Page last updated: 2024-10-27

fluorouracil and Chronic Kidney Failure

fluorouracil has been researched along with Chronic Kidney Failure in 30 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
" We sought to evaluate the pharmacokinetics of cisplatin and 5-fluorouracil in plasma and peritoneal dialysate in a patient being treated for esophageal adenocarcinoma."3.83A pharmacokinetic analysis of cisplatin and 5-fluorouracil in a patient with esophageal cancer on peritoneal dialysis. ( Beumer, JH; Eads, JR; Holleran, JL; Meropol, NJ; Negrea, L; Strychor, S, 2016)
"A 64-year-old man on chronic hemodialysis for end-stage renal disease developed peritoneal carcinomatosis, and palliative chemotherapy with fluorouracil was started."3.73Effect of hemodialysis on the metabolic clearance of 5-Fluorouracil in a patient with end-stage renal failure. ( Cartei, G; Ferrari, M; Ferrazzi, E; Gusella, M; Padrini, R; Rebeschini, M, 2005)
"Following gastrectomy for locally advanced adenocarcinomas, three patients developed microangiopathic hemolytic anemia and renal failure shortly after completing courses of adjuvant chemotherapy with mitomycin and 5-FU."3.66Microangiopathic hemolytic anemia, renal failure, and noncardiogenic pulmonary edema: a chemotherapy-induced syndrome. ( Band, PR; Bettez, P; Giroux, L; Gruber, J; Jolivet, J; Laurin, S, 1983)
"Fourteen patients with adenocarcinoma of the gastrointestinal tract and pancreas treated with mitomycin C(MMC) and 5-fluorouracil (5-FU) had renal impairment 6-11 months from the beginning of MMC therapy."3.66Renal disease after mitomycin C therapy. ( Hanna, WT; Krauss, S; Murphy, WM; Regester, RF, 1981)
"A 72 year old man with rectal adenocarcinoma developed chronic renal failure when treated by surgery and subsequent chemotherapy (5-fluorouracil, Mitomycin C and Cytosine arabinoside) and immunotherapy."3.66Severe glomerular mesangiolysis in a patient with rectal adenocarcinoma treated with cytotoxic drugs. ( Fornari, G; Mazzucco, G; Monga, G, 1982)
" Alternatively, the concept of prior dosing allows for the application of dialyzable chemotherapeutic drugs using a normal dose, with an HD followed shortly after to mimic normal renal function."2.58Chemotherapeutic agents eligible for prior dosing in pancreatic cancer patients requiring hemodialysis: a systematic review
. ( Egger, J; Hann, A; Hermann, PC; Keller, F; Nosalski, E; Seufferlein, T, 2018)
"Here, we report a case with recurrence of rectal cancer who received FOLFIRI with bevacizumab chemotherapy under haemodialysis, and obtained good tumor control."2.48[FOLFIRI with bevacizumab chemotherapy for a patient with recurrence of rectal cancer under haemodialysis for chronic renal failure]. ( Endo, T; Hasegawa, H; Hoshino, G; Hoshino, H; Hoshino, Y; Ishii, Y; Kitagawa, Y; Matsunaga, A; Ochiai, H; Seo, Y; Shigeta, K, 2012)
"Capecitabine (Xeloda) is an orally administered precursor of 5'deoxy-5-fluorouridine, which is a preferentially activated to 5-fluorouracil in tumors."1.38A retrospective observational study on the use of capecitabine in patients with severe renal impairment (GFR <30 mL/min) and end stage renal disease on hemodialysis. ( Flombaum, C; Jhaveri, KD; Latcha, S; Shah, M, 2012)
" The CDDP dosage was reduced to 40% and HD was started 30 minutes after CDDP administration."1.35[Successful treatment with 5-fluorouracil and cis-dichlorodiammineplatinum combined with 60Gy of radiation in a case of advanced esophageal cancer complicated with chronic renal failure treated with hemodialysis]. ( Arai, Y; Hotta, K; Miyata, Y; Oyama, T; Tomori, A, 2008)
