Page last updated: 2024-10-27

fluorouracil and Cicatrix

fluorouracil has been researched along with Cicatrix in 72 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Cicatrix: The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.

Research Excerpts

ExcerptRelevanceReference
" We concluded mitomycin C might be more effective in reducing intraocular pressure and increasing qualified success compared to 5-fluorouracil."8.98Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma? ( Pimentel, E; Schmidt, J, 2018)
"The objective of this review is to assess the effects of post-operative injections of 5-Fluorouracil in eyes of people undergoing surgery for glaucoma."8.81Post-operative 5-Fluorouracil for glaucoma surgery. ( Bunce, C; Wilkins, MR; Wormald, R, 2001)
"This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes."7.81Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes. ( Bi, XZ; Li, CH; Nan, KH; Pan, WH; Ren, ZJ; Song, ZM; Sun, M; Yu, XP, 2015)
"To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits."7.72Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits. ( Düzcan, E; Eşme, A; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2004)
"To determine whether 5-fluorouracil is effective in reducing scarring after strabismus surgery we used rectus muscle surgery in experimental animals to compare a single intraoperative dose of 5-fluorouracil with mitomycin C and to compare results in similarly treated controls not receiving these antimetabolites."7.69Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. ( Evan, AP; Helveston, EM; Mora, JS; Sprunger, DT, 1997)
"5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses."7.675-fluorouracil and glaucoma filtering surgery. II. A pilot study. ( Anderson, DR; Gressel, MG; Heuer, DK; Hodapp, E; Palmberg, PF; Parrish, RK, 1984)
"The effect of 5-fluorouracil (5-FU) subconjunctival injection on the bleb formation and intraocular pressure (IOP) following trabeculectomy was studied in 18 glaucoma patients (20 eyes) with poor surgical prognosis."7.675-Fluorouracil for trabeculectomy in glaucoma. ( Kitazawa, Y; Nakano, Y; Shirato, S; Taniguchi, T; Yamamoto, T, 1987)
"Four cases of cicatricial ectropion secondary to prolonged systemic administration of 5-fluorouracil are described."7.65Cicatricial ectropion secondary to 5-fluorouracil therapy. ( Ellerby, RA; Mausolf, FA; McCracken, JD; Straus, DJ, 1977)
"Raised intraocular pressure is a risk factor for glaucoma."6.52Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery. ( Cabourne, E; Clarke, JC; Evans, JR; Schlottmann, PG, 2015)
"Mitomycin C seems to be a better treatment than 5 fluorouracil."6.38[Mitomycin C in glaucoma surgery]. ( Collignon-Brach, J, 1993)
"5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation."5.275-fluorouracil and glaucoma filtering surgery: I. An animal model. ( Folberg, R; Gressel, MG; Parrish, RK, 1984)
"We conducted a prospective, randomized study to compare mitomycin with fluorouracil for efficacy and safety as an adjunct to trabeculectomy in eyes with glaucoma with poor surgical prognosis."5.07Trabeculectomy with mitomycin. A comparative study with fluorouracil. ( Kawase, K; Kitazawa, Y; Matsushita, H; Minobe, M, 1991)
" We concluded mitomycin C might be more effective in reducing intraocular pressure and increasing qualified success compared to 5-fluorouracil."4.98Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma? ( Pimentel, E; Schmidt, J, 2018)
"The objective of this review is to assess the effects of post-operative injections of 5-Fluorouracil in eyes of people undergoing surgery for glaucoma."4.81Post-operative 5-Fluorouracil for glaucoma surgery. ( Bunce, C; Wilkins, MR; Wormald, R, 2001)
"This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes."3.81Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes. ( Bi, XZ; Li, CH; Nan, KH; Pan, WH; Ren, ZJ; Song, ZM; Sun, M; Yu, XP, 2015)
"to investigate the ability of drug-loaded N,O-carboxymethyl chitosan (CMCS) hydrogels to modulate wound healing after glaucoma filtration surgery."3.76Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: synthesis, in vitro and in vivo evaluation. ( CAI, X; CHEN, RF; CHENG, LZ; FAN, JZ; GUO, H; LAN, YQ; YANG, LQ; ZHANG, LM; ZHOU, HS, 2010)
"To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits."3.72Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits. ( Düzcan, E; Eşme, A; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2004)
"To determine whether 5-fluorouracil is effective in reducing scarring after strabismus surgery we used rectus muscle surgery in experimental animals to compare a single intraoperative dose of 5-fluorouracil with mitomycin C and to compare results in similarly treated controls not receiving these antimetabolites."3.69Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. ( Evan, AP; Helveston, EM; Mora, JS; Sprunger, DT, 1997)
"Repeated doses of 5mg of 5-fluorouracil (5-FU) were injected subconjunctivally in 25 poor-prognosis glaucomatous eyes after filtering surgery to prevent filtering bleb scarring."3.68Regulating the dose of 5-fluorouracil to prevent filtering bleb scarring. ( Ophir, A; Ticho, U, 1991)
"5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses."3.675-fluorouracil and glaucoma filtering surgery. II. A pilot study. ( Anderson, DR; Gressel, MG; Heuer, DK; Hodapp, E; Palmberg, PF; Parrish, RK, 1984)
