 | Role of microsatellite instability in the management of colorectal cancers. ( Buecher, B; Cacheux, W; Dieumegard, B; Lièvre, A; Mitry, E; Rouleau, E, 2013) |
| "If almost all colorectal cancers (CRC) correspond to the same histopathological type (adenocarcinoma), molecular biology allowed the identification of two different molecular mechanisms of colorectal carcinogenesis: chromosomal instability characterized by recurrent allelic losses on chromosomes 17, 5, 18, 8 and 22 that contribute to the inactivation of tumor suppressor genes, and genetic instability characterized by the instability of microsatellite loci due to an alteration of DNA mismatch repair leading to the accumulation of mutations in genes involved in the control of cell cycle and apoptosis." | 2.43 | [Molecular biology in clinical cancer research: the example of digestive cancers]. ( Laurent-Puig, P; Lièvre, A, 2005) |
| "Here, we report the case of a Lynch syndrome PDA patient with an exceptional response to a single cycle of pembrolizumab immunotherapy." | 1.56 | Exceptional Response to A Single Cycle of Immunotherapy in a Lynch Syndrome Patient with Metastatic Pancreatic Adenocarcinoma. ( Khan, GN; Patil, NR, 2020) |
| "Lynch syndrome is an inherited syndrome with the development of the colorectal and various other cancers." | 1.48 | [A Case of Ascending Colon Cancer with Lynch Syndrome Who Underwent XELOX Adjuvant Chemotherapy]. ( Kagawa, Y; Kato, T; Katsura, Y; Kawai, K; Murakami, K; Murata, K; Naito, A; Nakatsuka, S; Nose, Y; Omura, Y; Sakamoto, T; Takase, K; Takeda, Y; Takeno, A; Tamura, S, 2018) |
| "Microsatellite instability was observed in all VCMsh2 strains and limited to the intestinal mucosa." | 1.36 | An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. ( Bronson, RT; Clark, AB; Edelmann, W; Fan, K; Hou, H; Jelicks, L; Kucherlapati, MH; Kucherlapati, R; Kunkel, TA; Lee, K; Li, H; Lipkin, M; Nguyen, AA; Rosulek, A; Yang, K, 2010) |
| "Colon cancer (CC) in hereditary nonpolyposis colorectal cancer (HNPCC) is due to a dysfunctioning MMR gene that leads to microsatellite instability (MSI)." | 1.32 | Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer. ( Cats, A; de Vos tot Nederveen Cappel, WH; Gelderblom, H; Griffioen, G; Kleibeuker, JH; Menko, FH; Meulenbeld, HJ; Morreau, H; Nagengast, FM; Vasen, HF, 2004) |
| "Gastrointestinal carcinoid tumors are often associated with other tumors, particularly colon adenocarcinomas; but the association between carcinoid tumors and hereditary nonpolyposis colorectal cancer (HNPCC) syndrome has not yet been explored." | 1.32 | An appendix carcinoid tumor in a patient with hereditary nonpolyposis colorectal cancer. ( Ducreux, M; Duvillard, P; Elias, D; Grandjouan, S; Miquel, C; Praz, F; Sabourin, JC; Viguier, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Yılmaz, A | 1 |
| Mirili, C | 1 |
| Bilici, M | 1 |
| Tekin, SB | 1 |
| Patil, NR | 1 |
| Khan, GN | 1 |
| Armstrong, S | 1 |
| Al-Ghawi, H | 1 |
| Helft, P | 1 |
| House, MG | 1 |
| Spittler, AJ | 1 |
| Wu, HH | 1 |
| Shahda, S | 1 |
| Takase, K | 1 |
| Murata, K | 1 |
| Kagawa, Y | 1 |
| Nose, Y | 1 |
| Kawai, K | 1 |
| Sakamoto, T | 1 |
| Naito, A | 1 |
| Murakami, K | 1 |
| Katsura, Y | 1 |
| Omura, Y | 1 |
| Takeno, A | 1 |
| Nakatsuka, S | 1 |
| Takeda, Y | 1 |
| Kato, T | 1 |
| Tamura, S | 1 |
| Battaglin, F | 1 |
| Naseem, M | 1 |
| Lenz, HJ | 1 |
| Salem, ME | 1 |
| Stadler, ZK | 1 |
| Neumann, JH | 1 |
| Jung, A | 1 |
| Kirchner, T | 1 |
| Sargent, DJ | 1 |
| Kucherlapati, MH | 1 |
| Lee, K | 1 |
| Nguyen, AA | 1 |
| Clark, AB | 1 |
| Hou, H | 1 |
| Rosulek, A | 1 |
| Li, H | 1 |
| Yang, K | 1 |
| Fan, K | 1 |
| Lipkin, M | 1 |
| Bronson, RT | 1 |
| Jelicks, L | 1 |
| Kunkel, TA | 1 |
| Kucherlapati, R | 1 |
| Edelmann, W | 1 |
| Dietmaier, W | 1 |
| Tejpar, S | 1 |
| Saridaki, Z | 1 |
| Delorenzi, M | 1 |
| Bosman, F | 1 |
| Roth, AD | 1 |
| Cubas Castillo, R | 1 |
| Ballarino, EA | 1 |
| Neirot, P | 1 |
| Grasso, RL | 1 |
| Buecher, B | 1 |
| Cacheux, W | 1 |
| Rouleau, E | 1 |
| Dieumegard, B | 1 |
| Mitry, E | 1 |
| Lièvre, A | 2 |
| Desselle, F | 1 |
| Verset, G | 1 |
| Polus, M | 1 |
| Louis, E | 1 |
| Van Daele, D | 1 |