" The dosage of each drug was based on that for a patient undergoing hemodialysis, and the plasma concentration of each drug was examined."1.33[Chemotherapy for an esophageal cancer patient undergoing continuous ambulatory peritoneal dialysis for chronic renal failure and measurement of plasma concentration of the drug]. ( Maruyama, K; Motoyama, S; Ogawa, J; Ohta, H; Okuyama, M; Oyake, J; Tsuchiya, N, 2005)
" S-1 has safe and potent antitumor effects in patients with gastric cancer via these respective functions."1.32Safety and efficacy of S-1, a novel oral fluorouracil antitumor drug, for a chronic renal failure patient maintained on hemodialysis. ( Arakawa, T; Fujiwara, Y; Hamaguchi, M; Higuchi, K; Matsumoto, T; Okazaki, H; Oshitani, N; Sasaki, E; Shiba, M; Suto, R; Tanigawa, T; Tominaga, K; Watanabe, T, 2004)
" Because no data are available for patients with severe renal failure, the pharmacokinetic parameters of 5-FU and its catabolites were determined for a patient with colorectal carcinoma and end-stage renal disease on maintenance hemodialysis therapy."1.31Pharmacokinetics of 5-fluorouracil and its catabolites determined by 19F nuclear magnetic resonance spectroscopy for a patient on chronic hemodialysis. ( Bommer, J; Göggelmann, C; Hull, WE; Rengelshausen, J; Schwenger, V; Walter-Sack, I, 2002)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19905 (16.67)18.7374
1990's3 (10.00)18.2507
2000's11 (36.67)29.6817
2010's10 (33.33)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Maruta, M1
Miyoshi, T1
Matsuo, N1
Yamashina, T1
Irie, K1
Tsuruta, M1
Tsukada, H1
Tsuruyama, M1
Nagano, M1
Hiraki, Y1
Hann, A1
Nosalski, E1
Hermann, PC1
Egger, J1
Seufferlein, T1
Keller, F1
Bolonesi, RM1
Rogers, JE1
Shureiqi, I1
Gori, S1
Lunardi, G1
Inno, A1
Magarotto, R1
Duranti, S1
Messa, MG1
Mucchino, C1
Cirillo, M1
Eads, JR1
Beumer, JH1
Negrea, L1
Holleran, JL1
Strychor, S1
Meropol, NJ1
Takeda, T1
Miyake, M2
Tanaka, K1
Uemura, M1
Ikeda, M1
Maeda, S1
Yamamoto, K1
Hama, N1
Nishikawa, K1
Miyamoto, A1
Miyazaki, M1
Hirao, M1
Nakamori, S1
Sekimoto, M1
Arai, Y1
Oyama, T1
Hotta, K1
Tomori, A1
Miyata, Y1
Saito, Y1
Shimada, K1
Ohno, Y1
Toshima, H1
Kobayashi, K1
Miyashita, K1
Tsuchiya, S1
Takinishi, Y1
Miyokawa, A1
Itoh, T1
Sakashita, A1
Kuwabara, H1
Baba, H2
Wakabayashi, M1
Nakamura, H1
Sanada, T1
Nakajima, K1
Goseki, N1
Jhaveri, KD1
Flombaum, C1
Shah, M1
Latcha, S1
Hoshino, H1
Ishii, Y1
Hasegawa, H1
Endo, T1
Ochiai, H1
Hoshino, Y1
Matsunaga, A1
Shigeta, K1
Seo, Y1
Hoshino, G1
Kitagawa, Y1
Kitade, H1
Shimasaki, T1
Yoshimitsu, Y1
Okuda, M1
Hokkoku, K1
Mori, M1
Shintaku, K1
Sakuma, H1
Ueda, H1
Nakai, M1
Tominaga, K1
Higuchi, K1
Okazaki, H1
Suto, R1
Hamaguchi, M1
Tanigawa, T1
Sasaki, E1
Shiba, M1
Watanabe, T1
Fujiwara, Y1
Oshitani, N1
Matsumoto, T1
Arakawa, T1
Tanaka, T1
Fujita, S1
Tanaka, N2
Ooka, M1
Okajima, S1
Okuyama, M1
Motoyama, S1
Maruyama, K1
Ohta, H1
Tsuchiya, N1
Oyake, J1
Ogawa, J1
Gusella, M1
Rebeschini, M1
Cartei, G1
Ferrazzi, E1
Ferrari, M1
Padrini, R1
Cicin, I1
Karagol, H1
Uzunoglu, S1
Uygun, K1
Vénat-Bouvet, L1
Saint-Marcoux, F1
Lagarde, C1
Peyronnet, P1
Lebrun-Ly, V1
Tubiana-Mathieu, N1
Ohnishi, T1
Kanoh, T1
Shiozaki, K1
Kimura, Y1
Iwazawa, T1
Tono, T1
Nakano, Y1
Yano, K1
Mizuno, H1
Shin, S1
Monden, T1
Jolivet, J1
Giroux, L1
Laurin, S1
Gruber, J1
Bettez, P1
Band, PR1
Hanna, WT1
Krauss, S1
Regester, RF1
Murphy, WM1
Mazzucco, G1
Fornari, G1
Monga, G1
Watanabe, A1
Saito, T1
Sakamoto, K1
Arita, S1
Hisikawa, E1
Yaguchi, H1
Arima, H1
Matsumoto, M1
Hachisu, T1
Kashiwabara, H1
Yokoyama, T1
Maruyama, M1
Irie, T1
Yoshida, T1
Nagahama, T1
Sugano, N1
Ebuchi, M1
Cho, H1
Imada, T1
Masudo, K1
Doi, C1
Inaba, M1
Tokunaga, M1
Takanashi, Y1
Iwasaki, A1
Tanizaki, A1
Ohbayashi, Y1
Nagahata, S1
Takahashi, N1
Rengelshausen, J1
Hull, WE1
Schwenger, V1
Göggelmann, C1
Walter-Sack, I1
Bommer, J1
Claycomb, CL1
Berkovic, M1
Tamura, J1
Kamano, T1
Azuma, N1
Katami, A1
Sato, T2
Uchida, N1
Kanno, T1
Kiyatake, I1
Kakuhara, T1

