fluorouracil has been researched along with Chronic Pancreatitis in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic pancreatitis is characterized by chronic inflammation and fibrosis, processes heightened by activated pancreatic stellate cells (PSCs)." | 1.91 | 5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro. ( Almanzar, VMD; Bialkowska, AB; Cheung, J; Ju, J; LaComb, JF; Mojumdar, A; Patel, HR; Shah, K; Tang, M, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Almanzar, VMD | 1 |
| Shah, K | 1 |
| LaComb, JF | 1 |
| Mojumdar, A | 1 |
| Patel, HR | 1 |
| Cheung, J | 1 |
| Tang, M | 1 |
| Ju, J | 1 |
| Bialkowska, AB | 1 |
| Gurzu, S | 1 |
| Jung, I | 1 |
| Comsulea, M | 1 |
| Kadar, Z | 1 |
| Azamfirei, L | 1 |
| Molnar, C | 1 |
2 other studies available for fluorouracil and Chronic Pancreatitis
| Article | Year |
|---|---|
5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro.
Topics: Animals; Cell Proliferation; Fibrosis; Fluorouracil; Mice; MicroRNAs; Pancreatic Stellate Cells; Pan | 2023 |
Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman.
Topics: Acute Disease; Adenocarcinoma; Adult; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protoco | 2013 |