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fluorouracil and Chromosome-Defective Micronuclei

fluorouracil has been researched along with Chromosome-Defective Micronuclei in 6 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Health-care personnel handling antineoplastic drugs could be at risk for adverse health effects."1.51Antineoplastic drug occupational exposure: a new integrated approach to evaluate exposure and early genotoxic and cytotoxic effects by no-invasive Buccal Micronucleus Cytome Assay biomarker. ( Boccia, R; Buresti, G; Carbonari, D; Cavallo, D; Chiarella, P; Ciervo, A; Colosio, C; Delrio, P; Fresegna, AM; Iavicoli, S; Jemos, C; Maiello, R; Maiolino, P; Mandić-Rajčević, S; Marchetti, P; Omodeo Salè, E; Rubino, FM; Ursini, CL, 2019)
"5-fluorouracil induced an increase in micronucleus frequency, which could significantly be enhanced by the concurrent application of 2,6-dihydroxypyridine, an inhibitor of dihydropyrimidine dehydrogenase."1.29Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction. ( Kühnel, A; Podschun, B; Stopper, H, 1994)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ursini, CL1
Omodeo Salè, E1
Fresegna, AM1
Ciervo, A1
Jemos, C1
Maiello, R1
Buresti, G1
Colosio, C1
Rubino, FM1
Mandić-Rajčević, S1
Chiarella, P1
Carbonari, D1
Delrio, P1
Maiolino, P1
Marchetti, P1
Boccia, R1
Iavicoli, S1
Cavallo, D1
Araújo, APDC1
Mesak, C1
Montalvão, MF1
Freitas, ÍN1
Chagas, TQ1
Malafaia, G1
Kang, SJ1
Lee, YJ1
Kim, BM1
Kim, YJ1
Woo, HD1
Jeon, HK1
Chung, HW1
Truter, EJ1
Santos, AS1
Els, WJ1
Zúñiga-González, GM1
Gómez-Meda, BC1
Zamora-Perez, AL1
Ramos-Ibarra, ML1
Batista-González, CM1
Lemus-Varela, ML1
Rodríguez-Avila, JL1
Gallegos-Arreola, MP1
Stopper, H1
Kühnel, A1
Podschun, B1

Other Studies

6 other studies available for fluorouracil and Chromosome-Defective Micronuclei

ArticleYear
Antineoplastic drug occupational exposure: a new integrated approach to evaluate exposure and early genotoxic and cytotoxic effects by no-invasive Buccal Micronucleus Cytome Assay biomarker.
    Toxicology letters, 2019, Volume: 316

    Topics: Adult; Antineoplastic Agents; Biomarkers; Case-Control Studies; Deoxycytidine; DNA Glycosylases; Env

2019
Anti-cancer drugs in aquatic environment can cause cancer: Insight about mutagenicity in tadpoles.
    The Science of the total environment, 2019, Feb-10, Volume: 650, Issue:Pt 2

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Erythrocytes; Fl

2019
Effect of Bupleuri Radix extracts on the toxicity of 5-fluorouracil in HepG2 hepatoma cells and normal human lymphocytes.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 103, Issue:4

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Bupleurum; Cell Cycle; Cell Line, Tum

2008
Correlation between cell survival, clonogenic activity and micronuclei induction in DMBA-OC-1R cells treated with immunospecific albumin microspheres containing cisplatin and 5-fluorouracil.
    Cell biology international, 2002, Volume: 26, Issue:6

    Topics: Adenocarcinoma; Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell

2002
Micronucleated erythrocyte frequencies in old and new world primates: measurement of micronucleated erythrocyte frequencies in peripheral blood of Callithrix jacchus as a model for evaluating genotoxicity in primates.
    Environmental and molecular mutagenesis, 2005, Volume: 46, Issue:4

    Topics: Animals; Antineoplastic Agents; Callithrix; Cyclophosphamide; Cytarabine; Erythrocytes; Fluorouracil

2005
Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction.
    Biochemical and biophysical research communications, 1994, Sep-15, Volume: 203, Issue:2

    Topics: Animals; Binding Sites; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; L Cells; Liver;

1994