"The effect of 5-fluorouracil (5-FU) subconjunctival injection on the bleb formation and intraocular pressure (IOP) following trabeculectomy was studied in 18 glaucoma patients (20 eyes) with poor surgical prognosis."3.675-Fluorouracil for trabeculectomy in glaucoma. ( Kitazawa, Y; Nakano, Y; Shirato, S; Taniguchi, T; Yamamoto, T, 1987)
"Four cases of cicatricial ectropion secondary to prolonged systemic administration of 5-fluorouracil are described."3.65Cicatricial ectropion secondary to 5-fluorouracil therapy. ( Ellerby, RA; Mausolf, FA; McCracken, JD; Straus, DJ, 1977)
"The oral mucositis is a mucosal alteration that usually arises from oncological treatments, such as chemotherapy, and it is characterized as an inflammatory process."3.30The chromatographic constitution of andiroba oil and his healing effects, compared to the LLLT outcomes, in oral mucositis induced in golden Syrian hamsters: a new treatment option. ( Alcantara, DDFA; Burbano, RMR; Gomes, JT; Júnior, SMA; Oliveira, CP; Rodrigues, EM; Soares, BM; Soares, RHFC; Tuji, FM; Wanzeler, AMV, 2023)
"Hypertrophic scars and keloids may complicate wound healing secondary to trauma or surgery."2.69Treatment of inflamed hypertrophic scars using intralesional 5-FU. ( Fitzpatrick, RE, 1999)
"An approach to scar management that targets specific characteristics of a scar using a combination of surgical and nonsurgical modalities can significantly improve the appearance of most scars."2.55Treating Scars of the Cheek Region. ( Boahene, KD; Owusu, JA, 2017)
"Periorbital scarring with eyelid retraction can have serious visual effects and can lead to loss of vision or even loss of the eye."2.55Periorbital Scar Correction. ( Chambers, CB; Moe, KS, 2017)
"New modalities such as the scar team approach, autologous fat transfer, and ablative fractional laser resurfacing suggest a promising future for children who suffer symptomatically from their scars."2.53Scar Management in the Pediatric and Adolescent Populations. ( Donelan, MB; Krakowski, AC; Shumaker, PR; Totri, CR, 2016)
"Surgical scars are best treated with a combination approach to address various features of the scar."2.53A Combination Approach to Surgical Scars. ( Cohen, JL; Eilers, RE; Ortiz, AE; Ross, EV, 2016)
"Raised intraocular pressure is a risk factor for glaucoma."2.52Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery. ( Cabourne, E; Clarke, JC; Evans, JR; Schlottmann, PG, 2015)
"Though both forms of pathologic scarring are distinct entities at the macro and microscopic level, their etiologies and treatment are often similar."2.46The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review. ( Basdag, B; Magarakis, M; Manson, PN; Rosson, GD; Shridharani, SM; Singh, NK, 2010)
"For atrophic scars, different types of lasers represent modern treatment modalities with satisfactory results."2.42Novel opportunities in the treatment and prevention of scarring. ( Berman, B; Ramirez, CC; Villa, AM, 2004)
"The use of antiscarring agents, particularly the antimetabolites 5-fluorouracil and mitomycin C, have revolutionized glaucoma surgery over the past decade."2.39Current techniques in wound healing modulation in glaucoma surgery. ( Khaw, PT; Migdal, CS, 1996)
"The implantation of cervical cancer in an episiotomy scar is very rare."2.38Squamous cell carcinoma of the cervix implanting in the episiotomy site. ( Issa, PY; Khalil, AM; Khatib, RA; Mufarrij, AA; Tawil, AN, 1993)
"Mitomycin C seems to be a better treatment than 5 fluorouracil."2.38[Mitomycin C in glaucoma surgery]. ( Collignon-Brach, J, 1993)
"Filtering bleb encapsulation may, in some cases, be a severe complication following filtering surgery."2.38Encapsulated filtering bleb. A selective review--new deductions. ( Ophir, A, 1992)
"The area and the height of the bleb in the conjunctivae with radial incision (Ain and Hin, respectively) were compared with the area and the height of the bleb in the conjunctivae without radial incision (Ano and Hno, respectively)."1.35Restricted post-trabeculectomy bleb formation by conjunctival scarring. ( Inatani, M; Iwao, K; Ogata-Iwao, M; Takihara, Y; Tanihara, H, 2009)
"To study the effect of tissue plasminogen activator (t-PA) in combination with 5-fluorouracil (5-Fu) polyphase liposome on the prevention of scar formation in filtration surgery."1.30[The inhibitory effect of tissue plasminogen activator combined with 5-fluorouracil polyphase liposome on the scar formation in experimental filtration surgery]. ( Chen, R; Jing, M; Xi, S, 1997)
"A review of 20 patients with postburn scar carcinoma is presented."1.28Postburn scar carcinoma. ( Aron, NK; Tajuri, S, 1989)
" In addition, toxic effects of 5-FU on existing fibroblasts, in rabbits and in vitro, were demonstrated."1.28Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy. ( Ophir, A; Ticho, U, 1992)
"5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation."1.275-fluorouracil and glaucoma filtering surgery: I. An animal model. ( Folberg, R; Gressel, MG; Parrish, RK, 1984)
"Ater eight days, a hypertrophic scar formed, with the corneal endothelium extending over the scarred surface."1.27Q-switched neodymium-YAG laser trabeculopuncture in monkeys. ( Epstein, DL; Melamed, S; Pei, J; Puliafito, CA, 1985)
"A case of extensive Bowen's disease of the skin treated successfully with topical 5-fluor-uracil is described."1.26[Therapy of morbus Bowen with 5-fluoro-uracil ointment (author's transl)]. ( Grussendorf, EI; Krause, H, 1979)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-199016 (22.22)18.7374
1990's19 (26.39)18.2507
2000's13 (18.06)29.6817
2010's20 (27.78)24.3611
2020's4 (5.56)2.80

