fluorouracil has been researched along with Cirrhoses, Experimental Liver in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of the rats at a dose of 1." | 1.37 | Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats. ( Arimori, K; Hatakeyama, K; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2011) |
| " After 3 weeks of the ligation in two different groups of animals for in vitro and pharmacokinetic experiments, significant increases in serum bilirubin level and spleen weight were found in both groups." | 1.30 | Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats. ( Kobayashi, S; Kumai, T; Nakura, H; Nishiyama, T; Ogura, K; Sakata, SF; Tamaki, N; Tanaka, M; Tateishi, T; Watabe, T; Watanabe, M, 1999) |
| "Tegafur (FT) is a masked compound of 5-fluorouracil (5-FU) and supposed to be activated in the liver." | 1.28 | [Anti-tumor effect of fluoropyrimidines on human tumor cell lines transplanted in nude mice with CCl4-induced liver dysfunction]. ( Imai, S; Nio, Y; Ohgaki, K; Shiraishi, T; Tobe, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qu, K | 1 |
| Yan, Z | 1 |
| Wu, Y | 1 |
| Chen, Y | 1 |
| Qu, P | 1 |
| Xu, X | 1 |
| Yuan, P | 1 |
| Huang, X | 1 |
| Xing, J | 1 |
| Zhang, H | 1 |
| Liu, C | 1 |
| Zhang, J | 1 |
| Nagata, M | 1 |
| Hidaka, Y | 1 |
| Hatakeyama, K | 1 |
| Kawano, Y | 1 |
| Iwakiri, T | 1 |
| Okumura, M | 1 |
| Arimori, K | 1 |
| Seong, J | 1 |
| Han, KH | 1 |
| Park, YN | 1 |
| Nam, SH | 1 |
| Kim, SH | 1 |
| Keum, WS | 1 |
| Kim, KS | 1 |
| Tateishi, T | 1 |
| Watanabe, M | 1 |
| Nakura, H | 1 |
| Tanaka, M | 1 |
| Kumai, T | 1 |
| Sakata, SF | 1 |
| Tamaki, N | 1 |
| Ogura, K | 1 |
| Nishiyama, T | 1 |
| Watabe, T | 1 |
| Kobayashi, S | 1 |
| Nio, Y | 1 |
| Imai, S | 1 |
| Shiraishi, T | 1 |
| Ohgaki, K | 1 |
| Tobe, T | 1 |
| Aguiar, JL | 1 |
| Berger, MR | 1 |
| Frank, N | 1 |
6 other studies available for fluorouracil and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Chemoembolization, Therapeutic; Disea | 2015 |
Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Carbon Tetrachloride; Dihydrouracil Dehy | 2011 |
Lethal hepatic injury by combined treatment of radiation plus chemotherapy in rats with thioacetamide-induced liver cirrhosis.
Topics: Animals; Combined Modality Therapy; Fluorouracil; Liver; Liver Cirrhosis, Experimental; Liver Failur | 2003 |
Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Bile Ducts; Blotting, Northern; Body Weight; Cytochrome P- | 1999 |
[Anti-tumor effect of fluoropyrimidines on human tumor cell lines transplanted in nude mice with CCl4-induced liver dysfunction].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride; Cell Line; Colonic Ne | 1989 |
Locoregional application of 5-fluorouracil to the liver: alteration of pharmacokinetics and bone marrow toxicity in rats with thioacetamide-induced cirrhosis.
Topics: Alanine Transaminase; Animals; Bone Marrow; Female; Fluorouracil; Kinetics; Liver; Liver Cirrhosis, | 1987 |