Reviews

2 reviews available for fluorouracil and Chronic Kidney Failure

ArticleYear
Chemotherapeutic agents eligible for prior dosing in pancreatic cancer patients requiring hemodialysis: a systematic review
.
    Clinical nephrology, 2018, Volume: 90, Issue:2

    Topics: Afatinib; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carci

2018
[FOLFIRI with bevacizumab chemotherapy for a patient with recurrence of rectal cancer under haemodialysis for chronic renal failure].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:6

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camp

2012

Trials

1 trial available for fluorouracil and Chronic Kidney Failure

ArticleYear
[Pharmacokinetic study of UFT in cancer patients receiving maintenance dialysis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuva

1995

Other Studies

27 other studies available for fluorouracil and Chronic Kidney Failure

ArticleYear
Clinical pharmacokinetics of oxaliplatin in a hemodialysis patient with advanced gastric cancer.
    Journal of chemotherapy (Florence, Italy), 2021, Volume: 33, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Fluorouracil; Huma

2021
A case report--treatment of metastatic colorectal cancer in a patient on hemodialysis.
    Journal of gastrointestinal cancer, 2014, Volume: 45 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Hu

2014
Pharmacokinetics of oxaliplatin in a hemodialyzed patient: chemotherapy dose adjustment and timing of dialysis.
    Clinical colorectal cancer, 2014, Volume: 13, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response

2014
A pharmacokinetic analysis of cisplatin and 5-fluorouracil in a patient with esophageal cancer on peritoneal dialysis.
    Cancer chemotherapy and pharmacology, 2016, Volume: 77, Issue:2

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Dialysis Solutions; Esoph

2016
[XELOX plus Bevacizumab Chemotherapy for a Patient with Postoperative Recurrence of Colorectal Cancer Under Hemodialysis for Chronic Renal Failure].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2015, Volume: 42, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colectomy; Combined

2015
[Successful treatment with 5-fluorouracil and cis-dichlorodiammineplatinum combined with 60Gy of radiation in a case of advanced esophageal cancer complicated with chronic renal failure treated with hemodialysis].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2008, Volume: 105, Issue:10

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy P

2008
[5-FU/l-LV therapy is useful for hemodialysis patients with advanced gastric cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:3

    Topics: Aged; Biopsy; Fluorouracil; Humans; Kidney Failure, Chronic; Leucovorin; Male; Neoplasm Staging; Ren

2011
[mFOLFOX6 and FOLFIRI/bevacizumab treatment in a patient on hemodialysis with metastatic colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:12

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Pro

2011
A retrospective observational study on the use of capecitabine in patients with severe renal impairment (GFR <30 mL/min) and end stage renal disease on hemodialysis.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2012, Volume: 18, Issue:1