Authors

AuthorsStudies
Gupta, R1
Thomas, R1
Almukhtar, F1
Kiran, A1
Gomes, JT1
Wanzeler, AMV1
Júnior, SMA1
Soares, RHFC1
Oliveira, CP1
Rodrigues, EM1
Soares, BM1
Alcantara, DDFA1
Burbano, RMR1
Tuji, FM1
Chen, KT1
Madison, R1
Moore, J1
Jin, D1
Fleischmann, Z1
Newberg, J1
Schrock, A1
Bhardwaj, N1
Lofgren, KT1
He, J1
Frampton, G1
Hegde, P1
Fabrizio, D1
Pishvaian, MJ1
Ebot, E1
Singhi, A1
Sokol, E1
Searle, T1
Al-Niaimi, F1
Ali, FR1
Wenande, E1
Erlendsson, AM1
Haedersdal, M1
Pimentel, E1
Schmidt, J1
Irvine, LE1
Nassif, PS1
Green, E1
Wilkins, M1
Bunce, C2
Wormald, R2
Cabourne, E1
Clarke, JC1
Schlottmann, PG1
Evans, JR1
Bi, XZ1
Pan, WH1
Yu, XP1
Song, ZM1
Ren, ZJ1
Sun, M1
Li, CH1
Nan, KH1
Krakowski, AC1
Totri, CR1
Donelan, MB1
Shumaker, PR1
Eilers, RE1
Ross, EV1
Cohen, JL1
Ortiz, AE1
Tsui, M1
Tajirian, A1
Boahene, KD1
Owusu, JA1
Chambers, CB1
Moe, KS1
Zarkovic, A1
Chow, K1
Mora, JS2
Iwao, K1
Inatani, M1
Ogata-Iwao, M1
Takihara, Y1
Tanihara, H1
How, A1
Chua, JL1
Charlton, A1
Su, R1
Lim, M1
Kumar, RS1
Crowston, JG1
Wong, TT1
Shridharani, SM1
Magarakis, M1
Manson, PN1
Singh, NK1
Basdag, B1
Rosson, GD1
Xu, XD1
Liang, L1
Chen, CS1
Lu, B1
Wang, NL1
Jiang, FG1
Zhang, XZ1
Zhuo, RX1
YANG, LQ1
LAN, YQ1
GUO, H1
CHENG, LZ1
FAN, JZ1
CAI, X1
ZHANG, LM1
CHEN, RF1
ZHOU, HS1
Nikkhah, D1
Abood, A1
Watt, D1
Duman, L1
Büyükyavuz, BI1
Altuntas, I1
Gökcimen, A1
Ceyhan, L1
Darici, H1
Aylak, F1
Tomruk, O1
Simon, S1
Temlett, J1
Chehade, M1
Selva, D1
Takanashi, K1
Katsuki, S1
Fujita, T1
Waga, E1
Shimodate, Y1
Sasaki, K1
Someya, T1
Ohno, K1
Fujita, M1
Spinks, RL1
Baker, SN1
Jackson, A1
Khaw, PT4
Lemon, RN1
Fraser, S1
Eşme, A1
Yildirim, C1
Tatlipinar, S1
Düzcan, E1
Yaylali, V1
Ozden, S1
Berman, B1
Villa, AM1
Ramirez, CC1
Klink, T1
Guthoff, R1
Grehn, F1
Schlunck, G1
Lemperle, G1
Rullan, PP1
Gauthier-Hazan, N1
Müller, M1
Pape, S1
Kusserow, C1
Hoerauf, H1
Laqua, H1
Labbé, A1
Khammari, C1
Baudouin, C1
Reish, RG1
Eriksson, E1
Heuer, DK1
Parrish, RK2
Gressel, MG2
Hodapp, E1
Palmberg, PF1
Anderson, DR1
Galentine, P1
Sloas, H1
Hargett, N1
Cupples, HP1
Folberg, R1
