fluorouracil has been researched along with Chromosomal Triplication in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 56-year-old woman diagnosed with a poorly differentiated cecal adenocarcinoma with metastases to ovaries, omentum, and sigmoid colon went into remission after 12 cycles of infusional 5-fluorouracil, luecovorin, and oxaliplatin (FOLFOX-4 regimen)." | 3.73 | Oxaliplatin-related acute myelogenous leukemia. ( Carneiro, BA; Eldibany, M; Kaminer, L; Kaul, K; Locker, GY; Sreekantaiah, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandez, KS | 1 |
| Baum, R | 1 |
| Fung, B | 1 |
| Yeager, N | 1 |
| Leonis, MA | 1 |
| Wagner, LM | 1 |
| Tiao, G | 1 |
| Ross, ME | 1 |
| Carneiro, BA | 1 |
| Kaminer, L | 1 |
| Eldibany, M | 1 |
| Sreekantaiah, C | 1 |
| Kaul, K | 1 |
| Locker, GY | 1 |
| Terpstra, W | 1 |
| Ploemacher, RE | 1 |
| Prins, A | 1 |
| van Lom, K | 1 |
| Pouwels, K | 1 |
| Wognum, AW | 1 |
| Wagemaker, G | 1 |
| Löwenberg, B | 1 |
| Wielenga, JJ | 1 |
| Carlson, PS | 1 |
4 other studies available for fluorouracil and Chromosomal Triplication
| Article | Year |
|---|---|
Chemoresistant hepatoblastoma in a patient with mosaic trisomy 18 treated with orthotopic liver transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Chromosomes, H | 2011 |
Oxaliplatin-related acute myelogenous leukemia.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C | 2006 |
Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture.
Topics: Acute Disease; Animals; Base Sequence; Chromosomes, Human, Pair 8; DNA Primers; Fluorouracil; Granul | 1996 |
Notes on the mechanism of action of gibberellic acid.
Topics: Amylases; Aneuploidy; Calcium; Diploidy; Edible Grain; Enzyme Induction; Fluorouracil; Genes; Geneti | 1972 |