fluorouracil has been researched along with Collagen Diseases in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that collagen was equivalent to connective tissue, but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term collagen diseases now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Two patients with nasopharyngeal carcinoma complicated by collagen diseases (dermatomyositis in one, and Sjögren's syndrome with mixed connective tissue disease in the other) were given radiotherapy combined with chemotherapy consisting of cis-platinum and 5-fluorouracil." | 4.79 | Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature. ( Asakura, K; Hareyama, M; Hattori, A; Horikoshi, T; Hyodo, K; Imai, K; Koshiba, H; Morita, K; Nagakura, H; Oouchi, A; Sakata, K; Shido, M; Tamakawa, M; Tanaka, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hareyama, M | 2 |
| Nagakura, H | 2 |
| Tamakawa, M | 2 |
| Hyodo, K | 2 |
| Asakura, K | 2 |
| Horikoshi, T | 2 |
| Oouchi, A | 2 |
| Shido, M | 2 |
| Morita, K | 2 |
| Tanaka, S | 1 |
| Imai, K | 1 |
| Hattori, A | 1 |
| Koshiba, H | 1 |
| Sakata, K | 1 |
1 review available for fluorouracil and Collagen Diseases
| Article | Year |
|---|---|
Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Collagen Diseas | 1996 |
1 other study available for fluorouracil and Collagen Diseases
| Article | Year |
|---|---|
Severe reaction after chemoradiotherapy of nasopharyngeal carcinoma with collagen disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Collagen Diseases; Combined Modality Ther | 1995 |