Ryan, RF1
Litwin, MS1
Krementz, ET1
Khalil, AM1
Khatib, RA1
Mufarrij, AA1
Tawil, AN1
Issa, PY1
Hurwitz, BS1
Collignon-Brach, J1
Jing, M2
Xi, S2
Chen, R2
Schmidbauer, JM1
Höh, H1
Jähnig, T1
Daberkow, I1
Khan, U1
Occleston, NL1
McGrouther, DA1
Lewandowska-Furmanik, M1
Toczołowski, J1
Migdal, CS1
Fitzpatrick, RE1
Xu, Y1
Yang, G1
Jin, W1
Mackay, HJ1
Williamson, EC1
Vasey, P1
Harnett, AN1
Sprunger, DT1
Helveston, EM1
Evan, AP1
Wilkins, MR1
Kriukov, AI2
Sharkov, SM2
Shubin, MN2
Kalashnikova, EA2
Khamzalieva, RB2
Akhmedov, ShM2
Kaplan, LA1
Walter, JF1
Macknet, KD1
Krause, H1
Grussendorf, EI1
Straus, DJ1
Mausolf, FA1
Ellerby, RA1
McCracken, JD1
Ophir, A4
Ticho, U2
Dietze, PJ1
Feldman, RM1
Gross, RL1
Kitazawa, Y2
Kawase, K1
Matsushita, H1
Minobe, M1
Grierson, I1
Hitchings, RA1
Rice, NS1
Aron, NK1
Tajuri, S1
Heath, TD1
Lopez, NG1
Lewis, GP1
Stern, WH1
Taniguchi, T1
Nakano, Y1
Shirato, S1
Yamamoto, T1
Flynn, JT1
Melamed, S1
Pei, J1
Puliafito, CA1
Epstein, DL1
Dickinson, JT1
Rooker, DW1
Leonard, JR1
Richardson, JR1
Linton, PC1
Leadbetter, GW1
Peck, GL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489]Phase 470 participants Interventional2004-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

21 reviews available for fluorouracil and Cicatrix

ArticleYear
5-Fluorouracil in Dermatology: The Diverse Uses Beyond Malignant and Premalignant Skin Disease.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2021, 03-01, Volume: 47, Issue:3

    Topics: Adrenal Cortex Hormones; Cicatrix; Combined Modality Therapy; Cosmetic Techniques; Dermatitis; Derma

2021
Opportunities for laser-assisted drug delivery in the treatment of cutaneous disorders.
    Seminars in cutaneous medicine and surgery, 2017, Volume: 36, Issue:4

    Topics: Administration, Cutaneous; Anesthetics, Local; Antineoplastic Agents; Cicatrix; Cosmetic Techniques;

2017
Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma?
    Medwave, 2018, Jan-18, Volume: 18, Issue:1

    Topics: Antimetabolites; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mitomycin; Randomiz

