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fluorouracil and Chromosomal Triplication

fluorouracil has been researched along with Chromosomal Triplication in 4 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"A 56-year-old woman diagnosed with a poorly differentiated cecal adenocarcinoma with metastases to ovaries, omentum, and sigmoid colon went into remission after 12 cycles of infusional 5-fluorouracil, luecovorin, and oxaliplatin (FOLFOX-4 regimen)."3.73Oxaliplatin-related acute myelogenous leukemia. ( Carneiro, BA; Eldibany, M; Kaminer, L; Kaul, K; Locker, GY; Sreekantaiah, C, 2006)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fernandez, KS1
Baum, R1
Fung, B1
Yeager, N1
Leonis, MA1
Wagner, LM1
Tiao, G1
Ross, ME1
Carneiro, BA1
Kaminer, L1
Eldibany, M1
Sreekantaiah, C1
Kaul, K1
Locker, GY1
Terpstra, W1
Ploemacher, RE1
Prins, A1
van Lom, K1
Pouwels, K1
Wognum, AW1
Wagemaker, G1
Löwenberg, B1
Wielenga, JJ1
Carlson, PS1

Other Studies

4 other studies available for fluorouracil and Chromosomal Triplication

ArticleYear
Chemoresistant hepatoblastoma in a patient with mosaic trisomy 18 treated with orthotopic liver transplantation.
    Pediatric blood & cancer, 2011, Volume: 56, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Chromosomes, H

2011
Oxaliplatin-related acute myelogenous leukemia.
    The oncologist, 2006, Volume: 11, Issue:3

    Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C

2006
Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture.
    Blood, 1996, Sep-15, Volume: 88, Issue:6

    Topics: Acute Disease; Animals; Base Sequence; Chromosomes, Human, Pair 8; DNA Primers; Fluorouracil; Granul

1996
Notes on the mechanism of action of gibberellic acid.
    Nature: New biology, 1972, May-10, Volume: 237, Issue:71

    Topics: Amylases; Aneuploidy; Calcium; Diploidy; Edible Grain; Enzyme Induction; Fluorouracil; Genes; Geneti

1972