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Creatinine; Deoxycytidine; D

2012
[A case of colon cancer with chronic renal dysfunction responding to effective retreatment with FOLFIRI].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil;

2012
Safety and efficacy of S-1, a novel oral fluorouracil antitumor drug, for a chronic renal failure patient maintained on hemodialysis.
    Oncology, 2004, Volume: 66, Issue:5

    Topics: Administration, Oral; Drug Administration Schedule; Drug Combinations; Fluorouracil; Humans; Kidney

2004
[TS-1 treatment for progressive gastric cancer in a patient on chronic dialysis--assessment of dosage regimen by monitoring blood concentrations of therapeutic drugs (TDM)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:6

    Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Area Under Curve; Drug Administration Schedu

2005
[Chemotherapy for an esophageal cancer patient undergoing continuous ambulatory peritoneal dialysis for chronic renal failure and measurement of plasma concentration of the drug].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cisplatin; Dose-Response Relations

2005
Effect of hemodialysis on the metabolic clearance of 5-Fluorouracil in a patient with end-stage renal failure.
    Therapeutic drug monitoring, 2005, Volume: 27, Issue:6

    Topics: Antimetabolites, Antineoplastic; Fluorouracil; Humans; Injections, Intravenous; Kidney Failure, Chro

2005
Efficient and safe application of a FOLFIRI/bevacizumab combination to a patient with locally advanced rectal cancer and severe chronic renal failure.
    Onkologie, 2007, Volume: 30, Issue:1-2

    Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopl

2007
Irinotecan-based chemotherapy in a metastatic colorectal cancer patient under haemodialysis for chronic renal dysfunction: two cases considered.
    Anti-cancer drugs, 2007, Volume: 18, Issue:8

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Ch

2007
[FOLFOX 4 in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Routes; Female; Fluorourac

2007
Microangiopathic hemolytic anemia, renal failure, and noncardiogenic pulmonary edema: a chemotherapy-induced syndrome.
    Cancer treatment reports, 1983, Volume: 67, Issue:5

    Topics: Adenocarcinoma; Adult; Anemia, Hemolytic; Drug Therapy, Combination; Female; Fluorouracil; Humans; K

1983
Renal disease after mitomycin C therapy.
    Cancer, 1981, Dec-15, Volume: 48, Issue:12

    Topics: Acute Kidney Injury; Adenocarcinoma; Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Creatinine; F

1981
Severe glomerular mesangiolysis in a patient with rectal adenocarcinoma treated with cytotoxic drugs.
    Virchows Archiv. A, Pathological anatomy and histopathology, 1982, Volume: 398, Issue:2

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Cytarabine; Fluorescent Antibody Technique; Fluorouraci

1982
[Treatment of tongue squamous cell carcinoma under hemodialysis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1995, Volume: 22, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali

1995
[Hemodynamics at hepatoarterial infusion of 5-FU in a chronic renal failure patient maintained by hemodialysis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:14

    Topics: Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Fluorouracil; Hepatic Artery; Humans; I

1999
[Combined 5-FU and CDDP in a gastric cancer patient undergoing hemodialysis--pharmacokinetics of 5-FU and CDDP].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:13

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fema

2000
[Chemotherapy with nedaplatin for an oral floor cancer patient undergoing chronic hemodialysis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:14

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Drug Administration

2000
Pharmacokinetics of 5-fluorouracil and its catabolites determined by 19F nuclear magnetic resonance spectroscopy for a patient on chronic hemodialysis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 39, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Colonic Neoplasms;

2002
Microangiopathic hemolytic anemia, noncardiac pulmonary edema, and renal failure after treatment of metastatic adenocarcinoma of the colon with 5-fluorouracil and mitomycin-C: report of a case.
    The Journal of the American Osteopathic Association, 1986, Volume: 86, Issue:8

    Topics: Adenocarcinoma; Anemia, Hemolytic; Colonic Neoplasms; Female; Fluorouracil; Humans; Kidney Failure,

1986
[Absorption of 5-FU orally administered in a patient with postoperative gastric cancer under artificial dialysis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:9

    Topics: Administration, Oral; Combined Modality Therapy; Fluorouracil; Gastrectomy; Humans; Kidney Failure,

1987