2018
5-Fluorouracil for glaucoma surgery.
    The Cochrane database of systematic reviews, 2014, Feb-19, Issue:2

    Topics: Antimetabolites; Cicatrix; Fluorouracil; Glaucoma; Humans; Randomized Controlled Trials as Topic; Tr

2014
Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery.
    The Cochrane database of systematic reviews, 2015, Nov-06, Issue:11

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Press

2015
Scar Management in the Pediatric and Adolescent Populations.
    Pediatrics, 2016, Volume: 137, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimetabolites; Child; Cicatrix; Com

2016
A Combination Approach to Surgical Scars.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2016, Volume: 42 Suppl 2

    Topics: Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Atrophy; Cicatrix; Combined Modality Thera

2016
Treating Scars of the Cheek Region.
    Facial plastic surgery clinics of North America, 2017, Volume: 25, Issue:1

    Topics: Anti-Inflammatory Agents; Antimetabolites; Cheek; Cicatrix; Combined Modality Therapy; Fluorouracil;

2017
Periorbital Scar Correction.
    Facial plastic surgery clinics of North America, 2017, Volume: 25, Issue:1

    Topics: Antimetabolites; Blepharoplasty; Cicatrix; Ectropion; Entropion; Eyelids; Fluorouracil; Humans

2017
The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review.
    Annals of plastic surgery, 2010, Volume: 64, Issue:3

    Topics: Antineoplastic Agents; Bleomycin; Cicatrix; Fluorouracil; Humans; Hypertrophy; Interferon-alpha; Kel

2010
Novel opportunities in the treatment and prevention of scarring.
    Journal of cutaneous medicine and surgery, 2004, Volume: 8 Suppl 3

    Topics: Bleomycin; Botulinum Toxins, Type A; Celecoxib; Cicatrix; Fluorouracil; Humans; Immunosuppressive Ag

2004
[Postoperative care after glaucoma filtration surgery].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2006, Volume: 103, Issue:9

    Topics: Administration, Topical; Cicatrix; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Immunosuppress

2006
Avoiding and treating dermal filler complications.
    Plastic and reconstructive surgery, 2006, Volume: 118, Issue:3 Suppl

    Topics: Adipose Tissue; Adrenal Cortex Hormones; Animals; Autoimmune Diseases; Biocompatible Materials; Catt

2006
[Wound healing modulation in glaucoma surgery].
    Journal francais d'ophtalmologie, 2007, Volume: 30, Issue:6

    Topics: Adult; Animals; Cataract Extraction; Child; Cicatrix; Eye Diseases; Filtering Surgery; Fluorouracil;

2007
Scar treatments: preclinical and clinical studies.
    Journal of the American College of Surgeons, 2008, Volume: 206, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bandages; Bleomycin; Cicatrix; Clinical Trials as

2008
Squamous cell carcinoma of the cervix implanting in the episiotomy site.
    Gynecologic oncology, 1993, Volume: 51, Issue:3

    Topics: Adult; Carcinoma, Squamous Cell; Cicatrix; Cisplatin; Doxorubicin; Episiotomy; Female; Fluorouracil;

1993
[Mitomycin C in glaucoma surgery].
    Bulletin de la Societe belge d'ophtalmologie, 1993, Volume: 247, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Midd

1993
Current techniques in wound healing modulation in glaucoma surgery.
    Current opinion in ophthalmology, 1996, Volume: 7, Issue:2

    Topics: Animals; Antimetabolites; Cataract Extraction; Cicatrix; Filtering Surgery; Fluorouracil; Glaucoma;

1996
Post-operative 5-Fluorouracil for glaucoma surgery.
    The Cochrane database of systematic reviews, 2001, Issue:3

    Topics: Antimetabolites; Cicatrix; Fluorouracil; Glaucoma; Humans; Trabeculectomy; Wound Healing

2001
Encapsulated filtering bleb. A selective review--new deductions.
    Eye (London, England), 1992, Volume: 6 ( Pt 4)

    Topics: Animals; Blister; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Post

1992
[Prevention of eye scarring by 5-fluorouracil].
    Harefuah, 1987, Nov-15, Volume: 113, Issue:10

    Topics: Animals; Cicatrix; Disease Models, Animal; Eye; Fluorouracil; Glaucoma; Humans; Postoperative Compli

1987

Trials

4 trials available for fluorouracil and Cicatrix

ArticleYear
The chromatographic constitution of andiroba oil and his healing effects, compared to the LLLT outcomes, in oral mucositis induced in golden Syrian hamsters: a new treatment option.
    Oncotarget, 2023, 01-12, Volume: 14

