fluorouracil has been researched along with Chronic Hepatitis B in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because previous studies showed that long-term telbivudine treatment improved renal function in chronic hepatitis B virus (HBV) infected patients, we conducted a case-control study to evaluate the clinical outcome of telbivudine preemptive therapy in HBV-related advanced HCC patients treated by combination chemotherapy comprising 5-fluorouracil, mitoxantrone and cisplatin (FMP)." | 5.19 | Significant renoprotective effect of telbivudine during preemptive antiviral therapy in advanced liver cancer patients receiving cisplatin-based chemotherapy: a case-control study. ( Chang, ML; Chen, YC; Chien, RN; Hsu, CW; Lin, CL; Yeh, C; Yeh, CT, 2014) |
| "Pegylated liposomal doxorubicin-based combination chemotherapy with capecitabine or gemcitabine was not effective as salvage therapy in advanced hepatocellular carcinoma." | 5.11 | Pegylated liposomal doxorubicin-based combination chemotherapy as salvage treatment in patients with advanced hepatocellular carcinoma. ( Bai, LY; Chen, PM; Poh, SB, 2005) |
| " Transcatheter arterial chemoembolization is a standard treatment option for patients with unresectable HCC, especially when combined with other therapies." | 1.35 | A patient with huge hepatocellular carcinoma who had a complete clinical response to p53 gene combined with chemotherapy and transcatheter arterial chemoembolization. ( Liu, J; Sui, J; Tian, G, 2009) |
| "Case 1 was a 71-year-old woman with a hepatocellular carcinoma (HCC), 45 mm in diameter, with liver cirrhosis." | 1.34 | [Three cases of hepatocellular carcinoma, over 3 cm in diameter, with liver cirrhosis treated with combination of radiofrequency ablation and continuous hepatic arterial infusion chemotherapy]. ( Hirashita, T; Nakashima, K; Sakai, I; Sakai, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, J | 1 |
| Zhang, X | 1 |
| Cui, R | 1 |
| Zhang, J | 2 |
| Wang, Z | 1 |
| Jia, Y | 1 |
| Miao, R | 1 |
| Dong, Y | 1 |
| Ma, X | 1 |
| Fan, H | 1 |
| Wang, H | 1 |
| Ren, L | 1 |
| Li, Y | 1 |
| Niu, W | 1 |
| Qu, K | 1 |
| Liu, C | 1 |
| Lin, CL | 1 |
| Chien, RN | 1 |
| Yeh, C | 1 |
| Hsu, CW | 1 |
| Chang, ML | 1 |
| Chen, YC | 1 |
| Yeh, CT | 1 |
| Park, KW | 1 |
| Seo, CJ | 1 |
| Yun, DY | 1 |
| Kim, MK | 1 |
| Kim, BS | 1 |
| Han, YS | 1 |
| Oh, HK | 1 |
| Lee, CH | 1 |
| Kanayama, M | 1 |
| Nagai, H | 2 |
| Sumino, Y | 2 |
| Momiyama, K | 1 |
| Tian, G | 1 |
| Liu, J | 1 |
| Sui, J | 1 |
| Poh, SB | 1 |
| Bai, LY | 1 |
| Chen, PM | 1 |
| Yeo, W | 1 |
| Mo, FK | 1 |
| Chan, SL | 1 |
| Leung, NW | 1 |
| Hui, P | 1 |
| Lam, WY | 1 |
| Mok, TS | 1 |
| Lam, KC | 1 |
| Ho, WM | 1 |
| Koh, J | 1 |
| Tang, JW | 1 |
| Chan, AT | 1 |
| Chan, PK | 1 |
| Hirashita, T | 1 |
| Nakashima, K | 1 |
| Sakai, M | 1 |
| Sakai, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Observational, Single-center Post-marketing Surveillance Study of Telbivudine in Chronic Hepatitis B Adults With HBeAg Positive/Negative.[NCT00970216] | 160 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00970216)
Timeframe: 48 weeks
| Intervention | participants (Number) |
|---|---|
| Chronic Hepatitis B | 79 |
4 trials available for fluorouracil and Chronic Hepatitis B
| Article | Year |
|---|---|
Significant renoprotective effect of telbivudine during preemptive antiviral therapy in advanced liver cancer patients receiving cisplatin-based chemotherapy: a case-control study.
Topics: Acute Kidney Injury; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2014 |
Influence of the etiology of liver cirrhosis on the response to combined intra-arterial chemotherapy in patients with advanced hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocel | 2009 |
Pegylated liposomal doxorubicin-based combination chemotherapy as salvage treatment in patients with advanced hepatocellular carcinoma.
Topics: Adult; Aged; alpha-Fetoproteins; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy P | 2005 |
Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined C | 2007 |
5 other studies available for fluorouracil and Chronic Hepatitis B
| Article | Year |
|---|---|
Prognostic predictors for patients with hepatocellular carcinoma receiving adjuvant transcatheter arterial chemoembolization.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy | 2019 |
A case of hepatoblastoma misdiagnosed as combined hepatocellular carcinoma and cholangiocarcinoma in an adult.
Topics: Adult; Carcinoma, Hepatocellular; Cholangiocarcinoma; Cisplatin; Diagnostic Errors; Doxorubicin; Dru | 2015 |
Changes of host immunity in relation to efficacy in liver cirrhosis patients with advanced hepatocellular carcinoma treated by intra-arterial chemotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Case-Control Studie | 2009 |
A patient with huge hepatocellular carcinoma who had a complete clinical response to p53 gene combined with chemotherapy and transcatheter arterial chemoembolization.
Topics: Adenoviruses, Human; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, | 2009 |
[Three cases of hepatocellular carcinoma, over 3 cm in diameter, with liver cirrhosis treated with combination of radiofrequency ablation and continuous hepatic arterial infusion chemotherapy].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; | 2007 |