fluorouracil has been researched along with Chromosome-Defective Micronuclei in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Health-care personnel handling antineoplastic drugs could be at risk for adverse health effects." | 1.51 | Antineoplastic drug occupational exposure: a new integrated approach to evaluate exposure and early genotoxic and cytotoxic effects by no-invasive Buccal Micronucleus Cytome Assay biomarker. ( Boccia, R; Buresti, G; Carbonari, D; Cavallo, D; Chiarella, P; Ciervo, A; Colosio, C; Delrio, P; Fresegna, AM; Iavicoli, S; Jemos, C; Maiello, R; Maiolino, P; Mandić-Rajčević, S; Marchetti, P; Omodeo Salè, E; Rubino, FM; Ursini, CL, 2019) |
| "5-fluorouracil induced an increase in micronucleus frequency, which could significantly be enhanced by the concurrent application of 2,6-dihydroxypyridine, an inhibitor of dihydropyrimidine dehydrogenase." | 1.29 | Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction. ( Kühnel, A; Podschun, B; Stopper, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ursini, CL | 1 |
| Omodeo Salè, E | 1 |
| Fresegna, AM | 1 |
| Ciervo, A | 1 |
| Jemos, C | 1 |
| Maiello, R | 1 |
| Buresti, G | 1 |
| Colosio, C | 1 |
| Rubino, FM | 1 |
| Mandić-Rajčević, S | 1 |
| Chiarella, P | 1 |
| Carbonari, D | 1 |
| Delrio, P | 1 |
| Maiolino, P | 1 |
| Marchetti, P | 1 |
| Boccia, R | 1 |
| Iavicoli, S | 1 |
| Cavallo, D | 1 |
| Araújo, APDC | 1 |
| Mesak, C | 1 |
| Montalvão, MF | 1 |
| Freitas, ÍN | 1 |
| Chagas, TQ | 1 |
| Malafaia, G | 1 |
| Kang, SJ | 1 |
| Lee, YJ | 1 |
| Kim, BM | 1 |
| Kim, YJ | 1 |
| Woo, HD | 1 |
| Jeon, HK | 1 |
| Chung, HW | 1 |
| Truter, EJ | 1 |
| Santos, AS | 1 |
| Els, WJ | 1 |
| Zúñiga-González, GM | 1 |
| Gómez-Meda, BC | 1 |
| Zamora-Perez, AL | 1 |
| Ramos-Ibarra, ML | 1 |
| Batista-González, CM | 1 |
| Lemus-Varela, ML | 1 |
| Rodríguez-Avila, JL | 1 |
| Gallegos-Arreola, MP | 1 |
| Stopper, H | 1 |
| Kühnel, A | 1 |
| Podschun, B | 1 |
6 other studies available for fluorouracil and Chromosome-Defective Micronuclei
| Article | Year |
|---|---|
Antineoplastic drug occupational exposure: a new integrated approach to evaluate exposure and early genotoxic and cytotoxic effects by no-invasive Buccal Micronucleus Cytome Assay biomarker.
Topics: Adult; Antineoplastic Agents; Biomarkers; Case-Control Studies; Deoxycytidine; DNA Glycosylases; Env | 2019 |
Anti-cancer drugs in aquatic environment can cause cancer: Insight about mutagenicity in tadpoles.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Erythrocytes; Fl | 2019 |
Effect of Bupleuri Radix extracts on the toxicity of 5-fluorouracil in HepG2 hepatoma cells and normal human lymphocytes.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Bupleurum; Cell Cycle; Cell Line, Tum | 2008 |
Correlation between cell survival, clonogenic activity and micronuclei induction in DMBA-OC-1R cells treated with immunospecific albumin microspheres containing cisplatin and 5-fluorouracil.
Topics: Adenocarcinoma; Albumins; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell | 2002 |
Micronucleated erythrocyte frequencies in old and new world primates: measurement of micronucleated erythrocyte frequencies in peripheral blood of Callithrix jacchus as a model for evaluating genotoxicity in primates.
Topics: Animals; Antineoplastic Agents; Callithrix; Cyclophosphamide; Cytarabine; Erythrocytes; Fluorouracil | 2005 |
Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction.
Topics: Animals; Binding Sites; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; L Cells; Liver; | 1994 |