    Topics: Animals; Cicatrix; Cricetinae; Fluorouracil; Low-Level Light Therapy; Mesocricetus; Stomatitis

2023
[Use of 5-fluorouracil shortly after trabeculectomy].
    Klinika oczna, 1996, Volume: 98, Issue:6

    Topics: Antimetabolites; Cicatrix; Conjunctiva; Fluorouracil; Humans; Injections; Middle Aged; Ocular Hypert

1996
Treatment of inflamed hypertrophic scars using intralesional 5-FU.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1999, Volume: 25, Issue:3

    Topics: Acne Vulgaris; Adult; Aged; Anti-Inflammatory Agents; Antimetabolites; Cicatrix; Female; Fluorouraci

1999
Trabeculectomy with mitomycin. A comparative study with fluorouracil.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:12

    Topics: Adult; Aged; Cicatrix; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Intraocula

1991

Other Studies

47 other studies available for fluorouracil and Cicatrix

ArticleYear
Use of 5-Fluorouracil Injections in Traumatic Cicatricial Malposition of Eyelids.
    Plastic and reconstructive surgery, 2022, 09-01, Volume: 150, Issue:3

    Topics: Cicatrix; Ectropion; Eyelids; Fluorouracil; Humans

2022
A Novel HRD Signature Is Predictive of FOLFIRINOX Benefit in Metastatic Pancreatic Cancer.
    The oncologist, 2023, 08-03, Volume: 28, Issue:8

    Topics: Albumins; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BRCA2 Protein; Cicatrix; De

2023
Use of 5-Fluorouracil for Management of the Thick-Skinned Nose.
    Facial plastic surgery : FPS, 2018, Volume: 34, Issue:1

    Topics: Adult; Cicatrix; Cohort Studies; Esthetics; Female; Fluorouracil; Follow-Up Studies; Humans; Injecti

2018
Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Anterior Eye Segment; Cicatrix; Delayed-Action Preparations; Fluorouracil; Glaucoma; Glauco

2015
Cicatricial Ectropion With Topical 5% Fluorouracil Cream.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2016, Volume: 42, Issue:8

    Topics: Administration, Cutaneous; Aged, 80 and over; Antimetabolites, Antineoplastic; Cicatrix; Ectropion;

2016
Comparison of 90-s versus 5-min intraoperative 5-fluorouracil in trabeculectomy.
    International ophthalmology, 2010, Volume: 30, Issue:1

    Topics: Aged; Antihypertensive Agents; Antimetabolites; Blister; Cicatrix; Female; Fluorouracil; Follow-Up S

2010
Restricted post-trabeculectomy bleb formation by conjunctival scarring.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2009, Volume: 247, Issue:8

    Topics: Antimetabolites; Blister; Cicatrix; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; C

2009
Combined treatment with bevacizumab and 5-fluorouracil attenuates the postoperative scarring response after experimental glaucoma filtration surgery.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimet

2010
Peptide hydrogel as an intraocular drug delivery system for inhibition of postoperative scarring formation.
    ACS applied materials & interfaces, 2010, Volume: 2, Issue:9

    Topics: Animals; Cicatrix; Drug Carriers; Fluorouracil; Hydrogels; Oligopeptides; Ophthalmic Solutions; Post

2010
Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: synthesis, in vitro and in vivo evaluation.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:12

    Topics: Administration, Topical; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevaciz

2010
Cicatricial ectropion: a complication of topical 5-fluorouracil.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2012, Volume: 65, Issue:1

    Topics: Administration, Topical; Aged, 80 and over; Cicatrix; Ectropion; Facial Dermatoses; Fluorouracil; Fo

2012
The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn.
    Journal of pediatric surgery, 2011, Volume: 46, Issue:10

    Topics: Animals; Burns, Chemical; Caustics; Cell Differentiation; Cell Division; Cicatrix; Drug Evaluation,

2011
Medial rectus Botox injection with pterygium excision and autograft as a novel technique for management of recurrent pterygium.
    Clinical & experimental ophthalmology, 2012, Volume: 40, Issue:6

    Topics: Aged; Antimetabolites; Botulinum Toxins, Type A; Cicatrix; Combined Modality Therapy; Conjunctiva; F

2012
[A case of advanced primary colorectal carcinoma accompanied by liver metastasis in which ileus developed due to marked fibrosis with cicatricial formation in primary colorectal cancer treated by chemotherapy including bevacizumab].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2012, Volume: 109, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carc

