Page last updated: 2024-10-27

fluorouracil and Chromosomal Translocation

fluorouracil has been researched along with Chromosomal Translocation in 7 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Forty-six patients with cT4b esophageal cancer, including borderline cT4b lesions, were eligible."5.72Strategy Treatment of cT4b Esophageal Squamous Cell Carcinoma Using Docetaxel, Cisplatin, and 5-Fluorouracil. ( Ihara, K; Kikuchi, M; Kojima, K; Kubo, T; Morita, S; Muroi, H; Nakagawa, M; Nakajima, M; Nakamura, T; Takise, S; Yamaguchi, S, 2022)
"We report a breast cancer patient who developed acute myeloid leukemia (AML) one year following her adjuvant chemotherapy consisting of cyclophosphamide, adriamycin and 5-fluorouracil."3.73t(8;16) AML developed subsequent to breast cancer therapy. ( Akçali, Z; Boğa, S; DemIrhan, B; Karakuş, S; Sahin, FI; Yilmaz, Z, 2006)
"Forty-six patients with cT4b esophageal cancer, including borderline cT4b lesions, were eligible."1.72Strategy Treatment of cT4b Esophageal Squamous Cell Carcinoma Using Docetaxel, Cisplatin, and 5-Fluorouracil. ( Ihara, K; Kikuchi, M; Kojima, K; Kubo, T; Morita, S; Muroi, H; Nakagawa, M; Nakajima, M; Nakamura, T; Takise, S; Yamaguchi, S, 2022)
"A 60-yr-old woman with breast cancer underwent breast-conserving surgery followed by 6 cycles of adjuvant chemotherapy (cyclophosphamide, epirubicin, and fluorouracil) and radiation therapy (dose, 5,040 cGy to the left breast and a 1,000 cGy boost to the tumor bed)."1.36A case of therapy-related ALL with MLL gene rearrangement following treatment of breast cancer. ( Cho, J; Hur, M; Lee, CH; Lee, HG; Moon, HW; Yun, YM, 2010)
"Melphalan (MEL) was the only drug used in single-drug chemotherapy."1.29Cytogenetic findings in 111 ovarian cancer patients: therapy-related chromosome aberrations and heterochromatic variants. ( Friberg, LG; Granberg, S; Islam, MQ; Köpf, I; Levan, A; Levan, G, 1993)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's3 (42.86)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Nakajima, M1
Muroi, H1
Kikuchi, M1
Kubo, T1
Takise, S1
Ihara, K1
Nakagawa, M1
Morita, S1
Nakamura, T1
Yamaguchi, S1
Kojima, K1
Cho, J1
Hur, M1
Moon, HW1
Yun, YM1
Lee, CH1
Lee, HG1
Damodaran, S1
Bellavia, T1
Sait, SN1
Wang, ES1
Wetzler, M1
Khushalani, NI1
Lee, KC1
Hamstra, DA1
Bullarayasamudram, S1
Bhojani, MS1
Moffat, BA1
Dornfeld, KJ1
Ross, BD1
Rehemtulla, A1
Sahin, FI1
Yilmaz, Z1
Karakuş, S1
Boğa, S1
Akçali, Z1
DemIrhan, B1
Islam, MQ1
Köpf, I1
Levan, A1
Granberg, S1
Friberg, LG1
Levan, G1
Hao, SX1
Ren, R1

Other Studies

7 other studies available for fluorouracil and Chromosomal Translocation

ArticleYear
Strategy Treatment of cT4b Esophageal Squamous Cell Carcinoma Using Docetaxel, Cisplatin, and 5-Fluorouracil.
    Anticancer research, 2022, Volume: 42, Issue:7

    Topics: Cisplatin; Docetaxel; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fluorouracil; Humans

2022
A case of therapy-related ALL with MLL gene rearrangement following treatment of breast cancer.
    The Korean journal of laboratory medicine, 2010, Volume: 30, Issue:3

    Topics: Antibiotics, Antineoplastic; Blood Cell Count; Bone Marrow; Breast Neoplasms; Chemotherapy, Adjuvant

2010
Acute myeloid leukemia secondary to oxaliplatin treatment for esophageal cancer.
    Clinical colorectal cancer, 2012, Volume: 11, Issue:2

    Topics: Abnormal Karyotype; Adenocarcinoma; Antineoplastic Agents; Capecitabine; Clinical Trials, Phase II a

2012
Fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit.
    Gene therapy, 2006, Volume: 13, Issue:2

    Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Bystander Effect; Cell Line; Cytosine Deamin

2006
t(8;16) AML developed subsequent to breast cancer therapy.
    Hematology (Amsterdam, Netherlands), 2006, Volume: 11, Issue:3

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone M

2006
Cytogenetic findings in 111 ovarian cancer patients: therapy-related chromosome aberrations and heterochromatic variants.
    Cancer genetics and cytogenetics, 1993, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chil

1993
Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder.
    Molecular and cellular biology, 2000, Volume: 20, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; B-Lymphocytes; Base Sequence; Bone Marrow Transplantation;

2000