fluorouracil has been researched along with Cleft Palate in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cleft palate was induced in vitro as opposing palates overlapped in a narrowed oral cavity." | 1.29 | Effects of 5-fluorouracil on embryonic rat palate in vitro: fusion in the absence of proliferation. ( Abbott, BD; Buckalew, AR; Elstein, KH; Kavlock, RJ; Lau, C; Logsdon, TR; Setzer, W; Zucker, RM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, RM | 3 |
| Wong, DT | 2 |
| Suen, RS | 1 |
| Abbott, BD | 1 |
| Lau, C | 1 |
| Buckalew, AR | 1 |
| Logsdon, TR | 1 |
| Setzer, W | 1 |
| Zucker, RM | 1 |
| Elstein, KH | 1 |
| Kavlock, RJ | 1 |
| Montenegro, MA | 1 |
| Cubillo, P | 1 |
| Palomino, H | 1 |
| Williams, JP | 1 |
| Forsthoefel, PF | 1 |
| Dagg, CP | 1 |
| Schlager, G | 1 |
| Doerr, A | 1 |
8 other studies available for fluorouracil and Cleft Palate
| Article | Year |
|---|---|
Ultrastructural and cytochemical observations on 5-fluorouracil-induced cleft-palate development in hamster.
Topics: Acid Phosphatase; Animals; Cleft Palate; Cricetinae; Fluorouracil; Histocytochemistry; Mesocricetus; | 1984 |
Morphological study of cleft palate development in 5-fluorouracil-treated hamster fetuses.
Topics: Abnormalities, Drug-Induced; Animals; Biometry; Cleft Palate; Cricetinae; Fluorouracil; Mesocricetus | 1980 |
Effects of 5-fluorouracil on embryonic rat palate in vitro: fusion in the absence of proliferation.
Topics: Animals; Cell Cycle; Cell Division; Cleft Palate; DNA; Embryo, Mammalian; Fluorouracil; Gestational | 1993 |
[Induction of cleft palate in ball mice: the comparative effect of 5-fluorouracil, phenylbutazone and water and food deprivation (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Food Deprivation; Maternal | 1976 |
Cellular reactions during drug-induced cleft palate.
Topics: Acid Phosphatase; Animals; Cleft Palate; Cricetinae; Cyclic AMP; Female; Fluorouracil; Gestational A | 1986 |
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; E | 1971 |
The effects on mouse development of interactions of 5-fluorouracil with Strong's luxoid gene and its plus and minus modifiers.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Cleft Palate; Embryo, | 1972 |
Polygenic control of the teratogenicity of 5-fluorouracil in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Foot Deformities, Congenit | 1966 |