2012
Problem of dural scarring in recording from awake, behaving monkeys: a solution using 5-fluorouracil.
    Journal of neurophysiology, 2003, Volume: 90, Issue:2

    Topics: Animals; Antimetabolites; Cerebral Cortex; Cicatrix; Connective Tissue; Dura Mater; Electrophysiolog

2003
Trabeculectomy and antimetabolites.
    The British journal of ophthalmology, 2004, Volume: 88, Issue:7

    Topics: Antimetabolites; Cicatrix; Clinical Competence; Fluorouracil; Glaucoma; Humans; Mitomycin; Trabecule

2004
Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits.
    Strabismus, 2004, Volume: 12, Issue:3

    Topics: Animals; Cicatrix; Connective Tissue Diseases; Fluorouracil; Intraoperative Care; Mitomycin; Oculomo

2004
[Late needling with 5-fluorouracil when scarring of filtering bleb seems imminent].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2007, Volume: 104, Issue:4

    Topics: Blister; Cicatrix; Cicatrix, Hypertrophic; Drug Administration Schedule; Filtering Surgery; Fluorour

2007
5-fluorouracil and glaucoma filtering surgery. II. A pilot study.
    Ophthalmology, 1984, Volume: 91, Issue:4

    Topics: Adolescent; Adult; Aged; Cataract Extraction; Child; Cicatrix; Combined Modality Therapy; Dose-Respo

1984
Bilateral cicatricial ectropion following topical administration of 5-fluorouracil.
    Annals of ophthalmology, 1981, Volume: 13, Issue:5

    Topics: Administration, Topical; Aged; Cicatrix; Drug Eruptions; Ectropion; Facial Dermatoses; Fluorouracil;

1981
5-fluorouracil and glaucoma filtering surgery: I. An animal model.
    Ophthalmology, 1984, Volume: 91, Issue:4

    Topics: Animals; Aotus trivirgatus; Cicatrix; Combined Modality Therapy; Fibroblasts; Fluorouracil; Glaucoma

1984
A new concept in the management of Marjolin's ulcers.
    Annals of surgery, 1981, Volume: 193, Issue:5

    Topics: Administration, Topical; Adult; Carcinoma, Squamous Cell; Cicatrix; Female; Fluorouracil; Humans; Ma

1981
Cicatricial ectropion: a complication of systemic fluorouracil.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1993, Volume: 111, Issue:12

    Topics: Aged; Aged, 80 and over; Breast Neoplasms; Cicatrix; Colonic Neoplasms; Dexamethasone; Ectropion; Fe

1993
[Subconjunctival 5-fluorouracil polyphase liposome interference with scar formation in experimental filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1996, Volume: 32, Issue:1

    Topics: Animals; Cicatrix; Drug Carriers; Female; Filtering Surgery; Fluorouracil; Glaucoma; Liposomes; Male

1996
[Antiproliferative therapy with 5-fluorouracil in erbium:YAG laser sclerostomy ab externo].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1996, Volume: 93, Issue:5

    Topics: Antimetabolites; Cell Division; Cicatrix; Combined Modality Therapy; Female; Fluorouracil; Glaucoma;

1996
Single exposures to 5-fluorouracil: a possible mode of targeted therapy to reduce contractile scarring in the injured tendon.
    Plastic and reconstructive surgery, 1997, Volume: 99, Issue:2

    Topics: Animals; Antimetabolites; Cells, Cultured; Cicatrix; Collagen; Cytoskeleton; Fibroblasts; Fluorourac

1997
[Injectable bioerodible polymer with 5-fluorouracil used in filtration surgery in rabbits].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1997, Volume: 33, Issue:3

    Topics: Animals; Antimetabolites; Cicatrix; Drug Delivery Systems; Female; Filtering Surgery; Fluorouracil;

1997
[The inhibitory effect of tissue plasminogen activator combined with 5-fluorouracil polyphase liposome on the scar formation in experimental filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1997, Volume: 33, Issue:5

    Topics: Animals; Cicatrix; Drug Carriers; Drug Synergism; Drug Therapy, Combination; Female; Fibrosis; Fluor

1997
Recurrent inflammation in a site of previous necrotising fasciitis during intravenous CMF chemotherapy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:9

    Topics: Abdomen; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cicatrix; Cyclophosphamid

1999
Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 1997, Volume: 1, Issue:2