| de Vos tot Nederveen Cappel, WH | 1 |
| Meulenbeld, HJ | 1 |
| Kleibeuker, JH | 1 |
| Nagengast, FM | 1 |
| Menko, FH | 1 |
| Griffioen, G | 1 |
| Cats, A | 1 |
| Morreau, H | 1 |
| Gelderblom, H | 1 |
| Vasen, HF | 1 |
| Miquel, C | 1 |
| Sabourin, JC | 1 |
| Elias, D | 1 |
| Grandjouan, S | 1 |
| Viguier, J | 1 |
| Ducreux, M | 1 |
| Duvillard, P | 1 |
| Praz, F | 1 |
| Sorscher, SM | 1 |
| Laurent-Puig, P | 1 |
| Tampellini, M | 1 |
| Alabiso, I | 1 |
| Sculli, CM | 1 |
| Barberis, M | 1 |
| Giachino, D | 1 |
| Berruti, A | 1 |
| Dogliotti, L | 1 |
7 reviews available for fluorouracil and Colon Cancer, Familial Nonpolyposis
| Article | Year |
|---|---|
Microsatellite instability in colorectal cancer: overview of its clinical significance and novel perspectives.
Topics: Chemotherapy, Adjuvant; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Mismatch Repair; Fluorour | 2018 |
Diagnosis and management of DNA mismatch repair-deficient colorectal cancer.
Topics: Adenoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; C | 2015 |
[Molecular pathology of colorectal cancer].
Topics: Adenocarcinoma; Algorithms; Class I Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; Colorectal | 2015 |
[Hereditary nonpolyposis colorectal cancer: analysis of a case and review of management].
Topics: Adult; Antimetabolites, Antineoplastic; Colectomy; Colorectal Neoplasms, Hereditary Nonpolyposis; Fe | 2011 |
Role of microsatellite instability in the management of colorectal cancers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Colore | 2013 |
[Lynch syndrome and microsatellite instability: a review].
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Colorectal Neoplasms, Hereditary Nonpolyp | 2012 |
[Molecular biology in clinical cancer research: the example of digestive cancers].
Topics: Adenocarcinoma; Alleles; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agen | 2005 |
12 other studies available for fluorouracil and Colon Cancer, Familial Nonpolyposis
| Article | Year |
|---|---|
Colorectal cancer in Lynch syndrome associated with PMS2 and MSH6 mutations.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Colorectal Neoplasms, Hereditary | 2020 |
Exceptional Response to A Single Cycle of Immunotherapy in a Lynch Syndrome Patient with Metastatic Pancreatic Adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antin | 2020 |
Two Months of Therapy: A Case of Pathologic Complete Response to Chemoimmunotherapy in a Patient With Metastatic Colorectal Cancer.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combi | 2018 |
[A Case of Ascending Colon Cancer with Lynch Syndrome Who Underwent XELOX Adjuvant Chemotherapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Colon, | 2018 |
Advances in defective mismatch repair colon cancer.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Antineoplastic Combined Chemotherap | 2008 |
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Topics: Adenocarcinoma; Adenoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2010 |
[Microsatellite instability. A new predictive marker (?)].
Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Chemothera | 2010 |
Microsatellite instability, prognosis and drug sensitivity of stage II and III colorectal cancer: more complexity to the puzzle.
Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Colorectal Neoplasms, | 2011 |
Survival after adjuvant 5-FU treatment for stage III colon cancer in hereditary nonpolyposis colorectal cancer.
Topics: Adult; Antineoplastic Agents; Chemotherapy, Adjuvant; Colonic Neoplasms; Colorectal Neoplasms, Hered | 2004 |
An appendix carcinoid tumor in a patient with hereditary nonpolyposis colorectal cancer.
Topics: Adult; Antimetabolites, Antineoplastic; Appendiceal Neoplasms; Carcinoid Tumor; Chemotherapy, Adjuva | 2004 |
Predicting recurrence risk for synchronous primary colon cancers.
Topics: Adenocarcinoma; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Case Management; Cecal N | 2004 |
Stage IB malignant thymoma in a Lynch syndrome patient with multiple cancers: response to incidental administration of oxaliplatin and 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms, Hereditary Nonpolyposis; Femal | 2006 |