fluorouracil has been researched along with Cognitive Dysfunction in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU) is a chemotherapeutic drug with a good anti-cancer effect on various types of cancers, such as colorectal cancer and breast cancer." | 5.62 | Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice. ( Abulizi, A; An, Y; Huang, Z; Li, M; Lin, D; Lin, S; Lin, Z; Ran, J; Wang, L; Yang, B; Ye, Y; Zhang, Y; Zhou, H, 2021) |
| "Anthracyclines-based regimen (5-fluorouracil, doxorubicin, and cyclophosphamide (FAC); cyclophosphamide, epirubicin, and 5-fluorouracil [CEF]) and non-anthracycline based regimens (cyclophosphamide, methotrexate, and 5-fluorouracil [CMF]) are widely used as neoadjuvant chemotherapy for breast cancer patients." | 4.12 | Cognitive impairment and elevated peripheral cytokines in breast cancer patients receiving chemotherapy. ( Agarwal, N; Bhurani, D; Hoda, U; Khan, MA; Sehar, N, 2022) |
| "The aim of this study is to elucidate the role of taxanes on cognition when they are administered as a part of the treatment with a fluorouracil, epirubicin and cyclophosphamide (FEC) regimen for breast cancer (BC)." | 3.85 | Role of taxanes in chemotherapy-related cognitive impairment: A prospective longitudinal study. ( Arcusa, À; Cerulla, N; Chico, G; Enero, C; Fernández-Morales, L; Garolera, M; Navarro, JB, 2017) |
| "5-Fluorouracil (5-FU) is a chemotherapeutic drug with a good anti-cancer effect on various types of cancers, such as colorectal cancer and breast cancer." | 1.62 | Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice. ( Abulizi, A; An, Y; Huang, Z; Li, M; Lin, D; Lin, S; Lin, Z; Ran, J; Wang, L; Yang, B; Ye, Y; Zhang, Y; Zhou, H, 2021) |
| "As melatonin has been shown to enhance memory and hippocampal neurogenesis in animal models, this research investigated the neuroprotective effects of melatonin against spatial memory and hippocampal neurogenesis impairment in 5-fluorouracil (5-FU)-treated rats." | 1.56 | Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats. ( Aranarochana, A; Chaisawang, P; Pannangrong, W; Sirichoat, A; Suwannakot, K; Welbat, JU; Wigmore, P, 2020) |
| "Cancer chemotherapy-induced cognitive impairments are presumably associated with undesirable effects of chemotherapy on physiological functions of brain cells." | 1.51 | Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells. ( Efferth, T; Klauck, SM; Panossian, A; Seo, EJ, 2019) |
| "Depression was directly affected by fatigue (β=." | 1.43 | [Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer]. ( Lee, JR; Oh, PJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 7 (58.33) | 2.80 |
| Authors | Studies |
|---|---|
| Abulizi, A | 1 |
| Ran, J | 1 |
| Ye, Y | 1 |
| An, Y | 1 |
| Zhang, Y | 1 |
| Huang, Z | 1 |
| Lin, S | 1 |
| Zhou, H | 1 |
| Lin, D | 1 |
| Wang, L | 1 |
| Lin, Z | 1 |
| Li, M | 1 |
| Yang, B | 1 |
| Alhowail, AH | 3 |
| Almogbel, YS | 2 |
| Abdellatif, AAH | 2 |
| Aldubayan, MA | 3 |
| Almami, IS | 1 |
| Khan, MA | 1 |
| Bhurani, D | 1 |
| Hoda, U | 1 |
| Sehar, N | 1 |
| Agarwal, N | 1 |
| Alotayk, LI | 1 |
| Alenezi, SK | 1 |
| Anwar, MJ | 1 |
| Raafat, RS | 1 |
| Habib, MZ | 1 |
| AbdElfattah, AA | 1 |
| Olama, NK | 1 |
| Abdelraouf, SM | 1 |
| Hendawy, N | 1 |
| Kamal, KA | 1 |
| Nawishy, SA | 1 |
| Aboul-Fotouh, S | 1 |
| Sirichoat, A | 1 |
| Suwannakot, K | 1 |
| Chaisawang, P | 1 |
| Pannangrong, W | 1 |
| Aranarochana, A | 1 |
| Wigmore, P | 1 |
| Welbat, JU | 1 |
| Alsalehi, NF | 1 |
| Alghenaim, FA | 1 |
| Felemban, SG | 1 |
| Cerulla, N | 1 |
| Arcusa, À | 1 |
| Navarro, JB | 1 |
| Garolera, M | 1 |
| Enero, C | 1 |
| Chico, G | 1 |
| Fernández-Morales, L | 1 |
| Winocur, G | 2 |
| Berman, H | 1 |
| Nguyen, M | 1 |
| Binns, MA | 1 |
| Henkelman, M | 1 |
| van Eede, M | 1 |
| Piquette-Miller, M | 1 |
| Sekeres, MJ | 1 |
| Wojtowicz, JM | 2 |
| Yu, J | 1 |
| Zhang, H | 1 |
| Tannock, IF | 1 |
| Jiang, ZG | 1 |
| Shevtsova, O | 1 |
| Fuller, S | 1 |
| Ghanbari, HA | 1 |
| Seo, EJ | 1 |
| Klauck, SM | 1 |
| Efferth, T | 1 |
| Panossian, A | 1 |
| Oh, PJ | 1 |
| Lee, JR | 1 |
12 other studies available for fluorouracil and Cognitive Dysfunction
| Article | Year |
|---|---|
Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice.
Topics: Animals; Antineoplastic Agents; Cognitive Dysfunction; Disease Models, Animal; Fluorouracil; Male; M | 2021 |
Elucidating the mechanism underlying cognitive dysfunction by investigating the effects of CMF and MET treatment on hippocampal neurons.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cognitive Dysfunction; Cyclophosph | 2022 |
Cognitive impairment and elevated peripheral cytokines in breast cancer patients receiving chemotherapy.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cognitive Dysfunct | 2022 |
Comparative evaluation of doxorubicin, cyclophosphamide, 5-fluorouracil, and cisplatin on cognitive dysfunction in rats: Delineating the role of inflammation of hippocampal neurons and hypothyroidism.
Topics: Animals; Cisplatin; Cognitive Dysfunction; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Hipp | 2023 |
Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3β/β-catenin signaling in Wistar rats.
Topics: Amisulpride; Animals; beta Catenin; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunct | 2023 |
Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats.
Topics: Animals; Antimetabolites; Biomarkers; Cell Proliferation; Cognitive Dysfunction; Dentate Gyrus; Doub | 2020 |
CMF and MET treatment induce cognitive impairment through upregulation of IL-1α in rat brain.
Topics: Animals; Antineoplastic Agents; Brain; Cognitive Dysfunction; Cyclophosphamide; Dose-Response Relati | 2021 |
Role of taxanes in chemotherapy-related cognitive impairment: A prospective longitudinal study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cognitive Dysfunction | 2017 |
Neurobiological Mechanisms of Chemotherapy-induced Cognitive Impairment in a Transgenic Model of Breast Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognitive Dysfunct | 2018 |
PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats.
Topics: Animals; Antineoplastic Agents; Cognitive Dysfunction; Dentate Gyrus; Discrimination Learning; Disea | 2018 |
Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells.
Topics: Andrographis; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cognitive Dysfunction; Cycl | 2019 |
[Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer].
Topics: Adult; Aged; Anemia; Antineoplastic Agents; Anxiety; Camptothecin; Cognitive Dysfunction; Depression | 2016 |