    Topics: Administration, Topical; Animals; Antimetabolites; Cicatrix; Conjunctiva; Fluorouracil; Intraoperati

1997
[Prevention of postoperative scar processes in otorhinolaryngology experimental rationale].
    Vestnik otorinolaringologii, 2001, Issue:6

    Topics: Antimetabolites; Cell Movement; Cicatrix; Ear Diseases; Fibroblasts; Fluorouracil; Humans; Otologic

2001
[Prevention of postoperative scars in otorhinolaryngology: experimental rationale].
    Vestnik otorinolaringologii, 2002, Issue:2

    Topics: Cell Movement; Cicatrix; Fibroblasts; Fluorouracil; Immunosuppressive Agents; In Vitro Techniques; O

2002
Hypertrophic scarring as a complication of fluorouracil therapy.
    Archives of dermatology, 1979, Volume: 115, Issue:12

    Topics: Adult; Carcinoma, Basal Cell; Cicatrix; Fluocinonide; Fluorouracil; Humans; Hypertrophy; Male; Skin

1979
[Therapy of morbus Bowen with 5-fluoro-uracil ointment (author's transl)].
    Dermatosen in Beruf und Umwelt. Occupation and environment, 1979, Volume: 27, Issue:6

    Topics: Bowen's Disease; Carcinoma, Squamous Cell; Cicatrix; Fluorouracil; Humans; Male; Skin Neoplasms; Tim

1979
Cicatricial ectropion secondary to 5-fluorouracil therapy.
    Medical and pediatric oncology, 1977, Volume: 3, Issue:1

    Topics: Aged; Cicatrix; Ectropion; Female; Fluorouracil; Humans; Male; Middle Aged

1977
Toxic effects of 5-fluorouracil on fibroblasts following trabeculectomy.
    Ophthalmic research, 1992, Volume: 24, Issue:5

    Topics: Adult; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Inclusion Bodie

1992
Intraoperative application of 5-fluorouracil during trabeculectomy.
    Ophthalmic surgery, 1992, Volume: 23, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Cicatrix; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

1992
Regulating the dose of 5-fluorouracil to prevent filtering bleb scarring.
    Annals of ophthalmology, 1991, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Chamber; Child; Cicatrix; Conjunctiva; Dosage F

1991
5-fluorouracil and beyond.
    The British journal of ophthalmology, 1991, Volume: 75, Issue:10

    Topics: Child; Cicatrix; Fluorouracil; Glaucoma; Humans; Trabeculectomy

1991
Postburn scar carcinoma.
    Burns : journal of the International Society for Burn Injuries, 1989, Volume: 15, Issue:2

    Topics: Adult; Aged; Burns; Carcinoma, Squamous Cell; Cicatrix; Combined Modality Therapy; Female; Fluoroura

1989
Fluoropyrimidine treatment of ocular cicatricial disease.
    Investigative ophthalmology & visual science, 1986, Volume: 27, Issue:6

    Topics: Animals; Cell Division; Cicatrix; Eye Diseases; Fibroblasts; Floxuridine; Fluorouracil; Osmolar Conc

1986
5-Fluorouracil for trabeculectomy in glaucoma.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1987, Volume: 225, Issue:6

    Topics: Cicatrix; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Pos

1987
Problems in strabismus management.
    Transactions of the New Orleans Academy of Ophthalmology, 1986, Volume: 34

    Topics: Adolescent; Child; Cicatrix; Female; Fluorouracil; Humans; Male; Postoperative Complications; Strabi

1986
Q-switched neodymium-YAG laser trabeculopuncture in monkeys.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1985, Volume: 103, Issue:1

    Topics: Animals; Cicatrix; Fluorouracil; Hyaluronic Acid; Injections; Intraocular Pressure; Laser Therapy; M

1985
Minor surgery for benign and malignant facial lesions.
    American family physician, 1974, Volume: 10, Issue:5

    Topics: Acne Vulgaris; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cicatrix; Cortisone; Curettage; Cyst

1974
A new concept in the treatment of stomal stenosis.
    The Journal of urology, 1972, Volume: 108, Issue:1

    Topics: Cesium Isotopes; Child; Cicatrix; Fluorouracil; Humans; Ileum; Male; Mucus; Skin Diseases; Skin Tran

1972
Hypertrophic scar after cryotherapy and topical tretinoin.
    Archives of dermatology, 1973, Volume: 108, Issue:6

    Topics: Administration, Topical; Carcinoma, Basal Cell; Carmustine; Cicatrix; Connective Tissue; Cryosurgery

1973